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Johannes Zuber

The genetic complexity, heterogeneity, and plasticity of human cancers pose a daunting challenge for the development of effective targeted therapies. Despite their diversity, individual mutations converge at the functional level to dysregulate a limited number of cellular processes, which not only promote malignant growth but are thought to result in cancer-specific dependencies that can be exploited for therapeutic purposes. To systematically explore such ‘non-oncogene addictions’ and study them in a physiologically relevant setting, our lab combines genetically engineered mouse models (GEMMs) and advanced miRNA-based shRNA (shRNAmir) technologies optimized for multiplexed screening and studies in vivo.

Publications

Aarts, M., Georgilis, A., Beniazza, M., Beolchi, P., Banito, A., Carroll, T., Kulisic, M., Kaemena, DF., Dharmalingam, G., Martin, N., Reik, W., Zuber, J., Kaji, K., Chandra, T., Gil, J. (2017) Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. Genes Dev. 31(20):2085-2098
Adams, FF., Heckl, D., Hoffmann, T., Talbot, SR., Kloos, A., Thol, F., Heuser, M., Zuber, J., Schambach, A., Schwarzer, A. (2017) An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries. Biomaterials. 139:102-115
Greiner, G., Witzeneder, N., Berger, A., Schmetterer, K., Eisenwort, G., Schiefer, AI., Roos, S., Popow-Kraupp, T., Müllauer, L., Zuber, J., Sexl, V., Kenner, L., Sperr, WR., Valent, P., Mayerhofer, M., Hoermann, G. (2017) CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis. Blood. 129(3):371-382
Hein, N., Cameron, DP., Hannan, KM., Nguyen, NN., Fong, CY., Sornkom, J., Wall, M., Pavy, M., Cullinane, C., Diesch, J., Devlin, JR., George, AJ., Sanij, E., Quin, J., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D., Harrison, SJ., Rozario, JD., Powell, JA., Pitson, SM., Zuber, J., Johnstone, RW., Dawson, MA., Guthridge, MA., Wei, A., McArthur, GA., Pearson, RB., Hannan, RD. (2017) Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood. 129(21):2882-2895
Herzog, VA., Reichholf, B., Neumann, T., Rescheneder, P., Bhat, P., Burkard, TR., Wlotzka, W., von Haeseler, A., Zuber, J., Ameres, SL. (2017) Thiol-linked alkylation of RNA to assess expression dynamics. Nat Methods. 14(12):1198-1204
Hogg, SJ., Vervoort, SJ., Deswal, S., Ott, CJ., Li, J., Cluse, LA., Beavis, PA., Darcy, PK., Martin, BP., Spencer, A., Traunbauer, AK., Sadovnik, I., Bauer, K., Valent, P., Bradner, JE., Zuber, J., Shortt, J., Johnstone, RW. (2017) BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1. Cell Rep. 18(9):2162-2174
Housden, BE., Muhar, M., Gemberling, M., Gersbach, CA., Stainier, DY., Seydoux, G., Mohr, SE., Zuber, J., Perrimon, N. (2017) Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat Rev Genet. 18(1):24-40
Jacamo, R., Davis, RE., Ling, X., Sonnylal, S., Wang, Z., Ma, W., Zhang, M., Ruvolo, P., Ruvolo, V., Wang, RY., McQueen, T., Lowe, S., Zuber, J., Kornblau, SM., Konopleva, M., Andreeff, M. (2017) Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia. Oncotarget. 8(48):83354-83369
MacPherson, S., Horkoff, M., Gravel, C., Hoffmann, T., Zuber, J., Lum, JJ. (2017) STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth. Cell Rep. 19(5):910-918
Miller, TE., Liau, BB., Wallace, LC., Morton, AR., Xie, Q., Dixit, D., Factor, DC., Kim, LJY., Morrow, JJ., Wu, Q., Mack, SC., Hubert, CG., Gillespie, SM., Flavahan, WA., Hoffmann, T., Thummalapalli, R., Hemann, MT., Paddison, PJ., Horbinski, CM., Zuber, J., Scacheri, PC., Bernstein, BE., Tesar, PJ., Rich, JN. (2017) Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature. 547(7663):355-359
