Publications Johannes Zuber | Scientific Papers Zuber Lab

Elewaut, A., Estivill, G., Bayerl, F., Castillon, L., Novatchkova, M., Pottendorfer, E., Hoffmann-Haas, L., Schönlein, M., Nguyen, TV., Lauss, M., Andreatta, F., Vulin, M., Krecioch, I., Bayerl, J., Pedde, AM., Fabre, N., Holstein, F., Cronin, SM., Rieser, S., Laniti, DD., Barras, D., Coukos, G., Quek, C., Bai, X., Muñoz I Ordoño, M., Wiesner, T., Zuber, J., Jönsson, G., Böttcher, JP., Vanharanta, S., Obenauf, AC. (2025)

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity.

Nature. 637(8046):716-725

Zuber, J., Palm, W. (2025)

Modelling and deciphering tumour metabolism in CRISPR screens.

Nat Rev Cancer. 25(1):1-2

Militello, G., Greig, A., Bi, C., Vasileva, A., Zavodszky, MI., Lo, SC., Guilmette, E., Clarner, P., Liu, B., Bhat, G., Suh, J., Dow, L., Zuber, J., Fellmann, C., Premsrirut, PK. (2025)

Engineered microRNA scaffolds for potent gene silencing in vivo.

Sci Rep. 15(1):21419

Soderholm, A., Vunjak, M., de Almeida, M., Popitsch, N., Podvalnaya, N., Araguas-Rodriguez, P., Scinicariello, S., Nischwitz, E., Butter, F., Ketting, RF., Ameres, SL., Müller-McNicoll, M., Zuber, J., Versteeg, GA. (2025)

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA.

Nucleic Acids Res. 53(12)

Troester, S., Eder, T., Wukowits, N., Piontek, M., Fernández-Pernas, P., Schmoellerl, J., Haladik, B., Manhart, G., Allram, M., Maurer-Granofszky, M., Scheidegger, N., Nebral, K., Superti-Furga, G., Meisel, R., Bornhauser, B., Valent, P., Dworzak, MN., Zuber, J., Boztug, K., Grebien, F. (2025)

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

Nat Commun. 16(1):4656

Hermann, J., Borteçen, T., Kalis, R., Kowar, A., Pechincha, C., Vogt, V., Schneider, M., Helm, D., Krijgsveld, J., Loayza-Puch, F., Zuber, J., Palm, W. (2025)

mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery.

Nat Commun. 16(1):4201

Ciriello, G., Magnani, L., Aitken, SJ., Akkari, L., Behjati, S., Hanahan, D., Landau, DA., Lopez-Bigas, N., Lupiáñez, DG., Marine, JC., Martin-Villalba, A., Natoli, G., Obenauf, AC., Oricchio, E., Scaffidi, P., Sottoriva, A., Swarbrick, A., Tonon, G., Vanharanta, S., Zuber, J. (2024)

Cancer Evolution: A Multifaceted Affair.

Cancer Discov. 14(1):36-48

Greiner, G., Witzeneder, N., Klein, K., Tangermann, S., Kodajova, P., Jaeger, E., Ratzinger, F., Gerner, MC., Jawhar, M., Baumgartner, S., Fruehwirth, K., Schmetterer, KG., Zuber, J., Gleixner, KV., Mayerhofer, M., Schwarzinger, I., Simonitsch-Klupp, I., Esterbauer, H., Baer, C., Walter, W., Meggendorfer, M., Strassl, R., Haferlach, T., Hartmann, K., Kenner, L., Sperr, WR., Reiter, A., Sexl, V., Arock, M., Valent, P., Hoermann, G. (2024)

Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis.

Blood. 143(11):1006-1017

Blahetek, G., Mayer, C., Zuber, J., Lenter, M., Strobel, B. (2024)

Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Mol Ther Methods Clin Dev. 32(3):101280

Kagiou, C., Cisneros, JA., Farnung, J., Liwocha, J., Offensperger, F., Dong, K., Yang, K., Tin, G., Horstmann, CS., Hinterndorfer, M., Paulo, JA., Scholes, NS., Sanchez Avila, J., Fellner, M., Andersch, F., Hannich, JT., Zuber, J., Kubicek, S., Gygi, SP., Schulman, BA., Winter, GE. (2024)

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.

