Publications

The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling

BrainTrawler: A visual analytics framework for iterative exploration of heterogeneous big brain data

A Data Structure for Real-Time Aggregation Queries of Big Brain Networks.

Spectral Clustering Improves Label-Free Quantification of Low-Abundant Proteins.

A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.

Transcriptional cofactors display specificity for distinct types of core promoters.

Functional-genetic approaches to understanding drug response and resistance.

Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.

Absolute quantification of cohesin, CTCF and their regulators in human cells.

The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study.

Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.

The H3 histone chaperone NASPSIM3 escorts CenH3 in Arabidopsis.

A comparative perspective on brain regeneration in amphibians and teleost fish.

No evidence for a magnetite-based magnetoreceptor in the lagena of pigeons.

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.

Sequencing cell-type-specific transcriptomes with SLAM-ITseq.

Publisher Correction: Sequencing cell-type-specific transcriptomes with SLAM-ITseq.

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets.

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.

Tinbergen's challenge for the neuroscience of behavior.

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast.

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.

Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.

Structural analysis of urinary light chains and proteomic analysis of hyaline tubular casts in light chain associated kidney disorders.

A role for miR-132 in learned safety.

Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism.

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.

Improved Sensitivity in Low-Input Proteomics using Micro-Pillar Array-based Chromatography.

Optimized fragmentation improves the identification of peptides cross-linked by MS-cleavable reagents.

Structure of McsB, a protein kinase for regulated arginine phosphorylation.

Spectral recording of gene expression history by fluorescent timer protein.

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy.

Human blood vessel organoids as a model of diabetic vasculopathy.

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.

Pooled Generation of Lentiviral Tetracycline-Regulated microRNA Embedded Short Hairpin RNA Libraries.

Cell-type specific sequencing of microRNAs from complex animal tissues.

A high-throughput method to identify trans-activation domains within transcription factor sequences.

Epigenetic regulation of brain region-specific microglia clearance activity.

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

Experimental and computational framework for a dynamic protein atlas of human cell division.

Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

apQuant: Accurate Label-Free Quantification by Quality Filtering.

CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction.

PhoStar: Identifying Tandem Mass Spectra of Phosphorylated Peptides before Database Search.

The IAP family member BRUCE regulates autophagosome-lysosome fusion.

Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds.

Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation.

Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.

Predicting functional neuroanatomical maps from fusing brain networks with genetic information.

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.

Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect.

Dorsal tegmental dopamine neurons gate associative learning of fear.

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

A new era of proactive melanoma therapy: hit hard, hit early.

Eukaryotic core promoters and the functional basis of transcription initiation.

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.

Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia).

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.

Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations.

Sensorimotor Integration for Decision Making: How the Worm Steers.

Control of B-1a cell development by instructive BCR signaling.

Cryptochrome: The magnetosensor with a sinister side?

Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".

Ectopic otoconial formation in the lagena of the pigeon inner ear.

SLAM-ITseq: sequencing cell type-specific transcriptomes without cell sorting.

Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.

Senescence-associated reprogramming promotes cancer stemness.

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

Resolving systematic errors in widely used enhancer activity assays in human cells.

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.

The axolotl genome and the evolution of key tissue formation regulators.

Author Correction: The axolotl genome and the evolution of key tissue formation regulators.

Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.

Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.

Reply to 'Defining distance restraints in HADDOCK'.

Author Correction: Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.

Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.

Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.

Prespliceosome structure provides insights into spliceosome assembly and regulation.

Stress peptides sensitize fear circuitry to promote passive coping.

Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing in Caenorhabditis elegans.

A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans.

Mutations that prevent methylation of cohesin render sensitivity to DNA damage.

Necroptosis microenvironment directs lineage commitment in liver cancer.

Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy.

High-speed volumetric imaging of neuronal activity in freely moving rodents.

Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents.

Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.

Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities.

Dynamics of sister chromatid resolution during cell cycle progression.

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

Regenerating tissues.

Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

A Guide to Emerging Technologies for Large-Scale and Whole-Brain Optical Imaging of Neuronal Activity.

Expressing Multi-subunit Complexes Using biGBac.

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.

TCEA1 regulates the proliferative potential of mouse myeloid cells.

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.

An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries.

A framework for understanding the roles of miRNAs in animal development.

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.

Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution.

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.

Tubulins and brain development - The origins of functional specification.

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.

Promoting transcription over long distances.

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.

Root diffusion barrier control by a vasculature-derived peptide binding to the SGN3 receptor.

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.

Probing the canonicity of the Wnt/Wingless signaling pathway.

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.

A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.

Thiol-linked alkylation of RNA to assess expression dynamics.

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.

Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans.

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.

STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth.

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

A global brain state underlies C. elegans sleep behavior.

Is magnetogenetics the new optogenetics?

Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance.

Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy.

Magnetoreception-A sense without a receptor.

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.

A right-handed signalling pathway drives heart looping in vertebrates.

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

Urinary neprilysin in the critically ill patient.

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.

R Loops in the Regulation of Antibody Gene Diversification.

Prediction of potent shRNAs with a sequential classification algorithm.

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

Combinatorial function of transcription factors and cofactors.

Phosphoproteomics with Activated Ion Electron Transfer Dissociation.

Nodal patterning without Lefty inhibitory feedback is functional but fragile.

Non-model model organisms.

DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes.

A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protist Tetrahymena.

BIME2, a novel gene required for interhomolog meiotic recombination in the protist model organism Tetrahymena.

Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.

Control of type III protein secretion using a minimal genetic system.

Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.

Virtual reality for freely moving animals.

A vital sugar code for ricin toxicity.

Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.

Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

Proceedings of the EuBIC Winter School 2017.

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.

Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Decoding sORF translation - from small proteins to gene regulation.

Musk Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop.

Rapid movement and transcriptional re-localization of human cohesin on DNA.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.

Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.

Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.

Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.

Structural basis for the disaggregase activity and regulation of Hsp104.

Topology and structure of an engineered human cohesin complex bound to Pds5B.

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis.

Molecular basis of outer kinetochore assembly on CENP-T.

Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans.

ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.

Measuring APC/C-Dependent Ubiquitylation In Vitro.

SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Sororin actively maintains sister chromatid cohesion.

A de novo frameshift in HNRNPK causing a Kabuki-like syndrome with nodular heterotopia.

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation.

Oxygen-induced social behaviours in Pristionchus pacificus have a distinct evolutionary history and genetic regulation from Caenorhabditis elegans.

Gene Regulation: Activation through Space.

MEK1 is required for the development of NRAS-driven leukemia.

Activation of an exonic splice-donor site in exon 30 of CDK5RAP2 in a patient with severe microcephaly and pigmentary abnormalities.

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.

Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore.

Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Fast volumetric calcium imaging across multiple cortical layers using sculpted light.

Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

Correction to "Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1".

Editorial overview: Cell reprogramming, regeneration and repair.

Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation.

RANKL/RANK control Brca1 mutation-driven mammary tumors.

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.

RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2.

Chemical Biology Interrogates Protein Arginine Phosphorylation.

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.

Direct detection of a single photon by humans.

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.

Adaptive and Background-Aware GAL4 Expression Enhancement of Co-registered Confocal Microscopy Images.

Arginine phosphorylation marks proteins for degradation by a Clp protease.

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.

DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.

A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.

C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves.

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.

Anion-exchange chromatography of phosphopeptides: weak anion exchange versus strong anion exchange and anion-exchange chromatography versus electrostatic repulsion-hydrophilic interaction chromatography.

An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client.

The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.

The histone chaperone CAF-1 safeguards somatic cell identity.

Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement.

Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.

No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening.

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Coordinating the human looks.

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.

Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies.

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.

Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.

Transgenesis in axolotl (Ambystoma mexicanum).

Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.

Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers.

Predicting the Dynamics of Network Connectivity in the Neocortex.

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3.