Pelossof, R., Fairchild, L., Huang, CH., Widmer, C., Sreedharan, VT., Sinha, N., Lai, DY., Guan, Y., Premsrirut, PK., Tschaharganeh, DF., Hoffmann, T., Thapar, V., Xiang, Q., Garippa, RJ., Rätsch, G., Zuber, J., Lowe, SW., Leslie, CS., Fellmann, C. (2017) Prediction of potent shRNAs with a sequential classification algorithm. Nat Biotechnol. 35(4):350-353
Samwer, M., Schneider, MWG., Hoefler, R., Schmalhorst, PS., Jude, JG., Zuber, J., Gerlich, DW. (2017) DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes. Cell. 170(5):956-972.e23
Smeenk, L., Fischer, M., Jurado, S., Jaritz, M., Azaryan, A., Werner, B., Roth, M., Zuber, J., Stanulla, M., den Boer, ML., Mullighan, CG., Strehl, S., Busslinger, M. (2017) Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia. EMBO J. 36(6):718-735
Taubenschmid, J., Stadlmann, J., Jost, M., Klokk, TI., Rillahan, CD., Leibbrandt, A., Mechtler, K., Paulson, JC., Jude, J., Zuber, J., Sandvig, K., Elling, U., Marquardt, T., Thiel, C., Koerner, C., Penninger, JM. (2017) A vital sugar code for ricin toxicity. Cell Res. 27(11):1351-1364
Valerio, DG., Xu, H., Chen, CW., Hoshii, T., Eisold, ME., Delaney, C., Cusan, M., Deshpande, AJ., Huang, CH., Lujambio, A., Zheng, YG., Zuber, J., Pandita, TK., Lowe, SW., Armstrong, SA. (2017) Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. Cancer Res. 77(7):1753-1762
van der Lelij, P., Lieb, S., Jude, J., Wutz, G., Santos, CP., Falkenberg, K., Schlattl, A., Ban, J., Schwentner, R., Hoffmann, T., Kovar, H., Real, FX., Waldman, T., Pearson, MA., Kraut, N., Peters, JM., Zuber, J., Petronczki, M. (2017) Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. Elife. 6
Wutz, G., Várnai, C., Nagasaka, K., Cisneros, DA., Stocsits, RR., Tang, W., Schoenfelder, S., Jessberger, G., Muhar, M., Hossain, MJ., Walther, N., Koch, B., Kueblbeck, M., Ellenberg, J., Zuber, J., Fraser, P., Peters, JM. (2017) Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. EMBO J.
Baker, A., Gregory, GP., Verbrugge, I., Kats, L., Hilton, JJ., Vidacs, E., Lee, EM., Lock, RB., Zuber, J., Shortt, J., Johnstone, RW. (2016) The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia. Cancer Res. 76(5):1158-69
Bigenzahn, JW., Fauster, A., Rebsamen, M., Kandasamy, RK., Scorzoni, S., Vladimer, GI., Müller, AC., Gstaiger, M., Zuber, J., Bennett, KL., Superti-Furga, G. (2016) An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client. Mol Cell Proteomics. 15(3):1139-50
Ghisi, M., Kats, L., Masson, F., Li, J., Kratina, T., Vidacs, E., Gilan, O., Doyle, MA., Newbold, A., Bolden, JE., Fairfax, KA., de Graaf, CA., Firth, M., Zuber, J., Dickins, RA., Corcoran, LM., Dawson, MA., Belz, GT., Johnstone, RW. (2016) Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 30(1):59-74
Nowacka, JD., Baumgartner, C., Pelorosso, C., Roth, M., Zuber, J., Baccarini, M. (2016) MEK1 is required for the development of NRAS-driven leukemia. Oncotarget. 7(49):80113-80130
Sdelci, S., Lardeau, CH., Tallant, C., Klepsch, F., Klaiber, B., Bennett, J., Rathert, P., Schuster, M., Penz, T., Fedorov, O., Superti-Furga, G., Bock, C., Zuber, J., Huber, KV., Knapp, S., Müller, S., Kubicek, S. (2016) Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat Chem Biol. 12(7):504-10
Tordella, L., Khan, S., Hohmeyer, A., Banito, A., Klotz, S., Raguz, S., Martin, N., Dhamarlingam, G., Carroll, T., González Meljem, JM., Deswal, S., Martínez-Barbera, JP., García-Escudero, R., Zuber, J., Zender, L., Gil, J. (2016) SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev. 30(19):2187-2198
Bigenzahn, JW., Fauster, A., Rebsamen, M., Kandasamy, RK., Scorzoni, S., Vladimer, GI., Mueller, AC., Gstaiger, M., Zuber, J., Bennett, KL., Superti-Furga, G. (2015) An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client. Mol Cell Proteomics.
