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Publications

IMP scientists publish 60 to 90 scientific papers in international peer-review journals every year. This evidence for the productivity and high scientific standard of the IMP is listed here in full – a directory of all scientific publications by IMP scientists since the establishment of the institute, organised by years and research groups.

Cikes, D., Leutner, M., Cronin, SJF., Novatchkova, M., Pfleger, L., Klepochová, R., Lair, B., Lac, M., Bergoglio, C., Viguerie, N., Dürnberger, G., Roitinger, E., Grivej, M., Rullman, E., Gustafsson, T., Hagelkruys, A., Tavernier, G., Bourlier, V., Knauf, C., Krebs, M., Kautzky-Willer, A., Moro, C., Krssak, M., Orthofer, M., Penninger, JM. (2024)

Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism.

Nat Aging. 4(1):80-94
Lorenzo-Orts, L., Strobl, M., Steinmetz, B., Leesch, F., Pribitzer, C., Roehsner, J., Schutzbier, M., Dürnberger, G., Pauli, A. (2024)

eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.

Show Preprint EMBO Rep. 25(1):404-427
Pre-print Rappol, T., Waldl, M., Chugunova, A., Hofacker, IL., Pauli, A., Vilardo, E. (2024)

tRNA expression and modification landscapes, and their dynamics during zebrafish embryo development

bioRxiv. 2024.01.30.575011
Amann, SJ., Keihsler, D., Bodrug, T., Brown, NG., Haselbach, D. (2023)

Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.

Structure. 31(1):4-19
Appel, LM., Benedum, J., Engl, M., Platzer, S., Schleiffer, A., Strobl, X., Slade, D. (2023)

SPOC domain proteins in health and disease.

Genes Dev. 37(5-6):140-170
Banigan, EJ., Tang, W., van den Berg, AA., Stocsits, RR., Wutz, G., Brandão, HB., Busslinger, GA., Peters, JM., Mirny, LA. (2023)

Transcription shapes 3D chromatin organization by interacting with loop extrusion.

Show Preprint Proc Natl Acad Sci U S A. 120(11):e2210480120
Barth, R., Pradhan, B., Kim, E., Davidson, IF., van der Torre, J., Peters, JM., Dekker, C. (2023)

Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments.

Sci Rep. 13(1):8100
Batty, P., Langer, CC., Takács, Z., Tang, W., Blaukopf, C., Peters, JM., Gerlich, DW. (2023)

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase.

EMBO J. :e113475
Bayerl, F., Meiser, P., Donakonda, S., Hirschberger, A., Lacher, SB., Pedde, AM., Hermann, CD., Elewaut, A., Knolle, M., Ramsauer, L., Rudolph, TJ., Grassmann, S., Öllinger, R., Kirchhammer, N., Trefny, M., Anton, M., Wohlleber, D., Höchst, B., Zaremba, A., Krüger, A., Rad, R., Obenauf, AC., Schadendorf, D., Zippelius, A., Buchholz, VR., Schraml, BU., Böttcher, JP. (2023)

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Immunity. 56(6):1341-1358.e11
Bhat, P., Cabrera-Quio, LE., Herzog, VA., Fasching, N., Pauli, A., Ameres, SL. (2023)

SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.

Show Preprint Cell Rep. 42(2):112070
Birklbauer, MJ., Matzinger, M., Müller, F., Mechtler, K., Dorfer, V. (2023)

MS Annika 2.0 Identifies Cross-Linked Peptides in MS2-MS3-Based Workflows at High Sensitivity and Specificity.

J Proteome Res.
Bodrug, T., Welsh, KA., Bolhuis, DL., Paulаkonis, E., Martinez-Chacin, RC., Liu, B., Pinkin, N., Bonacci, T., Cui, L., Xu, P., Roscow, O., Amann, SJ., Grishkovskaya, I., Emanuele, MJ., Harrison, JS., Steimel, JP., Hahn, KM., Zhang, W., Zhong, ED., Haselbach, D., Brown, NG. (2023)

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).

Nat Struct Mol Biol. 30(11):1663-1674
Brandstoetter, T., Schmoellerl, J., Grausenburger, R., Kollmann, S., Doma, E., Huuhtanen, J., Klampfl, T., Eder, T., Grebien, F., Hoermann, G., Zuber, J., Mustjoki, S., Maurer, B., Sexl, V. (2023)

SBNO2 is a critical mediator of STAT3-driven hematological malignancies.

Blood.
Carlet, M., Schmelz, K., Vergalli, J., Herold, T., Senft, D., Jurinovic, V., Hoffmann, T., Proba, J., Weichert, N., Junghanß, C., Roth, M., Eschenburg, G., Barz, M., Henze, G., Eckert, C., Eggert, A., Zuber, J., Hundsdoerfer, P., Jeremias, I. (2023)

X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

EMBO Mol Med. 15(1):e14557
Chan, YC., Kienle, E., Oti, M., Di Liddo, A., Mendez-Lago, M., Aschauer, DF., Peter, M., Pagani, M., Arnold, C., Vonderheit, A., Schön, C., Kreuz, S., Stark, A., Rumpel, S. (2023)

An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo.

Sci Rep. 13(1):6745
Cikes, D., Elsayad, K., Sezgin, E., Koitai, E., Torma, F., Orthofer, M., Yarwood, R., Heinz, LX., Sedlyarov, V., Miranda, ND., Taylor, A., Grapentine, S., Al-Murshedi, F., Abot, A., Weidinger, A., Kutchukian, C., Sanchez, C., Cronin, SJF., Novatchkova, M., Kavirayani, A., Schuetz, T., Haubner, B., Haas, L., Hagelkruys, A., Jackowski, S., Kozlov, AV., Jacquemond, V., Knauf, C., Superti-Furga, G., Rullman, E., Gustafsson, T., McDermot, J., Lowe, M., Radak, Z., Chamberlain, JS., Bakovic, M., Banka, S., Penninger, JM. (2023)

Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

Nat Metab.
Cikes, D., Elsayad, K., Sezgin, E., Koitai, E., Torma, F., Orthofer, M., Yarwood, R., Heinz, LX., Sedlyarov, V., Miranda, ND., Taylor, A., Grapentine, S., Al-Murshedi, F., Abot, A., Weidinger, A., Kutchukian, C., Sanchez, C., Cronin, SJF., Novatchkova, M., Kavirayani, A., Schuetz, T., Haubner, B., Haas, L., Hagelkruys, A., Jackowski, S., Kozlov, AV., Jacquemond, V., Knauf, C., Superti-Furga, G., Rullman, E., Gustafsson, T., McDermot, J., Lowe, M., Radak, Z., Chamberlain, JS., Bakovic, M., Banka, S., Penninger, JM. (2023)

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

Nat Metab. 5(3):495-515
Costea, J., Schoeberl, UE., Malzl, D., von der Linde, M., Fitz, J., Gupta, A., Makharova, M., Goloborodko, A., Pavri, R. (2023)

A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination.

Show Preprint Mol Cell. 83(5):681-697.e7
Ctortecka, C., Hartlmayr, D., Seth, A., Mendjan, S., Tourniaire, G., Udeshi, ND., Carr, SA., Mechtler, K. (2023)

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

Mol Cell Proteomics. :100665
D'Artista, L., Moschopoulou, AA., Barozzi, I., Craig, AJ., Seehawer, M., Herrmann, L., Minnich, M., Kang, TW., Rist, E., Henning, M., Klotz, S., Heinzmann, F., Harbig, J., Sipos, B., Longerich, T., Eilers, M., Dauch, D., Zuber, J., Wang, XW., Zender, L. (2023)

MYC determines lineage commitment in kras driven primary liver cancer development.

