The IMP publishes 60 to 90 scientific papers in international peer-review journals every year. This evidence for the productivity and high scientific standard of the IMP is listed here in full – a directory of all scientific publications by IMP scientists since the establishment of the institute, organised by years and research groups.
A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.
J Exp Med. 218(1)Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife. 9MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cell Reports. 14(3):374-389Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
PLoS Genet. 16(10):e1009151A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes.
Nat Commun. 11(1):742Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.
Nat Commun. 11(1):3101Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition.
Cancer Discov.The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.
Blood.MicroRNAs: From Mechanism to Organism.
Front Cell Dev Biol. 8:409A human tissue screen identifies a regulator of ER secretion as a brain size determinant.
Science.Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
EMBO J. :e103303Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction.
Nat Genet.Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.
Cell Death Dis. 11(7):499Species-specific mechanisms during fertilization.
Curr Top Dev Biol. 140:121-144Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Nature.The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.
Sci Adv. 6(33):eabb9110Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales.
Neuron. 105(3):562-576.e9Brain-wide representations of ongoing behavior: a universal principle?
Curr Opin Neurobiol. 64:60-69HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases.
Cancer Res.The H3 histone chaperone NASPSIM3 escorts CenH3 in Arabidopsis.
Plant J. 101(1):71-86A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse.
PLoS Genet. 16(11):e1009104LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.
EMBO Mol Med. :e12525Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Nat Struct Mol Biol. 27(6):550-560Fast and highly efficient affinity enrichment of Azide-A-DSBSO cross-linked peptides.
J Proteome Res.Cleavable Cross-Linkers and Mass Spectrometry for the Ultimate Task of Profiling Protein-Protein Interaction Networks in Vivo.
J Proteome Res.Activation by substoichiometric inhibition.
Proc Natl Acad Sci U S A. 117(3):1414-1418Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.
Mol Syst Biol. 16(2):e8985Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles.
Nat Methods. 17(7):708-716Conformation of sister chromatids in the replicated human genome.
Nature. 586(7827):139-144PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
J Biol Chem. 295(1):146-157A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.
Sci Rep. 10(1):915Introducing www.axolotl-omics.org - an integrated -omics data portal for the axolotl research community.
Exp Cell Res. :112143Identification of ALK in Thinness.
Cell.RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.
Nature.A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.
Sci Adv. 6(22):eaba0365Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.
Proc Natl Acad Sci U S A.ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science. 369(6503):524-530Structure of the human core transcription-export complex reveals a hub for multivalent interactions.
Elife. 9Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.
Oncotarget. 11(9):875-890CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia.
Blood.Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes.
J Cell Biol. 219(4)Quantifying the heterogeneity of macromolecular machines by mass photometry.
Nat Commun. 11(1):1772A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.
Elife. 9Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters.
Nat Biotechnol.STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance. 3(7)ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.
Elife. 9Structure-function analysis of microRNA 3'-end trimming by Nibbler.
Proc Natl Acad Sci U S A.Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells.
Sci Adv. 6(14):eaax5692The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.
Elife. 8The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
PLoS Genet. 15(7):e1008268The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
Nat Struct Mol Biol. 26(8):720-731Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
EMBO J. 38(2)Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.
Mol Cell. 75(2):252-266.e8Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature. 572(7769):E18The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.
Biol Open.DNA loop extrusion by human cohesin.
Science.apQuant: Accurate Label-Free Quantification by Quality Filtering.
J Proteome Res. 18(1):535-541Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Nat Immunol.Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 14(8):2597Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling
Nature Metabolism. 1:350–359BrainTrawler: A visual analytics framework for iterative exploration of heterogeneous big brain data
Computer & Graphics. 82:304-320A Data Structure for Real-Time Aggregation Queries of Big Brain Networks.
Neuroinformatics.Spectral Clustering Improves Label-Free Quantification of Low-Abundant Proteins.
J Proteome Res. 18(4):1477-1485Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment.
Front Immunol. 10:2746Transcriptional cofactors display specificity for distinct types of core promoters.
Nature. 570(7759):122-126Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids.
Endocrinology. 160(10):2282-2297Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
Nat Commun. 10(1):4781Functional-genetic approaches to understanding drug response and resistance.
Curr Opin Genet Dev. 54:41-47Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.
