Publications Johannes Zuber | Scientific Papers Zuber Lab

Navalayeu, T., Beer, N., Bebjaková, M., Kalis, RW., Hohmann, U., Stejskal, K., Krššáková, G., Fasching, N., Herzog, VA., Popitsch, N., Roitinger, E., Plaschka, C., Zuber, J., Ameres, SL. (2026)

Cellular assembly and functional resilience of the mammalian RNA exosome.

EMBO J. 45(15):5423-5456

Chiesa, A., Poli, V., Croci, O., Biagioni, F., Fuentes, P., Marenda, M., Dondi, A., Rodighiero, S., Filipuzzi, M., Sberna, S., Marzi, M., Nicassio, F., Zuber, J., Campaner, S. (2026)

Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity.

Cell Death Differ.

Centonze, A., Roura, AJ., Novillo-Font, M., Giordano, C., Hernando-Momblona, X., Llanses, M., Prats, P., Sevillano, M., Cabot, D., Novell, M., Pabst, G., Andersch, F., Cañellas-Socias, A., Zhang, C., Giakoumakis, NN., Sparks, H., Dunsby, C., Colombelli, J., Fernández-Barral, A., Sancho, E., Stephan-Otto Attolini, C., Muñoz, A., Barbachano, A., Palmer, HG., Martínez-Quintanilla, J., Zuber, J., Blaj, C., Quintana, E., Cortina, C., Marti-Renom, MA., Batlle, E. (2026)

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

Cancer Discov. 16(2):320-344

Brunner, HL., Kalis, RW., Grundmann, L., Hodáková, Z., Koskova, Z., Grishkovskaya, I., de Almeida, M., Hinterndorfer, M., Knaudt, H., Höfflin, S., Andersch, F., Kotisch, H., Dickmanns, A., Cuylen-Haering, S., Zuber, J., Haselbach, D. (2026)

A multivalent adaptor mechanism drives the nuclear import of proteasomes.

Nat Commun.

Calderón, L., Schäfer, M., Rončević, M., Rauschmeier, R., Jaritz, M., Schwickert, TA., Sun, Q., Pauli, A., Zuber, J., Busslinger, M. (2026)

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation.

J Exp Med. 223(3)

Queralt, C., Moreta-Moraleda, C., Costa, M., Grau-Leal, F., Diesch, J., Vendrell-Ayats, C., Musulén, E., Wright, RHG., Bugés, C., Manzano, JL., Cabrero-de Las Heras, S., Zuber, J., Buschbeck, M., Forcales, SV., Martínez-Balibrea, E. (2025)

Loss-of-function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5-fluorouracil and irinotecan treatment in colorectal cancer.

Clin Transl Med. 15(12):e70543

Pastoors, D., Havermans, M., Mulet-Lazaro, R., Smeenk, L., Ottema, S., Erpelinck-Verschueren, C., van Herk, S., Anthonissen, M., Grob, T., Subramanian, S., Thoms, JAI., Pimanda, JE., Wouters, BJ., Beverloo, B., Haferlach, T., Haferlach, C., Zuber, J., Bindels, E., Delwel, R. (2025)

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia.

Blood. 146(25):3098-3105

Höckendorf, U., Dutta, S., Kloos, A., Runtsch, M., Zötsch, C., Vosberg, S., Wang, Y., Kienreich, S., Flasch, B., Malovan, G., Jäger, V., Stanzer, S., Prein, S., Odinius, TO., Wagner, CV., Buschhorn, L., Dill, V., Perfler, B., Haferlach, T., Döhner, K., Götze, KS., Ruland, J., Bassermann, F., Wahida, A., Heikenwälder, M., Branca, C., Schmöllerl, J., Zuber, J., Burk, AC., Zeiser, R., Sill, H., Jayavelu, AK., Zebisch, A., Heuser, M., Dengler, MA., Jost, PJ. (2025)

Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice.

Sci Transl Med. 17(826):eadu3313

Groessl, S., Kalis, R., Snaebjornsson, MT., Wambach, L., Haider, J., Andersch, F., Schulze, A., Palm, W., Zuber, J. (2025)

Acidosis orchestrates adaptations of energy metabolism in tumors.

Science. 390(6769):eadp7603

Militello, G., Greig, A., Bi, C., Vasileva, A., Zavodszky, MI., Lo, SC., Guilmette, E., Clarner, P., Liu, B., Bhat, G., Suh, J., Dow, L., Zuber, J., Fellmann, C., Premsrirut, PK. (2025)

Engineered microRNA scaffolds for potent gene silencing in vivo.

Sci Rep. 15(1):21419

Soderholm, A., Vunjak, M., de Almeida, M., Popitsch, N., Podvalnaya, N., Araguas-Rodriguez, P., Scinicariello, S., Nischwitz, E., Butter, F., Ketting, RF., Ameres, SL., Müller-McNicoll, M., Zuber, J., Versteeg, GA. (2025)

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA.

Nucleic Acids Res. 53(12)

Troester, S., Eder, T., Wukowits, N., Piontek, M., Fernández-Pernas, P., Schmoellerl, J., Haladik, B., Manhart, G., Allram, M., Maurer-Granofszky, M., Scheidegger, N., Nebral, K., Superti-Furga, G., Meisel, R., Bornhauser, B., Valent, P., Dworzak, MN., Zuber, J., Boztug, K., Grebien, F. (2025)

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

Nat Commun. 16(1):4656

Hermann, J., Borteçen, T., Kalis, R., Kowar, A., Pechincha, C., Vogt, V., Schneider, M., Helm, D., Krijgsveld, J., Loayza-Puch, F., Zuber, J., Palm, W. (2025)

mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery.