J Hepatol.
Davidson, IF., Barth, R., Zaczek, M., van der Torre, J., Tang, W., Nagasaka, K., Janissen, R., Kerssemakers, J., Wutz, G., Dekker, C., Peters, JM. (2023)

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion.

Show Preprint Nature. 616(7958):822-827
de Almeida, BP., Schaub, C., Pagani, M., Secchia, S., Furlong, EEM., Stark, A. (2023)

Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo.

Nature.
Dekker, C., Haering, CH., Peters, JM., Rowland, BD. (2023)

How do molecular motors fold the genome?

Science. 382(6671):646-648
Delás, MJ., Kalaitzis, CM., Fawzi, T., Demuth, M., Zhang, I., Stuart, HT., Costantini, E., Ivanovitch, K., Tanaka, EM., Briscoe, J. (2023)

Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.

Dev Cell. 58(1):3-17.e8
Pre-print Deneke, VE., Blaha, A., Lu, Y., Draper, JM., Phan, CS., Panser, K., Schleiffer, A., Jacob, L., Humer, T., Stejskal, K., Krssakova, G., Handler, D., Kamoshita, M., Vance, TDR., Roitinger, E., Lee, JE., Ikawa, M., Pauli, A. (2023)

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

bioRxiv. 2023.07.27.550750
Devignot, S., Sha, TW., Burkard, TR., Schmerer, P., Hagelkruys, A., Mirazimi, A., Elling, U., Penninger, JM., Weber, F. (2023)

Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.

Life Sci Alliance. 6(7)
Dobbelaere, J., Su, TY., Erdi, B., Schleiffer, A., Dammermann, A. (2023)

A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.

EMBO J. :e113616
Dorl, S., Winkler, S., Mechtler, K., Dorfer, V. (2023)

MS Ana: Improving Sensitivity in Peptide Identification with Spectral Library Search.

J Proteome Res. 22(2):462-470
Ebner, J., Schmoellerl, J., Piontek, M., Manhart, G., Troester, S., Carter, BZ., Neubauer, H., Moriggl, R., Szakács, G., Zuber, J., Köcher, T., Andreeff, M., Sperr, WR., Valent, P., Grebien, F. (2023)

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.

Nat Commun. 14(1):5709
Ehrmann, JF., Grabarczyk, DB., Heinke, M., Deszcz, L., Kurzbauer, R., Hudecz, O., Shulkina, A., Gogova, R., Meinhart, A., Versteeg, GA., Clausen, T. (2023)

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.

Science. 379(6637):1117-1123
Falcon, F., Tanaka, EM., Rodriguez-Terrones, D. (2023)

Transposon waves at the water-to-land transition.

Curr Opin Genet Dev. 81:102059
Feng, C., Roitinger, E., Hudecz, O., Cuacos, M., Lorenz, J., Schubert, V., Wang, B., Wang, R., Mechtler, K., Heckmann, S. (2023)

TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana.

Nat Plants.
Gert, KRB., Panser, K., Surm, J., Steinmetz, BS., Schleiffer, A., Jovine, L., Moran, Y., Kondrashov, F., Pauli, A. (2023)

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.

Show Preprint Nat Commun. 14(1):3506
Gruenbacher, S., Jaritz, M., Hill, L., Schäfer, M., Busslinger, M. (2023)

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development.

J Exp Med. 220(12)
Gwosch, KC., Balzarotti, F., Pape, JK., Hoess, P., Ellenberg, J., Ries, J., Matti, U., Schmidt, R., Sahl, SJ., Hell, SW. (2023)

Reply to: Assessment of 3D MINFLUX data for quantitative structural biology in cells.

Nat Methods. 20(1):52-54
Heidari Khoei, H., Javali, A., Kagawa, H., Sommer, TM., Sestini, G., David, L., Slovakova, J., Novatchkova, M., Scholte Op Reimer, Y., Rivron, N. (2023)

Generating human blastoids modeling blastocyst-stage embryos and implantation.

Nat Protoc.
Hill, L., Jaritz, M., Tagoh, H., Schindler, K., Kostanova-Poliakova, D., Sun, Q., Schwickert, TA., Leeb, M., Busslinger, M. (2023)

Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus.

EMBO J. 42(15):e112741
Hill, L., Wutz, G., Jaritz, M., Tagoh, H., Calderón, L., Peters, JM., Goloborodko, A., Busslinger, M. (2023)

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells.

Nat Commun. 14(1):2316
Hodáková, Z., Grishkovskaya, I., Brunner, HL., Bolhuis, DL., Belačić, K., Schleiffer, A., Kotisch, H., Brown, NG., Haselbach, D. (2023)

Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.

EMBO J. 42(16):e113348
Hoffmann, T., Hörmann, A., Corcokovic, M., Zmajkovic, J., Hinterndorfer, M., Salkanovic, J., Spreitzer, F., Köferle, A., Gitschtaler, K., Popa, A., Oberndorfer, S., Andersch, F., Schaefer, M., Fellner, M., Budano, N., Ruppert, JG., Chetta, P., Wurm, M., Zuber, J., Neumüller, RA. (2023)

Precision RNAi using synthetic shRNAmir target sites.

Elife. 12
Hoi, DM., Junker, S., Junk, L., Schwechel, K., Fischel, K., Podlesainski, D., Hawkins, PME., van Geelen, L., Kaschani, F., Leodolter, J., Morreale, FE., Kleine, S., Guha, S., Rumpel, K., Schmiedel, VM., Weinstabl, H., Meinhart, A., Payne, RJ., Kaiser, M., Hartl, M., Boehmelt, G., Kazmaier, U., Kalscheuer, R., Clausen, T. (2023)

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

Cell. 186(10):2176-2192.e22
Huljev, K., Shamipour, S., Pinheiro, D., Preusser, F., Steccari, I., Sommer, CM., Naik, S., Heisenberg, CP. (2023)

A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.

Dev Cell.
Ishihara, K., Mukherjee, A., Gromberg, E., Brugués, J., Tanaka, EM., Jülicher, F. (2023)

Topological morphogenesis of neuroepithelial organoids.

Nat Phys. 19(2):177-183
Jacobs, J., Pagani, M., Wenzl, C., Stark, A. (2023)

Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila.

Science. 381(6654):198-204
Kaiser, FMP., Gruenbacher, S., Oyaga, MR., Nio, E., Jaritz, M., Sun, Q., van der Zwaag, W., Kreidl, E., Zopf, LM., Dalm, VASH., Pel, J., Gaiser, C., van der Vliet, R., Wahl, L., Rietman, A., Hill, L., Leca, I., Driessen, G., Laffeber, C., Brooks, A., Katsikis, PD., Lebbink, JHG., Tachibana, K., van der Burg, M., De Zeeuw, CI., Badura, A., Busslinger, M. (2023)

Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

J Exp Med. 220(1)
Kawaguchi, A., Tanaka, EM. (2023)

Chromosome Conformation Capture for Large Genomes.

Methods Mol Biol. 2562:291-318
Klaus, L., de Almeida, BP., Vlasova, A., Nemčko, F., Schleiffer, A., Bergauer, K., Hofbauer, L., Rath, M., Stark, A. (2023)

Systematic identification and characterization of repressive domains in Drosophila transcription factors.