Trends Mol Med.Absolute quantification of cohesin, CTCF and their regulators in human cells.
Elife. 8Evolution of neuronal anatomy and circuitry in two highly divergent nematode species.
Elife. 8The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study.
Anal Chem.Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Mol Cell.A comparative perspective on brain regeneration in amphibians and teleost fish.
Dev Neurobiol.No evidence for a magnetite-based magnetoreceptor in the lagena of pigeons.
Curr Biol. 29(1):R14-R15Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.
Development. 146(3)Sequencing cell-type-specific transcriptomes with SLAM-ITseq.
Nat Protoc. 14(8):2261-2278Publisher Correction: Sequencing cell-type-specific transcriptomes with SLAM-ITseq.
Nat Protoc.AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes.
Redox Biol. 29:101393Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell Stem Cell. 25(2):258-272.e9A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Nat Commun. 10(1):4741Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets.
BMC Bioinformatics. 20(1):258STARR-seq and UMI-STARR-seq: Assessing Enhancer Activities for Genome-Wide-, High-, and Low-Complexity Candidate Libraries.
Curr Protoc Mol Biol. 128(1):e105The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.
Genes Dev. 33(11-12):669-683All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell Death Dis. 10(12):944A Putative Mechanism for Magnetoreception by Electromagnetic Induction in the Pigeon Inner Ear.
Curr Biol. 29(23):4052-4059.e4SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.
Am J Physiol Renal Physiol. 316(1):F173-F185Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.
Mol Cell. 74(5):1069-1085.e11Tinbergen's challenge for the neuroscience of behavior.
Proc Natl Acad Sci U S A. 116(20):9704-9710Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast.
Cold Spring Harb Perspect Biol. 11(5)A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Nat Commun. 10(1):2921Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure. 27(7):1124-1136.e4Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.
EMBO J. 38(19):e101233Structural analysis of urinary light chains and proteomic analysis of hyaline tubular casts in light chain associated kidney disorders.
PeerJ. 7:e7819A role for miR-132 in learned safety.
Sci Rep. 9(1):528Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism.
EMBO J. 38(15):e101433Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Nat Immunol. 20(11):1517-1529MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Nat Genet. 51(6):990-998Self-organization of parS centromeres by the ParB CTP hydrolase.
Science.Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography.
Anal Chem. 91(22):14203-14207Optimized Fragmentation Improves the Identification of Peptides Cross-Linked by MS-Cleavable Reagents.
J Proteome Res. 18(3):1363-1370Structure of McsB, a protein kinase for regulated arginine phosphorylation.
Nat Chem Biol. 15(5):510-518Spectral recording of gene expression history by fluorescent timer protein.
Biotechniques. 67(4):154-164Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.
EMBO Mol Med. 11(8):e9266Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.
Nat Protoc. 14(3):756-780Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc Natl Acad Sci U S A.Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy.
Cell. 177(4):1050-1066.e14Human blood vessel organoids as a model of diabetic vasculopathy.
Nature. 565(7740):505-510A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates.
PeerJ. 7:e8218N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.
PLoS Biol. 17(7):e3000373Pooled Generation of Lentiviral Tetracycline-Regulated microRNA Embedded Short Hairpin RNA Libraries.
Hum Gene Ther Methods. 29(1):16-29Cell-type specific sequencing of microRNAs from complex animal tissues.
Nat Methods. 15(4):283-289A high-throughput method to identify trans-activation domains within transcription factor sequences.
EMBO J. 37(16)Epigenetic regulation of brain region-specific microglia clearance activity.
Nat Neurosci. 21(8):1049-1060CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Cancer Discov. 8(7):884-897Human tripartite motif protein 52 is required for cell context-dependent proliferation.
Oncotarget. 9(17):13565-13581Experimental and computational framework for a dynamic protein atlas of human cell division.
Nature. 561(7723):411-415Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.
Genes Dev. 32(3-4):202-223Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Cell Stem Cell. 22(4):543-558.e12The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature. 563(7732):564-568CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction.
J Proteome Res. 17(8):2581-2589PhoStar: Identifying Tandem Mass Spectra of Phosphorylated Peptides before Database Search.
J Proteome Res. 17(1):290-295The IAP family member BRUCE regulates autophagosome-lysosome fusion.