Nat Commun. 16(1):4201

Elewaut, A., Estivill, G., Bayerl, F., Castillon, L., Novatchkova, M., Pottendorfer, E., Hoffmann-Haas, L., Schönlein, M., Nguyen, TV., Lauss, M., Andreatta, F., Vulin, M., Krecioch, I., Bayerl, J., Pedde, AM., Fabre, N., Holstein, F., Cronin, SM., Rieser, S., Laniti, DD., Barras, D., Coukos, G., Quek, C., Bai, X., Muñoz I Ordoño, M., Wiesner, T., Zuber, J., Jönsson, G., Böttcher, JP., Vanharanta, S., Obenauf, AC. (2025)

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity.

Nature. 637(8046):716-725

Pre-printBrunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Häring S, Zuber J, Haselbach D (2024)

A multivalent adaptor mechanism drives the nuclear import of proteasomes

625870.

Schuetz, T., Dolejsi, T., Beck, E., Fugger, F., Bild, A., Duin, MT., Gavranovic-Novakovic, J., Hilbold, E., Hoffmann, T., Zuber, J., Bauer, A., Ruschitzka, F., Bär, C., Penninger, JM., Haubner, BJ. (2024)

Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling.

Sci Rep. 14(1):22661

Blahetek, G., Mayer, C., Zuber, J., Lenter, M., Strobel, B. (2024)

Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Mol Ther Methods Clin Dev. 32(3):101280

Kagiou, C., Cisneros, JA., Farnung, J., Liwocha, J., Offensperger, F., Dong, K., Yang, K., Tin, G., Horstmann, CS., Hinterndorfer, M., Paulo, JA., Scholes, NS., Sanchez Avila, J., Fellner, M., Andersch, F., Hannich, JT., Zuber, J., Kubicek, S., Gygi, SP., Schulman, BA., Winter, GE. (2024)

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.

Nat Commun. 15(1):5409

Greiner, G., Witzeneder, N., Klein, K., Tangermann, S., Kodajova, P., Jaeger, E., Ratzinger, F., Gerner, MC., Jawhar, M., Baumgartner, S., Fruehwirth, K., Schmetterer, KG., Zuber, J., Gleixner, KV., Mayerhofer, M., Schwarzinger, I., Simonitsch-Klupp, I., Esterbauer, H., Baer, C., Walter, W., Meggendorfer, M., Strassl, R., Haferlach, T., Hartmann, K., Kenner, L., Sperr, WR., Reiter, A., Sexl, V., Arock, M., Valent, P., Hoermann, G. (2024)

Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis.

Blood. 143(11):1006-1017

Ciriello, G., Magnani, L., Aitken, SJ., Akkari, L., Behjati, S., Hanahan, D., Landau, DA., Lopez-Bigas, N., Lupiáñez, DG., Marine, JC., Martin-Villalba, A., Natoli, G., Obenauf, AC., Oricchio, E., Scaffidi, P., Sottoriva, A., Swarbrick, A., Tonon, G., Vanharanta, S., Zuber, J. (2024)

Cancer Evolution: A Multifaceted Affair.

Cancer Discov. 14(1):36-48

Neault, M., Lebert-Ghali, CÉ., Fournier, M., Capdevielle, C., Garfinkle, EAR., Obermayer, A., Cotton, A., Boulay, K., Sawchyn, C., St-Amand, S., Nguyen, KH., Assaf, B., Mercier, FE., Delisle, JS., Drobetsky, EA., Hulea, L., Shaw, TI., Zuber, J., Gruber, TA., Melichar, HJ., Mallette, FA. (2023)

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.

Cell Rep. 42(9):113084

Kugler, E., Madiwale, S., Yong, D., Thoms, JAI., Birger, Y., Sykes, DB., Schmoellerl, J., Drakul, A., Priebe, V., Yassin, M., Aqaqe, N., Rein, A., Fishman, H., Geron, I., Chen, CW., Raught, B., Liu, Q., Ogana, H., Liedke, E., Bourquin, JP., Zuber, J., Milyavsky, M., Pimanda, J., Privé, GG., Izraeli, S. (2023)

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.

Nat Commun. 14(1):5871

Ebner, J., Schmoellerl, J., Piontek, M., Manhart, G., Troester, S., Carter, BZ., Neubauer, H., Moriggl, R., Szakács, G., Zuber, J., Köcher, T., Andreeff, M., Sperr, WR., Valent, P., Grebien, F. (2023)

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.

Nat Commun. 14(1):5709

Schwartz, I., Vunjak, M., Budroni, V., Cantoran García, A., Mastrovito, M., Soderholm, A., Hinterndorfer, M., de Almeida, M., Hacker, K., Wang, J., Froussios, K., Jude, J., Decker, T., Zuber, J., Versteeg, GA. (2023)

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

Elife. 12

Hoffmann, T., Hörmann, A., Corcokovic, M., Zmajkovic, J., Hinterndorfer, M., Salkanovic, J., Spreitzer, F., Köferle, A., Gitschtaler, K., Popa, A., Oberndorfer, S., Andersch, F., Schaefer, M., Fellner, M., Budano, N., Ruppert, JG., Chetta, P., Wurm, M., Zuber, J., Neumüller, RA. (2023)

Precision RNAi using synthetic shRNAmir target sites.

