The Proteomics Technology Hub is looking for a highly motivated Master's student (m/f/x, limited to 1 year, part-time 20 h/week) in the field of proteomics, focusing on method development in the field of single-cell proteomics (SCP) & multiomics.
Our Group. At the Proteomics Technology Hub at IMP/IMBA/GMI, we aim to develop new and powerful methods to increase sensitivity in protein identification, accuracy, and precision of protein quantification or post-translational modification detection. We establish comprehensive strategies in the field of structural proteomics, single-cell proteomics, multi-omics technologies, and spatial omics. Our cutting-edge method development strategies range from sample preparation to optimization of data acquisition, data analysis, and validation. To achieve these goals, we frequently collaborate with international research groups and industry. The group is equipped with state-of-the-art MS and liquid chromatography, as well as sample preparation robotics instrumentation.
The Project. Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased method for the investigation of cellular heterogeneity, thereby complementing transcriptomics and genomics data. Proteins are the main driver of cellular functionality, and understanding their regulation is crucial to understanding cellular development and pathogenesis.
This project is a collaborative effort with leading bioinformaticians from the University of Applied Sciences in Hagenberg/Upper Austria, as well as the NGS facility at the Vienna Biocenter and the lab of Elly Tanka/IMBA. The student will focus on setting up and optimizing a smart, miniaturized, and semi-automatized single-cell pipeline, working with material from the very same single to investigate the proteome and transcriptome to eventually investigate early neural asymmetry mechanisms. Using clonal neural tube organoid systems, we aim to answer which proteins are reproducibly asymmetrically distributed and how metabolic and mechanical reporters predict fate outcome.
The Candidate. The successful candidate should hold a B.Sc. degree in the fields of chemistry, biochemistry, molecular biology, or a related field. Experience in mass spectrometry as well as in the wet lab is desirable. Fluency in English is required, and English is used as the working language. The candidate should be curious, creative, and excited about learning new topics and skills! Despite the emphasis on technology development within our group, a candidate with experience, knowledge, or curiosity at the intersection of analytical chemistry and biochemistry will make a perfect match.
Our Environment. The Research Institute of Molecular Pathology (IMP) in Vienna is a basic research institute largely sponsored by Boehringer Ingelheim, embedded in the vibrant environment of the Vienna Biocenter—one of Europe’s largest science hubs, including four research institutes, three universities, and ~24 biotech companies. With around 250 employees from 40 countries, the IMP is committed to scientific discovery of fundamental molecular and cellular mechanisms underlying complex biological phenomena.
We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn at the intersection of biochemistry, proteomics, transcriptomics, and bioinformatics. The position is available from fall 2026 and remains open until it is filled. The student will receive a monthly stipend of EUR 1,090 for 20 h/week (i.e., EUR 15,260 gross per year).
Please send your application (motivation letter, CV, contact details of at least one reference) by mail to karl.mechtler[at]imp.ac.at and manuel.matzinger[at]imp.ac.at
Please note that we do not offer a full Master's program. Applicants will need to enroll in or be enrolled in a Master's program that allows for research to be conducted at external institutions.