Nat Commun. 15(1):5409

Schuetz, T., Dolejsi, T., Beck, E., Fugger, F., Bild, A., Duin, MT., Gavranovic-Novakovic, J., Hilbold, E., Hoffmann, T., Zuber, J., Bauer, A., Ruschitzka, F., Bär, C., Penninger, JM., Haubner, BJ. (2024)

Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling.

Sci Rep. 14(1):22661

Pre-printBrunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Häring S, Zuber J, Haselbach D (2024)

A multivalent adaptor mechanism drives the nuclear import of proteasomes

625870.

D'Artista, L., Moschopoulou, AA., Barozzi, I., Craig, AJ., Seehawer, M., Herrmann, L., Minnich, M., Kang, TW., Rist, E., Henning, M., Klotz, S., Heinzmann, F., Harbig, J., Sipos, B., Longerich, T., Eilers, M., Dauch, D., Zuber, J., Wang, XW., Zender, L. (2023)

MYC determines lineage commitment in kras driven primary liver cancer development.

J Hepatol.

Carlet, M., Schmelz, K., Vergalli, J., Herold, T., Senft, D., Jurinovic, V., Hoffmann, T., Proba, J., Weichert, N., Junghanß, C., Roth, M., Eschenburg, G., Barz, M., Henze, G., Eckert, C., Eggert, A., Zuber, J., Hundsdoerfer, P., Jeremias, I. (2023)

X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

EMBO Mol Med. 15(1):e14557

Brandstoetter, T., Schmoellerl, J., Grausenburger, R., Kollmann, S., Doma, E., Huuhtanen, J., Klampfl, T., Eder, T., Grebien, F., Hoermann, G., Zuber, J., Mustjoki, S., Maurer, B., Sexl, V. (2023)

SBNO2 is a critical mediator of STAT3-driven hematological malignancies.

Blood.

Schmoellerl, J., Barbosa, IAM., Minnich, M., Andersch, F., Smeenk, L., Havermans, M., Eder, T., Neumann, T., Jude, J., Fellner, M., Ebert, A., Steininger, M., Delwel, R., Grebien, F., Zuber, J. (2023)

EVI1 drives leukemogenesis through aberrant ERG activation.

Blood. 141(5):453-466

Scinicariello, S., Soderholm, A., Schäfer, M., Shulkina, A., Schwartz, I., Hacker, K., Gogova, R., Kalis, R., Froussios, K., Budroni, V., Bestehorn, A., Clausen, T., Kovarik, P., Zuber, J., Versteeg, GA. (2023)

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

Corresponding preprint Elife. 12

Hoffmann, T., Hörmann, A., Corcokovic, M., Zmajkovic, J., Hinterndorfer, M., Salkanovic, J., Spreitzer, F., Köferle, A., Gitschtaler, K., Popa, A., Oberndorfer, S., Andersch, F., Schaefer, M., Fellner, M., Budano, N., Ruppert, JG., Chetta, P., Wurm, M., Zuber, J., Neumüller, RA. (2023)

Precision RNAi using synthetic shRNAmir target sites.

Elife. 12

Kugler, E., Madiwale, S., Yong, D., Thoms, JAI., Birger, Y., Sykes, DB., Schmoellerl, J., Drakul, A., Priebe, V., Yassin, M., Aqaqe, N., Rein, A., Fishman, H., Geron, I., Chen, CW., Raught, B., Liu, Q., Ogana, H., Liedke, E., Bourquin, JP., Zuber, J., Milyavsky, M., Pimanda, J., Privé, GG., Izraeli, S. (2023)

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.

Nat Commun. 14(1):5871

Ebner, J., Schmoellerl, J., Piontek, M., Manhart, G., Troester, S., Carter, BZ., Neubauer, H., Moriggl, R., Szakács, G., Zuber, J., Köcher, T., Andreeff, M., Sperr, WR., Valent, P., Grebien, F. (2023)

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.

Nat Commun. 14(1):5709

Neault, M., Lebert-Ghali, CÉ., Fournier, M., Capdevielle, C., Garfinkle, EAR., Obermayer, A., Cotton, A., Boulay, K., Sawchyn, C., St-Amand, S., Nguyen, KH., Assaf, B., Mercier, FE., Delisle, JS., Drobetsky, EA., Hulea, L., Shaw, TI., Zuber, J., Gruber, TA., Melichar, HJ., Mallette, FA. (2023)

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.