Elife. 12

Michael, AK., Stoos, L., Crosby, P., Eggers, N., Nie, XY., Makasheva, K., Minnich, M., Healy, KL., Weiss, J., Kempf, G., Cavadini, S., Kater, L., Seebacher, J., Vecchia, L., Chakraborty, D., Isbel, L., Grand, RS., Andersch, F., Fribourgh, JL., Schübeler, D., Zuber, J., Liu, AC., Becker, PB., Fierz, B., Partch, CL., Menet, JS., Thomä, NH. (2023)

Cooperation between bHLH transcription factors and histones for DNA access.

Nature. 619(7969):385-393

Scinicariello, S., Soderholm, A., Schäfer, M., Shulkina, A., Schwartz, I., Hacker, K., Gogova, R., Kalis, R., Froussios, K., Budroni, V., Bestehorn, A., Clausen, T., Kovarik, P., Zuber, J., Versteeg, GA. (2023)

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

Corresponding preprint Elife. 12

D'Artista, L., Moschopoulou, AA., Barozzi, I., Craig, AJ., Seehawer, M., Herrmann, L., Minnich, M., Kang, TW., Rist, E., Henning, M., Klotz, S., Heinzmann, F., Harbig, J., Sipos, B., Longerich, T., Eilers, M., Dauch, D., Zuber, J., Wang, XW., Zender, L. (2023)

MYC determines lineage commitment in kras driven primary liver cancer development.

J Hepatol.

Brandstoetter, T., Schmoellerl, J., Grausenburger, R., Kollmann, S., Doma, E., Huuhtanen, J., Klampfl, T., Eder, T., Grebien, F., Hoermann, G., Zuber, J., Mustjoki, S., Maurer, B., Sexl, V. (2023)

SBNO2 is a critical mediator of STAT3-driven hematological malignancies.

Blood.

Schmoellerl, J., Barbosa, IAM., Minnich, M., Andersch, F., Smeenk, L., Havermans, M., Eder, T., Neumann, T., Jude, J., Fellner, M., Ebert, A., Steininger, M., Delwel, R., Grebien, F., Zuber, J. (2023)

EVI1 drives leukemogenesis through aberrant ERG activation.

Blood. 141(5):453-466

Carlet, M., Schmelz, K., Vergalli, J., Herold, T., Senft, D., Jurinovic, V., Hoffmann, T., Proba, J., Weichert, N., Junghanß, C., Roth, M., Eschenburg, G., Barz, M., Henze, G., Eckert, C., Eggert, A., Zuber, J., Hundsdoerfer, P., Jeremias, I. (2023)

X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

EMBO Mol Med. 15(1):e14557

Butz, S., Schmolka, N., Karemaker, ID., Villaseñor, R., Schwarz, I., Domcke, S., Uijttewaal, ECH., Jude, J., Lienert, F., Krebs, AR., de Wagenaar, NP., Bao, X., Zuber, J., Elling, U., Schübeler, D., Baubec, T. (2022)

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.

Nat Genet.

Le Pannérer, MM., Diesch, J., Casquero, R., Maher, M., Garcia, O., Haferlach, T., Zuber, J., Kündgen, A., Götze, KS., Buschbeck, M. (2022)

Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients.

Hemasphere. 6(11):e792

Pechincha, C., Groessl, S., Kalis, R., de Almeida, M., Zanotti, A., Wittmann, M., Schneider, M., de Campos, RP., Rieser, S., Brandstetter, M., Schleiffer, A., Müller-Decker, K., Helm, D., Jabs, S., Haselbach, D., Lemberg, MK., Zuber, J., Palm, W. (2022)

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

Science. 378(6615):eabn5637

Pinter, T., Fischer, M., Schäfer, M., Fellner, M., Jude, J., Zuber, J., Busslinger, M., Wöhner, M. (2022)

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.

Front Immunol. 13:979606

Peter, B., Eisenwort, G., Sadovnik, I., Bauer, K., Willmann, M., Rülicke, T., Berger, D., Stefanzl, G., Greiner, G., Hoermann, G., Keller, A., Wolf, D., Čulen, M., Winter, GE., Hoffmann, T., Schiefer, AI., Sperr, WR., Zuber, J., Mayer, J., Valent, P. (2022)

BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia.

Am J Hematol. 97(9):1215-1225

Wilding, B., Scharn, D., Böse, D., Baum, A., Santoro, V., Chetta, P., Schnitzer, R., Botesteanu, DA., Reiser, C., Kornigg, S., Knesl, P., Hörmann, A., Köferle, A., Corcokovic, M., Lieb, S., Scholz, G., Bruchhaus, J., Spina, M., Balla, J., Peric-Simov, B., Zimmer, J., Mitzner, S., Fett, TN., Beran, A., Lamarre, L., Gerstberger, T., Gerlach, D., Bauer, M., Bergner, A., Schlattl, A., Bader, G., Treu, M., Engelhardt, H., Zahn, S., Fuchs, JE., Zuber, J., Ettmayer, P., Pearson, M., Petronczki, M., Kraut, N., McConnell, DB., Solca, F., Neumüller, RA. (2022)

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.

