IMP scientists publish 60 to 90 scientific papers in international peer-review journals every year. This evidence for the productivity and high scientific standard of the IMP is listed here in full – a directory of all scientific publications by IMP scientists since the establishment of the institute, organised by years and research groups.
Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals.
Elife. 13Rational correction of pathogenic conformational defects in HTRA1.
Nat Commun. 15(1):5944Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.
Mol Ther Methods Clin Dev. 32(3):101280Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis.
bioRxiv.Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase
bioRxiv . 10.1101/2024.08.07.607117Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis
bioRxiv . 10.1101/2024.06.11.598492v1Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism.
Nat Aging. 4(1):80-94Cancer Evolution: A Multifaceted Affair.
Cancer Discov. 14(1):36-48Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo.
Nature. 626(7997):207-211Genomic surveillance of SARS-CoV-2 evolution by a centralised pipeline and weekly focused sequencing, Austria, January 2021 to March 2023.
Euro Surveill. 29(23)Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis.
Blood. 143(11):1006-1017Label-Free Sample Preparation for Single-Cell Proteomics.
Methods Mol Biol. 2817:1-7Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Nat Commun. 15(1):2005Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Nat Commun. 15(1):5409A chromatin code for limb segment identity in axolotl limb regeneration.
Dev Cell. 59(16):2239-2253.e9Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition.
Dev Cell. 59(15):1940-1953.e10The molecular mechanisms underpinning maternal mRNA dormancy.
Biochem Soc Trans.eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
Show Preprint EMBO Rep. 25(1):404-427Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types.
EMBO J. 43(12):2506-2525ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum.
Cell Stem Cell. 31(6):866-885.e14Micropillar arrays, wide window acquisition and AI-based data analysis improve comprehensiveness in multiple proteomic applications.
Nat Commun. 15(1):1019Proteome-scale tagging and functional screening in mammalian cells by ORFtag.
Nat Methods.Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation.
Diagnostics (Basel). 14(15)Pulling the strings on solid-to-liquid phase transitions in cell collectives.
Curr Opin Cell Biol. 86:102310Sororin is an evolutionary conserved antagonist of WAPL.
Nat Commun. 15(1):4729tRNA expression and modification landscapes, and their dynamics during zebrafish embryo development.
Show Preprint Nucleic Acids Res.Structural basis of human U5 snRNP late biogenesis and recycling.
Nat Struct Mol Biol.Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation
bioRxiv . 10.1101/2024.04.23.590688A dual ribosomal system in the zebrafish soma and germline
bioRxiv. doi:10.1101/2024.08.29.610041TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases
bioRxiv . 10.1101/2024.05.16.594269UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome.
Nat Commun. 15(1):6272Mechanism for the initiation of spliceosome disassembly.
Nature. 632(8024):443-450Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice.
Nat Commun. 15(1):4963Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.
Structure. 31(1):4-19SPOC domain proteins in health and disease.
Genes Dev. 37(5-6):140-170Transcription shapes 3D chromatin organization by interacting with loop extrusion.
Show Preprint Proc Natl Acad Sci U S A. 120(11):e2210480120Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments.
Sci Rep. 13(1):8100Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase.
EMBO J. :e113475Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.
Immunity. 56(6):1341-1358.e11SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.
Show Preprint Cell Rep. 42(2):112070MS Annika 2.0 Identifies Cross-Linked Peptides in MS2-MS3-Based Workflows at High Sensitivity and Specificity.
J Proteome Res.Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat Struct Mol Biol. 30(11):1663-1674SBNO2 is a critical mediator of STAT3-driven hematological malignancies.
Blood.X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.
EMBO Mol Med. 15(1):e14557An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo.
Sci Rep. 13(1):6745Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Nat Metab.PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Nat Metab. 5(3):495-515A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination.
Show Preprint Mol Cell. 83(5):681-697.e7An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.
Mol Cell Proteomics. :100665MYC determines lineage commitment in kras driven primary liver cancer development.
J Hepatol.CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion.
Show Preprint Nature. 616(7958):822-827How do molecular motors fold the genome?
Science. 382(6671):646-648Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.
Dev Cell. 58(1):3-17.e8A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates
bioRxiv. 2023.07.27.550750Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.
Life Sci Alliance. 6(7)A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.
EMBO J. :e113616MS Ana: Improving Sensitivity in Peptide Identification with Spectral Library Search.
J Proteome Res. 22(2):462-470ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.
Nat Commun. 14(1):5709Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science. 379(6637):1117-1123Transposon waves at the water-to-land transition.
Curr Opin Genet Dev. 81:102059TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana.
Nat Plants.Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.
Show Preprint Nat Commun. 14(1):3506Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development.
J Exp Med. 220(12)Reply to: Assessment of 3D MINFLUX data for quantitative structural biology in cells.
Nat Methods. 20(1):52-54Generating human blastoids modeling blastocyst-stage embryos and implantation.
Nat Protoc.Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus.
EMBO J. 42(15):e112741Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells.
Nat Commun. 14(1):2316Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
EMBO J. 42(16):e113348Precision RNAi using synthetic shRNAmir target sites.
Elife. 12Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Cell. 186(10):2176-2192.e22A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
Dev Cell.Topological morphogenesis of neuroepithelial organoids.
Nat Phys. 19(2):177-183Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila.
Science. 381(6654):198-204Cohesin and CTCF do not assemble TADs in Xenopus sperm and male pronuclei.
Genome Res. 33(12):2094-107Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.
J Exp Med. 220(1)Chromosome Conformation Capture for Large Genomes.
Methods Mol Biol. 2562:291-318Systematic identification and characterization of repressive domains in Drosophila transcription factors.
EMBO J. 42(3):e112100The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.
Nat Commun. 14(1):5871Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chromatin and DNA sequence signals
Show Preprint BioRxiv.A molecular network of conserved factors keeps ribosomes dormant in the egg.
Show Preprint Nature.Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.
Cancer Discov. 13(1):70-84Single-cell brain organoid screening identifies developmental defects in autism.
Nature. 621(7978):373-380StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement.
Nat Protoc. 18(1):239-264Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix.
EMBO J. 42(22):e113213Ethyl Cinnamate-Based Tissue Clearing Strategies.