Brondfield, S., Umesh, S., Corella, A., Zuber, J., Rappaport, AR., Gaillard, C., Lowe, SW., Goga, A., Kogan, SC. (2015) Direct and indirect targeting of MYC to treat acute myeloid leukemia. Cancer Chemother Pharmacol. 76(1):35-46
Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K. (2015) The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24
Grabner, B., Schramek, D., Mueller, KM., Moll, HP., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., Stiedl, P., Nivarthi, H., Bogner, E., Gruber, W., Mohr, T., Zwick, RH., Kenner, L., Poli, V., Aberger, F., Stoiber, D., Egger, G., Esterbauer, H., Zuber, J., Moriggl, R., Eferl, R., Győrffy, B., Penninger, JM., Popper, H., Casanova, E. (2015) Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 6:6285
Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., Barsyte-Lovejoy, D., Li, F., Poda, G., Schapira, M., Wu, H., Dong, A., Senisterra, G., Stukalov, A., Huber, KV., Schönegger, A., Marcellus, R., Bilban, M., Bock, C., Brown, PJ., Zuber, J., Bennett, KL., Al-Awar, R., Delwel, R., Nerlov, C., Arrowsmith, CH., Superti-Furga, G. (2015) Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 11(10):815
Matthews, GM., Mehdipour, P., Cluse, LA., Falkenberg, KJ., Wang, E., Roth, M., Santoro, F., Vidacs, E., Stanley, K., House, CM., Rusche, JR., Vakoc, CR., Zuber, J., Minucci, S., Johnstone, RW. (2015) Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. 126(21):2392-403
Murn, J., Zarnack, K., Yang, YJ., Durak, O., Murphy, EA., Cheloufi, S., Gonzalez, DM., Teplova, M., Curk, T., Zuber, J., Patel, DJ., Ule, J., Luscombe, NM., Tsai, LH., Walsh, CA., Shi, Y. (2015) Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes Dev. 29(5):501-12
Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, JS., Muhar, M., Deswal, S., Cerny-Reiterer, S., Peter, B., Jude, J., Hoffmann, T., Boryń, ŁM., Axelsson, E., Schweifer, N., Tontsch-Grunt, U., Dow, LE., Gianni, D., Pearson, M., Valent, P., Stark, A., Kraut, N., Vakoc, CR., Zuber, J. (2015) Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 525(7570):543-7
Rudolph, D., Impagnatiello, MA., Blaukopf, C., Sommer, C., Gerlich, DW., Roth, M., Tontsch-Grunt, U., Wernitznig, A., Savarese, F., Hofmann, MH., Albrecht, C., Geiselmann, L., Reschke, M., Garin-Chesa, P., Zuber, J., Moll, J., Adolf, GR., Kraut, N. (2015) Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia. J Pharmacol Exp Ther. 352(3):579-89
Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, AS., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zöchbauer-Müller, S., Zuber, J., Malumbres, M., Kollmann, K., Sexl, V. (2015) CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood. 125(1):90-101
Schwarzer, A., Holtmann, H., Brugman, M., Meyer, J., Schauerte, C., Zuber, J., Steinemann, D., Schlegelberger, B., Li, Z., Baum, C. (2015) Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia. Oncogene. 34(27):3593-604
Wedeh, G., Cerny-Reiterer, S., Eisenwort, G., Herrmann, H., Blatt, K., Hadzijusufovic, E., Sadovnik, I., Müllauer, L., Schwaab, J., Hoffmann, T., Bradner, JE., Radia, D., Sperr, WR., Hoermann, G., Reiter, A., Horny, HP., Zuber, J., Arock, M., Valent, P. (2015) Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Leukemia. 29(11):2230-7
Zhao, Z., Chen, CC., Rillahan, CD., Shen, R., Kitzing, T., McNerney, ME., Diaz-Flores, E., Zuber, J., Shannon, K., Le Beau, MM., Spector, MS., Kogan, SC., Lowe, SW. (2015) Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 47(5):539-43
Bots, M., Verbrugge, I., Martin, BP., Salmon, JM., Ghisi, M., Baker, A., Stanley, K., Shortt, J., Ossenkoppele, GJ., Zuber, J., Rappaport, AR., Atadja, P., Lowe, SW., Johnstone, RW. (2014) Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 123(9):1341-52
Burgess, MR., Hwang, E., Firestone, AJ., Huang, T., Xu, J., Zuber, J., Bohin, N., Wen, T., Kogan, SC., Haigis, KM., Sampath, D., Lowe, S., Shannon, K., Li, Q. (2014) Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124(26):3947-55