EMBO J. 42(3):e112100
Kugler, E., Madiwale, S., Yong, D., Thoms, JAI., Birger, Y., Sykes, DB., Schmoellerl, J., Drakul, A., Priebe, V., Yassin, M., Aqaqe, N., Rein, A., Fishman, H., Geron, I., Chen, CW., Raught, B., Liu, Q., Ogana, H., Liedke, E., Bourquin, JP., Zuber, J., Milyavsky, M., Pimanda, J., Privé, GG., Izraeli, S. (2023)

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.

Nat Commun. 14(1):5871
L Baumgartner, JJ Ipsaro, U Hohmann, D Handler, A Schleiffer, P Duchek, J Brennecke (2023)

Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chromatin and DNA sequence signals

Show Preprint BioRxiv.
Leesch, F., Lorenzo-Orts, L., Pribitzer, C., Grishkovskaya, I., Roehsner, J., Chugunova, A., Matzinger, M., Roitinger, E., Belačić, K., Kandolf, S., Lin, TY., Mechtler, K., Meinhart, A., Haselbach, D., Pauli, A. (2023)

A molecular network of conserved factors keeps ribosomes dormant in the egg.

Show Preprint Nature.
Leiendecker, L., Neumann, T., Jung, PS., Cronin, SM., Steinacker, TL., Schleiffer, A., Schutzbier, M., Mechtler, K., Kervarrec, T., Laurent, E., Bachiri, K., Coyaud, E., Murali, R., Busam, KJ., Itzinger-Monshi, B., Kirnbauer, R., Cerroni, L., Calonje, E., Rütten, A., Stubenrauch, F., Griewank, KG., Wiesner, T., Obenauf, AC. (2023)

Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.

Cancer Discov. 13(1):70-84
Li, C., Fleck, JS., Martins-Costa, C., Burkard, TR., Themann, J., Stuempflen, M., Peer, AM., Vertesy, Á., Littleboy, JB., Esk, C., Elling, U., Kasprian, G., Corsini, NS., Treutlein, B., Knoblich, JA. (2023)

Single-cell brain organoid screening identifies developmental defects in autism.

Nature. 621(7978):373-380
Lugmayr, W., Kotov, V., Goessweiner-Mohr, N., Wald, J., DiMaio, F., Marlovits, TC. (2023)

StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement.

Nat Protoc. 18(1):239-264
Martins-Costa, C., Pham, VA., Sidhaye, J., Novatchkova, M., Wiegers, A., Peer, A., Möseneder, P., Corsini, NS., Knoblich, JA. (2023)

Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix.

EMBO J. :e113213
Masselink, W., Tanaka, EM. (2023)

Ethyl Cinnamate-Based Tissue Clearing Strategies.

Methods Mol Biol. 2562:123-133
Matzinger, M., Müller, E., Dürnberger, G., Pichler, P., Mechtler, K. (2023)

Robust and Easy-to-Use One-Pot Workflow for Label-Free Single-Cell Proteomics.

Anal Chem. 95(9):4435-4445
Mayer, RL., Mechtler, K. (2023)

Immunopeptidomics in the Era of Single-Cell Proteomics.

Biology (Basel). 12(12)
Michael, AK., Stoos, L., Crosby, P., Eggers, N., Nie, XY., Makasheva, K., Minnich, M., Healy, KL., Weiss, J., Kempf, G., Cavadini, S., Kater, L., Seebacher, J., Vecchia, L., Chakraborty, D., Isbel, L., Grand, RS., Andersch, F., Fribourgh, JL., Schübeler, D., Zuber, J., Liu, AC., Becker, PB., Fierz, B., Partch, CL., Menet, JS., Thomä, NH. (2023)

Cooperation between bHLH transcription factors and histones for DNA access.

Nature. 619(7969):385-393
Murawala, P., Oliveira, CR., Okulski, H., Yun, MH., Tanaka, EM. (2023)

Baculovirus Production and Infection in Axolotls.

Methods Mol Biol. 2562:369-387
Nagasaka, K., Davidson, IF., Stocsits, RR., Tang, W., Wutz, G., Batty, P., Panarotto, M., Litos, G., Schleiffer, A., Gerlich, DW., Peters, JM. (2023)

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms.

Mol Cell.
Neault, M., Lebert-Ghali, CÉ., Fournier, M., Capdevielle, C., Garfinkle, EAR., Obermayer, A., Cotton, A., Boulay, K., Sawchyn, C., St-Amand, S., Nguyen, KH., Assaf, B., Mercier, FE., Delisle, JS., Drobetsky, EA., Hulea, L., Shaw, TI., Zuber, J., Gruber, TA., Melichar, HJ., Mallette, FA. (2023)

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.

Cell Rep. 42(9):113084
Nowoshilow, S., Tanaka, EM. (2023)

Navigation and Use of Custom Tracks within the Axolotl Genome Browser.

Methods Mol Biol. 2562:273-289
Pacheco-Fiallos, B., Vorländer, MK., Riabov-Bassat, D., Fin, L., O'Reilly, FJ., Ayala, FI., Schellhaas, U., Rappsilber, J., Plaschka, C. (2023)

mRNA recognition and packaging by the human transcription-export complex.

Nature.
Picchianti, L., Sánchez de Medina Hernández, V., Zhan, N., Irwin, NA., Groh, R., Stephani, M., Hornegger, H., Beveridge, R., Sawa-Makarska, J., Lendl, T., Grujic, N., Naumann, C., Martens, S., Richards, TA., Clausen, T., Ramundo, S., Karagöz, GE., Dagdas, Y. (2023)

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.

EMBO J. :e112053
Pinheiro, D. (2023)

How embryos sort themselves out.

Nat Rev Mol Cell Biol. 24(12):856
Remick, BC., Gaidt, MM., Vance, RE. (2023)

Effector-Triggered Immunity.

Annu Rev Immunol.
Reumann, D., Krauditsch, C., Novatchkova, M., Sozzi, E., Wong, SN., Zabolocki, M., Priouret, M., Doleschall, B., Ritzau-Reid, KI., Piber, M., Morassut, I., Fieseler, C., Fiorenzano, A., Stevens, MM., Zimmer, M., Bardy, C., Parmar, M., Knoblich, JA. (2023)

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.

Nat Methods. 20(12):2034-2047
Ross, SE., Vázquez-Marín, J., Gert, KRB., González-Rajal, Á., Dinger, ME., Pauli, A., Martínez-Morales, JR., Bogdanovic, O. (2023)

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species.

Show Preprint Nucleic Acids Res.
Schmidt, C., Deyett, A., Ilmer, T., Haendeler, S., Torres Caballero, A., Novatchkova, M., Netzer, MA., Ceci Ginistrelli, L., Mancheno Juncosa, E., Bhattacharya, T., Mujadzic, A., Pimpale, L., Jahnel, SM., Cirigliano, M., Reumann, D., Tavernini, K., Papai, N., Hering, S., Hofbauer, P., Mendjan, S. (2023)

Multi-chamber cardioids unravel human heart development and cardiac defects.

Cell. 186(25):5587-5605.e27
Schmoellerl, J., Barbosa, IAM., Minnich, M., Andersch, F., Smeenk, L., Havermans, M., Eder, T., Neumann, T., Jude, J., Fellner, M., Ebert, A., Steininger, M., Delwel, R., Grebien, F., Zuber, J. (2023)

EVI1 drives leukemogenesis through aberrant ERG activation.