STARR-seq - principles and applications.

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

3DSpectra: A 3-dimensional quantification algorithm for LC-MS labeled profile data.

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562.

MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

High-efficiency electroporation of the spinal cord in larval axolotl.

Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.

Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.

Optimizing and extending light-sculpting microscopy for fast functional imaging in neuroscience.

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.

Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

Burst muscle performance predicts the speed, acceleration, and turning performance of Anna's hummingbirds.

Laser-induced acoustic desorption of natural and functionalized biochromophores.

The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle.

Transcriptional regulators form diverse groups with context-dependent regulatory functions.

Visualizing KcsA conformational changes upon ion binding by infrared spectroscopy and atomistic modeling.

Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation.

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Modeling human development in 3D culture.

Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution.

Measuring the functional organization of the neocortex at large and small scales.

FlyMAD: rapid thermogenetic control of neuronal activity in freely walking Drosophila.

Neuronal control of Drosophila walking direction.

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Microtubules and neurodevelopmental disease: the movers and the makers.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Epigenetic control of immunity.

Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals.

Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.

Mathematical modeling of regenerative processes.

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Diversity and wiring variability of visual local neurons in the Drosophila medulla M6 stratum.

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Automated image-based tracking and its application in ecology.

ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.

Is salamander hindlimb regeneration similar to that of the forelimb? Anatomical and morphogenetic analysis of hindlimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative and developmental studies.

Is salamander limb regeneration really perfect? Anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental, and evolutionary studies.

Development of fore- and hindlimb muscles in GFP-transgenic axolotls: morphogenesis, the tetrapod bauplan, and new insights on the forelimb-hindlimb enigma.

MS Amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra.

Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.

CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration.

Ascending SAG neurons control sexual receptivity of Drosophila females.

Asymmetric processing of visual motion for simultaneous object and background responses.

Flying Drosophila stabilize their vision-based velocity controller by sensing wind with their antennae.

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.

Myosin chaperones.

Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A.

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Characterization of a DNA exit gate in the human cohesin ring.

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination.

Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl.

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

Development and performance evaluation of an ultralow flow nanoliquid chromatography-tandem mass spectrometry set-up.

Genome-scale functional characterization of Drosophila developmental enhancers in vivo.

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

"Uno, nessuno e centomila": the different faces of the budding yeast kinetochore.

Neural circuit components of the Drosophila OFF motion vision pathway.

3D reconstitution of the patterned neural tube from embryonic stem cells.

cis-regulatory requirements for tissue-specific programs of the circadian clock.

The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.

Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos.

Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation.

Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.

Genomics: Hiding in plain sight.

TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.

Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins.

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.

Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy.

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Structure of a pathogenic type 3 secretion system in action.

A dual role for autophagy in a murine model of lung cancer.

A conserved role for Snail as a potentiator of active transcription.

NDST1 missense mutations in autosomal recessive intellectual disability.

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.

H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress.

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response.

Stage-specific control of early B cell development by the transcription factor Ikaros.

Differential requirement for Nfil3 during NK cell development.

Transcriptional enhancers: from properties to genome-wide predictions.

Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin.

Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena.

Reverse Engineering Animal Vision with Virtual Reality and Genetics.

Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.

BRD4: a BET(ter) target for the treatment of AML?

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.

Cellular and behavioral functions of fruitless isoforms in Drosophila courtship.

A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis.

qcML: an exchange format for quality control metrics from mass spectrometry experiments.

Epigenetic targeting of activation-induced cytidine deaminase.

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.

Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features.

Cellular and molecular basis of decision-making.

Development of siRNA payloads to target KRAS-mutant cancer.

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Genome-wide quantitative enhancer activity maps identified by STARR-seq.

Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain.

Identification of transcription factor binding sites from ChIP-seq data at high resolution.

A multiplicative reinforcement learning model capturing learning dynamics and interindividual variability in mice.

Multiple mechanisms contribute to centriole separation in C. elegans.

Discriminating external and internal causes for heading changes in freely flying Drosophila.

Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

Spectrally coded optical nanosectioning (SpecON) with biocompatible metal-dielectric-coated substrates.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

An optimized microRNA backbone for effective single-copy RNAi.

Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain.

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.

Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD).

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.

EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.

CLP1 links tRNA metabolism to progressive motor-neuron loss.

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.

Interlaboratory studies and initiatives developing standards for proteomics.

Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain.

Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation.

Drosophila Embryo Stage Annotation using Label Propagation

Foamy virus for efficient gene transfer in regeneration studies.

Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.

Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration.

Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes.

An iron-rich organelle in the cuticular plate of avian hair cells.

A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain.

Parallel neural pathways mediate CO2 avoidance responses in Drosophila.

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.

A directional tuning map of Drosophila elementary motion detectors.

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.

CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.

Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.

Optimized nonlinear gradients for reversed-phase liquid chromatography in shotgun proteomics.

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl.

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.

Analysis of meiotic protein complexes from Arabidopsis and Brassica using affinity-based proteomics.

Transgenic mouse models enabling photolabeling of individual neurons in vivo.

Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.

Progressive specification rather than intercalation of segments during limb regeneration.

Studying the fragmentation behavior of peptides with arginine phosphorylation and its influence on phospho-site localization.

Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light.

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Limb regeneration.

Protein-mediated transformation of lipid vesicles into tubular networks.

Life(span) in balance: oxygen fuels a sophisticated neural network for lifespan homeostasis in C. elegans.

Regulatory Genomics - Decoding Drosophila Regulatory Sequences.

Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema.

Wapl is an essential regulator of chromatin structure and chromosome segregation.

High resolution anatomical mapping confirms the absence of a magnetic sense system in the rostral upper beak of pigeons.

Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes.

Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans.

Deciphering the transcriptional cis-regulatory code.

Circadian and circalunar clock interactions in a marine annelid.

Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.

Discrete neocortical dynamics predict behavioral categorization of sounds.

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Centrosomes can initiate a polarity axis from any position within one-cell C. elegans embryos.

Methods in cell biology: analysis of cell polarity in C. elegans embryos.

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.

The Arabidopsis HEI10 is a new ZMM protein related to Zip3.

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.

Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies.

A pipeline for the generation of shRNA transgenic mice.

Neural crest does not contribute to the neck and shoulder in the axolotl (Ambystoma mexicanum).

Inter-homolog crossing-over and synapsis in Arabidopsis meiosis are dependent on the chromosome axis protein AtASY3.

Induced heterodimerization and purification of two target proteins by a synthetic coiled-coil tag.

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis.

The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.

Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression.

Dopamine neurons modulate pheromone responses in Drosophila courtship learning.

Regeneration and reprogramming.

Analysis of protein mixtures from whole-cell extracts by single-run nanoLC-MS/MS using ultralong gradients.

The blueprint of the type-3 injectisome.

Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain.

HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature.

Auditory circuit in the Drosophila brain.

Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing.

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma.

Reconstitution of the central and peripheral nervous system during salamander tail regeneration.

Reconstitution of the central nervous system during salamander tail regeneration from the implanted neurospheres.

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

Update on sumoylation: defining core components of the plant SUMO conjugation system by phylogenetic comparison.

Exome sequencing can detect pathogenic mosaic mutations present at low allele frequencies.

A novel nonsense CDK5RAP2 mutation in a Somali child with primary microcephaly and sensorineural hearing loss.

Induction of immediate early genes in the mouse auditory cortex after auditory cued fear conditioning to complex sounds.

The many functions of cohesin--different rings to rule them all?

Sister chromatid cohesion.

SIMPATIQCO: a server-based software suite which facilitates monitoring the time course of LC-MS performance metrics on Orbitrap instruments.

Stem cells in the land of the rising sun: ISSCR 2012.

Diversity and roles of (t)RNA ligases.

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

CENP-T proteins are conserved centromere receptors of the Ndc80 complex.