Nat Cancer. 3(7):821-836

Kellner, MJ., Ross, JJ., Schnabl, J., Dekens, MPS., Matl, M., Heinen, R., Grishkovskaya, I., Bauer, B., Stadlmann, J., Menéndez-Arias, L., Straw, AD., Fritsche-Polanz, R., Traugott, M., Seitz, T., Zoufaly, A., Födinger, M., Wenisch, C., Zuber, J., Pauli, A., Brennecke, J. (2022)

A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.

Corresponding preprint Front Mol Biosci. 9:801309

Jobbins, AM., Haberman, N., Artigas, N., Amourda, C., Paterson, HAB., Yu, S., Blackford, SJI., Montoya, A., Dore, M., Wang, YF., Sardini, A., Cebola, I., Zuber, J., Rashid, ST., Lenhard, B., Vernia, S. (2022)

Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.

Nucleic Acids Res. 50(6):3379-3393

Haas, L., Elewaut, A., Gerard, CL., Umkehrer, C., Leiendecker, L., Pedersen, M., Krecioch, I., Hoffmann, D., Novatchkova, M., Kuttke, M., Neumann, T., da Silva, IP., Witthock, H., Cuendet, MA., Carotta, S., Harrington, KJ., Zuber, J., Scolyer, RA., Long, GV., Wilmott, JS., Michielin, O., Vanharanta, S., Wiesner, T., Obenauf, AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.

Nat Cancer. 2(7):693-708

de Almeida, M., Hinterndorfer, M., Brunner, H., Grishkovskaya, I., Singh, K., Schleiffer, A., Jude, J., Deswal, S., Kalis, R., Vunjak, M., Lendl, T., Imre, R., Roitinger, E., Neumann, T., Kandolf, S., Schutzbier, M., Mechtler, K., Versteeg, GA., Haselbach, D., Zuber, J. (2021)

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

Nature. 599(7885):491-496

Diesch, J., Le Pannérer, MM., Winkler, R., Casquero, R., Muhar, M., van der Garde, M., Maher, M., Herráez, CM., Bech-Serra, JJ., Fellner, M., Rathert, P., Brooks, N., Zamora, L., Gentilella, A., de la Torre, C., Zuber, J., Götze, KS., Buschbeck, M. (2021)

Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.

Nat Commun. 12(1):6060

Kheiroddin, P., Schöberl, P., Althammer, M., Cibali, E., Würfel, T., Wein, H., Kulawik, B., Buntrock-Döpke, H., Weigl, E., Gran, S., Gründl, M., Langguth, J., Lampl, B., Judex, G., Niggel, J., Pagel, P., Schratzenstaller, T., Schneider-Brachert, W., Gastiger, S., Bodenschatz, M., Konrad, M., Levchuk, A., Roth, C., Schöner, D., Schneebauer, F., Rohrmanstorfer, R., Dekens, MP., Brandstetter, S., Zuber, J., Wallerstorfer, D., Burkovski, A., Ambrosch, A., Wagner, T., Kabesch, M. (2021)

Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests.

Front Pediatr. 9:721518

Smeenk, L., Ottema, S., Mulet-Lazaro, R., Ebert, A., Havermans, M., Varea, AA., Fellner, M., Pastoors, D., van Herk, S., Erpelinck-Verschueren, C., Grob, T., Hoogenboezem, RM., Kavelaars, FG., Matson, DR., Bresnick, EH., Bindels, EM., Kentsis, A., Zuber, J., Delwel, R. (2021)

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Cancer Discov. 11(11):2868-2883

van der Kouwe, E., Heller, G., Czibere, A., Pulikkan, JA., Agreiter, C., Castilla, LH., Delwel, R., Di Ruscio, A., Ebralidze, AK., Forte, M., Grebien, F., Heyes, E., Kazianka, L., Klinger, J., Kornauth, C., Le, T., Lind, K., Barbosa, IAM., Pemovska, T., Pichler, A., Schmolke, AS., Schweicker, CM., Sill, H., Sperr, WR., Spittler, A., Surapally, S., Trinh, BQ., Valent, P., Vanura, K., Welner, RS., Zuber, J., Tenen, DG., Staber, PB. (2021)

Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.

Blood. 138(15):1345-1358

Willeit, P., Krause, R., Lamprecht, B., Berghold, A., Hanson, B., Stelzl, E., Stoiber, H., Zuber, J., Heinen, R., Köhler, A., Bernhard, D., Borena, W., Doppler, C., von Laer, D., Schmidt, H., Pröll, J., Steinmetz, I., Wagner, M. (2021)

Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study.

Lancet Reg Health Eur. 5:100086

Willeit, P., Bernar, B., Zurl, C., Al-Rawi, M., Berghold, A., Bernhard, D., Borena, W., Doppler, C., Kerbl, R., Köhler, A., Krause, R., Lamprecht, B., Pröll, J., Schmidt, H., Steinmetz, I., Stelzl, E., Stoiber, H., von Laer, D., Zuber, J., Müller, T., Strenger, V., Wagner, M. (2021)

Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.

Euro Surveill. 26(34)

Bauer, TL., Collmar, K., Kaltofen, T., Loeffler, AK., Decker, L., Mueller, J., Pinter, S., Eisler, SA., Mahner, S., Fraungruber, P., Kommoss, S., Staebler, A., Francis, L., Conlan, RS., Zuber, J., Jeschke, U., Trillsch, F., Rathert, P. (2021)

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.