Cell Rep. 42(9):113084

Schwartz, I., Vunjak, M., Budroni, V., Cantoran García, A., Mastrovito, M., Soderholm, A., Hinterndorfer, M., de Almeida, M., Hacker, K., Wang, J., Froussios, K., Jude, J., Decker, T., Zuber, J., Versteeg, GA. (2023)

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

Elife. 12

Michael, AK., Stoos, L., Crosby, P., Eggers, N., Nie, XY., Makasheva, K., Minnich, M., Healy, KL., Weiss, J., Kempf, G., Cavadini, S., Kater, L., Seebacher, J., Vecchia, L., Chakraborty, D., Isbel, L., Grand, RS., Andersch, F., Fribourgh, JL., Schübeler, D., Zuber, J., Liu, AC., Becker, PB., Fierz, B., Partch, CL., Menet, JS., Thomä, NH. (2023)

Cooperation between bHLH transcription factors and histones for DNA access.

Nature. 619(7969):385-393

Kellner, MJ., Ross, JJ., Schnabl, J., Dekens, MPS., Matl, M., Heinen, R., Grishkovskaya, I., Bauer, B., Stadlmann, J., Menéndez-Arias, L., Straw, AD., Fritsche-Polanz, R., Traugott, M., Seitz, T., Zoufaly, A., Födinger, M., Wenisch, C., Zuber, J., Pauli, A., Brennecke, J. (2022)

A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.

Corresponding preprint Front Mol Biosci. 9:801309

Pinter, T., Fischer, M., Schäfer, M., Fellner, M., Jude, J., Zuber, J., Busslinger, M., Wöhner, M. (2022)

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development.

Front Immunol. 13:979606

Pechincha, C., Groessl, S., Kalis, R., de Almeida, M., Zanotti, A., Wittmann, M., Schneider, M., de Campos, RP., Rieser, S., Brandstetter, M., Schleiffer, A., Müller-Decker, K., Helm, D., Jabs, S., Haselbach, D., Lemberg, MK., Zuber, J., Palm, W. (2022)

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

Science. 378(6615):eabn5637

Butz, S., Schmolka, N., Karemaker, ID., Villaseñor, R., Schwarz, I., Domcke, S., Uijttewaal, ECH., Jude, J., Lienert, F., Krebs, AR., de Wagenaar, NP., Bao, X., Zuber, J., Elling, U., Schübeler, D., Baubec, T. (2022)

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.

Nat Genet.

Le Pannérer, MM., Diesch, J., Casquero, R., Maher, M., Garcia, O., Haferlach, T., Zuber, J., Kündgen, A., Götze, KS., Buschbeck, M. (2022)

Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients.

Hemasphere. 6(11):e792

Wilding, B., Scharn, D., Böse, D., Baum, A., Santoro, V., Chetta, P., Schnitzer, R., Botesteanu, DA., Reiser, C., Kornigg, S., Knesl, P., Hörmann, A., Köferle, A., Corcokovic, M., Lieb, S., Scholz, G., Bruchhaus, J., Spina, M., Balla, J., Peric-Simov, B., Zimmer, J., Mitzner, S., Fett, TN., Beran, A., Lamarre, L., Gerstberger, T., Gerlach, D., Bauer, M., Bergner, A., Schlattl, A., Bader, G., Treu, M., Engelhardt, H., Zahn, S., Fuchs, JE., Zuber, J., Ettmayer, P., Pearson, M., Petronczki, M., Kraut, N., McConnell, DB., Solca, F., Neumüller, RA. (2022)

Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.

Nat Cancer. 3(7):821-836

Peter, B., Eisenwort, G., Sadovnik, I., Bauer, K., Willmann, M., Rülicke, T., Berger, D., Stefanzl, G., Greiner, G., Hoermann, G., Keller, A., Wolf, D., Čulen, M., Winter, GE., Hoffmann, T., Schiefer, AI., Sperr, WR., Zuber, J., Mayer, J., Valent, P. (2022)

BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia.

Am J Hematol. 97(9):1215-1225

Jobbins, AM., Haberman, N., Artigas, N., Amourda, C., Paterson, HAB., Yu, S., Blackford, SJI., Montoya, A., Dore, M., Wang, YF., Sardini, A., Cebola, I., Zuber, J., Rashid, ST., Lenhard, B., Vernia, S. (2022)

Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.

Nucleic Acids Res. 50(6):3379-3393

Umkehrer, C., Holstein, F., Formenti, L., Jude, J., Froussios, K., Neumann, T., Cronin, SM., Haas, L., Lipp, JJ., Burkard, TR., Fellner, M., Wiesner, T., Zuber, J., Obenauf, AC. (2021)

Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters.

