Browse the latest publications and preprints from the IMP. Here we list the most recent publications with IMP scientists as first- or corresponding authors in chronological order.
The sperm protein Spaca6 is essential for fertilization in zebrafishbioRxiv . 2021.11.19.469324
A molecular network of conserved factors keeps ribosomes dormant in the eggbioRxiv . 2021.11.03.467131
Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timingbioRxiv . 2021.11.03.467109
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.Proc Natl Acad Sci U S A. 118(39)
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.Elife. 10
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.Nat Chem Biol.
The Fertilization Enigma: How Sperm and Egg Fuse.Annu Rev Cell Dev Biol.
Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanomaNature Cancer . 2:693–708
Genome folding through loop extrusion by SMC complexes.Nat Rev Mol Cell Biol. 22(7):445-464
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.Sci Immunol. 6(61)
Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.PLoS Genet. 17(2):e1009390
Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.Elife. 10
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.Cancer Discov. 11(11):2868-2883
E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATPbioRxiv. 2021.05.10.443411
Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.medRxiv. 2021.01.19.21250079
Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.Cell. 184(21):5448-5464.e22
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.Nature. 599(7885):491-496
miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.Sci Adv. 7(42):eabh1434
Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.Br J Dermatol.
Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.Cold Spring Harb Perspect Biol.
The cellular and signaling dynamics of salamander limb regeneration.Curr Opin Cell Biol. 73:117-123
A self-generated Toddler gradient guides mesodermal cell migrationbioRxiv . 2021.12.16.472981