Methods Mol Biol. 2562:123-133Label-free single cell proteomics utilizing ultrafast LC and MS instrumentation: A valuable complementary technique to multiplexing.
Proteomics. :e2200162Improving single cell proteomics experiments: how can we best utilize latest-generation data acquisition and MS instrument architecture?
Expert Rev Proteomics. :1-3Robust and Easy-to-Use One-Pot Workflow for Label-Free Single-Cell Proteomics.
Anal Chem. 95(9):4435-4445Immunopeptidomics in the Era of Single-Cell Proteomics.
Biology (Basel). 12(12)Cooperation between bHLH transcription factors and histones for DNA access.
Nature. 619(7969):385-393Baculovirus Production and Infection in Axolotls.
Methods Mol Biol. 2562:369-387Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms.
Mol Cell.CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.
Cell Rep. 42(9):113084Navigation and Use of Custom Tracks within the Axolotl Genome Browser.
Methods Mol Biol. 2562:273-289mRNA recognition and packaging by the human transcription-export complex.
Nature.Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.
EMBO J. :e112053Enhancers display constrained sequence flexibility and context-specific modulation of motif function.
Genome Res.In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.
Nat Methods. 20(12):2034-2047Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species.
Show Preprint Nucleic Acids Res.Multi-chamber cardioids unravel human heart development and cardiac defects.
Cell. 186(25):5587-5605.e27EVI1 drives leukemogenesis through aberrant ERG activation.
Blood. 141(5):453-466SPOP targets the immune transcription factor IRF1 for proteasomal degradation.
Elife. 12HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Show Preprint Elife. 12Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns.
EMBO J. :e113519Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids.
Elife. 12Artificial Insemination in Axolotl.
Methods Mol Biol. 2562:417-423Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
Nat Commun. 14(1):5341ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
Nat Cell Biol.A High-Sensitivity Low-Nanoflow LC-MS Configuration for High-Throughput Sample-Limited Proteomics.
Anal Chem. 95(51):18673-18678Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
Nat Struct Mol Biol. 29(2):130-142The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.
Show Preprint Front Cell Dev Biol. 9:806982DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.
Nat Genet.Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.
Ann N Y Acad Sci. 1510(1):79-99DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers.
Nat Genet. 54(5):613-624MCM complexes are barriers that restrict cohesin-mediated loop extrusion.
Nature.The Axolotl's journey to the modern molecular era.
Curr Top Dev Biol. 147:631-658Amplification of human interneuron progenitors promotes brain tumors and neurological defects.
Science. 375(6579):eabf5546Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration.
Elife. 11The HUSH complex controls brain architecture and protocadherin fidelity.
Sci Adv. 8(44):eabo7247Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
J Med Chem. 65(6):4893-4908Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers.
Mol Cell. 82(19):3598-3612.e7Muscles are barely required for the patterning and cell dynamics in axolotl limb regeneration.
Front Genet. 13:1036641NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Show Preprint Genes Dev. 36(5-6):348-367Moyamoya disease: diagnosis and interventions.
Lancet Neurol.Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.
Nucleic Acids Res. 50(6):3379-3393The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.
EMBO J. 41(7):e108397Protocol for Human Blastoids Modeling Blastocyst Development and Implantation.
J Vis Exp. (186)Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.
J Exp Med. 219(9)Cryo-EM structure of the plant 26S proteasome.
Plant Commun. 3(3):100310Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.
Nat Commun. 13(1):6949A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.
Show Preprint Front Mol Biosci. 9:801309Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients.
Hemasphere. 6(11):e792Inducible and tissue-specific cell labeling in Cre-ERT2 transgenic Xenopus lines.
Dev Growth Differ. 64(5):243-253Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration.
Science. 377(6610):eabp9262Mimicked synthetic ribosomal protein complex for benchmarking crosslinking mass spectrometry workflows.
Nat Commun. 13(1):3975BacPROTACs mediate targeted protein degradation in bacteria.
Show Preprint Cell. 185(13):2338-2353.e18Nucleome programming is required for the foundation of totipotency in mammalian germline development.
EMBO J. :e110600Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
bioRxiv . 2022.09.23.509019Proteome-scale identification of transcriptional activators in human cells.
Mol Cell. 82(3):497-499Differential cofactor dependencies define distinct types of human enhancers.
Nature. 606(7913):406-413Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
Show Preprint Commun Biol. 5(1):332Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.
Dev Dyn. 251(6):913-921Mechanism-based combination therapies for metastatic cancer.
Sci Transl Med. 14(655):eadd0887Tig1 regulates proximo-distal identity during salamander limb regeneration.
Nat Commun. 13(1):1141Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.
Cold Spring Harb Perspect Biol. 14(6)Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury.
Life (Basel). 12(9)Cornelia de Lange syndrome mutations in NIPBL can impair cohesin-mediated DNA loop extrusion.
Proc Natl Acad Sci U S A. 119(18):e2201029119Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.
Science. 378(6615):eabn5637BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia.
Am J Hematol. 97(9):1215-1225DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations.
Science. 377(6612):eabj5502Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.
Front Immunol. 13:979606Interferons reshape the 3D conformation and accessibility of macrophage chromatin.
iScience. 25(3):103840The specialist in regeneration-the Axolotl-a suitable model to study bone healing?
NPJ Regen Med. 7(1):35SMC complexes can traverse physical roadblocks bigger than their ring size.
Show Preprint Cell Rep. 41(3):111491Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Nat Struct Mol Biol. 29(9):942-953Sororin is an evolutionary conserved antagonist of WAPL
bioRxiv . 2022.10.24.513534Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.
J Exp Med. 219(2)An allosteric HTRA1-calpain 2 complex with restricted activation profile.
Proc Natl Acad Sci U S A. 119(14):e2113520119Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscape
bioRxiv . 2022.05.21.492925Deep Proteome Profiling with Reduced Carryover Using Superficially Porous Microfabricated nanoLC Columns.
Anal Chem.A self-generated Toddler gradient guides mesodermal cell migration.
Show Preprint Sci Adv. 8(37):eadd2488Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets.
EMBO J. :e111118Structural basis of mRNA maturation: Time to put it together.
