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Joris van der Veeken

T cells are principal cellular effectors of the vertebrate immune system. T cell activation during the course of an immune response induces rapid proliferative expansion and the acquisition of specialised effector functions that enable the elimination of a wide range of invading pathogens and tumours. Concomitantly, a dedicated immunosuppressive subset of regulatory T cells maintains self-tolerance by dominantly suppressing the activity of autoreactive T cells. We seek to understand the molecular mechanisms underlying T cell differentiation and function in health and disease using genetics, genomics, and cellular immunology techniques.



Leng, F., Zhang, W., Ramirez, RN., Leon, J., Zhong, Y., Hou, L., Yuki, K., van der Veeken, J., Rudensky, AY., Benoist, C., Hur, S. (2022)

The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.

Immunity. 55(8):1354-1369.e8
van der Veeken, J., Campbell, C., Pritykin, Y., Schizas, M., Verter, J., Hu, W., Wang, ZM., Matheis, F., Mucida, D., Charbonnier, LM., Chatila, TA., Rudensky, AY. (2022)

Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells.

Immunity. 55(7):1173-1184.e7
Zhong, Y., Walker, SK., Pritykin, Y., Leslie, CS., Rudensky, AY., van der Veeken, J. (2022)

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.

Nat Immunol. 23(1):122-134


Hu, W., Wang, ZM., Feng, Y., Schizas, M., Hoyos, BE., van der Veeken, J., Verter, JG., Bou-Puerto, R., Rudensky, AY. (2021)

Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.

Nat Immunol. 22(9):1163-1174
Pritykin, Y., van der Veeken, J., Pine, AR., Zhong, Y., Sahin, M., Mazutis, L., Pe'er, D., Rudensky, AY., Leslie, CS. (2021)

A unified atlas of CD8 T cell dysfunctional states in cancer and infection.

Mol Cell. 81(11):2477-2493.e10


Campbell, C., Marchildon, F., Michaels, AJ., Takemoto, N., van der Veeken, J., Schizas, M., Pritykin, Y., Leslie, CS., Intlekofer, AM., Cohen, P., Rudensky, AY. (2020)

FXR mediates T cell-intrinsic responses to reduced feeding during infection.

Proc Natl Acad Sci U S A. 117(52):33446-33454
van der Veeken, J., Glasner, A., Zhong, Y., Hu, W., Wang, ZM., Bou-Puerto, R., Charbonnier, LM., Chatila, TA., Leslie, CS., Rudensky, AY. (2020)

The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries.

Immunity. 53(5):971-984.e5


van der Veeken, J., Zhong, Y., Sharma, R., Mazutis, L., Dao, P., Pe'er, D., Leslie, CS., Rudensky, AY. (2019)

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells.

Immunity. 50(5):1202-1217.e7


van der Veeken, J., Gonzalez, AJ., Cho, H., Arvey, A., Hemmers, S., Leslie, CS., Rudensky, AY. (2016)

Memory of Inflammation in Regulatory T Cells.

Cell. 166(4):977-990


Arvey, A., van der Veeken, J., Plitas, G., Rich, SS., Concannon, P., Rudensky, AY. (2015)

Genetic and epigenetic variation in the lineage specification of regulatory T cells.

Elife. 4:e07571
Feng, Y., van der Veeken, J., Shugay, M., Putintseva, EV., Osmanbeyoglu, HU., Dikiy, S., Hoyos, BE., Moltedo, B., Hemmers, S., Treuting, P., Leslie, CS., Chudakov, DM., Rudensky, AY. (2015)

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

Nature. 528(7580):132-136
Pucella, JN., Yen, WF., Kim, MV., van der Veeken, J., Luo, CT., Socci, ND., Naito, Y., Li, MO., Iwai, N., Chaudhuri, J. (2015)

miR-182 is largely dispensable for adaptive immunity: lack of correlation between expression and function.

J Immunol. 194(6):2635-42


Arvey, A., van der Veeken, J., Samstein, RM., Feng, Y., Stamatoyannopoulos, JA., Rudensky, AY. (2014)

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells.

Nat Immunol. 15(6):580-587
Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., Rudensky, AY. (2014)

Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.

Cell. 158(4):749-763


Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, JR., Pfeffer, K., Coffer, PJ., Rudensky, AY. (2013)

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Nature. 504(7480):451-5
van der Veeken, J., Arvey, A., Rudensky, A. (2013)

Transcriptional control of regulatory T-cell differentiation.

Cold Spring Harb Symp Quant Biol. 78:215-22


van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., van der Veeken, J., Roovers, RC., van Bergen en Henegouwen, PM., Storm, G., Hennink, WE., Schiffelers, RM., Kok, RJ. (2012)

Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment.

J Control Release. 159(2):281-9


Oliveira, S., Schiffelers, RM., van der Veeken, J., van der Meel, R., Vongpromek, R., van Bergen En Henegouwen, PM., Storm, G., Roovers, RC. (2010)

Downregulation of EGFR by a novel multivalent nanobody-liposome platform.

J Control Release. 145(2):165-75


van der Veeken, J., Oliveira, S., Schiffelers, RM., Storm, G., van Bergen En Henegouwen, PM., Roovers, RC. (2009)

Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy.

Curr Cancer Drug Targets. 9(6):748-60