Regenerative biology: Skin, heal thyself.

Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins.

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior.

Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons.

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Cancer stem cell definitions and terminology: the devil is in the details.

Seventy-five genetic loci influencing the human red blood cell.

Reshaping the optical dimension in optogenetics.

Essential role of EBF1 in the generation and function of distinct mature B cell types.

Actin branching in the initiation and maintenance of lamellipodia.

The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.

Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.

WNTing embryonic stem cells.

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.

Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding.

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation.

X Inactivation and Progenitor Cancer Cells

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis.

A computational pipeline for comparative ChIP-seq analyses.

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis.

General statistical modeling of data from protein relative expression isobaric tags.

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

Gene expression profile of the regeneration epithelium during axolotl limb regeneration.

HTRA proteases: regulated proteolysis in protein quality control.

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Using MATLAB to Achieve Nanoscale Optical Sectioning in the Vicinity of Metamaterial Substrates by Simulating Emitter-Substrate Interactions

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails.

Vibrational excitons in ionophores: experimental probes for quantum coherence-assisted ion transport and selectivity in ion channels

Regulation of GATA-3 expression during CD4 lineage differentiation.

Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.

Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.

CTCF-binding elements mediate control of V(D)J recombination.

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.

Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster.

A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.

Modification of the conformational skin structure by treatment with liposomal formulations and its correlation to the penetration depth of aciclovir.

High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species.

Systematic phosphorylation analysis of human mitotic protein complexes.

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins.

Neural-specific elongation of 3' UTRs during Drosophila development.

Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.

An RNA-Seq strategy to detect the complete coding and non-coding transcriptome including full-length imprinted macro ncRNAs.

Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species.

Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure.

Comment on 'Jobs for the boys'.

Altered Mascot search results by changing the m/z range of MS/MS spectra: analysis and potential applications.

Quality control in LC-MS/MS.

Ultra-high-pressure RPLC hyphenated to an LTQ-Orbitrap Velos reveals a linear relation between peak capacity and number of identified peptides.

Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.

A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

A high-resolution map of human evolutionary constraint using 29 mammals.

Multiplicative dynamics underlie the emergence of the log-normal distribution of spine sizes in the neocortex in vivo.

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.

Random mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residues.

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells.

Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component.

Pax5: a master regulator of B cell development and leukemogenesis.

Protein quality control in the bacterial periplasm.

Limb regeneration: a new development?

Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.

A system for imaging the regulatory noncoding Xist RNA in living mouse embryonic stem cells.

Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development.

Improved precision of iTRAQ and TMT quantification by an axial extraction field in an Orbitrap HCD cell.

HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

Immersion freezing of biological specimens: rationale, principles, and instrumentation.

Membrane lipidome of an epithelial cell line.

Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.

Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects.

Three-dimensional model of Salmonella's needle complex at subnanometer resolution.

EMCD real space maps of Magnetospirillum magnetotacticum.

Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1.

The cellular basis for animal regeneration.

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.

Universal and confident phosphorylation site localization using phosphoRS.

Substrate-induced remodeling of the active site regulates human HTRA1 activity.

Neuronal control of Drosophila courtship song.

Confined activation and subdiffractive localization enables whole-cell PALM with genetically expressed probes.

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

ConteXt of change--X inactivation and disease.

X inactivation and disease.

Peptide orientation affects selectivity in ion-exchange chromatography.

Vertebrates that regenerate as models for guiding stem cels.

Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans.

CD14 is a coreceptor of Toll-like receptors 7 and 9.

Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain.

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I.

Tuba8 is expressed at low levels in the developing mouse and human brain.

Sexual dimorphism in the fly brain.

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.

Navigating intermediate targets: the nervous system midline.

Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

Multifrequency parallelized near-field optical imaging with anistropic metal-dielectric stacks

Temperature dependence of the near-field superlensing effect for single metal layers and stacked metal-dielectric films

Fast near-field imaging of spectrally broad sources using layered metallic structures

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.

