Research at the IMP is driven by scientific curiosity. Research questions are chosen by each principal investigator and the entire institute works towards supporting the labs’ search for answers. Below, you can find a short summary of the most burning questions that fuel our passion for science and our dedication to research.
How can light-based methods provide maximal information on biological processes?
How do transcription factors control the development of B cells and plasma cells?
How does the structure of chaperones and proteases that control protein quality relate to their function, and how could this be used to tackle disease and antibiotic resistance?
How does the innate immune system recognize pathogens and induce inflammation?
How are molecular machines designed to fulfil their productive function? How is the failure of such machines prevented?
What is the neural basis of emotions and how do genes and drugs control them?
What are the molecular mechanisms behind cancer? How can we exploit the vulnerabilities of cancer cells to find opportunities for new therapies?
What are the molecular mechanisms that drive fertilisation and embryonic development?
How do B cells control targeted mutation in the antibody genes to generate a vast repertoire of high-affinity antibodies?
How can one cell divide into two identical daughter cells in a way that ensures the genome is precisely copied and partitioned?
How is mRNA processing regulated, and how do these mechanisms work in atomic detail?
How is gene regulation and therefore the development of our bodies encoded in our DNA sequence?
What gives a stem cell its ability to regenerate into a whole limb, and why is that ability lost in mammals?
Joris van der Veeken
What are the mechanisms that direct T cell differentiation and function?
Why are cancer cells immortal, what genes do they depend on, and how can we exploit cancer-specific vulnerabilities for cancer therapy?
Adjunct investigators are principal investigators who have moved with their labs from the IMP, but maintain and affiliated status for a certain period of time to support the transition.
How do animals sense the earth’s magnetic field? and what genes are required to build a human brain?
How can imaging technologies for the brain-wide recording and manipulation of neural activity be developed to understand how brain structure leads to function?
How do neural circuits in the brain compute information to produce behaviour?