Curr Opin Struct Biol. 75:102431Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.
Nat Cancer. 3(7):821-836The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.
Front Immunol. 13:859598SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection.
Show Preprint Exp Mol Med.Deep Single-Shot NanoLC-MS Proteome Profiling with a 1500 Bar UHPLC System, Long Fully Porous Columns, and HRAM MS.
J Proteome Res. 21(10):2545-2551Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.
Nat Immunol. 23(1):122-134E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
bioRxiv. 2021.05.10.443411Gaze mechanisms enabling the detection of faint stars in the night sky.
Eur J Neurosci. 54(4):5357-5367PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Nat Commun. 12(1):6078The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Mol Cell. 81(12):2520-2532.e16The expression, localisation and interactome of pigeon CRY2.
Sci Rep. 11(1):20293The cellular and signaling dynamics of salamander limb regeneration.
Curr Opin Cell Biol. 73:117-123Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.
Cell. 184(21):5448-5464.e22Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.
Cancers (Basel). 13(15)Visualization of loop extrusion by DNA nanoscale tracing in single human cells
bioRxiv . 2021.04.12.439407Systematic refinement of gene annotations by parsing mRNA 3' end sequencing datasets.
Methods Enzymol. 655:205-223Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle.
Elife. 10Down-regulation of A20 promotes immune escape of lung adenocarcinomas.
Sci Transl Med. 13(601)Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.
PLoS Genet. 17(2):e1009390Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Sci Immunol. 6(61)Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users.
EMBO Rep. 22(6):e52626Comparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition.
Mol Cell Proteomics. :100177Quantitative Accuracy and Precision in Multiplexed Single-Cell Proteomics.
Anal Chem.Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.
Elife. 10Genome folding through loop extrusion by SMC complexes.
Nat Rev Mol Cell Biol. 22(7):445-464AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
Nature. 599(7885):491-496The Fertilization Enigma: How Sperm and Egg Fuse.
Annu Rev Cell Dev Biol.Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.
Nat Commun. 12(1):6060MS Amanda 2.0: Advancements in the standalone implementation.
Rapid Commun Mass Spectrom. 35(11):e9088Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Mol Cell. 81(4):830-844.e13Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue.
Mucosal Immunol. 14(3):585-593The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.
Show Preprint Proc Natl Acad Sci U S A. 118(39)Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing
bioRxiv . 2021.11.03.467109Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.
Immunity. 54(9):2005-2023.e10HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat Chem Biol.Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect.
Mol Psychiatry. 26(2):534-544Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos
bioRxiv . 2021.11.03.467172miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.
Sci Adv. 7(42):eabh1434Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma
Nature Cancer . 2:693–708Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.
Nat Cancer. 2(7):693-708A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.
J Exp Med. 218(1)McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
Show Preprint Elife. 10Cardioids reveal self-organizing principles of human cardiogenesis.
Cell. 184(12):3299-3317.e22Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.
EMBO J. :e108375MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells.
Proc Natl Acad Sci U S A. 118(37)Human blastoids model blastocyst development and implantation.
Nature.Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.
medRxiv. 2021.01.19.21250079Concepts and functions of small RNA pathways in C. elegans.
Curr Top Dev Biol. 144:45-89Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests.
Front Pediatr. 9:721518Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.
Cell Stem Cell. 28(8):1362-1379.e7Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.
Br J Dermatol.Fibroblast dedifferentiation as a determinant of successful regeneration.
Dev Cell. 56(10):1541-1551.e6A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells.
Sci Rep. 11(1):12973Toward whole tissue imaging of axolotl regeneration.
Dev Dyn. 250(6):800-806Cleavable Cross-Linkers and Mass Spectrometry for the Ultimate Task of Profiling Protein-Protein Interaction Networks in Vivo.
J Proteome Res. 20(1):78-93Giant lungfish genome elucidates the conquest of land by vertebrates.
Nature. 590(7845):284-289Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation.
Nat Commun. 12(1):1546RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.
Nature. 589(7842):442-447Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation.
PLoS One. 16(5):e0244038How DNA loop extrusion mediated by cohesin enables V(D)J recombination.
Curr Opin Cell Biol. 70:75-83DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations
bioRxiv . 2021.05.29.446276A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
Nucleic Acids Res. 49(8):4350-4370MS Annika: A New Cross-Linking Search Engine.
J Proteome Res. 20(5):2560-2569Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
Nat Commun. 12(1):3483The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
Show Preprint Elife. 10Structure of the peripheral arm of a minimalistic respiratory complex I.
Structure.The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.
Proc Natl Acad Sci U S A. 118(15)Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.
Genes Dev. 35(5-6):392-409Insights into gene regulation: From regulatory genomic elements to DNA-protein and protein-protein interactions.
Curr Opin Cell Biol. 70:58-66Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.
Cancer Discov. 11(11):2868-2883Ultrasensitive NanoLC-MS of Subnanogram Protein Samples Using Second Generation Micropillar Array LC Technology with Orbitrap Exploris 480 and FAIMS PRO.
Anal Chem. 93(25):8704-8710Self-organized cell migration across scales - from single cell movement to tissue formation.
Development. 148(7)Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters.
Nat Biotechnol. 39(2):174-178Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.
Hemasphere. 5(3):e536Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
Blood. 138(15):1345-1358Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.
PLoS Genet. 17(7):e1009663GSK3-mediated phosphorylation of DEK3 regulates chromatin accessibility and stress tolerance in Arabidopsis.
FEBS J.Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics.
Commun Biol. 4(1):732Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.
Euro Surveill. 26(34)Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study.
Lancet Reg Health Eur. 5:100086Cellular Control of Protein Turnover via the Modification of the Amino Terminus.
Int J Mol Sci. 22(7)Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.
Nat Commun. 12(1):3132Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife. 9MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cell Reports. 14(3):374-389Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
PLoS Genet. 16(10):e1009151Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
ACS Cent Sci. 6(7):1223-1230A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes.
Nat Commun. 11(1):742Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.
Nat Commun. 11(1):3101Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.
Cancer Discov. 10(10):1500-1513The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.
Blood. 136(8):957-973Combinatorial Action of Temporally Segregated Transcription Factors.