Nat Commun. 9(1):599Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds.
J R Soc Interface. 15(145)Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 13(12):2908-2943Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation.
EMBO J. 37(8)Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.
Dev Biol. 433(1):47-60Predicting functional neuroanatomical maps from fusing brain networks with genetic information.
Neuroimage. 170:113-120Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.
Science. 362(6413)The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Oncogene. 37(20):2687-2701Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect.
Mol Psychiatry.Dorsal tegmental dopamine neurons gate associative learning of fear.
Nat Neurosci. 21(7):952-962Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Nat Neurosci. 21(2):207-217Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Nat Neurosci.A new era of proactive melanoma therapy: hit hard, hit early.
Br J Dermatol. 178(4):817-820Eukaryotic core promoters and the functional basis of transcription initiation.
Nat Rev Mol Cell Biol. 19(10):621-637Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.
Stem Cell Reports. 11(2):537-551Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
Cell. 172(3):454-464.e11UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
Nat Commun. 9(1):484The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Science. 361(6406):1029-1033Improved Genome Assembly and Annotation for the Rock Pigeon (Columba livia).
G3 (Bethesda). 8(5):1391-1398The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.
EMBO J. 37(15)Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations.
Philos Trans R Soc Lond B Biol Sci. 373(1758)Sensorimotor Integration for Decision Making: How the Worm Steers.
Neuron. 97(2):258-260Control of B-1a cell development by instructive BCR signaling.
Curr Opin Immunol. 51:24-31Cryptochrome: The magnetosensor with a sinister side?
PLoS Biol. 16(10):e3000018Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".
Elife. 7Ectopic otoconial formation in the lagena of the pigeon inner ear.
Biol Open. 7(8)SLAM-ITseq: sequencing cell type-specific transcriptomes without cell sorting.
Development. 145(13)Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
Stem Cell Reports. 10(6):1751-1765Senescence-associated reprogramming promotes cancer stemness.
Nature. 553(7686):96-100CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.
Blood.Resolving systematic errors in widely used enhancer activity assays in human cells.
Nat Methods. 15(2):141-149SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.
Science. 360(6390):800-805The axolotl genome and the evolution of key tissue formation regulators.
Nature. 554(7690):50-55Author Correction: The axolotl genome and the evolution of key tissue formation regulators.
Nature. 559(7712):E2Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.
Dev Biol. 433(2):262-275Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.
Nat Protoc. 13(3):478-494Reply to 'Defining distance restraints in HADDOCK'.
Nat Protoc. 13(7):1503-1505Author Correction: Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data.
Nat Protoc.Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.
Plant J. 93(1):17-33Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.
Leukemia. 32(4):1016-1022Prespliceosome structure provides insights into spliceosome assembly and regulation.
Nature. 559(7714):419-422Stress peptides sensitize fear circuitry to promote passive coping.
Mol Psychiatry.Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing in Caenorhabditis elegans.
Bio Protoc. 8(1)A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans.
Lab Chip. 18(3):505-513Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe.
J Cell Sci. 131(13)Necroptosis microenvironment directs lineage commitment in liver cancer.
Nature. 562(7725):69-75Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy.
Methods Cell Biol. 144:287-305High-speed volumetric imaging of neuronal activity in freely moving rodents.
Nat Methods.Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents.
Nat Methods. 15(6):469Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.
Cell Rep. 22(4):953-966MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nat Commun. 9(1):1983An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Nature. 553(7688):342-346Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities.
Proteomics. 18(13):e1700436Dynamics of sister chromatid resolution during cell cycle progression.
J Cell Biol. 217(6):1985-2004The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
PLoS Pathog. 14(11):e1007397Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Neuron. 100(6):1354-1368.e5Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.
Trends Cell Biol.A Guide to Emerging Technologies for Large-Scale and Whole-Brain Optical Imaging of Neuronal Activity.
Annu Rev Neurosci.Expressing Multi-subunit Complexes Using biGBac.
Methods Mol Biol. 1764:329-343Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.
J Cell Biol. 217(9):3285-3300TCEA1 regulates the proliferative potential of mouse myeloid cells.
Exp Cell Res.Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Genes Dev. 31(20):2085-2098An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries.
Biomaterials. 139:102-115A framework for understanding the roles of miRNAs in animal development.
