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Latest Publications

Browse the latest publications and preprints from the IMP. Here we list the most recent publications with IMP scientists as first- or corresponding authors in chronological order.

2022

Binner, MI., Kogan, A., Panser, K., Schleiffer, A., Deneke, VE., Pauli, A. (2022)

The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.

Corresponding preprint Front Cell Dev Biol. 9:806982

2021

Pre-printStock,J., Kazmar,T., Schlumm,F., Hannezo,E., Pauli,A. (2021)

A self-generated Toddler gradient guides mesodermal cell migration

bioRxiv . 2021.12.16.472981
Leiendecker, L., Jung, PS., Obenauf, AC. (2021)

Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma.

Br J Dermatol.
de Almeida, M., Hinterndorfer, M., Brunner, H., Grishkovskaya, I., Singh, K., Schleiffer, A., Jude, J., Deswal, S., Kalis, R., Vunjak, M., Lendl, T., Imre, R., Roitinger, E., Neumann, T., Kandolf, S., Schutzbier, M., Mechtler, K., Versteeg, GA., Haselbach, D., Zuber, J. (2021)

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

Nature. 599(7885):491-496
Bassat, E., Tanaka, EM. (2021)

The cellular and signaling dynamics of salamander limb regeneration.

Curr Opin Cell Biol. 73:117-123
Bauer, BW., Davidson, IF., Canena, D., Wutz, G., Tang, W., Litos, G., Horn, S., Hinterdorfer, P., Peters, JM. (2021)

Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.

Cell. 184(21):5448-5464.e22
Smeenk, L., Ottema, S., Mulet-Lazaro, R., Ebert, A., Havermans, M., Varea, AA., Fellner, M., Pastoors, D., van Herk, S., Erpelinck-Verschueren, C., Grob, T., Hoogenboezem, RM., Kavelaars, FG., Matson, DR., Bresnick, EH., Bindels, EM., Kentsis, A., Zuber, J., Delwel, R. (2021)

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Cancer Discov. 11(11):2868-2883
Pre-printLeesch,KF., Lorenzo-Orts,L., Pribitzer,C., Grishkovskaya,I., Matzinger,M., Roitinger,E., Belacic,K., Kandolf,S., Lin, TY., Mechtler,K., Meinhart,A., Haselbach,D., Pauli,A. (2021)

A molecular network of conserved factors keeps ribosomes dormant in the egg

bioRxiv . 2021.11.03.467131
Pre-printGert,KR., Cabrera Quio,LE., Novatchkova,M., Guo,Y., Cairns,BR., Pauli,A. (2021)

Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing

bioRxiv . 2021.11.03.467109
Gutiérrez-Pérez, P., Santillán, EM., Lendl, T., Wang, J., Schrempf, A., Steinacker, TL., Asparuhova, M., Brandstetter, M., Haselbach, D., Cochella, L. (2021)

miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.

Sci Adv. 7(42):eabh1434
Otsuki, L., Tanaka, EM. (2021)

Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.

Cold Spring Harb Perspect Biol.
Fujihara, Y., Herberg, S., Blaha, A., Panser, K., Kobayashi, K., Larasati, T., Novatchkova, M., Theussl, HC., Olszanska, O., Ikawa, M., Pauli, A. (2021)

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.

Corresponding preprint Proc Natl Acad Sci U S A. 118(39)
Hajdusits, B., Suskiewicz, MJ., Hundt, N., Meinhart, A., Kurzbauer, R., Leodolter, J., Kukura, P., Clausen, T. (2021)

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Corresponding preprint Elife. 10
Grabarczyk, DB., Petrova, OA., Deszcz, L., Kurzbauer, R., Murphy, P., Ahel, J., Vogel, A., Gogova, R., Faas, V., Kordic, D., Schleiffer, A., Meinhart, A., Imre, R., Lehner, A., Neuhold, J., Bader, G., Stolt-Bergner, P., Böttcher, J., Wolkerstorfer, B., Fischer, G., Grishkovskaya, I., Haselbach, D., Kessler, D., Clausen, T. (2021)

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.

Nat Chem Biol.
Deneke, VE., Pauli, A. (2021)

The Fertilization Enigma: How Sperm and Egg Fuse.

Annu Rev Cell Dev Biol.
Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Nature Cancer . 2:693–708
Davidson, IF., Peters, JM. (2021)

Genome folding through loop extrusion by SMC complexes.

Nat Rev Mol Cell Biol. 22(7):445-464
Calderón, L., Schindler, K., Malin, SG., Schebesta, A., Sun, Q., Schwickert, T., Alberti, C., Fischer, M., Jaritz, M., Tagoh, H., Ebert, A., Minnich, M., Liston, A., Cochella, L., Busslinger, M. (2021)

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.

Sci Immunol. 6(61)
Cabrera-Quio, LE., Schleiffer, A., Mechtler, K., Pauli, A. (2021)

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.

PLoS Genet. 17(2):e1009390
Cura Costa, E., Otsuki, L., Rodrigo Albors, A., Tanaka, EM., Chara, O. (2021)

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.

Elife. 10
Pre-printAhel J, Fletcher A, Grabarczyk DB, Roitinger E, Deszcz L, Lehner A, Virdee S, Clausen T. (2021)

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

bioRxiv. 2021.05.10.443411
Pre-printKellner MJ, Matl M, Ross JJ, Schnabl J, Handler D, Heinen R, Schaeffer J, Hufnagl P, Indra A, Dekens MPS, Fritsche-Polanz R, Födinger M, Zuber J, Vienna Covid-19 Detection Initiative (VCDI), Allerberger F, Pauli A, Brennecke J (2021)

Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.

medRxiv. 2021.01.19.21250079