Cancers (Basel). 13(15)

Cai, SF., Chu, SH., Goldberg, AD., Parvin, S., Koche, RP., Glass, JL., Stein, EM., Tallman, MS., Sen, F., Famulare, CA., Cusan, M., Huang, CH., Chen, CW., Zou, L., Cordner, KB., DelGaudio, NL., Durani, V., Kini, M., Rex, M., Tian, HS., Zuber, J., Baslan, T., Lowe, SW., Rienhoff, HY., Letai, A., Levine, RL., Armstrong, SA. (2020)

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.

Cancer Discov. 10(10):1500-1513

Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Nature Cancer. 2:693–708

van der Lelij, P., Newman, JA., Lieb, S., Jude, J., Katis, V., Hoffmann, T., Hinterndorfer, M., Bader, G., Kraut, N., Pearson, MA., Peters, JM., Zuber, J., Gileadi, O., Petronczki, M. (2020)

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

Life Sci Alliance. 3(7)

Lindner, B., Martin, E., Steininger, M., Bundalo, A., Lenter, M., Zuber, J., Schuler, M. (2021)

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells.

Sci Rep. 11(1):12973

Pinter, S., Knodel, F., Choudalakis, M., Schnee, P., Kroll, C., Fuchs, M., Broehm, A., Weirich, S., Roth, M., Eisler, SA., Zuber, J., Jeltsch, A., Rathert, P. (2021)

A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.

Nucleic Acids Res. 49(8):4350-4370

Klotz-Noack, K., Klinger, B., Rivera, M., Bublitz, N., Uhlitz, F., Riemer, P., Lüthen, M., Sell, T., Kasack, K., Gastl, B., Ispasanie, SSS., Simon, T., Janssen, N., Schwab, M., Zuber, J., Horst, D., Blüthgen, N., Schäfer, R., Morkel, M., Sers, C. (2020)

SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.

Cell Rep. 32(12):108184

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The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

Cancer Res. 76(5):1158-69

Yuan, TL., Fellmann, C., Lee, CS., Ritchie, CD., Thapar, V., Lee, LC., Hsu, DJ., Grace, D., Carver, JO., Zuber, J., Luo, J., McCormick, F., Lowe, SW. (2014)

Development of siRNA payloads to target KRAS-mutant cancer.

Cancer Discov. 4(10):1182-1197

Matthews, GM., Mehdipour, P., Cluse, LA., Falkenberg, KJ., Wang, E., Roth, M., Santoro, F., Vidacs, E., Stanley, K., House, CM., Rusche, JR., Vakoc, CR., Zuber, J., Minucci, S., Johnstone, RW. (2015)

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood. 126(21):2392-403

Wedeh, G., Cerny-Reiterer, S., Eisenwort, G., Herrmann, H., Blatt, K., Hadzijusufovic, E., Sadovnik, I., Müllauer, L., Schwaab, J., Hoffmann, T., Bradner, JE., Radia, D., Sperr, WR., Hoermann, G., Reiter, A., Horny, HP., Zuber, J., Arock, M., Valent, P. (2015)

Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.

Leukemia. 29(11):2230-7

Grabner, B., Schramek, D., Mueller, KM., Moll, HP., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., Stiedl, P., Nivarthi, H., Bogner, E., Gruber, W., Mohr, T., Zwick, RH., Kenner, L., Poli, V., Aberger, F., Stoiber, D., Egger, G., Esterbauer, H., Zuber, J., Moriggl, R., Eferl, R., Győrffy, B., Penninger, JM., Popper, H., Casanova, E. (2015)

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Nat Commun. 6:6285

Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K. (2015)

The histone chaperone CAF-1 safeguards somatic cell identity.

Nature. 528(7581):218-24

Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., Barsyte-Lovejoy, D., Li, F., Poda, G., Schapira, M., Wu, H., Dong, A., Senisterra, G., Stukalov, A., Huber, KV., Schönegger, A., Marcellus, R., Bilban, M., Bock, C., Brown, PJ., Zuber, J., Bennett, KL., Al-Awar, R., Delwel, R., Nerlov, C., Arrowsmith, CH., Superti-Furga, G. (2015)

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Nat Chem Biol. 11(10):815

Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, JS., Muhar, M., Deswal, S., Cerny-Reiterer, S., Peter, B., Jude, J., Hoffmann, T., Boryń, ŁM., Axelsson, E., Schweifer, N., Tontsch-Grunt, U., Dow, LE., Gianni, D., Pearson, M., Valent, P., Stark, A., Kraut, N., Vakoc, CR., Zuber, J. (2015)

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

Nature. 525(7570):543-547

Brondfield, S., Umesh, S., Corella, A., Zuber, J., Rappaport, AR., Gaillard, C., Lowe, SW., Goga, A., Kogan, SC. (2015)

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

Cancer Chemother Pharmacol. 76(1):35-46

Schwarzer, A., Holtmann, H., Brugman, M., Meyer, J., Schauerte, C., Zuber, J., Steinemann, D., Schlegelberger, B., Li, Z., Baum, C. (2015)

Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

Oncogene. 34(27):3593-604

Zhao, Z., Chen, CC., Rillahan, CD., Shen, R., Kitzing, T., McNerney, ME., Diaz-Flores, E., Zuber, J., Shannon, K., Le Beau, MM., Spector, MS., Kogan, SC., Lowe, SW. (2015)

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Nat Genet. 47(5):539-43

Valent, P., Zuber, J. (2014)

BRD4: a BET(ter) target for the treatment of AML?