Chen, C., Liu, Y., Rappaport, AR., Kitzing, T., Schultz, N., Zhao, Z., Shroff, AS., Dickins, RA., Vakoc, CR., Bradner, JE., Stock, W., LeBeau, MM., Shannon, KM., Kogan, S., Zuber, J., Lowe, SW. (2014) MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 25(5):652-65
Demajo, S., Uribesalgo, I., Gutiérrez, A., Ballaré, C., Capdevila, S., Roth, M., Zuber, J., Martín-Caballero, J., Di Croce, L. (2014) ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia. Oncogene. 33(48):5501-10
Huang, CH., Lujambio, A., Zuber, J., Tschaharganeh, DF., Doran, MG., Evans, MJ., Kitzing, T., Zhu, N., de Stanchina, E., Sawyers, CL., Armstrong, SA., Lewis, JS., Sherr, CJ., Lowe, SW. (2014) CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev. 28(16):1800-14
Liu, GJ., Cimmino, L., Jude, JG., Hu, Y., Witkowski, MT., McKenzie, MD., Kartal-Kaess, M., Best, SA., Tuohey, L., Liao, Y., Shi, W., Mullighan, CG., Farrar, MA., Nutt, SL., Smyth, GK., Zuber, J., Dickins, RA. (2014) Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. Genes Dev. 28(12):1337-50
Rudalska, R., Dauch, D., Longerich, T., McJunkin, K., Wuestefeld, T., Kang, TW., Hohmeyer, A., Pesic, M., Leibold, J., von Thun, A., Schirmacher, P., Zuber, J., Weiss, KH., Powers, S., Malek, NP., Eilers, M., Sipos, B., Lowe, SW., Geffers, R., Laufer, S., Zender, L. (2014) In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nat Med. 20(10):1138-46
Schwickert, TA., Tagoh, H., Gültekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., Dickins, RA., Zuber, J., Jaritz, M., Busslinger, M. (2014) Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol. 15(3):283-93
Valent, P., Zuber, J. (2014) BRD4: a BET(ter) target for the treatment of AML? Cell Cycle. 13(5):689-90
Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, AM., Bradner, J., Muhar, M., Zuber, J., Müller, M., Decker, T. (2014) Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins. Mol Cell Biol. 34(3):415-27
Yuan, TL., Fellmann, C., Lee, CS., Ritchie, CD., Thapar, V., Lee, LC., Hsu, DJ., Grace, D., Carver, JO., Zuber, J., Luo, J., McCormick, F., Lowe, SW. (2014) Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov. 4(10):1182-97
Zaiss, AK., Zuber, J., Chu, C., Machado, HB., Jiao, J., Catapang, AB., Ishikawa, TO., Gil, JS., Lowe, SW., Herschman, HR. (2014) Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference. PLoS One. 9(7):e101263
Zhao, X., Chen, A., Yan, X., Zhang, Y., He, F., Hayashi, Y., Dong, Y., Rao, Y., Li, B., Conway, RM., Maiques-Diaz, A., Elf, SE., Huang, N., Zuber, J., Xiao, Z., Tse, W., Tenen, DG., Wang, Q., Chen, W., Mulloy, JC., Nimer, SD., Huang, G. (2014) Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood. 123(11):1729-38
Fellmann, C., Hoffmann, T., Sridhar, V., Hopfgartner, B., Muhar, M., Roth, M., Lai, DY., Barbosa, IA., Kwon, JS., Guan, Y., Sinha, N., Zuber, J. (2013) An optimized microRNA backbone for effective single-copy RNAi. Cell Rep. 5(6):1704-13
Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, SW., Vakoc, CR. (2013) The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene. 32(7):930-8
Shi, J., Whyte, WA., Zepeda-Mendoza, CJ., Milazzo, JP., Shen, C., Roe, JS., Minder, JL., Mercan, F., Wang, E., Eckersley-Maslin, MA., Campbell, AE., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, RG., Wigler, MH., Blobel, GA., Zuber, J., Spector, DL., Young, RA., Vakoc, CR. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev. 27(24):2648-62
Bergerson, RJ., Collier, LS., Sarver, AL., Been, RA., Lugthart, S., Diers, MD., Zuber, J., Rappaport, AR., Nixon, MJ., Silverstein, KA., Fan, D., Lamblin, AF., Wolff, L., Kersey, JH., Delwel, R., Lowe, SW., O'Sullivan, MG., Kogan, SC., Adams, DJ., Largaespada, DA. (2012) An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 119(19):4512-23
Dow, LE., Premsrirut, PK., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, RA., Hannon, GJ., Lowe, SW. (2012) A pipeline for the generation of shRNA transgenic mice. Nat Protoc. 7(2):374-93
Glaser, SP., Lee, EF., Trounson, E., Bouillet, P., Wei, A., Fairlie, WD., Izon, DJ., Zuber, J., Rappaport, AR., Herold, MJ., Alexander, WS., Lowe, SW., Robb, L., Strasser, A. (2012) Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev. 26(2):120-5
