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Nanostructures of the Infective Apparatus of Salmonella

02 Jun 2006

In Salmonella, structural changes to the molecular infection apparatus also signal an end to its further assembly. The mechanistic details of this sophisticated feedback system, which takes place at molecular level, have now been published in NATURE. Better understanding of how this pathogen’s needle-like secretion injectisome is formed will offer new approaches to preventing the infection process in future. The results obtained by the team of Thomas Marlovits, joint IMP-IMBA Group Leader and head of the new "Spot of Excellence" at the Campus Vienna Biocenter, have now been explained by using modern techniques of three-dimensional cryo electron microscopy.

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