Dev Cell. 55(4):483-499.e7MicroRNAs: From Mechanism to Organism.
Front Cell Dev Biol. 8:409Two MicroRNAs Are Sufficient for Embryonic Patterning in C. elegans.
Curr Biol. 30(24):5058-5065.e5A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.
Science. 370(6519):935-941Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
EMBO J. 39(24):e103303Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings.
J R Soc Interface. 17(173):20200459Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling.
Nat Metab. 2(1):126Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction.
Nat Genet. 52(5):505-515A Data Structure for Real-Time Aggregation Queries of Big Brain Networks.
Neuroinformatics. 18(1):131-149Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.
Cell Death Dis. 11(7):499Species-specific mechanisms during fertilization.
Curr Top Dev Biol. 140:121-144Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Nature. 584(7819):142-147The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.
Sci Adv. 6(33):eabb9110Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales.
Neuron. 105(3):562-576.e9Brain-wide representations of ongoing behavior: a universal principle?
Curr Opin Neurobiol. 64:60-69The amygdala instructs insular feedback for affective learning.
Elife. 9SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.
Cell Rep. 32(12):108184HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Cancer Res. 80(14):3009-3022DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster.
Bio Protoc. 10(21):e3809The H3 histone chaperone NASPSIM3 escorts CenH3 in Arabidopsis.
Plant J. 101(1):71-86A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse.
PLoS Genet. 16(11):e1009104LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.
EMBO Mol Med. 12(11):e12525Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.
Cell. 180(3):536-551.e17Repression of the B cell identity factor Pax5 is not required for plasma cell development.
J Exp Med. 217(11)Neuronal circuits and the magnetic sense: central questions.
J Exp Biol. 223(Pt 21)Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Nat Struct Mol Biol. 27(6):550-560AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes.
Redox Biol. 29:101393Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides.
J Proteome Res. 19(5):2071-2079Activation by substoichiometric inhibition.
Proc Natl Acad Sci U S A. 117(3):1414-1418Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.
Mol Syst Biol. 16(2):e8985Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles.
Nat Methods. 17(7):708-716Conformation of sister chromatids in the replicated human genome.
Nature. 586(7827):139-144PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
J Biol Chem. 295(1):146-157A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.
Sci Rep. 10(1):915Introducing www.axolotl-omics.org - an integrated -omics data portal for the axolotl research community.
Exp Cell Res. 394(1):112143Identification of ALK in Thinness.
Cell. 181(6):1246-1262.e22A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.
Sci Adv. 6(22):eaba0365Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.
Proc Natl Acad Sci U S A. 117(36):22101-22112ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science. 369(6503):524-530Stress peptides sensitize fear circuitry to promote passive coping.
Mol Psychiatry. 25(2):428-441Structure of the human core transcription-export complex reveals a hub for multivalent interactions.
Elife. 9Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.
Oncotarget. 11(9):875-890CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.
Blood. 136(4):387-400A Human Retinal Pigment Epithelium-Based Screening Platform Reveals Inducers of Photoreceptor Outer Segments Phagocytosis.
Stem Cell Reports. 15(6):1347-1361Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes.
J Cell Biol. 219(4)Quantifying the heterogeneity of macromolecular machines by mass photometry.
Nat Commun. 11(1):1772Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.
Front Cell Dev Biol. 8:622308A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.
Elife. 9Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.
Cell Rep. 32(3):107929STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance. 3(7)ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.
Elife. 9Structure-function analysis of microRNA 3'-end trimming by Nibbler.
Proc Natl Acad Sci U S A. 117(48):30370-30379Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells.
Sci Adv. 6(14):eaax5692The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.
Elife. 8The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
PLoS Genet. 15(7):e1008268The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
Nat Struct Mol Biol. 26(8):720-731Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
EMBO J. 38(2)Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.
Mol Cell. 75(2):252-266.e8Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature. 572(7769):E18The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.
Biol Open. 8(7)DNA loop extrusion by human cohesin.
Science. 366(6471):1338-1345apQuant: Accurate Label-Free Quantification by Quality Filtering.
J Proteome Res. 18(1):535-541Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Nat Immunol. 20(9):1161-1173Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 14(8):2597Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling
Nature Metabolism. 1:350–359BrainTrawler: A visual analytics framework for iterative exploration of heterogeneous big brain data
Computer & Graphics. 82:304-320Spectral Clustering Improves Label-Free Quantification of Low-Abundant Proteins.
J Proteome Res. 18(4):1477-1485Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment.
Front Immunol. 10:2746Transcriptional cofactors display specificity for distinct types of core promoters.
Nature. 570(7759):122-126Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids.
Endocrinology. 160(10):2282-2297Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun. 10(1):4781Functional-genetic approaches to understanding drug response and resistance.
Curr Opin Genet Dev. 54:41-47Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.
Trends Mol Med. 25(9):760-774Absolute quantification of cohesin, CTCF and their regulators in human cells.
Elife. 8Evolution of neuronal anatomy and circuitry in two highly divergent nematode species.
Elife. 8First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.
Anal Chem. 91(11):6953-6961Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Mol Cell. 74(1):158-172.e9Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Elife. 8A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish.
Dev Neurobiol. 79(5):424-436No evidence for a magnetite-based magnetoreceptor in the lagena of pigeons.
Curr Biol. 29(1):R14-R15Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.
Development. 146(3)Sequencing cell-type-specific transcriptomes with SLAM-ITseq.
Nat Protoc. 14(8):2261-2278Publisher Correction: Sequencing cell-type-specific transcriptomes with SLAM-ITseq.
Nat Protoc. 14(8):2597Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell Stem Cell. 25(2):258-272.e9A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Nat Commun. 10(1):4741Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets.
BMC Bioinformatics. 20(1):258STARR-seq and UMI-STARR-seq: Assessing Enhancer Activities for Genome-Wide-, High-, and Low-Complexity Candidate Libraries.
Curr Protoc Mol Biol. 128(1):e105The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.
Genes Dev. 33(11-12):669-683All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell Death Dis. 10(12):944A Putative Mechanism for Magnetoreception by Electromagnetic Induction in the Pigeon Inner Ear.
