About Rushad Pavri's lab
The laboratory of Dr. Rushad Pavri at King’s College London is inviting applications for a postdoctoral position for a project focused on understanding the molecular mechanisms of antibody somatic hypermutation and its impact on autoimmune disease.
The Pavri group has a long-standing interest and expertise in the molecular mechanisms of antibody maturation and associated genome instability in B lymphocytes. Specifically, we investigate how transcription, chromatin architecture, DNA replication and epigenetic features regulate the key processes of antibody somatic hypermutation and class switch recombination as well as the oncogenic chromosomal translocations arising from these mutagenic pathways. In addition, we study the physiology of germinal centers in murine lymphoid tissues, which is where the antibody maturation reactions occur. The laboratory uses a multi-disciplinary approach including mouse genetics, immunological assays, genetic screening and various genomics tools. A list lab projects and publications from the group can be found here: https://www.kcl.ac.uk/research/pavri-group
More information about the position can be found here.