Cell Cycle. 13(5):689-90

Murn, J., Zarnack, K., Yang, YJ., Durak, O., Murphy, EA., Cheloufi, S., Gonzalez, DM., Teplova, M., Curk, T., Zuber, J., Patel, DJ., Ule, J., Luscombe, NM., Tsai, LH., Walsh, CA., Shi, Y. (2015)

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

Genes Dev. 29(5):501-12

Rudolph, D., Impagnatiello, MA., Blaukopf, C., Sommer, C., Gerlich, DW., Roth, M., Tontsch-Grunt, U., Wernitznig, A., Savarese, F., Hofmann, MH., Albrecht, C., Geiselmann, L., Reschke, M., Garin-Chesa, P., Zuber, J., Moll, J., Adolf, GR., Kraut, N. (2015)

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.

J Pharmacol Exp Ther. 352(3):579-89

Scheicher, R., Hoelbl-Kovacic, A., Bellutti, F., Tigan, AS., Prchal-Murphy, M., Heller, G., Schneckenleithner, C., Salazar-Roa, M., Zöchbauer-Müller, S., Zuber, J., Malumbres, M., Kollmann, K., Sexl, V. (2015)

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.

Blood. 125(1):90-101

Burgess, MR., Hwang, E., Firestone, AJ., Huang, T., Xu, J., Zuber, J., Bohin, N., Wen, T., Kogan, SC., Haigis, KM., Sampath, D., Lowe, S., Shannon, K., Li, Q. (2014)

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Blood. 124(26):3947-55

Zaiss, AK., Zuber, J., Chu, C., Machado, HB., Jiao, J., Catapang, AB., Ishikawa, TO., Gil, JS., Lowe, SW., Herschman, HR. (2014)

Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.

PLoS One. 9(7):e101263

Salmon, JM., Bots, M., Vidacs, E., Stanley, KL., Atadja, P., Zuber, J., Johnstone, RW. (2015)

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.

Clin Epigenetics. 7:2

Demajo, S., Uribesalgo, I., Gutiérrez, A., Ballaré, C., Capdevila, S., Roth, M., Zuber, J., Martín-Caballero, J., Di Croce, L. (2014)

ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.

Oncogene. 33(48):5501-10

Rudalska, R., Dauch, D., Longerich, T., McJunkin, K., Wuestefeld, T., Kang, TW., Hohmeyer, A., Pesic, M., Leibold, J., von Thun, A., Schirmacher, P., Zuber, J., Weiss, KH., Powers, S., Malek, NP., Eilers, M., Sipos, B., Lowe, SW., Geffers, R., Laufer, S., Zender, L. (2014)

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med. 20(10):1138-46

Huang, CH., Lujambio, A., Zuber, J., Tschaharganeh, DF., Doran, MG., Evans, MJ., Kitzing, T., Zhu, N., de Stanchina, E., Sawyers, CL., Armstrong, SA., Lewis, JS., Sherr, CJ., Lowe, SW. (2014)

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev. 28(16):1800-14

Fellmann, C., Hoffmann, T., Sridhar, V., Hopfgartner, B., Muhar, M., Roth, M., Lai, DY., Barbosa, IA., Kwon, JS., Guan, Y., Sinha, N., Zuber, J. (2013)

An optimized microRNA backbone for effective single-copy RNAi.

Cell Rep. 5(6):1704-13

Liu, GJ., Cimmino, L., Jude, JG., Hu, Y., Witkowski, MT., McKenzie, MD., Kartal-Kaess, M., Best, SA., Tuohey, L., Liao, Y., Shi, W., Mullighan, CG., Farrar, MA., Nutt, SL., Smyth, GK., Zuber, J., Dickins, RA. (2014)

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Genes Dev. 28(12):1337-50

Chen, C., Liu, Y., Rappaport, AR., Kitzing, T., Schultz, N., Zhao, Z., Shroff, AS., Dickins, RA., Vakoc, CR., Bradner, JE., Stock, W., LeBeau, MM., Shannon, KM., Kogan, S., Zuber, J., Lowe, SW. (2014)

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Cancer Cell. 25(5):652-65

Zhao, X., Chen, A., Yan, X., Zhang, Y., He, F., Hayashi, Y., Dong, Y., Rao, Y., Li, B., Conway, RM., Maiques-Diaz, A., Elf, SE., Huang, N., Zuber, J., Xiao, Z., Tse, W., Tenen, DG., Wang, Q., Chen, W., Mulloy, JC., Nimer, SD., Huang, G. (2014)

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Blood. 123(11):1729-38

Bots, M., Verbrugge, I., Martin, BP., Salmon, JM., Ghisi, M., Baker, A., Stanley, K., Shortt, J., Ossenkoppele, GJ., Zuber, J., Rappaport, AR., Atadja, P., Lowe, SW., Johnstone, RW. (2014)

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood. 123(9):1341-52

Schwickert, TA., Tagoh, H., Gültekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., Dickins, RA., Zuber, J., Jaritz, M., Busslinger, M. (2014)

Stage-specific control of early B cell development by the transcription factor Ikaros.

