Browse the latest publications and preprints from the IMP. Here we list the most recent publications with IMP scientists as first- or corresponding authors in chronological order.
Enhancers display constrained sequence flexibility and context-specific modulation of motif function.Genome Res.
EVI1 drives leukemogenesis through aberrant ERG activation.Blood. 141(5):453-466
Systematic identification and characterization of repressive domains in Drosophila transcription factors.EMBO J. 42(3):e112100
A molecular network of conserved factors keeps ribosomes dormant in the egg.Corresponding preprint Nature.
The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.Front Immunol. 13:859598
Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.Cancer Discov. 13(1):70-84
Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.Structure. 31(1):4-19
SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection.Corresponding preprint Exp Mol Med.
Artificial Insemination in Axolotl.Methods Mol Biol. 2562:417-423
Baculovirus Production and Infection in Axolotls.Methods Mol Biol. 2562:369-387
Chromosome Conformation Capture for Large Genomes.Methods Mol Biol. 2562:291-318
Navigation and Use of Custom Tracks within the Axolotl Genome Browser.Methods Mol Biol. 2562:273-289
Ethyl Cinnamate-Based Tissue Clearing Strategies.Methods Mol Biol. 2562:123-133
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers.Mol Cell. 82(19):3598-3612.e7
Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.Front Immunol. 13:979606
A self-generated Toddler gradient guides mesodermal cell migration.Corresponding preprint Sci Adv. 8(37):eadd2488
DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations.Science. 377(6612):eabj5502
Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration.Science. 377(6610):eabp9262
Distinct features in fish Bouncer proteins determine sperm-egg compatibilitybioRxiv . 506233
Structural basis of mRNA maturation: Time to put it together.Curr Opin Struct Biol. 75:102431
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.J Exp Med. 219(9)
Mechanism-based combination therapies for metastatic cancer.Sci Transl Med. 14(655):eadd0887
The specialist in regeneration-the Axolotl-a suitable model to study bone healing?NPJ Regen Med. 7(1):35
Inducible and tissue-specific cell labeling in Cre-ERT2 transgenic Xenopus lines.Dev Growth Differ. 64(5):243-253
BacPROTACs mediate targeted protein degradation in bacteria.Corresponding preprint Cell. 185(13):2338-2353.e18
Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.Cold Spring Harb Perspect Biol. 14(6)
Differential cofactor dependencies define distinct types of human enhancers.Nature. 606(7913):406-413
Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration.Elife. 11
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers.Nat Genet. 54(5):613-624
The Axolotl's journey to the modern molecular era.Curr Top Dev Biol. 147:631-658
The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.EMBO J. 41(7):e108397
Proteome-scale identification of transcriptional activators in human cells.Mol Cell. 82(3):497-499
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.J Exp Med. 219(2)
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.Nat Immunol. 23(1):122-134
Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.Nat Cancer. 2(7):693-708
The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.Corresponding preprint Front Cell Dev Biol. 9:806982
Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.Br J Dermatol.
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.Nature. 599(7885):491-496
The cellular and signaling dynamics of salamander limb regeneration.Curr Opin Cell Biol. 73:117-123
Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.Cell. 184(21):5448-5464.e22
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.Cancer Discov. 11(11):2868-2883
Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timingbioRxiv . 2021.11.03.467109
miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.Sci Adv. 7(42):eabh1434
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.Corresponding preprint Proc Natl Acad Sci U S A. 118(39)
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.Corresponding preprint Elife. 10
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.Nat Chem Biol.
The Fertilization Enigma: How Sperm and Egg Fuse.Annu Rev Cell Dev Biol.
Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanomaNature Cancer . 2:693–708
Genome folding through loop extrusion by SMC complexes.Nat Rev Mol Cell Biol. 22(7):445-464
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.Sci Immunol. 6(61)
Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.PLoS Genet. 17(2):e1009390
Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.Elife. 10
E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATPbioRxiv. 2021.05.10.443411
Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.medRxiv. 2021.01.19.21250079
Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscapebioRxiv . 2022.05.21.492925