Herrmann, H., Blatt, K., Shi, J., Gleixner, KV., Cerny-Reiterer, S., Müllauer, L., Vakoc, CR., Sperr, WR., Horny, HP., Bradner, JE., Zuber, J., Valent, P. (2012) Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. Oncotarget. 3(12):1588-99
Mattarollo, SR., West, AC., Steegh, K., Duret, H., Paget, C., Martin, B., Matthews, GM., Shortt, J., Chesi, M., Bergsagel, PL., Bots, M., Zuber, J., Lowe, SW., Johnstone, RW., Smyth, MJ. (2012) NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma. Blood. 120(15):3019-29
Valent, P., Bonnet, D., De Maria, R., Lapidot, T., Copland, M., Melo, JV., Chomienne, C., Ishikawa, F., Schuringa, JJ., Stassi, G., Huntly, B., Herrmann, H., Soulier, J., Roesch, A., Schuurhuis, GJ., Wöhrer, S., Arock, M., Zuber, J., Cerny-Reiterer, S., Johnsen, HE., Andreeff, M., Eaves, C. (2012) Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer. 12(11):767-75
Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, AR., Simon, J., Zhang, J., Luo, W., Hicks, J., Zender, L., Wang, XW., Powers, S., Wigler, M., Lowe, SW. (2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A. 109(21):8212-7
Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, SP., Vanhaelen, Q., Shukalyuk, AI., Schmauss, G., Schramek, D., Schnuetgen, F., von Melchner, H., Ecker, JR., Stanford, WL., Zuber, J., Stark, A., Penninger, JM. (2011) Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74
Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, CD., Dickins, RA., Xu, Q., Hengartner, MO., Elledge, SJ., Hannon, GJ., Lowe, SW. (2011) Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell. 41(6):733-46
McJunkin, K., Mazurek, A., Premsrirut, PK., Zuber, J., Dow, LE., Simon, J., Stillman, B., Lowe, SW. (2011) Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proc Natl Acad Sci U S A. 108(17):7113-8
Pardee, TS., Zuber, J., Lowe, SW. (2011) Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner. Exp Hematol. 39(4):473-485.e4
Premsrirut, PK., Dow, LE., Kim, SY., Camiolo, M., Malone, CD., Miething, C., Scuoppo, C., Zuber, J., Dickins, RA., Kogan, SC., Shroyer, KR., Sordella, R., Hannon, GJ., Lowe, SW. (2011) A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. 145(1):145-58
Zuber, J., McJunkin, K., Fellmann, C., Dow, LE., Taylor, MJ., Hannon, GJ., Lowe, SW. (2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol. 29(1):79-83
Zuber, J., Rappaport, AR., Luo, W., Wang, E., Chen, C., Vaseva, AV., Shi, J., Weissmueller, S., Fellmann, C., Fellman, C., Taylor, MJ., Weissenboeck, M., Graeber, TG., Kogan, SC., Vakoc, CR., Lowe, SW. (2011) An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 25(15):1628-40
Zuber, J., Shi, J., Wang, E., Rappaport, AR., Herrmann, H., Sison, EA., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, MJ., Johns, C., Chicas, A., Mulloy, JC., Kogan, SC., Brown, P., Valent, P., Bradner, JE., Lowe, SW., Vakoc, CR. (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 478(7370):524-8
Mavrakis, KJ., Wolfe, AL., Oricchio, E., Palomero, T., de Keersmaecker, K., McJunkin, K., Zuber, J., James, T., Khan, AA., Leslie, CS., Parker, JS., Paddison, PJ., Tam, W., Ferrando, A., Wendel, HG. (2010) Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat Cell Biol. 12(4):372-9
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Bric, A., Miething, C., Bialucha, CU., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M., Hicks, J., McCombie, RW., Hemann, MT., Hannon, GJ., Powers, S., Lowe, SW. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 16(4):324-35
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Tchernitsa, OI., Sers, C., Zuber, J., Hinzmann, B., Grips, M., Schramme, A., Lund, P., Schwendel, A., Rosenthal, A., Schäfer, R. (2004) Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells. Oncogene. 23(26):4536-55
Trappe, RU., Riess, H., Lippek, F., Plotkin, M., Schumacher, V., Royer-Pokora, B., Hildebrandt, B., Zuber, J., Mapara, MY., Oertel, S., Dörken, B. (2004) Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene. J Pediatr Hematol Oncol. 26(12):820-3
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