Nat Immunol. 15(3):283-93

Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, AM., Bradner, J., Muhar, M., Zuber, J., Müller, M., Decker, T. (2014)

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

Mol Cell Biol. 34(3):415-27

Shi, J., Whyte, WA., Zepeda-Mendoza, CJ., Milazzo, JP., Shen, C., Roe, JS., Minder, JL., Mercan, F., Wang, E., Eckersley-Maslin, MA., Campbell, AE., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, RG., Wigler, MH., Blobel, GA., Zuber, J., Spector, DL., Young, RA., Vakoc, CR. (2013)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Genes Dev. 27(24):2648-62

Herrmann, H., Blatt, K., Shi, J., Gleixner, KV., Cerny-Reiterer, S., Müllauer, L., Vakoc, CR., Sperr, WR., Horny, HP., Bradner, JE., Zuber, J., Valent, P. (2012)

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

Oncotarget. 3(12):1588-99

Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, SW., Vakoc, CR. (2013)

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

Oncogene. 32(7):930-8

Valent, P., Bonnet, D., De Maria, R., Lapidot, T., Copland, M., Melo, JV., Chomienne, C., Ishikawa, F., Schuringa, JJ., Stassi, G., Huntly, B., Herrmann, H., Soulier, J., Roesch, A., Schuurhuis, GJ., Wöhrer, S., Arock, M., Zuber, J., Cerny-Reiterer, S., Johnsen, HE., Andreeff, M., Eaves, C. (2012)

Cancer stem cell definitions and terminology: the devil is in the details.

Nat Rev Cancer. 12(11):767-75

Mattarollo, SR., West, AC., Steegh, K., Duret, H., Paget, C., Martin, B., Matthews, GM., Shortt, J., Chesi, M., Bergsagel, PL., Bots, M., Zuber, J., Lowe, SW., Johnstone, RW., Smyth, MJ. (2012)

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma.

Blood. 120(15):3019-29

Dow, LE., Premsrirut, PK., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, RA., Hannon, GJ., Lowe, SW. (2012)

A pipeline for the generation of shRNA transgenic mice.

Nat Protoc. 7(2):374-93

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, AR., Simon, J., Zhang, J., Luo, W., Hicks, J., Zender, L., Wang, XW., Powers, S., Wigler, M., Lowe, SW. (2012)

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.

Proc Natl Acad Sci U S A. 109(21):8212-7

Bergerson, RJ., Collier, LS., Sarver, AL., Been, RA., Lugthart, S., Diers, MD., Zuber, J., Rappaport, AR., Nixon, MJ., Silverstein, KA., Fan, D., Lamblin, AF., Wolff, L., Kersey, JH., Delwel, R., Lowe, SW., O'Sullivan, MG., Kogan, SC., Adams, DJ., Largaespada, DA. (2012)

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Blood. 119(19):4512-23

Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, SP., Vanhaelen, Q., Shukalyuk, AI., Schmauss, G., Schramek, D., Schnuetgen, F., von Melchner, H., Ecker, JR., Stanford, WL., Zuber, J., Stark, A., Penninger, JM. (2011)

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Cell Stem Cell. 9(6):563-74

Glaser, SP., Lee, EF., Trounson, E., Bouillet, P., Wei, A., Fairlie, WD., Izon, DJ., Zuber, J., Rappaport, AR., Herold, MJ., Alexander, WS., Lowe, SW., Robb, L., Strasser, A. (2012)

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.

Genes Dev. 26(2):120-5

Zuber, J., Shi, J., Wang, E., Rappaport, AR., Herrmann, H., Sison, EA., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, MJ., Johns, C., Chicas, A., Mulloy, JC., Kogan, SC., Brown, P., Valent, P., Bradner, JE., Lowe, SW., Vakoc, CR. (2011)

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

Nature. 478(7370):524-8

Zuber, J., Rappaport, AR., Luo, W., Wang, E., Chen, C., Vaseva, AV., Shi, J., Weissmueller, S., Fellmann, C., Fellman, C., Taylor, MJ., Weissenboeck, M., Graeber, TG., Kogan, SC., Vakoc, CR., Lowe, SW. (2011)

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.

Genes Dev. 25(15):1628-40

McJunkin, K., Mazurek, A., Premsrirut, PK., Zuber, J., Dow, LE., Simon, J., Stillman, B., Lowe, SW. (2011)

Reversible suppression of an essential gene in adult mice using transgenic RNA interference.

Proc Natl Acad Sci U S A. 108(17):7113-8

Pardee, TS., Zuber, J., Lowe, SW. (2011)

Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner.

Exp Hematol. 39(4):473-485.e4

Premsrirut, PK., Dow, LE., Kim, SY., Camiolo, M., Malone, CD., Miething, C., Scuoppo, C., Zuber, J., Dickins, RA., Kogan, SC., Shroyer, KR., Sordella, R., Hannon, GJ., Lowe, SW. (2011)

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Cell. 145(1):145-58

Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, CD., Dickins, RA., Xu, Q., Hengartner, MO., Elledge, SJ., Hannon, GJ., Lowe, SW. (2011)

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

Mol Cell. 41(6):733-46

Zuber, J., McJunkin, K., Fellmann, C., Dow, LE., Taylor, MJ., Hannon, GJ., Lowe, SW. (2011)

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

Nat Biotechnol. 29(1):79-83

Zhao, Z., Zuber, J., Diaz-Flores, E., Lintault, L., Kogan, SC., Shannon, K., Lowe, SW. (2010)

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.