Curr Biol. 29(23):4052-4059.e4SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.
Am J Physiol Renal Physiol. 316(1):F173-F185Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.
Mol Cell. 74(5):1069-1085.e11Tinbergen's challenge for the neuroscience of behavior.
Proc Natl Acad Sci U S A. 116(20):9704-9710Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast.
Cold Spring Harb Perspect Biol. 11(5)A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Nat Commun. 10(1):2921Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure. 27(7):1124-1136.e4Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.
EMBO J. 38(19):e101233Structural analysis of urinary light chains and proteomic analysis of hyaline tubular casts in light chain associated kidney disorders.
PeerJ. 7:e7819A role for miR-132 in learned safety.
Sci Rep. 9(1):528Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism.
EMBO J. 38(15):e101433Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Nat Immunol. 20(11):1517-1529MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Nat Genet. 51(6):990-998Self-organization of parS centromeres by the ParB CTP hydrolase.
Science. 366(6469):1129-1133Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography.
Anal Chem. 91(22):14203-14207Optimized Fragmentation Improves the Identification of Peptides Cross-Linked by MS-Cleavable Reagents.
J Proteome Res. 18(3):1363-1370Structure of McsB, a protein kinase for regulated arginine phosphorylation.
Nat Chem Biol. 15(5):510-518Spectral recording of gene expression history by fluorescent timer protein.
Biotechniques. 67(4):154-164Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.
EMBO Mol Med. 11(8):e9266Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.
Nat Protoc. 14(3):756-780Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.
Trends Cell Biol. 29(2):117-134Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc Natl Acad Sci U S A. 116(35):17280-17289Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy.
Cell. 177(4):1050-1066.e14Human blood vessel organoids as a model of diabetic vasculopathy.
Nature. 565(7740):505-510A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates.
PeerJ. 7:e8218N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.
PLoS Biol. 17(7):e3000373Pooled Generation of Lentiviral Tetracycline-Regulated microRNA Embedded Short Hairpin RNA Libraries.
Hum Gene Ther Methods. 29(1):16-29Cell-type specific sequencing of microRNAs from complex animal tissues.
Nat Methods. 15(4):283-289A high-throughput method to identify trans-activation domains within transcription factor sequences.
EMBO J. 37(16)Epigenetic regulation of brain region-specific microglia clearance activity.
Nat Neurosci. 21(8):1049-1060CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Cancer Discov. 8(7):884-897Human tripartite motif protein 52 is required for cell context-dependent proliferation.
Oncotarget. 9(17):13565-13581Experimental and computational framework for a dynamic protein atlas of human cell division.
Nature. 561(7723):411-415Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.
Genes Dev. 32(3-4):202-223Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Cell Stem Cell. 22(4):543-558.e12The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature. 563(7732):564-568CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction.
J Proteome Res. 17(8):2581-2589PhoStar: Identifying Tandem Mass Spectra of Phosphorylated Peptides before Database Search.
J Proteome Res. 17(1):290-295The IAP family member BRUCE regulates autophagosome-lysosome fusion.
Nat Commun. 9(1):599Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds.
J R Soc Interface. 15(145)Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 13(12):2908-2943Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation.
EMBO J. 37(8)Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.
Dev Biol. 433(1):47-60Predicting functional neuroanatomical maps from fusing brain networks with genetic information.
Neuroimage. 170:113-120Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.
Science. 362(6413)The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Oncogene. 37(20):2687-2701Dorsal tegmental dopamine neurons gate associative learning of fear.
Nat Neurosci. 21(7):952-962Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Nat Neurosci. 21(2):207-217Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Nat Neurosci. 21(8):1139A new era of proactive melanoma therapy: hit hard, hit early.
Br J Dermatol. 178(4):817-820Eukaryotic core promoters and the functional basis of transcription initiation.
Nat Rev Mol Cell Biol. 19(10):621-637Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.
Stem Cell Reports. 11(2):537-551Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
Cell. 172(3):454-464.e11UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
Nat Commun. 9(1):484The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Science. 361(6406):1029-1033Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia).
G3 (Bethesda). 8(5):1391-1398The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.
EMBO J. 37(15)Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations.
Philos Trans R Soc Lond B Biol Sci. 373(1758)Sensorimotor Integration for Decision Making: How the Worm Steers.
Neuron. 97(2):258-260Control of B-1a cell development by instructive BCR signaling.
Curr Opin Immunol. 51:24-31Cryptochrome: The magnetosensor with a sinister side?
PLoS Biol. 16(10):e3000018Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".
Elife. 7Ectopic otoconial formation in the lagena of the pigeon inner ear.
Biol Open. 7(8)SLAM-ITseq: sequencing cell type-specific transcriptomes without cell sorting.
Development. 145(13)Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
Stem Cell Reports. 10(6):1751-1765Senescence-associated reprogramming promotes cancer stemness.
Nature. 553(7686):96-100CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.
Blood. 132(18):1936-1950Resolving systematic errors in widely used enhancer activity assays in human cells.
Nat Methods. 15(2):141-149SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.
Science. 360(6390):800-805The axolotl genome and the evolution of key tissue formation regulators.
Nature. 554(7690):50-55Author Correction: The axolotl genome and the evolution of key tissue formation regulators.
Nature. 559(7712):E2Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.
Dev Biol. 433(2):262-275Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.
Nat Protoc. 13(3):478-494Reply to 'Defining distance restraints in HADDOCK'.
Nat Protoc. 13(7):1503-1505Author Correction: Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.
Nat Protoc. 13(7):1724Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.
Plant J. 93(1):17-33Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.
Leukemia. 32(4):1016-1022Prespliceosome structure provides insights into spliceosome assembly and regulation.
Nature. 559(7714):419-422Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing in Caenorhabditis elegans.
Bio Protoc. 8(1)A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans.
Lab Chip. 18(3):505-513Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe.
J Cell Sci. 131(13)Necroptosis microenvironment directs lineage commitment in liver cancer.
Nature. 562(7725):69-75Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy.
Methods Cell Biol. 144:287-305High-speed volumetric imaging of neuronal activity in freely moving rodents.
Nat Methods. 15(6):429-432Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents.
Nat Methods. 15(6):469Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.
