Meinrad Busslinger

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development.

Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus.

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells.

Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.

Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.

Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.

Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue.

Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.

Repression of the B cell identity factor Pax5 is not required for plasma cell development.

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.

Epigenetic regulation of brain region-specific microglia clearance activity.

Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.

Control of B-1a cell development by instructive BCR signaling.

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells.

Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.

Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562.

MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Epigenetic control of immunity.

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

Stage-specific control of early B cell development by the transcription factor Ikaros.

Differential requirement for Nfil3 during NK cell development.

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.

Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.

Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.

The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

Essential role of EBF1 in the generation and function of distinct mature B cell types.

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Regulation of GATA-3 expression during CD4 lineage differentiation.

CTCF-binding elements mediate control of V(D)J recombination.

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells.

Pax5: a master regulator of B cell development and leukemogenesis.

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

STAT5 in B cell development and leukemia.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

Mcl-1 is essential for germinal center formation and B cell memory.

SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Developmental plasticity of lymphocytes.

B young again.

Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

In vitro differentiation of murine embryonic stem cells toward a renal lineage.

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

Pax5: the guardian of B cell identity and function.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

Life beyond cleavage: the case of Ago2 and hematopoiesis.

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.

Epigenetic control of lymphopoiesis.

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.

The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.

Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons.

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.

Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.

Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow.

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.

Tissue-specific expression of cre recombinase from the Pax8 locus.

Transcriptional control of early B cell development.

Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.

Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.

Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes.

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.

Nephric lineage specification by Pax2 and Pax8.

Reversion of B cell commitment upon loss of Pax5 expression.

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers.

Transcriptional control of B-cell development.

Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.

The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle.

The role of PAX5 (BSAP) in early and late B-cell development.

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis.

Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.

Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.

Lineage commitment in lymphopoiesis.

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.

A syndrome involving intrauterine growth retardation, microcephaly, cerebellar hypoplasia, B lymphocyte deficiency, and progressive pancytopenia.

Fidelity and infidelity in commitment to B-lymphocyte lineage development.

twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.

The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins.

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.

The molecular basis of B-cell lineage commitment.

Independent regulation of the two Pax5 alleles during B-cell development.

Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene.

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors.

Pax2/5 and Pax6 subdivide the early neural tube into three domains.

Role of the transcription factor BSAP [Pax-5] in B-cell development.

PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis.

Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma.

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments.

Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function.

Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis.

Isolation and amino acid sequence analysis reveal an ancient evolutionary origin of the cleavage stage (CS) histones of the sea urchin.

ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death.

The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 subfamily.

Regulation of human epsilon germline transcription: role of B-cell-specific activator protein.

Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.

The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.

Essential functions of Pax-5 (BSAP) in pro-B cell development.

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations.

The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter.

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development.

Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma.

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.

Normal brainstem auditory evoked potentials in Pax5-deficient mice despite morphologic alterations in the auditory midbrain region.

Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.

The role of BSAP (Pax-5) in B-cell development.

Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis.

DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5).

Deregulated expression of PAX5 in medulloblastoma.

Low affinity binding of interleukin-1 beta and intracellular signaling via NF-kappa B identify Fit-1 as a distant member of the interleukin-1 receptor family.

The gene coding for the B cell surface protein CD19 is localized on human chromosome 16p11.

The PAX5 gene: a linkage and mutation analysis in candidate human primary immunodeficiencies.

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.

Identification of AP-1-regulated genes.

The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription.

Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes.

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP.

An intragenic TaqI RFLP at the PAX5 locus.

SSCP/SacI polymorphism in the PAX5 gene.

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins.

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.

Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts.

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

Identification of Fos target genes by the use of selective induction systems.

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion.

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.

Dangerous liaisons: spermatozoa as natural vectors for foreign DNA?

Further liaisons with sperm.

In vivo and in vitro expression of U7 snRNA genes: cis- and trans-acting elements required for RNA polymerase II-directed transcription.

The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts.

Promoter of a somatic histone H2B gene of the sea urchin.

The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

Developmental regulation of micro-injected histone genes in sea urchin embryos.

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.

Characterization of two nonallelic pairs of late histone H2A and H2B genes of the sea urchin: differential regulation in the embryo and tissue-specific expression in the adult.

Transcription termination and 3' processing: the end is in site!

Synthesis of sperm and late histone cDNAs of the sea urchin with a primer complementary to the conserved 3' terminal palindrome: evidence for tissue-specific and more general histone gene variants.

Regulation of histone gene expression.

The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing.

The sequence GGCmCGG is resistant to MspI cleavage.

DNA methylation and the regulation of globin gene expression.

DNA methylation and the regulation of globin gene expression.

Structure and expression of the human globin genes and murine histocompatibility antigen genes.

The structure and expression of mammalian gene clusters.

Phenotypic analysis of globin gene expression: the thalassaemias.

The structure and expression of the haemoglobin genes.

Beta + thalassemia: aberrant splicing results from a single point mutation in an intron.

Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants.

A regulatory sequence near the 3' end of sea urchin histone genes.

Aspects of the regulation of histone genes.

Rotational diffusion of band 3 proteins in the human erythrocyte membrane.