Regulation of Tbx22 during facial and palatal development.

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.

The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system.

A model for cyst lumen expansion and size regulation via fluid secretion.

Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production.

Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae.

Conversion of a regulatory into a degradative protease.

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

Proteomic analysis of the outer membrane of Protochlamydia amoebophila elementary bodies.

Expression and regulation of ANTXR1 in the chick embryo.

The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans.

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression.

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Morphologic, functional, and occlusal characterization of mandibular lateral displacement malocclusion.

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.

The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus.

Human rhinovirus 14 enters rhabdomyosarcoma cells expressing icam-1 by a clathrin-, caveolin-, and flotillin-independent pathway.

MIPs are ancestral ligands for the sex peptide receptor.

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties.

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.

Polycomb complexes act redundantly to repress genomic repeats and genes.

Mechanistic concepts in X inactivation underlying dosage compensation in mammals.

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment.

MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena.

Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.

From an electrophoretic mobility shift assay to isolated transcription factors: a fast genomic-proteomic approach.

Epithelial-Mesenchymal Transition in Pancreatic Carcinoma

NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells.

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

STAT5 in B cell development and leukemia.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

Type III secretion systems shape up as they ship out.

Tracing antigen signatures in the human IgE repertoire.

Annexin A1 attenuates EMT and metastatic potential in breast cancer.

A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes.

Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.

QIKS--Quantitative identification of kinase substrates.

Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/MS spectra and noise reduction.

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Photounbinding of calmodulin from a family of CaM binding peptides.

Sororin mediates sister chromatid cohesion by antagonizing Wapl.

An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila.

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.

Peptide labeling with isobaric tags yields higher identification rates using iTRAQ 4-plex compared to TMT 6-plex and iTRAQ 8-plex on LTQ Orbitrap.

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

The actin cytoskeleton in whole mount preparations and sections.

Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma.

Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila.

Transcriptional repression of ceramide kinase in LPS-challenged macrophages.

Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.

Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.

The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone.

Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos.

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

Systematic genetic analysis of muscle morphogenesis and function in Drosophila.

Topology and organization of the Salmonella typhimurium type III secretion needle complex components.

RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.

Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors.

Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts.

Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts.

Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway.

Electron tomography reveals unbranched networks of actin filaments in lamellipodia.

Mcl-1 is essential for germinal center formation and B cell memory.

Organization and coordinated assembly of the type III secretion export apparatus.

An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.

Sixteen New Cases Contributing to the Characterization of Patients with Distal 22q11.2 Microduplications.

Cellular organization of the neural circuit that drives Drosophila courtship behavior.

Developmental gene regulation in the era of genomics.

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence.

SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.

Cancer progenitors and epigenetic contexts: an Xisting connection.

Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.

Breast cancer stem cells: eradication by differentiation therapy?

Charting the molecular network of the drug target Bcr-Abl.

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.

BrainGazer--visual queries for neurobiology research.

Automated monitoring to reduce electron microscope downtime.

Improving Phosphopeptide/Protein Identification Using a New Data Mining Framework for MS/MS Spectra Preprocessing

FLYSNPdb: a high-density SNP database of Drosophila melanogaster.

An improved strategy for tandem affinity purification-tagging of Schizosaccharomyces pombe genes.

Turning meiosis into mitosis.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

Reprogramming of Xist against the pluripotent state in fusion hybrids.

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor.

Induction of autophagy by spermidine promotes longevity.

Defining a superlens operating regime for imaging fluorescent molecules.

RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR.

TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.

Central control of fever and female body temperature by RANKL/RANK.

Transcriptional networks controlling skeletal development.

Sensory neurons in the Drosophila genital tract regulate female reproductive behavior.

Peptidic small molecule activators of the stress sensor DegS.

Selectivity profiling of DegP substrates and inhibitors.

Beyond photobleaching, laser illumination unbinds fluorescent proteins.

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Stoichiometry determination of the MP1-p14 complex using a novel and cost-efficient method to produce an equimolar mixture of standard peptides.