Cell Rep. 22(4):953-966MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nat Commun. 9(1):1983An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Nature. 553(7688):342-346Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities.
Proteomics. 18(13):e1700436Dynamics of sister chromatid resolution during cell cycle progression.
J Cell Biol. 217(6):1985-2004The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
PLoS Pathog. 14(11):e1007397Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Neuron. 100(6):1354-1368.e5A Guide to Emerging Technologies for Large-Scale and Whole-Brain Optical Imaging of Neuronal Activity.
Annu Rev Neurosci. 41:431-452Expressing Multi-subunit Complexes Using biGBac.
Methods Mol Biol. 1764:329-343Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.
J Cell Biol. 217(9):3285-3300TCEA1 regulates the proliferative potential of mouse myeloid cells.
Exp Cell Res. 370(2):551-560Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Genes Dev. 31(20):2085-2098An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries.
Biomaterials. 139:102-115A framework for understanding the roles of miRNAs in animal development.
Development. 144(14):2548-2559Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.
Elife. 6Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution.
Nat Biotechnol. 35(2):136-144Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.
Nat Microbiol. 2:17047Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Behav Brain Res. 323:47-55Tubulins and brain development - The origins of functional specification.
Mol Cell Neurosci. 84:58-67Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.
Hum Mol Genet. 26(2):258-269Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Nature. 544(7651):503-507Promoting transcription over long distances.
Nat Genet. 49(7):972-973A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.
J Vis Exp. (130)Root diffusion barrier control by a vasculature-derived peptide binding to the SGN3 receptor.
Science. 355(6322):280-284A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Nature. 550(7674):114-118Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.
Proc Natl Acad Sci U S A. 114(47):12501-12506Probing the canonicity of the Wnt/Wingless signaling pathway.
PLoS Genet. 13(4):e1006700Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Cell Rep. 20(9):2116-2130A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.
EMBO J. 36(24):3600-3618CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.
Blood. 129(3):371-382Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.
Cancer Discov. 7(8):900-917Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood. 129(21):2882-2895Thiol-linked alkylation of RNA to assess expression dynamics.
Nat Methods. 14(12):1198-1204BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Cell Rep. 18(9):2162-2174Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
Nat Rev Genet. 18(1):24-40Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.
Methods Mol Biol. 1597:43-55Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.
Oncotarget. 8(48):83354-83369Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 114(7):E1263-E1272Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.
Nat Immunol. 18(4):442-455STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth.
Cell Rep. 19(5):910-918CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.
Nat Methods. 14(12):1191-1197Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Nature. 547(7663):355-359A global brain state underlies C. elegans sleep behavior.
Science. 356(6344)Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance.
Elife. 6Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy.
Nat Methods. 14(8):811-818Magnetoreception-A sense without a receptor.
PLoS Biol. 15(10):e2003234Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Elife. 6A right-handed signalling pathway drives heart looping in vertebrates.
Nature. 549(7670):86-90The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.
Nat Plants. 3(12):973-982BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.
Curr Biol. 27(19):2915-2927.e7Urinary neprilysin in the critically ill patient.
BMC Nephrol. 18(1):172Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.
Oncotarget. 8(70):115002-115017Prediction of potent shRNAs with a sequential classification algorithm.
Nat Biotechnol. 35(4):350-353RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Genes Dev. 31(20):2099-2112Combinatorial function of transcription factors and cofactors.
Curr Opin Genet Dev. 43:73-81Phosphoproteomics with Activated Ion Electron Transfer Dissociation.
Anal Chem. 89(12):6367-6376Nodal patterning without Lefty inhibitory feedback is functional but fragile.
Elife. 6Non-model model organisms.
BMC Biol. 15(1):55DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes.
Cell. 170(5):956-972.e23A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protist Tetrahymena.
Mol Biol Cell. 28(6):825-833BIME2, a novel gene required for interhomolog meiotic recombination in the protist model organism Tetrahymena.
Chromosome Res. 25(3-4):291-298Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.
EMBO J. 36(6):718-735Control of type III protein secretion using a minimal genetic system.
Nat Commun. 8:14737Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.
Nature. 549(7673):538-542Virtual reality for freely moving animals.
Nat Methods. 14(10):995-1002A vital sugar code for ricin toxicity.
Cell Res. 27(11):1351-1364Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.
Dev Biol. 432(1):63-71Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
Cancer Res. 77(7):1753-1762Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.
Elife. 6Proceedings of the EuBIC Winter School 2017.
J Proteomics. 161:78-80Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
EMBO J. 36(24):3573-3599Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.
Cell Rep. 17(12):3142-3152NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.
J Immunol. 196(4):1753-67Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
EMBO Rep. 17(11):1624-1640The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.
Cancer Res. 76(5):1158-69An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.
Mol Cell Proteomics. 15(3):1139-50Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.
Development. 143(7):1126-33Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Nat Genet. 48(11):1349-1358Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell. 165(6):1440-1453Decoding sORF translation - from small proteins to gene regulation.
RNA Biol. 13(11):1051-1059MuSK Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop.
Sci Rep. 6:33583Rapid movement and transcriptional re-localization of human cohesin on DNA.
EMBO J. 35(24):2671-2685The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Immunity. 44(1):103-115Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.
PLoS Pathog. 12(12):e1006071Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.
Genes Dev. 30(18):2042-2047Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.
Proc Natl Acad Sci U S A. 113(38):10553-8Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
Cancer Cell. 30(1):59-74De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.
Cell Rep. 15(10):2251-2265Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.
J Med Genet. 53(3):152-62Structural basis for the disaggregase activity and regulation of Hsp104.
Elife. 5Topology and structure of an engineered human cohesin complex bound to Pds5B.
Nat Commun. 7:12523β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.
Development. 143(20):3826-3838Molecular basis of outer kinetochore assembly on CENP-T.
Elife. 5Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans.
Elife. 5ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.
J Cell Biol. 212(6):647-59Measuring APC/C-Dependent Ubiquitylation In Vitro.
Methods Mol Biol. 1342:287-303SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
J Cell Sci. 129(24):4607-4621Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.
Science. 351(6269):186-90Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.
PLoS Genet. 12(2):e1005865A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.
Cancer Cell. 30(2):359-360Sororin actively maintains sister chromatid cohesion.