Nat Biotechnol. 39(2):174-178

Endres, T., Solvie, D., Heidelberger, JB., Andrioletti, V., Baluapuri, A., Ade, CP., Muhar, M., Eilers, U., Vos, SM., Cramer, P., Zuber, J., Beli, P., Popov, N., Wolf, E., Gallant, P., Eilers, M. (2021)

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.

Mol Cell. 81(4):830-844.e13

Pre-printKellner MJ, Matl M, Ross JJ, Schnabl J, Handler D, Heinen R, Schaeffer J, Hufnagl P, Indra A, Dekens MPS, Fritsche-Polanz R, Födinger M, Zuber J, Vienna Covid-19 Detection Initiative (VCDI), Allerberger F, Pauli A, Brennecke J (2021)

Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.

medRxiv. 2021.01.19.21250079

Lindner, B., Martin, E., Steininger, M., Bundalo, A., Lenter, M., Zuber, J., Schuler, M. (2021)

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells.

Sci Rep. 11(1):12973

Smeenk, L., Ottema, S., Mulet-Lazaro, R., Ebert, A., Havermans, M., Varea, AA., Fellner, M., Pastoors, D., van Herk, S., Erpelinck-Verschueren, C., Grob, T., Hoogenboezem, RM., Kavelaars, FG., Matson, DR., Bresnick, EH., Bindels, EM., Kentsis, A., Zuber, J., Delwel, R. (2021)

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Cancer Discov. 11(11):2868-2883

Pinter, S., Knodel, F., Choudalakis, M., Schnee, P., Kroll, C., Fuchs, M., Broehm, A., Weirich, S., Roth, M., Eisler, SA., Zuber, J., Jeltsch, A., Rathert, P. (2021)

A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.

Nucleic Acids Res. 49(8):4350-4370

Valent, P., Orfao, A., Kubicek, S., Staber, P., Haferlach, T., Deininger, M., Kollmann, K., Lion, T., Virgolini, I., Winter, G., Hantschel, O., Kenner, L., Zuber, J., Grebien, F., Moriggl, R., Hoermann, G., Hermine, O., Andreeff, M., Bock, C., Mughal, T., Constantinescu, SN., Kralovics, R., Sexl, V., Skoda, R., Superti-Furga, G., Jäger, U. (2021)

Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.

Hemasphere. 5(3):e536

Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Nature Cancer. 2:693–708

de Almeida, M., Hinterndorfer, M., Brunner, H., Grishkovskaya, I., Singh, K., Schleiffer, A., Jude, J., Deswal, S., Kalis, R., Vunjak, M., Lendl, T., Imre, R., Roitinger, E., Neumann, T., Kandolf, S., Schutzbier, M., Mechtler, K., Versteeg, GA., Haselbach, D., Zuber, J. (2021)

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

Nature. 599(7885):491-496

Kheiroddin, P., Schöberl, P., Althammer, M., Cibali, E., Würfel, T., Wein, H., Kulawik, B., Buntrock-Döpke, H., Weigl, E., Gran, S., Gründl, M., Langguth, J., Lampl, B., Judex, G., Niggel, J., Pagel, P., Schratzenstaller, T., Schneider-Brachert, W., Gastiger, S., Bodenschatz, M., Konrad, M., Levchuk, A., Roth, C., Schöner, D., Schneebauer, F., Rohrmanstorfer, R., Dekens, MP., Brandstetter, S., Zuber, J., Wallerstorfer, D., Burkovski, A., Ambrosch, A., Wagner, T., Kabesch, M. (2021)

Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests.

Front Pediatr. 9:721518

Diesch, J., Le Pannérer, MM., Winkler, R., Casquero, R., Muhar, M., van der Garde, M., Maher, M., Herráez, CM., Bech-Serra, JJ., Fellner, M., Rathert, P., Brooks, N., Zamora, L., Gentilella, A., de la Torre, C., Zuber, J., Götze, KS., Buschbeck, M. (2021)

Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.

Nat Commun. 12(1):6060

Willeit, P., Bernar, B., Zurl, C., Al-Rawi, M., Berghold, A., Bernhard, D., Borena, W., Doppler, C., Kerbl, R., Köhler, A., Krause, R., Lamprecht, B., Pröll, J., Schmidt, H., Steinmetz, I., Stelzl, E., Stoiber, H., von Laer, D., Zuber, J., Müller, T., Strenger, V., Wagner, M. (2021)

Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.