Blood. 141(5):453-466
Schwartz, I., Vunjak, M., Budroni, V., Cantoran García, A., Mastrovito, M., Soderholm, A., Hinterndorfer, M., de Almeida, M., Hacker, K., Wang, J., Froussios, K., Jude, J., Decker, T., Zuber, J., Versteeg, GA. (2023)

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

Elife. 12
Scinicariello, S., Soderholm, A., Schäfer, M., Shulkina, A., Schwartz, I., Hacker, K., Gogova, R., Kalis, R., Froussios, K., Budroni, V., Bestehorn, A., Clausen, T., Kovarik, P., Zuber, J., Versteeg, GA. (2023)

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

Show Preprint Elife. 12
Serebreni, L., Pleyer, LM., Haberle, V., Hendy, O., Vlasova, A., Loubiere, V., Nemčko, F., Bergauer, K., Roitinger, E., Mechtler, K., Stark, A. (2023)

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns.

EMBO J. :e113519
Sidhaye, J., Trepte, P., Sepke, N., Novatchkova, M., Schutzbier, M., Dürnberger, G., Mechtler, K., Knoblich, JA. (2023)

Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids.

Elife. 12
Tanaka, EM. (2023)

Now that We Got There, What Next?

Methods Mol Biol. 2562:471-479
Taniguchi-Sugiura, Y., Tanaka, EM. (2023)

Artificial Insemination in Axolotl.

Methods Mol Biol. 2562:417-423
Vainorius, G., Novatchkova, M., Michlits, G., Baar, JC., Raupach, C., Lee, J., Yelagandula, R., Wernig, M., Elling, U. (2023)

Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.

Nat Commun. 14(1):5341
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Carbohydrate receptor-mediated gene transfer to human T leukaemic cells.

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP.

Cell. 79(5):901-12
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Retroviral capture of c-erbB proto-oncogene sequences: rapid evolution of distinct viral genomes carrying mutant v-erbB genes with different transforming capacities.

Oncogene. 9(5):1307-20
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An intragenic TaqI RFLP at the PAX5 locus.

Hum Mol Genet. 3(4):681
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SSCP/SacI polymorphism in the PAX5 gene.

Hum Mol Genet. 3(5):839
Wagner, E., Curiel, D., Cotten, M. (1994)

Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis.

Advanced Drug Delivery Reviews. 14:113-36
Wagner, EF. (1994)

Embryonic stem cell as a tool for analyzing mammalian hematopoietic development and disease.

Schering Res. Foundation Workshop. 11:58-67
Wagner, EF., Risau, W. (1994)

Oncogenes in the study of endothelial cell growth and differentiation.

Semin Cancer Biol. 5(2):137-45
Wang, ZQ., Fung, MR., Barlow, DP., Wagner, EF. (1994)

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.

Nature. 372(6505):464-7
Weith, A. (1994)

The analysis of disease-specific chromosomal rearrangements with microcloned DNA markers.

Methods in Molecular Genetics (ed. Adolph, K.). 5: Gene and Chromosome Analysis, Part C:169-94
Zatloukal, K., Cotten, M., Berger, M., Schmidt, W., Wagner, E., Birnstiel, ML. (1994)

In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery.

Proc Natl Acad Sci U S A. 91(11):5148-52
Zatloukal, K., Schneeberger, A., Berger, M., Koszik, F., Schmidt, W., Wagner, E., Cotten, M., Buschle, M., Maass, G., Stingl, G. (1994)

Genetic modification of cells by receptor-mediated adenovirus-augmented gene delivery: a new approach for immunotherapy of cancer.

Verh Dtsch Ges Pathol. 78:171-6
Aguzzi, A., Wagner, EF., Netzer, KO., Bothe, K., Anhauser, I., Rethwilm, A. (1993)

Human foamy virus proteins accumulate in neurons and induce multinucleated giant cells in the brain of transgenic mice.

Am J Pathol. 142(4):1061-71
Barettino, D., Bugge, TH., Bartunek, P., Vivanco Ruiz, MD., Sonntag-Buck, V., Beug, H., Zenke, M., Stunnenberg, HG. (1993)

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.

EMBO J. 12(4):1343-54
Barlow, DP. (1993)

Methylation and imprinting: from host defense to gene regulation?

Science. 260(5106):309-10
Braselmann, S., Graninger, P., Busslinger, M. (1993)

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins.

Proc Natl Acad Sci U S A. 90(5):1657-61
Breitwieser, W., Price, C., Schuster, T. (1993)

Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae.

Yeast. 9(5):551-6
Briegel, K., Lim, KC., Plank, C., Beug, H., Engel, JD., Zenke, M. (1993)

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.

Genes Dev. 7(6):1097-109
Cotten, M., Wagner, E. (1993)

Non-viral approaches to gene therapy.

Curr Opin Biotechnol. 4(6):705-10
Cotten, M., Wagner, E., Birnstiel, ML. (1993)

Receptor-mediated transport of DNA into eukaryotic cells.

Methods Enzymol. 217:618-44
Cvrcková, F., Nasmyth, K. (1993)

Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation.

EMBO J. 12(13):5277-86
Czerny, T., Schaffner, G., Busslinger, M. (1993)

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

Genes Dev. 7(10):2048-61
Errede, B., Gartner, A., Zhou, Z., Nasmyth, K., Ammerer, G. (1993)

MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro.

Nature. 362(6417):261-4
Gao, L., Wagner, E., Cotten, M., Agarwal, S., Harris, C., Rømer, M., Miller, L., Hu, PC., Curiel, D. (1993)

Direct in vivo gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes.

Hum Gene Ther. 4(1):17-24
Gautel, M., Lakey, A., Barlow, DP., Holmes, Z., Scales, S., Leonard, K., Labeit, S., Mygland, A., Gilhus, NE., Aarli, JA. (1993)

Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin.

Neurology. 43(8):1581-5
Grigoriadis, AE., Schellander, K., Wang, ZQ., Wagner, EF. (1993)

Osteoblasts are target cells for transformation in c-fos transgenic mice.

J Cell Biol. 122(3):685-701
Grigoriadis, AE., Wang, ZQ., Wagner, EF. (1993)

c-Fos oncogene expression in cartilage and bone tissues of transgenic and chimaeric mice.

Cell. and Mol. of the Bone (ed. Noda, M.). :497-537
Hilberg, F., Aguzzi, A., Howells, N., Wagner, EF. (1993)

c-jun is essential for normal mouse development and hepatogenesis.

Nature. 365(6442):179-81
Himmelbauer, H., Artzt, K., Barlow, D., Fischer-Lindahl, K., Lyon, M., Klein, J., Silver, LM. (1993)

Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17.

Mamm Genome. 4 Spec No:S230-52
Koch, C., Moll, T., Neuberg, M., Ahorn, H., Nasmyth, K. (1993)

A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.

Science. 261(5128):1551-7
Kozmik, Z., Kurzbauer, R., Dörfler, P., Busslinger, M. (1993)

Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

Mol Cell Biol. 13(10):6024-35
Lakey, A., Labeit, S., Gautel, M., Ferguson, C., Barlow, DP., Leonard, K., Bullard, B. (1993)

Kettin, a large modular protein in the Z-disc of insect muscles.

EMBO J. 12(7):2863-71
Larsen, J., Meyer, S., Steinlein, P., Beug, H., Hayman, MJ. (1993)

Transformation of chicken bone marrow cells by the v-ski oncogene.

Oncogene. 8(12):3221-8
Michael, SI., Huang, CH., Rømer, MU., Wagner, E., Hu, PC., Curiel, DT. (1993)

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway.