EMBO J. 35(6):635-53A de novo frameshift in HNRNPK causing a Kabuki-like syndrome with nodular heterotopia.
Clin Genet. 90(3):258-62CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
Nat Immunol. 17(10):1187-96Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
Science. 352(6284):459-63Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach.
Oncotarget. 7(16):22295-323Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.
Nat Immunol. 17(3):331-43The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.
Sci Transl Med. 8(327):327ra26A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation.
Cell. 167(2):539-552.e14Oxygen-induced social behaviours in Pristionchus pacificus have a distinct evolutionary history and genetic regulation from Caenorhabditis elegans.
Proc Biol Sci. 283(1825):20152263Gene Regulation: Activation through Space.
Curr Biol. 26(19):R895-R898MEK1 is required for the development of NRAS-driven leukemia.
Oncotarget. 7(49):80113-80130Activation of an exonic splice-donor site in exon 30 of CDK5RAP2 in a patient with severe microcephaly and pigmentary abnormalities.
Clin Case Rep. 4(10):952-956PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.
Leukemia. 30(6):1375-87Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.
Curr Biol. 26(15):1943-1954Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.
Development. 143(10):1788-99CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore.
Curr Biol. 26(17):2370-8Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.
PLoS Genet. 12(6):e1006102Fast volumetric calcium imaging across multiple cortical layers using sculpted light.
Nat Methods. 13(12):1021-1028Mechanism of APC/CCDC20 activation by mitotic phosphorylation.
Proc Natl Acad Sci U S A. 113(19):E2570-8Correction to "Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1".
J Proteome Res. 15(5):1732Editorial overview: Cell reprogramming, regeneration and repair.
Curr Opin Genet Dev. 40:iv-viMolecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.
EMBO J. 35(22):2417-2434An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.
Mol Cell. 63(2):318-328Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
Nat Chem Biol. 12(7):504-10Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation.
PLoS One. 11(8):e0161997RANKL/RANK control Brca1 mutation- .
Cell Res. 26(7):761-74The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
FEBS Lett. 590(11):1663-71RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2.
Proc Natl Acad Sci U S A. 113(45):E7030-E7038Chemical Biology Interrogates Protein Arginine Phosphorylation.
Cell Chem Biol. 23(8):888-90Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.
Nat Immunol. 17(3):323-30Direct detection of a single photon by humans.
Nat Commun. 7:12172SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.
Genes Dev. 30(19):2187-2198Adaptive and Background-Aware GAL4 Expression Enhancement of Co-registered Confocal Microscopy Images.
Neuroinformatics. 14(2):221-33Arginine phosphorylation marks proteins for degradation by a Clp protease.
Nature. 539(7627):48-53Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.
J Innate Immun. 8(2):111-20biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.
Proc Natl Acad Sci U S A. 113(19):E2564-9DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.
Cell Rep. 17(11):2927-2942A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
G3 (Bethesda). 6(8):2467-78C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves.
Cell Rep. 14(7):1641-1654Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.
J Exp Med. 213(7):1201-21Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol Cell. 63(4):593-607Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.
Trends Genet. 32(12):801-814Anion-exchange chromatography of phosphopeptides: weak anion exchange versus strong anion exchange and anion-exchange chromatography versus electrostatic repulsion-hydrophilic interaction chromatography.
Anal Chem. 87(9):4704-11An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client.
Mol Cell Proteomics.The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.
J Comp Neurol. 523(15):2161-86Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer Chemother Pharmacol. 76(1):35-46RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.
Proc Natl Acad Sci U S A. 112(17):5272-9ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
Nat Methods. 12(9):859-65The histone chaperone CAF-1 safeguards somatic cell identity.
Nature. 528(7581):218-24Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.
PLoS Genet. 11(11):e1005652Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement.
Nat Methods. 12(4):361-365Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.
Adv Immunol. 128:93-121No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening.
Proc Natl Acad Sci U S A. 112(1):262-7Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.
Am J Physiol Renal Physiol. 308(12):F1409-20Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
Nat Commun. 6:6285Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol. 11(10):815G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
J Biol Chem. 290(43):26141-50Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.
Nat Commun. 6:6643Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies.
Hum Mol Genet. 24(21):6146-59Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.
Am J Hum Genet. 97(6):790-800Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.
Cell. 163(3):656-69Transgenesis in axolotl (Ambystoma mexicanum).
Methods Mol Biol. 1290:269-77Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.
Cell Rep. 11(12):1953-65Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.
Dev Biol. 402(2):291-305Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers.
PLoS Genet. 11(7):e1005372Predicting the Dynamics of Network Connectivity in the Neocortex.
J Neurosci. 35(36):12535-44Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
Blood. 126(21):2392-403Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3.
Elife. 4STARR-seq - principles and applications.
Genomics. 106(3):145-150Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
Genes Dev. 29(5):501-12The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.
Cell Cycle. 14(12):1799-8083DSpectra: A 3-dimensional quantification algorithm for LC-MS labeled profile data.
J Proteomics. 112:156-65Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562.
J Immunol. 195(3):766-72MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.
Science. 349(6251):989-93Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
Hum Mol Genet. 24(13):3732-41Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.
PLoS One. 10(10):e0139504Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.
PLoS Genet. 11(5):e1005225Determinants of amyloid fibril degradation by the PDZ protease HTRA1.
Nat Chem Biol. 11(11):862-9Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.
J Proteome Res. 14(12):5048-62Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Nature. 525(7570):543-547High-efficiency electroporation of the spinal cord in larval axolotl.
Methods Mol Biol. 1290:115-25Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.
Elife. 4:e10230Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.
Mol Cell Proteomics. 14(3):556-71Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
J Pharmacol Exp Ther. 352(3):579-89Optimizing and extending light-sculpting microscopy for fast functional imaging in neuroscience.
Biomed Opt Express. 6(2):353-68Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.
Clin Epigenetics. 7:2CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.
Blood. 125(1):90-101The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.
Cell. 162(5):1016-28Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.
Oncogene. 34(27):3593-604Burst muscle performance predicts the speed, acceleration, and turning performance of Anna's hummingbirds.
Elife. 4:e11159Laser-induced acoustic desorption of natural and functionalized biochromophores.
