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The IMP - Research Institute of Molecular Pathology - cordially invites to the talk:

"The VHL Tumor Suppressor Protein: Insights into Oxygen Sensing, Cancer Metabolism and Drugging the Undruggable" by William Kaelin of the Dana-Farber Cancer Institute (Boston, Massachusetts).

The talk will be held in the frame of the IMP’s Max Birnstiel Lecture series.

Date: Thursday, 29 June 2017, 11.00 a.m.
Venue: IMP Lecture Hall, Campus-Vienna-Biocenter 1, 1030 Vienna
Hosted by Johannes Zuber

William Kaelin is a Professor in the Department of Medicine at the Dana-Farber Cancer Institute, Harvard Medical School, and Associate Director of Basic Science for the Dana-Farber/Harvard Cancer Center.

William Kaelin has dedicated his research career to investigating how mutations in tumour-suppressor genes cause cancer, and how this mechanistic knowledge can be exploited for the development of rational cancer therapies. William Kaelin’s work on the VHL protein helped to motivate the successful clinical testing of VEGF inhibitors for the treatment of kidney cancer. Relevant beyond cancer biology, this line of his research led to new insights into how cells sense and respond to changes in oxygen with implications for diseases such as anaemia, myocardial infarction and stroke.

Last year, William Kaelin was awarded the Lasker Prize, the most recent achievement in a long string of outstanding scientific honours. William Kaelin is a HHMI investigator and elected member of the National Academy of Sciences. Furthermore, he is a recipient of numerous national and international scientific awards, marking his position as one of the World’s leading experts in cancer research.

Further information on William Kaelin’s research and scientific biography:
http://kaelin.dfci.harvard.edu/Kaelin_Lab_website/ 

About the Max Birnstiel Lectures

The Max Birnstiel Lectures are a special series of seminars at the Research Institute of Molecular Pathology (IMP) in Vienna and represent the highest award that the IMP can give to outside scientists. They are named after the founding director of the institute, Max L. Birnstiel, who passed away in 2014. Each year, five to six scientists are invited to deliver one of these lectures, among them a number of Nobel Prize laureates. The Max Birnstiel Lectures attract considerable attention on campus and within the wider scientific community and invariably draw a large audience to the IMP.

Programme of the Max Birnstiel Lectures:
https://www.imp.ac.at/calendar/cat/max-birnstiel-lecture/