J Biol Chem. 268(10):6866-9
Micklem, G., Rowley, A., Harwood, J., Nasmyth, K., Diffley, JF. (1993)

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.

Nature. 366(6450):87-9
Moll, T., Schwob, E., Koch, C., Moore, A., Auer, H., Nasmyth, K. (1993)

Transcription factors important for starting the cell cycle in yeast.

Philos Trans R Soc Lond B Biol Sci. 340(1293):351-60
Muñoz, A., Wrighton, C., Seliger, B., Bernal, J., Beug, H. (1993)

Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12.

J Cell Biol. 121(2):423-38
Nasmyth, K. (1993)

Regulating the HO endonuclease in yeast.

Curr Opin Genet Dev. 3(2):286-94
Nasmyth, K. (1993)

Control of the yeast cell cycle by the Cdc28 protein kinase.

Curr Opin Cell Biol. 5(2):166-79
Nasmyth, K., Hunt, T. (1993)

Cell cycle. Dams and sluices.

Nature. 366(6456):634-5
Netzer, KO., Schliephake, A., Maurer, B., Watanabe, R., Aguzzi, A., Rethwilm, A. (1993)

Identification of pol-related gene products of human foamy virus.

Virology. 192(1):336-8
Pavlik, P., Simon, M., Schuster, T., Ruis, H. (1993)

The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization.

Curr Genet. 24(1-2):21-5
Saatcioglu, F., Bartunek, P., Deng, T., Zenke, M., Karin, M. (1993)

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

Mol Cell Biol. 13(6):3675-85
Sokanathan, S., Moll, T., Siegmund, R., Dirick, L., Koch, C., Beug, H. (1993)

Switching genes on at the START of the yeast cell cycle.

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Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.

Nat Genet. 3(4):292-8
Stöger, R., Kubicka, P., Liu, CG., Kafri, T., Razin, A., Cedar, H., Barlow, DP. (1993)

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.

Cell. 73(1):61-71
Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., Nasmyth, K. (1993)

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

EMBO J. 12(5):1969-78
Tebb, G., Moll, T., Dowzer, C., Nasmyth, K. (1993)

SWI5 instability may be necessary but is not sufficient for asymmetric HO expression in yeast.

Genes Dev. 7(3):517-28
Thomas, JE., Aguzzi, A., Soriano, P., Wagner, EF., Brugge, JS. (1993)

Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.

Oncogene. 8(9):2521-9
Wagner, EF, Aguzzi, A. (1993)

Exploring the pathogenic potential of polyoma middle T, c-fos and human foamy virus in transgenic mice.

Transgenic animals as models for human diseases (eds. Theuring, F., Wagner, EF.). 6:109-28
Wang, ZQ., Grigoriadis, AE., Wagner, EF. (1993)

Stable murine chondrogenic cell lines derived from c-fos-induced cartilage tumors.

J Bone Miner Res. 8(7):839-47
Weith, A. (1993)

Tumour preventing genes in neuroblastoma.

Eur. J. Canc.. 29A S6:S38
Weith, A., Kleiner, E., Ellmeier, W., Stapleton, P., Barnas, C. (1993)

Towards physical linkage map of the human chromosome 1p36 region.

Human Neuroblastoma (ed. Schwab, M.). :251-61
Zatloukal, K., Schmidt, W., Cotten, M., Wagner, E., Stingl, G., Birnstiel, ML. (1993)

Somatic gene therapy for cancer: the utility of transferrinfection in generating 'tumor vaccines'.

Gene. 135(1-2):199-207
Zenke, M. (1993)

v-erbA.

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Adams, B., Dörfler, P., Aguzzi, A., Kozmik, Z., Urbánek, P., Maurer-Fogy, I., Busslinger, M. (1992)

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

Genes Dev. 6(9):1589-607
Aguzzi, A., Bothe, K., Anhauser, I., Horak, I., Rethwilm, A., Wagner, EF. (1992)

Expression of human foamy virus is differentially regulated during development in transgenic mice.

New Biol. 4(3):225-37
Aguzzi, A., Bothe, K., Wagner, EF., Rethwilm, A., Horak, I. (1992)

Human foamy virus: an underestimated neuropathogen?

Brain Pathol. 2(1):61-9
Aguzzi, A., Ellmeier, W., Weith, A. (1992)

Dominant and recessive molecular changes in neuroblastomas.

Brain Pathol. 2(3):195-208
Amon, A., Surana, U., Muroff, I., Nasmyth, K. (1992)

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae.

Nature. 355(6358):368-71
Barlow, DP. (1992)

Preparation, restriction and hybridization analysis of mammalian genomic DNA for pulsed-field gel electrophoresis.

Methods, Applications and Theories in Pulsed-Field gel Electrophoresis (eds. Burmeister, M., Ulanovsky, L.). :107-28
Beug, H., Doederlein, G., Zenke, M. (1992)

Independent modulation of differentiation and proliferation in erythroid progenitors.

Nuclear Processes and Oncogenes. :53-84
Beyer, A., Kalchhauser, H., Wolschann, P. (1992)

Molecular modeling on garuganin-I.

Monatshefte für Chemie. 123:417-23
Boehmelt, G., Walker, A., Kabrun, N., Mellitzer, G., Beug, H., Zenke, M., Enrietto, PJ. (1992)

Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression.

EMBO J. 11(12):4641-52
Boulter, CA., Aguzzi, A., Evans, MJ., Affara, N. (1992)

A chimaeric mouse model for autosomal-dominant polycystic kidney disease.

Contrib Nephrol. 97:60-70
Braselmann, S., Bergers, G., Wrighton, C., Graninger, P., Superti-Furga, G., Busslinger, M. (1992)

Identification of Fos target genes by the use of selective induction systems.

J Cell Sci Suppl. 16:97-109
Brüstle, O., Aguzzi, A., Talarico, D., Basilico, C., Kleihues, P., Wiestler, OD. (1992)

Angiogenic activity of the K-fgf/hst oncogene in neural transplants.

Oncogene. 7(6):1177-83
Cotten, M., Wagner, E., Zatloukal, K., Phillips, S., Curiel, DT., Birnstiel, ML. (1992)

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

Proc Natl Acad Sci U S A. 89(13):6094-8
Curiel, DT., Agarwal, S., Rømer, MU., Wagner, E., Cotten, M., Birnstiel, ML., Boucher, RC. (1992)

Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway.

Am J Respir Cell Mol Biol. 6(3):247-52
Curiel, DT., Wagner, E., Cotten, M., Birnstiel, ML., Agarwal, S., Li, CM., Loechel, S., Hu, PC. (1992)

High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes.

Hum Gene Ther. 3(2):147-54
Dirick, L., Moll, T., Auer, H., Nasmyth, K. (1992)

A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast.

Nature. 357(6378):508-13
Ellmeier, W., Aguzzi, A., Kleiner, E., Kurzbauer, R., Weith, A. (1992)

Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

EMBO J. 11(7):2563-71
Engel, JD., Beug, H., LaVail, JH., Zenke, MW., Mayo, K., Leonard, MW., Foley, KP., Yang, Z., Kornhauser, JM., Ko, LJ. (1992)

cis and trans regulation of tissue-specific transcription.