Anal Chem. 87(11):5614-9The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle.
EMBO Rep. 16(2):178-91Transcriptional regulators form diverse groups with context-dependent regulatory functions.
Nature. 528(7580):147-51Visualizing KcsA conformational changes upon ion binding by infrared spectroscopy and atomistic modeling.
J Phys Chem B. 119(18):5824-31Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.
Leukemia. 29(11):2230-7Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.
Leukemia. 29(6):1301-11Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
J Mol Biol. 427(8):1748-64Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.
Immunity. 42(6):1048-61The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.
Curr Biol. 25(17):2290-9Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation.
Nature. 518(7540):556-9Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Nat Genet. 47(5):539-43Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution.
Nat Genet. 46(7):685-92Measuring the functional organization of the neocortex at large and small scales.
Neuron. 83(4):756-8FlyMAD: rapid thermogenetic control of neuronal activity in freely walking Drosophila.
Nat Methods. 11(7):756-62Neuronal control of Drosophila walking direction.
Science. 344(6179):97-101Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood. 123(9):1341-52Microtubules and neurodevelopmental disease: the movers and the makers.
Adv Exp Med Biol. 800:75-96Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.
Mol Cell. 56(2):246-260Preclinical efficacy of MEK inhibition in Nras-mutant AML.
Blood. 124(26):3947-55Epigenetic control of immunity.
Cold Spring Harb Perspect Biol. 6(6)Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals.
Nat Neurosci. 17(9):1240-8Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.
Invest Ophthalmol Vis Sci. 55(8):5431-44Mathematical modeling of regenerative processes.
Curr Top Dev Biol. 108:283-317MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.
Cancer Cell. 25(5):652-65Diversity and wiring variability of visual local neurons in the Drosophila medulla M6 stratum.
J Comp Neurol. 522(17):3795-816Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.
Genes Dev. 28(1):34-43Automated image-based tracking and its application in ecology.
Trends Ecol Evol. 29(7):417-28ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.
Oncogene. 33(48):5501-10RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.
Mol Cell. 54(6):975-86Is salamander hindlimb regeneration similar to that of the forelimb? Anatomical and morphogenetic analysis of hindlimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative and developmental studies.
J Anat. 224(4):459-68Is salamander limb regeneration really perfect? Anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental, and evolutionary studies.
Anat Rec (Hoboken). 297(6):1076-89Development of fore- and hindlimb muscles in GFP-transgenic axolotls: morphogenesis, the tetrapod bauplan, and new insights on the forelimb-hindlimb enigma.
J Exp Zool B Mol Dev Evol. 322(2):106-27MS Amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra.
J Proteome Res. 13(8):3679-84Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.
Mol Cell Proteomics. 13(8):1993-2003CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration.
Stem Cell Reports. 3(3):444-59Ascending SAG neurons control sexual receptivity of Drosophila females.
Neuron. 83(1):135-48Asymmetric processing of visual motion for simultaneous object and background responses.
Curr Biol. 24(24):2913-9Flying Drosophila stabilize their vision-based velocity controller by sensing wind with their antennae.
Proc Natl Acad Sci U S A. 111(13):E1182-91Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.
Annu Rev Microbiol. 68:415-38Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.
Dev Cell. 29(6):729-39A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.
J Cell Biol. 206(4):509-24Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.
Am J Hum Genet. 94(2):278-87CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.
Genes Dev. 28(16):1800-14Characterization of a DNA exit gate in the human cohesin ring.
Science. 346(6212):968-72The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
EMBO J. 33(24):2922-36Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
Cell. 157(3):636-50Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination.
Nat Protoc. 9(3):529-40Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl.
Stem Cell Reports. 2(2):243Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Cell. 157(2):340-356Development and performance evaluation of an ultralow flow nanoliquid chromatography-tandem mass spectrometry set-up.
Proteomics. 14(17-18):1999-2007Genome-scale functional characterization of Drosophila developmental enhancers in vivo.
Nature. 512(7512):91-5Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.
Curr Biol. 24(19):2228-37Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.
Genes Dev. 28(12):1337-50"Uno, nessuno e centomila": the different faces of the budding yeast kinetochore.
Chromosoma. 123(5):447-57Neural circuit components of the Drosophila OFF motion vision pathway.
Curr Biol. 24(4):385-923D reconstitution of the patterned neural tube from embryonic stem cells.
Stem Cell Reports. 3(6):987-99cis-regulatory requirements for tissue-specific programs of the circadian clock.
Curr Biol. 24(1):1-10The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.
Proc Natl Acad Sci U S A. 111(45):16166-71Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos.
Cell Rep. 8(5):1380-90Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation.
J Proteome Res. 13(10):4310-24Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.
PLoS Biol. 12(1):e1001765TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.
Hum Mol Genet. 23(19):5147-58Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins.
Nat Commun. 5:5396Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.
Nature. 511(7507):104-7Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy.
Nat Methods. 11(7):727-730B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Cell. 159(7):1524-37Structure of a pathogenic type 3 secretion system in action.
Nat Struct Mol Biol. 21(1):82-7A dual role for autophagy in a murine model of lung cancer.
Nat Commun. 5:3056A conserved role for Snail as a potentiator of active transcription.
Genes Dev. 28(2):167-81NDST1 missense mutations in autosomal recessive intellectual disability.
Am J Med Genet A. 164A(11):2753-63In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.
Nat Med. 20(10):1138-46Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.
Cell Stem Cell. 14(2):174-87H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress.
Genome Res. 24(11):1808-20Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response.
Mol Cell Proteomics. 13(2):537-50Stage-specific control of early B cell development by the transcription factor Ikaros.
Nat Immunol. 15(3):283-93Differential requirement for Nfil3 during NK cell development.
J Immunol. 192(6):2667-76Transcriptional enhancers: from properties to genome-wide predictions.
Nat Rev Genet. 15(4):272-86Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin.
Mol Cell. 54(1):180-192Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena.
Genetics. 198(3):983-93Reverse Engineering Animal Vision with Virtual Reality and Genetics.
Computer. 14(190):38–45Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.
Plant Cell. 26(11):4547-60Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.
Mol Cell Proteomics. 13(8):1953-64