A Double Role for Tumour Genes
Rhabdomyosarcoma is the most common soft-tissue tumour in children. It originates in muscle cells and is often located at the head or neck. A team of researchers at the IMP, led by Erwin Wagner, was able to elucidate the role of certain oncogenes in the development, but also in the prevention of the tumour in mice. The scientists publish their work in the current issue of the journal Cancer Cell. A comment in Nature also highlights the IMP-publication.
Alexander Fleischmann, Wolfram Bochum, Robert Eferl, James Witowsky, Erwin F Wagner: Rhabdomyosarcoma development in mice lacking Trp53 and Fos. Cancer Cell 4(6): 477-482, 1 December 2003.
- Press Release (German) (pdf, 81 KB)