Development. 144(14):2548-2559Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.
Elife. 6Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution.
Nat Biotechnol. 35(2):136-144Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.
Nat Microbiol. 2:17047Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Behav Brain Res. 323:47-55Tubulins and brain development - The origins of functional specification.
Mol Cell Neurosci.Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.
Hum Mol Genet. 26(2):258-269Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Nature. 544(7651):503-507Promoting transcription over long distances.
Nat Genet. 49(7):972-973A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.
J Vis Exp. (130)Root diffusion barrier control by a vasculature-derived peptide binding to the SGN3 receptor.
Science. 355(6322):280-284A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Nature. 550(7674):114-118Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.
Proc Natl Acad Sci U S A.Probing the canonicity of the Wnt/Wingless signaling pathway.
PLoS Genet. 13(4):e1006700Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Cell Rep. 20(9):2116-2130A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.
EMBO J. 36(24):3600-3618CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.
Blood. 129(3):371-382Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.
Cancer Discov. 7(8):900-917Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood. 129(21):2882-2895Thiol-linked alkylation of RNA to assess expression dynamics.
Nat Methods. 14(12):1198-1204BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Cell Rep. 18(9):2162-2174Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
Nat Rev Genet. 18(1):24-40Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.
Methods Mol Biol. 1597:43-55Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.
Oncotarget. 8(48):83354-83369Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 114(7):E1263-E1272Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.
Nat Immunol. 18(4):442-455STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth.
Cell Rep. 19(5):910-918CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.
Nat Methods. 14(12):1191-1197Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Nature. 547(7663):355-359A global brain state underlies C. elegans sleep behavior.
Science. 356(6344)Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance.
Elife. 6Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy.
Nat Methods. 14(8):811-818Magnetoreception-A sense without a receptor.
PLoS Biol. 15(10):e2003234Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Elife. 6A right-handed signalling pathway drives heart looping in vertebrates.
Nature. 549(7670):86-90The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.
Nat Plants. 3(12):973-982Urinary neprilysin in the critically ill patient.
BMC Nephrol. 18(1):172Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.
Oncotarget. 8(70):115002-115017Prediction of potent shRNAs with a sequential classification algorithm.
Nat Biotechnol. 35(4):350-353RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Genes Dev.Combinatorial function of transcription factors and cofactors.
Curr Opin Genet Dev. 43:73-81Phosphoproteomics with Activated Ion Electron Transfer Dissociation.
Anal Chem. 89(12):6367-6376Nodal patterning without Lefty inhibitory feedback is functional but fragile.
Elife. 6Non-model model organisms.
BMC Biol. 15(1):55DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes.
Cell. 170(5):956-972.e23A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protist Tetrahymena.
Mol Biol Cell. 28(6):825-833BIME2, a novel gene required for interhomolog meiotic recombination in the protist model organism Tetrahymena.
Chromosome Res. 25(3-4):291-298Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.
EMBO J. 36(6):718-735Control of type III protein secretion using a minimal genetic system.
Nat Commun. 8:14737Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.
Nature. 549(7673):538-542Virtual reality for freely moving animals.
Nat Methods. 14(10):995-1002A vital sugar code for ricin toxicity.
Cell Res. 27(11):1351-1364Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.
Dev Biol. 432(1):63-71Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
Cancer Res. 77(7):1753-1762Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.
Elife. 6Proceedings of the EuBIC Winter School 2017.
J Proteomics. 161:78-80Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
EMBO J.Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.
Cell Rep. 17(12):3142-3152NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.
J Immunol. 196(4):1753-67Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
EMBO Rep. 17(11):1624-1640The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.
Cancer Res. 76(5):1158-69An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.
Mol Cell Proteomics. 15(3):1139-50Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.
Development. 143(7):1126-33Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Nat Genet. 48(11):1349-1358Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell. 165(6):1440-1453Decoding sORF translation - from small proteins to gene regulation.
RNA Biol. 13(11):1051-1059Musk Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop.
Sci Rep. 6:33583Rapid movement and transcriptional re-localization of human cohesin on DNA.
EMBO J. 35(24):2671-2685The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Immunity. 44(1):103-15Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.
PLoS Pathog. 12(12):e1006071Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.
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Proc Natl Acad Sci U S A. 113(38):10553-8Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
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