J Cell Sci Suppl. 16:21-31
Fitch, I., Dahmann, C., Surana, U., Amon, A., Nasmyth, K., Goetsch, L., Byers, B., Futcher, B. (1992)

Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

Mol Biol Cell. 3(7):805-18
Fuerstenberg, S., Leitner, I., Schroeder, C., Schwarz, H., Vennström, B., Beug, H. (1992)

Transcriptional repression of band 3 and CAII in v-erbA transformed erythroblasts accounts for an important part of the leukaemic phenotype.

EMBO J. 11(9):3355-65
Juillerat-Jeanneret, L., Aguzzi, A., Wiestler, OD., Darekar, P., Janzer, RC. (1992)

Dexamethasone selectively regulates the activity of enzymatic markers of cerebral endothelial cell lines.

In Vitro Cell Dev Biol. 28A(7-8):537-43
Kozmik, Z., Wang, S., Dörfler, P., Adams, B., Busslinger, M. (1992)

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

Mol Cell Biol. 12(6):2662-72
Larson, DE., Hoffmann, I., Zahradka, P., Birnstiel, ML., Sells, BH. (1992)

Histone H4 mRNA levels are down-regulated by 3' RNA processing during terminal differentiation of myoblasts.

Biochim Biophys Acta. 1131(2):139-44
Moll, T., Dirick, L., Auer, H., Bonkovsky, J., Nasmyth, K. (1992)

SWI6 is a regulatory subunit of two different cell cycle START-dependent transcription factors in Saccharomyces cerevisiae.

J Cell Sci Suppl. 16:87-96
Nasmyth, K. (1992)

How do cells control the timing of DNA replication and mitosis?

Harvey Lect. 88:141-71
Patel, G., Nasmyth, K., Jones, N. (1992)

A new method for the isolation of recombinant baculovirus.

Nucleic Acids Res. 20(1):97-104
Phillips, S., Cotten, M., Laengle-Rouault, F., Schaffner, G., Birnstiel, ML. (1992)

Amphibian oocytes and sphere organelles: are the U snRNA genes amplified?

Chromosoma. 101(9):549-56
Phillips, SC., Birnstiel, ML. (1992)

Analysis of a gene cluster coding for the Xenopus laevis U7 snRNA.

Biochim Biophys Acta. 1131(1):95-8
Primig, M., Sockanathan, S., Auer, H., Nasmyth, K. (1992)

Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae.

Nature. 358(6387):593-7
Quarto, R., Dozin, B., Tacchetti, C., Robino, G., Zenke, M., Campanile, G., Cancedda, R. (1992)

Constitutive myc expression impairs hypertrophy and calcification in cartilage.

Dev Biol. 149(1):168-76
Redemann, N., Holzmann, B., von Rüden, T., Wagner, EF., Schlessinger, J., Ullrich, A. (1992)

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

Mol Cell Biol. 12(2):491-8
Reichmann, E., Schwarz, H., Deiner, EM., Leitner, I., Eilers, M., Berger, J., Busslinger, M., Beug, H. (1992)

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion.

Cell. 71(7):1103-16
Silver LM., Artzt K., Barlow D., Fischer-Lindahl K., Lyon MF., Klein J., Snyder L. (1992)

Mouse Chromosome 17

Mammalian Genome. 3(1 Supplement):S241-S260
Silver, LM., Artzt, K., Barlow, D., Fischer-Lindahl, K., Lyon, MF., Klein, J., Snyder, L. (1992)

Mouse chromosome 17.

Mamm Genome. 3 Spec No:S241-60
Treisman, R., Ammerer, G. (1992)

The SRF and MCM1 transcription factors.

Curr Opin Genet Dev. 2(2):221-6
Vidal, SM., Epstein, DJ., Malo, D., Weith, A., Vekemans, M., Gros, P. (1992)

Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1.

Genomics. 14(1):32-7
von Rüden, T., Kandels, S., Radaszkiewicz, T., Ullrich, A., Wagner, EF. (1992)

Development of a lethal mast cell disease in mice reconstituted with bone marrow cells expressing the v-erbB oncogene.

Blood. 79(12):3145-58
Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, DT., Birnstiel, ML. (1992)

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

Proc Natl Acad Sci U S A. 89(13):6099-103
Wagner, EF. (1992)

Towards a molecular understanding of mammalian development and disease?

Proc. of the 10th Discoveries Symposium "Basic Life Sciences and Human Society", Alexander von Humboldt Foundation. :63-71
Wang, ZQ., Ovitt, C., Grigoriadis, AE., Möhle-Steinlein, U., Rüther, U., Wagner, EF. (1992)

Bone and haematopoietic defects in mice lacking c-fos.

Nature. 360(6406):741-5
Wiestler, OD., Aguzzi, A., Schneemann, M., Eibl, R., von Deimling, A., Kleihues, P. (1992)

Oncogene complementation in fetal brain transplants.

Cancer Res. 52(13):3760-7
Wiestler, OD., Brüstle, O., Eibl, RH., Radner, H., Aguzzi, A., Kleihues, P. (1992)

Retrovirus-mediated oncogene transfer into neural transplants.

Brain Pathol. 2(1):47-59
Zatloukal, K., Wagner, E., Cotten, M., Phillips, S., Plank, C., Steinlein, P., Curiel, DT., Birnstiel, ML. (1992)

Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells.

Ann N Y Acad Sci. 660:136-53
Zimmer, A., Wang, ZQ., Wagner, EF., Gruss, P. (1992)

Homologous recombination in embryonic stem cells as a means to generate mice with defined mutations.

Mechanisms of Eukaryotic DNA Recombination (eds. Gottesman, ME., Vogel, HZ.). :29-40
Aguzzi, A., Kleihues, P., Heckl, K., Wiestler, OD. (1991)

Cell type-specific tumor induction in neural transplants by retrovirus-mediated oncogene transfer.

Oncogene. 6(1):113-8
Alexander, WS., Lyman, SD., Wagner, EF. (1991)

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

EMBO J. 10(12):3683-91
Artzt, K., Barlow, D., Dove, WF., Fischer-Lindahl, K., Klein, J., Lyon, MF., Silver, LM. (1991)

Mouse chromosome 17.

Mamm Genome. 1 Spec No:S280-300
Barlow, DP., Stöger, R., Herrmann, BG., Saito, K., Schweifer, N. (1991)

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.

Nature. 349(6304):84-7
Benn, A., Antoine, M., Beug, H., Niessing, J. (1991)

Primary structure and expression of a chicken cDNA encoding a protein with zinc-finger motifs.

Gene. 106(2):207-12
Beug, H., Vennström, B. (1991)

Avian erythroleukemia: Possible mechanisms involved in v-erbA oncogene function.

Nuclear Hormone Receptors (ed. Parker, MD.). :355-75
Boulter, CA., Aguzzi, A., Williams, RL., Wagner, EF., Evans, MJ., Beddington, R. (1991)

Expression of v-src induces aberrant development and twinning in chimaeric mice.

Development. 111(2):357-66
Burkert, U., von Rüden, T., Wagner, EF. (1991)

Early fetal hematopoietic development from in vitro differentiated embryonic stem cells.

New Biol. 3(7):698-708
Cotten, M., Oberhauser, B., Brunar, H., Holzner, A., Issakides, G., Noe, CR., Schaffner, G., Wagner, E., Birnstiel, ML. (1991)

2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event.

Nucleic Acids Res. 19(10):2629-35
Cross, S., Kovarik, P., Schmidtke, J., Bird, A. (1991)

Non-methylated islands in fish genomes are GC-poor.