Dynamic localisation of Ran GTPase during the cell cycle.

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.

Generation of transgenic axolotls (Ambystoma mexicanum).

Axolotl (Ambystoma mexicanum) in vitro fertilization.

A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast.

High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all.

Axolotl (Ambystoma mexicanum) limb and tail amputation.

Grafting axolotl (Ambystoma mexicanum) limb skin and cartilage from GFP+ donors to normal hosts.

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.

X chromosome inactivation sparked by non-coding RNAs.

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment.

Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.

Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information.

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.

Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome.

Preventing carryover of peptides and proteins in nano LC-MS separations.

Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy.

An innovative method to study target protein-drug interactions by mass spectrometry.

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.

Axolotl (Ambystoma mexicanum) embryonic transplantation methods.

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

ANNIE: integrated de novo protein sequence annotation.

With Happyhour, everyone's under the table.

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.

Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.

Cohesin acetylation: from antiestablishment to establishment.

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.

The temporomandibular joint in a rheumatoid arthritis patient after orthodontic treatment.

The protein tyrosine kinase Tec regulates mast cell function.

Induction of RNA-directed DNA methylation upon decondensation of constitutive heterochromatin.

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis.

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.

Learning the transcriptional regulatory code.

Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes.

Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.

Considering the evolution of regeneration in the central nervous system.

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.

Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge.

Ambystoma mexicanum, the axolotl: a versatile amphibian model for regeneration, development, and evolution studies.

The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.

How cohesin and CTCF cooperate in regulating gene expression.

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

Oct4 to count 2.

Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p.

Moving AHEAD with an international human epigenome project.

A guide to accurate measurement of diffusion using fluorescence correlation techniques with blinking quantum dot nanoparticle labels.

Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.

Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system.

Comparative analysis of sequence features involved in the recognition of tandem splice sites.

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.

High-resolution, high-throughput SNP mapping in Drosophila melanogaster.

Developmental plasticity of lymphocytes.

Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grains.

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit.

Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.

Wired for sex: the neurobiology of Drosophila mating decisions.

Podoplanin is a novel fos target gene in skin carcinogenesis.

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1.

Expression and regulation of HTRA1 during chick and early mouse development.

Role of Growth factors in Bone development and differentiation.

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.

When flies and mice develop cancer. Meeting on development and cancer.

Redundant mechanisms for regulation of midline crossing in Drosophila.

B young again.

Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.

Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.

The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion.

Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms.

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.

Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.

Targeting c-Jun and JunB proteins as potential anticancer cell therapy.

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.

The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice.

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.

Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.

Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.

GraFix: sample preparation for single-particle electron cryomicroscopy.

JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion.

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells.

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

The different functions of Stat5 and chromatin alteration through Stat5 proteins.

Novel insights into the flexibility of cell and positional identity during urodele limb regeneration.

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.

Structural basis for the regulated protease and chaperone function of DegP.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.

Complications of needle electromyography: hematoma risk and correlation with anticoagulation and antiplatelet therapy.

SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers.

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation.

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.

Epithelial Plasticity of Hepatocytes During Liver Tumor Progression

DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena.

Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.

Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.

Checkpoint control: the journey continues.

The cohesin complex and its roles in chromosome biology.

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice.

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.

Arabidopsis SMG7 protein is required for exit from meiosis.

Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases.

Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.

Enhanced detection and identification of multiply phosphorylated peptides using TiO2 enrichment in combination with MALDI TOF/TOF MS.

Positional cloning by fast-track SNP-mapping in Drosophila melanogaster.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Transcript versus transcription?

Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation.

Unravelling the structure of the lamellipodium.

Longitudinal alteration of the occlusal plane and development of different dentoskeletal frames during growth.

Micromanaging regeneration.

Heads or tails: can Wnt tell which one is up?

Ca2+/Calmodulin-dependent kinase II signaling causes skeletal overgrowth and premature chondrocyte maturation.

Polo and Aurora kinases: lessons derived from chemical biology.