Genes Dev. 24(13):1389-402

Mavrakis, KJ., Wolfe, AL., Oricchio, E., Palomero, T., de Keersmaecker, K., McJunkin, K., Zuber, J., James, T., Khan, AA., Leslie, CS., Parker, JS., Paddison, PJ., Tam, W., Ferrando, A., Wendel, HG. (2010)

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.

Nat Cell Biol. 12(4):372-9

Blobel, GA., Kadauke, S., Wang, E., Lau, AW., Zuber, J., Chou, MM., Vakoc, CR. (2009)

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

Mol Cell. 36(6):970-83

Guo, X., Keyes, WM., Papazoglu, C., Zuber, J., Li, W., Lowe, SW., Vogel, H., Mills, AA. (2009)

TAp63 induces senescence and suppresses tumorigenesis in vivo.

Nat Cell Biol. 11(12):1451-7

Bric, A., Miething, C., Bialucha, CU., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M., Hicks, J., McCombie, RW., Hemann, MT., Hannon, GJ., Powers, S., Lowe, SW. (2009)

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

Cancer Cell. 16(4):324-35

Zuber, J., Radtke, I., Pardee, TS., Zhao, Z., Rappaport, AR., Luo, W., McCurrach, ME., Yang, MM., Dolan, ME., Kogan, SC., Downing, JR., Lowe, SW. (2009)

Mouse models of human AML accurately predict chemotherapy response.

Genes Dev. 23(7):877-89

Zender, L., Xue, W., Zuber, J., Semighini, CP., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, JM., Schirmacher, P., McCombie, WR., Wigler, M., Hicks, J., Hannon, GJ., Powers, S., Lowe, SW. (2008)

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

Cell. 135(5):852-64

Zender, L., Zuber, J., Lowe, SW. (2007)

Snapshot: genetic mouse models of cancer.

Cell. 129(4):838

Trappe, RU., Riess, H., Lippek, F., Plotkin, M., Schumacher, V., Royer-Pokora, B., Hildebrandt, B., Zuber, J., Mapara, MY., Oertel, S., Dörken, B. (2004)

Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene.

J Pediatr Hematol Oncol. 26(12):820-3

Herzog, H., Zuber, J., Stroszczynski, C. (2004)

[Cyclosporin A-induced posterior reversible encephalopathy syndrome (PRES) in MRI].

Rofo. 176(9):1326-7

Tchernitsa, OI., Sers, C., Zuber, J., Hinzmann, B., Grips, M., Schramme, A., Lund, P., Schwendel, A., Rosenthal, A., Schäfer, R. (2004)

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.

Oncogene. 23(26):4536-55

Schäfer, R., Tchernitsa, OI., Zuber, J., Sers, C. (2003)

Dissection of signal-regulated transcriptional modules by signaling pathway interference in oncogene-transformed cells.

Adv Enzyme Regul. 43:379-91

Baskaynak, G., Kreuzer, KA., Schwarz, M., Zuber, J., Audring, H., Riess, H., Dörken, B., le Coutre, P. (2003)

Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment.

Eur J Haematol. 70(4):231-4

Sers, C., Tchernitsa, OI., Zuber, J., Diatchenko, L., Zhumabayeva, B., Desai, S., Htun, S., Hyder, K., Wiechen, K., Agoulnik, A., Scharff, KM., Siebert, PD., Schäfer, R. (2002)

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

Adv Enzyme Regul. 42:63-82

Zuber, J., Tchernitsa, OI., Hinzmann, B., Schmitz, AC., Grips, M., Hellriegel, M., Sers, C., Rosenthal, A., Schäfer, R. (2000)

A genome-wide survey of RAS transformation targets.

Nat Genet. 24(2):144-52

Tchernitsa, OI., Zuber, J., Sers, C., Brinckmann, R., Britsch, SK., Adams, V., Schäfer, R. (1999)

Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators.

Oncogene. 18(39):5448-54

Zuber, J., Palm, W. (2025)

Modelling and deciphering tumour metabolism in CRISPR screens.

Nat Rev Cancer. 25(1):1-2

Matsushima, W., Herzog, VA., Neumann, T., Gapp, K., Zuber, J., Ameres, SL., Miska, EA. (2019)

Publisher Correction: Sequencing cell-type-specific transcriptomes with SLAM-ITseq.

Nat Protoc. 14(8):2597

Gstrein, T., Edwards, A., Přistoupilová, A., Leca, I., Breuss, M., Pilat-Carotta, S., Hansen, AH., Tripathy, R., Traunbauer, AK., Hochstoeger, T., Rosoklija, G., Repic, M., Landler, L., Stránecký, V., Dürnberger, G., Keane, TM., Zuber, J., Adams, DJ., Flint, J., Honzik, T., Gut, M., Beltran, S., Mechtler, K., Sherr, E., Kmoch, S., Gut, I., Keays, DA. (2018)

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

Nat Neurosci. 21(8):1139

Bigenzahn, JW., Fauster, A., Rebsamen, M., Kandasamy, RK., Scorzoni, S., Vladimer, GI., Mueller, AC., Gstaiger, M., Zuber, J., Bennett, KL., Superti-Furga, G. (2015)

An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client.

Mol Cell Proteomics.

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