Nucleic Acids Res. 19(7):1469-74
Curiel, DT., Agarwal, S., Wagner, E., Cotten, M. (1991)

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

Proc Natl Acad Sci U S A. 88(19):8850-4
Dirick, L., Nasmyth, K. (1991)

Positive feedback in the activation of G1 cyclins in yeast.

Nature. 351(6329):754-7
Disela, C., Glineur, C., Bugge, T., Sap, J., Stengl, G., Dodgson, J., Stunnenberg, H., Beug, H., Zenke, M. (1991)

v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.

Genes Dev. 5(11):2033-47
Disela, C., Walter, C., Dodgson, J., Stunnenberg, H., Beug, H., Zenke, M. (1991)

The v-erbA oncoprotein efficiently suppresses erythrocyte-specific CA II expression.

Proceedings on carbonic anhydrases (ed. Botrè, F., Gros, G., Storey, BT.. :139-43
Eckert, WA., Plass, C., Weith, A., Traut, W., Winking, H. (1991)

Transcripts from amplified sequences of an inherited homogeneously staining region in chromosome 1 of the house mouse (Mus musculus).

Mol Cell Biol. 11(4):2229-35
Eckner, R., Ellmeier, W., Birnstiel, ML. (1991)

Mature mRNA 3' end formation stimulates RNA export from the nucleus.

EMBO J. 10(11):3513-22
Hiller, S., Breit, S., Wang, ZQ., Wagner, EF., Schwab, M. (1991)

Localization of regulatory elements controlling human MYCN expression.

Oncogene. 6(6):969-77
Khazaie, K., Panayotou, G., Aguzzi, A., Samarut, J., Gazzolo, L., Jurdic, P. (1991)

EGF promotes in vivo tumorigenic growth of primary chicken embryo fibroblasts expressing v-myc and enhances in vitro transformation by the v-erbA oncogene.

Oncogene. 6(1):21-8
Lengauer, C., Eckelt, A., Weith, A., Endlich, N., Ponelies, N., Lichter, P., Greulich, KO., Cremer, T. (1991)

Painting of defined chromosomal regions by in situ suppression hybridization of libraries from laser-microdissected chromosomes.

Cytogenet Cell Genet. 56(1):27-30
Lydall, D., Ammerer, G., Nasmyth, K. (1991)

A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription.

Genes Dev. 5(12B):2405-19
Morrison, LE., Boehmelt, G., Beug, H., Enrietto, PJ. (1991)

Expression of v-rel in a replication competent virus: transformation and biochemical characterization.

Oncogene. 6(9):1657-66
Nadeau, JH., Herrmann, B., Bucan, M., Burkart, D., Crosby, JL., Erhart, MA., Kosowsky, M., Kraus, JP., Michiels, F., Schnattinger, A. (1991)

Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci.

Genomics. 9(1):78-89
Nasmyth, K., Dirick, L. (1991)

The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast.

Cell. 66(5):995-1013
Nasmyth, K., Dirick, L., Surana, U., Amon, A., Cvrckova, F. (1991)

Some facts and thoughts on cell cycle control in yeast.

Cold Spring Harb Symp Quant Biol. 56:9-20
Simon, D., Knowles, BB., Weith, A. (1991)

Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.

Oncogene. 6(5):765-70
Smith, HO., Tabiti, K., Schaffner, G., Soldati, D., Albrecht, U., Birnstiel, ML. (1991)

Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides.

Proc Natl Acad Sci U S A. 88(21):9784-8
Superti-Furga, G., Bergers, G., Picard, D., Busslinger, M. (1991)

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

Proc Natl Acad Sci U S A. 88(12):5114-8
Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, AB., Nasmyth, K. (1991)

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.

Cell. 65(1):145-61
Taba, MR., Muroff, I., Lydall, D., Tebb, G., Nasmyth, K. (1991)

Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast.

Genes Dev. 5(11):2000-13
Tanaka, EM., Kirschner, MW. (1991)

Microtubule behavior in the growth cones of living neurons during axon elongation.

J Cell Biol. 115(2):345-63
Vennström, B., Beug, H., Damm, K., Engel, D., Gehring, U., Graf, T., Munoz, A., Sap, J., Zenke, M. (1991)

Biological effects of the v-erbA oncogene in transformation of avian erythroid cells.

Molecular Mechanisms in Cellular Growth and Differentiation (eds. Bellve, AR., Vogel, JH.). :137-47
von Rüden, T., Mouchiroud, G., Bourette, RP., Ouazana, R., Blanchet, JP., Wagner, EF. (1991)

Expression of human CSF-1 receptor induces CSF-1-dependent proliferation in murine myeloid but not in T-lymphoid cells.

Leukemia. 5(1):3-7
Wagner EF. (1991)

Transgenic mouse models for bone and vascular diseases and gene transfer into hematopoietic cells.

Human Gene Transfer (eds. Cohen-Haguenauer, O., Boiron, M.). 219:227-34
Wagner, E., Cotten, M., Foisner, R., Birnstiel, ML. (1991)

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

Proc Natl Acad Sci U S A. 88(10):4255-9
Wagner, E., Oberhauser, B., Holzner, A., Brunar, H., Issakides, G., Schaffner, G., Cotten, M., Knollmüller, M., Noe, CR. (1991)

A simple procedure for the preparation of protected 2'-O-methyl or 2'-O-ethyl ribonucleoside-3'-O-phosphoramidites.

Nucleic Acids Res. 19(21):5965-71
Wagner, EF., Wang, ZQ., Grigoriadis, AE., Möhle-Steinlein, U., Aguzzi, A., Risau, W. (1991)

Analysis of oncogene function in ES cells and chimaeric mice.

Origins of Human Cancer (CSH Lab Press). :1030-6
Wang, ZQ., Grigoriadis, AE., Möhle-Steinlein, U., Wagner, EF. (1991)

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.

EMBO J. 10(9):2437-50
Zenke, M., Khazaie, K., Beug, H. (1991)

V-myc-transformed macrophages expressing the normal human EGF receptor are induced to proliferate by EGF via a non-autocrine mechanism.

Molecular Biology of Haematopiesis (eds. Sachs, I., Abraham, NG., Weidemann, C., Konwalinka, G.. :453-67
Aguzzi, A., Wagner, EF., Williams, RL., Courtneidge, SA. (1990)

Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen.

New Biol. 2(6):533-43
Barberis, A., Widenhorn, K., Vitelli, L., Busslinger, M. (1990)

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

Genes Dev. 4(5):849-59
Beyer, A., Schuster, P. (1990)

Internal dynamics of flexible molecules.

Cyclohexane, Monatshefte f. Chemie . 1212:2339/349
Birnstiel, ML. (1990)

Gene isolation is 25 years old this month.

Trends Genet. 6(12):380-1
Cotten, M. (1990)

The in vivo application of ribozymes.

Trends Biotechnol. 8(7):174-8
Cotten, M., Längle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H., Birnstiel, ML. (1990)

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

Proc Natl Acad Sci U S A. 87(11):4033-7
Forrest, D., Muñoz, A., Raynoschek, C., Vennström, B., Beug, H. (1990)

Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.

Oncogene. 5(3):309-16
Fuerstenberg, S., Beug, H., Introna, M., Khazaie, K., Muñoz, A., Ness, S., Nordström, K., Sap, J., Stanley, I., Zenke, M. (1990)

Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector.

J Virol. 64(12):5891-902
Glineur, C., Zenke, M., Beug, H., Ghysdael, J. (1990)

Phosphorylation of the v-erbA protein is required for its function as an oncogene.