The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.

Twenty years of cell-cycle conferences in Roscoff.

Antagonistic control of cell fates by JNK and p38-MAPK signaling.

Developmentally informed research on the effectiveness of clinical trials: a primer for assessing how developmental issues may influence treatment responses among adolescents with alcohol use problems.

Architecture and flexibility of the yeast Ndc80 kinetochore complex.

Cohesin mediates transcriptional insulation by CCCTC-binding factor.

14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation.

c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.

A receptor that mediates the post-mating switch in Drosophila reproductive behaviour.

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

Neuroscience: hidden female talent.

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease.

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation.

Differential regulation of Foxo3a target genes in erythropoiesis.

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

In vitro differentiation of murine embryonic stem cells toward a renal lineage.

Identification of new targets using expression profiling.

Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

Pax5: the guardian of B cell identity and function.

Ran and Rac in mouse eggs: cortical polarity and spindle positioning.

Acto-myosin reorganization and PAR polarity in C. elegans.

Neurobiology of behaviour.

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila.

Simultaneous generation of fra-2 conditional and fra-2 knock-out mice.

PSD-95 is required for activity-driven synapse stabilization.

The ring between ring fingers (RBR) protein family.

Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?

Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.

PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs.

The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity.

Tandem affinity purification of functional TAP-tagged proteins from human cells.

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.

The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer.

Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

MASPECTRAS: a platform for management and analysis of proteomics LC-MS/MS data.

Skeletal development--Wnts are in control.

Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.

Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.

Dscam diversity is essential for neuronal wiring and self-recognition.

Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling.

p53 is regulated by the lysine demethylase LSD1.

p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.

p38alpha: a suppressor of cell proliferation and tumorigenesis.

A physical assay for sister chromatid cohesion in vitro.

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing.

A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database.

Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.

Drosophila olfactory memory: single genes to complex neural circuits.

Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone.

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.

Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor.

HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.

Life beyond cleavage: the case of Ago2 and hematopoiesis.

Towards complete sets of farnesylated and geranylgeranylated proteins.

Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.

LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.

The complete removal of cohesin from chromosome arms depends on separase.

pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.

Xist and the order of silencing.

Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections.

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

JunB is a gatekeeper for B-lymphoid leukemia.

A chemical proteomics approach to phosphatidylinositol 3-kinase signaling in macrophages.

A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination.

The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis.

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.

Cell biology: the checkpoint brake relieved.

Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.

c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes.

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.

The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila.

Annexin A2/P11 interaction: new insights into annexin A2 tetramer structure by chemical crosslinking, high-resolution mass spectrometry, and computational modeling.

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.

Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.

Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.

A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene.

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.

Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action.

Molecular biology. How and when the genome sticks together.

RNA degradation in fission yeast mitochondria is stimulated by a member of a new family of proteins that are conserved in lower eukaryotes.

Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT.

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.

Xist function: bridging chromatin and stem cells.

X inactivation Xplained.

NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.

The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches.

Epigenetics

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Protein prenylation: an (almost) comprehensive overview on discovery history, enzymology and significance in physiology and disease.

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.

Wiring stability of the adult Drosophila olfactory circuit after lesion.

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division.

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Netrins guide Drosophila commissural axons at short range.

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.

Histone modification patterns associated with the human X chromosome.

How APC/C orders destruction.

Epigenetic control of lymphopoiesis.

A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced.

Phosphoproteomics as a tool to unravel plant regulatory mechanisms

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

Regulation of commissural axon pathfinding by slit and its Robo receptors.

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

Histone modification and the control of heterochromatic gene silencing in Drosophila.

Biomolecular Mechanisms with Computational Biology

The polycomb group protein EZH2 is required for mammalian circadian clock function.

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.

Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.

Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.

A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes.

The role of human HtrA1 in arthritic disease.

High-throughput knockout screen in fission yeast.

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.

Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.

A Wnt canon orchestrating osteoblastogenesis.

Bone and Cartilage.