Euro Surveill. 26(34)

Willeit, P., Krause, R., Lamprecht, B., Berghold, A., Hanson, B., Stelzl, E., Stoiber, H., Zuber, J., Heinen, R., Köhler, A., Bernhard, D., Borena, W., Doppler, C., von Laer, D., Schmidt, H., Pröll, J., Steinmetz, I., Wagner, M. (2021)

Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study.

Lancet Reg Health Eur. 5:100086

Bauer, TL., Collmar, K., Kaltofen, T., Loeffler, AK., Decker, L., Mueller, J., Pinter, S., Eisler, SA., Mahner, S., Fraungruber, P., Kommoss, S., Staebler, A., Francis, L., Conlan, RS., Zuber, J., Jeschke, U., Trillsch, F., Rathert, P. (2021)

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.

Cancers (Basel). 13(15)

van der Kouwe, E., Heller, G., Czibere, A., Pulikkan, JA., Agreiter, C., Castilla, LH., Delwel, R., Di Ruscio, A., Ebralidze, AK., Forte, M., Grebien, F., Heyes, E., Kazianka, L., Klinger, J., Kornauth, C., Le, T., Lind, K., Barbosa, IAM., Pemovska, T., Pichler, A., Schmolke, AS., Schweicker, CM., Sill, H., Sperr, WR., Spittler, A., Surapally, S., Trinh, BQ., Valent, P., Vanura, K., Welner, RS., Zuber, J., Tenen, DG., Staber, PB. (2021)

Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.

Blood. 138(15):1345-1358

Haas, L., Elewaut, A., Gerard, CL., Umkehrer, C., Leiendecker, L., Pedersen, M., Krecioch, I., Hoffmann, D., Novatchkova, M., Kuttke, M., Neumann, T., da Silva, IP., Witthock, H., Cuendet, MA., Carotta, S., Harrington, KJ., Zuber, J., Scolyer, RA., Long, GV., Wilmott, JS., Michielin, O., Vanharanta, S., Wiesner, T., Obenauf, AC. (2021)

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma.

Nat Cancer. 2(7):693-708

Zepeda-Martinez, JA., Pribitzer, C., Wang, J., Bsteh, D., Golumbeanu, S., Zhao, Q., Burkard, TR., Reichholf, B., Rhie, SK., Jude, J., Moussa, HF., Zuber, J., Bell, O. (2020)

Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells.

Sci Adv. 6(14):eaax5692

Michlits, G., Jude, J., Hinterndorfer, M., de Almeida, M., Vainorius, G., Hubmann, M., Neumann, T., Schleiffer, A., Burkard, TR., Fellner, M., Gijsbertsen, M., Traunbauer, A., Zuber, J., Elling, U. (2020)

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles.

Nat Methods. 17(7):708-716

Cai, SF., Chu, SH., Goldberg, AD., Parvin, S., Koche, RP., Glass, JL., Stein, EM., Tallman, MS., Sen, F., Famulare, CA., Cusan, M., Huang, CH., Chen, CW., Zou, L., Cordner, KB., DelGaudio, NL., Durani, V., Kini, M., Rex, M., Tian, HS., Zuber, J., Baslan, T., Lowe, SW., Rienhoff, HY., Letai, A., Levine, RL., Armstrong, SA. (2020)

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.

Cancer Discov. 10(10):1500-1513

van der Lelij, P., Newman, JA., Lieb, S., Jude, J., Katis, V., Hoffmann, T., Hinterndorfer, M., Bader, G., Kraut, N., Pearson, MA., Peters, JM., Zuber, J., Gileadi, O., Petronczki, M. (2020)

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

Life Sci Alliance. 3(7)

Gastl, B., Klotz-Noack, K., Klinger, B., Ispasanie, S., Salib, KHF., Zuber, J., Mamlouk, S., Bublitz, N., Blüthgen, N., Horst, D., Morkel, M., Schäfer, R., Sers, C. (2020)

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.

Cell Death Dis. 11(7):499

Schmoellerl, J., Barbosa, IAM., Eder, T., Brandstoetter, T., Schmidt, L., Maurer, B., Troester, S., Pham, HTT., Sagarajit, M., Ebner, J., Manhart, G., Aslan, E., Terlecki-Zaniewicz, S., Van der Veen, C., Hoermann, G., Duployez, N., Petit, A., Lapillonne, H., Puissant, A., Itzykson, R., Moriggl, R., Heuser, M., Meisel, R., Valent, P., Sexl, V., Zuber, J., Grebien, F. (2020)

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.