Genes Dev. 4(10):1663-76
Goralczyk, R., Closs, EI., Rüther, U., Wagner, EF., Strauss, PG., Erfle, V., Schmidt, J. (1990)

Characterization of fos-induced osteogenic tumours and tumour-derived murine cell lines.

Differentiation. 44(2):122-31
Hengerer, B., Lindholm, D., Heumann, R., Rüther, U., Wagner, EF., Thoenen, H. (1990)

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

Proc Natl Acad Sci U S A. 87(10):3899-903
Labeit, S., Barlow, DP., Gautel, M., Gibson, T., Holt, J., Hsieh, CL., Francke, U., Leonard, K., Wardale, J., Whiting, A. (1990)

A regular pattern of two types of 100-residue motif in the sequence of titin.

Nature. 345(6272):273-6
Meehan, R., Antequera, F., Lewis, J., MacLeod, D., McKay, S., Kleiner, E., Bird, AP. (1990)

A nuclear protein that binds preferentially to methylated DNA in vitro may play a role in the inaccessibility of methylated CpGs in mammalian nuclei.

Philos Trans R Soc Lond B Biol Sci. 326(1235):199-205
Montesano, R., Pepper, MS., Möhle-Steinlein, U., Risau, W., Wagner, EF., Orci, L. (1990)

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene.

Cell. 62(3):435-45
Nasmyth, KA. (1990)

FAR-reaching discoveries about the regulation of START.

Cell. 63(6):1117-20
Schroeder, C., Raynoschek, C., Fuhrmann, U., Damm, K., Vennström, B., Beug, H. (1990)

The v-erb A oncogene causes repression of erythrocyte-specific genes and an immature, aberrant differentiation phenotype in normal erythroid progenitors.

Oncogene. 5(10):1445-53
Sved, J., Bird, A. (1990)

The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model.

Proc Natl Acad Sci U S A. 87(12):4692-6
Tazi, J., Bird, A. (1990)

Alternative chromatin structure at CpG islands.

Cell. 60(6):909-20
Vasserot, AP., Hoffmann, I., Tabiti, K., Birnstiel, ML. (1990)

3 processing of histone RNA precursors.

Mol Biol Rep. 14(2-3):211-2
Wagner, E., Zenke, M., Cotten, M., Beug, H., Birnstiel, ML. (1990)

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

Proc Natl Acad Sci U S A. 87(9):3410-4
Wagner, EF. (1990)

Oncogenes and transgenic mice.

Growth factors, differentiaion factors and cytokines (ed. Habenicht, A.). :662-83
Yamamoto, M., Ko, LJ., Leonard, MW., Beug, H., Orkin, SH., Engel, JD. (1990)

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

Genes Dev. 4(10):1650-62
Zenke, M., Muñoz, A., Sap, J., Vennström, B., Beug, H. (1990)

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.

Cell. 61(6):1035-49
Zenke, M., Steinlein, P., Wagner, E., Cotten, M., Beug, H., Birnstiel, ML. (1990)

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.

Proc Natl Acad Sci U S A. 87(10):3655-9
Barberis, A., Superti-Furga, G., Busslinger, M. (1989)

The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.

Nucleic Acids Res. 17(17):7114
Barberis, A., Superti-Furga, G., Vitelli, L., Kemler, I., Busslinger, M. (1989)

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.

Genes Dev. 3(5):663-75
Beug, H., Graf, T. (1989)

Co-operation between viral oncogenes in avian erythroid and myeloid leukaemia.

Eur J Clin Invest. 19(6):491-502
Bird, AP. (1989)

Two classes of observed frequency for rare-cutter sites in CpG islands.

Nucleic Acids Res. 17(22):9485
Birnstiel, ML., Busslinger, M. (1989)

Further liaisons with sperm.

Science. 245(4915):243-4
Birnstiel, ML., Busslinger, M. (1989)

Dangerous liaisons: spermatozoa as natural vectors for foreign DNA?

Cell. 57(5):701-2
Cotten, M., Birnstiel, ML. (1989)

Ribozyme mediated destruction of RNA in vivo.

EMBO J. 8(12):3861-6
Harashima, S., Miller, AM., Tanaka, K., Kusumoto, K., Tanaka, K., Mukai, Y., Nasmyth, K., Oshima, Y. (1989)

Mating-type control in Saccharomyces cerevisiae: isolation and characterization of mutants defective in repression by a1-alpha 2.

Mol Cell Biol. 9(10):4523-30
Heckl, K., Wagner, EF. (1989)

In situ analysis of c-fos expression in transgenic mice.

Current Communications in Molecular Biology: Molecular Genetics of Early Drosophila and Mouse Development (ed. Capecchi, MR.). :117-29
Meehan, RR., Lewis, JD., McKay, S., Kleiner, EL., Bird, AP. (1989)

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

Cell. 58(3):499-507
Rüther, U., Komitowski, D., Schubert, FR., Wagner, EF. (1989)

c-fos expression induces bone tumors in transgenic mice.

Oncogene. 4(7):861-5
Rüther, U., Wagner, EF. (1989)

The specific consequences of c-fos expression in transgenic mice.

Prog Nucleic Acid Res Mol Biol. 36:235-45
Superti-Furga, G., Barberis, A., Schreiber, E., Busslinger, M. (1989)

The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts.

Biochim Biophys Acta. 1007(2):237-42
Trotter, J., Boulter, CA., Sontheimer, H., Schachner, M., Wagner, EF. (1989)

Expression of v-src arrests murine glial cell differentiation.

Oncogene. 4(4):457-64
Wagner, EF., Williams, RL., Rüther, U. (1989)

c-fos and polyoma middle T oncogene expression in transgenic mice and embroyonal stem cell chimaeras.

NATO ASI Series. H26, Cell to cell signals in mammalian development (ed. de Laat, SW.):301-10
Wiestler, OD., Aguzzi, A., Williams, RL., Wagner, EF., Boulter, CA., Kleihues, P. (1989)

Tumour induction in fetal brain transplants exposed to the viral oncogenes polyoma middle T and v-src.

IARC Sci Publ. (96):267-74
Williams, RL., Risau, W., Zerwes, HG., Drexler, H., Aguzzi, A., Wagner, EF. (1989)

Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment.

Cell. 57(6):1053-63
Cosson, J., Kemler, I., Tanno, S., Busslinger, M. (1988)

Promoter of a somatic histone H2B gene of the sea urchin.

Nucleic Acids Res. 16(9):4175
Cotten, M., Gick, O., Vasserot, A., Schaffner, G., Birnstiel, ML. (1988)

Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction.

EMBO J. 7(3):801-8
Frykberg, L., Metz, T., Brady, G., Introna, M., Beug, H., Vennström, B., Graf, T. (1988)

A point mutation in the DNA binding domain of the v-myb oncogene of E26 virus confers temperature sensitivity for transformation of myelomonocytic cells.

Oncogene Res. 3(4):313-22
Gilmartin, GM., Schaufele, F., Schaffner, G., Birnstiel, ML. (1988)

Functional analysis of the sea urchin U7 small nuclear RNA.

Mol Cell Biol. 8(3):1076-84
Graf, T., Kahn, P., Leutz, A., Beug, H., Vennström, B. (1988)

Cooperativity of viral oncogenes in avian leukaemia.

IARC Sci Publ. (92):165-70
Superti-Furga, G., Barberis, A., Schaffner, G., Busslinger, M. (1988)

The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

EMBO J. 7(10):3099-107