Blood. 136(4):387-400

Carmichael, CL., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., Milne, AR., Samuel, S., Gillinder, K., Hediyeh-Zadeh, S., Vo, ANQ., Huang, Y., Knezevic, K., McInnes, WRL., Shields, BJ., Mitchell, H., Ritchie, ME., Lammens, T., Lintermans, B., Van Vlierberghe, P., Wong, NC., Haigh, K., Thoms, JAI., Toulmin, E., Curtis, DJ., Oxley, EP., Dickins, RA., Beck, D., Perkins, A., McCormack, MP., Davis, MJ., Berx, G., Zuber, J., Pimanda, JE., Kile, BT., Goossens, S., Haigh, JJ. (2020)

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.

Blood. 136(8):957-973

Schlager, S., Salomon, C., Olt, S., Albrecht, C., Ebert, A., Bergner, O., Wachter, J., Trapani, F., Gerlach, D., Voss, T., Traunbauer, A., Jude, J., Hinterndorfer, M., Minnich, M., Schweifer, N., Blake, SM., Zinzalla, V., Drobits, B., McConnell, DB., Kraut, N., Pearson, M., Zuber, J., Koegl, M. (2020)

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.

Oncotarget. 11(9):875-890

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Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

Oncogene. 34(27):3593-604

Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K. (2015)

The histone chaperone CAF-1 safeguards somatic cell identity.

Nature. 528(7581):218-24

Matthews, GM., Mehdipour, P., Cluse, LA., Falkenberg, KJ., Wang, E., Roth, M., Santoro, F., Vidacs, E., Stanley, K., House, CM., Rusche, JR., Vakoc, CR., Zuber, J., Minucci, S., Johnstone, RW. (2015)

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood. 126(21):2392-403

Grabner, B., Schramek, D., Mueller, KM., Moll, HP., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., Stiedl, P., Nivarthi, H., Bogner, E., Gruber, W., Mohr, T., Zwick, RH., Kenner, L., Poli, V., Aberger, F., Stoiber, D., Egger, G., Esterbauer, H., Zuber, J., Moriggl, R., Eferl, R., Győrffy, B., Penninger, JM., Popper, H., Casanova, E. (2015)

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Nat Commun. 6:6285

Wedeh, G., Cerny-Reiterer, S., Eisenwort, G., Herrmann, H., Blatt, K., Hadzijusufovic, E., Sadovnik, I., Müllauer, L., Schwaab, J., Hoffmann, T., Bradner, JE., Radia, D., Sperr, WR., Hoermann, G., Reiter, A., Horny, HP., Zuber, J., Arock, M., Valent, P. (2015)

Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.

Leukemia. 29(11):2230-7

Bigenzahn, JW., Fauster, A., Rebsamen, M., Kandasamy, RK., Scorzoni, S., Vladimer, GI., Mueller, AC., Gstaiger, M., Zuber, J., Bennett, KL., Superti-Furga, G. (2015)

An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client.

Mol Cell Proteomics.

Demajo, S., Uribesalgo, I., Gutiérrez, A., Ballaré, C., Capdevila, S., Roth, M., Zuber, J., Martín-Caballero, J., Di Croce, L. (2014)

ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.

Oncogene. 33(48):5501-10

Valent, P., Zuber, J. (2014)

BRD4: a BET(ter) target for the treatment of AML?

Cell Cycle. 13(5):689-90

Huang, CH., Lujambio, A., Zuber, J., Tschaharganeh, DF., Doran, MG., Evans, MJ., Kitzing, T., Zhu, N., de Stanchina, E., Sawyers, CL., Armstrong, SA., Lewis, JS., Sherr, CJ., Lowe, SW. (2014)

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev. 28(16):1800-14

Zaiss, AK., Zuber, J., Chu, C., Machado, HB., Jiao, J., Catapang, AB., Ishikawa, TO., Gil, JS., Lowe, SW., Herschman, HR. (2014)

Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.

PLoS One. 9(7):e101263

Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, AM., Bradner, J., Muhar, M., Zuber, J., Müller, M., Decker, T. (2014)

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

Mol Cell Biol. 34(3):415-27

Schwickert, TA., Tagoh, H., Gültekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., Dickins, RA., Zuber, J., Jaritz, M., Busslinger, M. (2014)

Stage-specific control of early B cell development by the transcription factor Ikaros.

Nat Immunol. 15(3):283-93

Zhao, X., Chen, A., Yan, X., Zhang, Y., He, F., Hayashi, Y., Dong, Y., Rao, Y., Li, B., Conway, RM., Maiques-Diaz, A., Elf, SE., Huang, N., Zuber, J., Xiao, Z., Tse, W., Tenen, DG., Wang, Q., Chen, W., Mulloy, JC., Nimer, SD., Huang, G. (2014)

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Blood. 123(11):1729-38

Bots, M., Verbrugge, I., Martin, BP., Salmon, JM., Ghisi, M., Baker, A., Stanley, K., Shortt, J., Ossenkoppele, GJ., Zuber, J., Rappaport, AR., Atadja, P., Lowe, SW., Johnstone, RW. (2014)

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood. 123(9):1341-52

Burgess, MR., Hwang, E., Firestone, AJ., Huang, T., Xu, J., Zuber, J., Bohin, N., Wen, T., Kogan, SC., Haigis, KM., Sampath, D., Lowe, S., Shannon, K., Li, Q. (2014)

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Blood. 124(26):3947-55

Yuan, TL., Fellmann, C., Lee, CS., Ritchie, CD., Thapar, V., Lee, LC., Hsu, DJ., Grace, D., Carver, JO., Zuber, J., Luo, J., McCormick, F., Lowe, SW. (2014)

Development of siRNA payloads to target KRAS-mutant cancer.

Cancer Discov. 4(10):1182-1197

Chen, C., Liu, Y., Rappaport, AR., Kitzing, T., Schultz, N., Zhao, Z., Shroff, AS., Dickins, RA., Vakoc, CR., Bradner, JE., Stock, W., LeBeau, MM., Shannon, KM., Kogan, S., Zuber, J., Lowe, SW. (2014)

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Cancer Cell. 25(5):652-65

Rudalska, R., Dauch, D., Longerich, T., McJunkin, K., Wuestefeld, T., Kang, TW., Hohmeyer, A., Pesic, M., Leibold, J., von Thun, A., Schirmacher, P., Zuber, J., Weiss, KH., Powers, S., Malek, NP., Eilers, M., Sipos, B., Lowe, SW., Geffers, R., Laufer, S., Zender, L. (2014)

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med. 20(10):1138-46

Liu, GJ., Cimmino, L., Jude, JG., Hu, Y., Witkowski, MT., McKenzie, MD., Kartal-Kaess, M., Best, SA., Tuohey, L., Liao, Y., Shi, W., Mullighan, CG., Farrar, MA., Nutt, SL., Smyth, GK., Zuber, J., Dickins, RA. (2014)

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Genes Dev. 28(12):1337-50

Fellmann, C., Hoffmann, T., Sridhar, V., Hopfgartner, B., Muhar, M., Roth, M., Lai, DY., Barbosa, IA., Kwon, JS., Guan, Y., Sinha, N., Zuber, J. (2013)

An optimized microRNA backbone for effective single-copy RNAi.

Cell Rep. 5(6):1704-13

Shi, J., Whyte, WA., Zepeda-Mendoza, CJ., Milazzo, JP., Shen, C., Roe, JS., Minder, JL., Mercan, F., Wang, E., Eckersley-Maslin, MA., Campbell, AE., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, RG., Wigler, MH., Blobel, GA., Zuber, J., Spector, DL., Young, RA., Vakoc, CR. (2013)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Genes Dev. 27(24):2648-62

Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, SW., Vakoc, CR. (2013)

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

Oncogene. 32(7):930-8

Mattarollo, SR., West, AC., Steegh, K., Duret, H., Paget, C., Martin, B., Matthews, GM., Shortt, J., Chesi, M., Bergsagel, PL., Bots, M., Zuber, J., Lowe, SW., Johnstone, RW., Smyth, MJ. (2012)

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma.

Blood. 120(15):3019-29

Valent, P., Bonnet, D., De Maria, R., Lapidot, T., Copland, M., Melo, JV., Chomienne, C., Ishikawa, F., Schuringa, JJ., Stassi, G., Huntly, B., Herrmann, H., Soulier, J., Roesch, A., Schuurhuis, GJ., Wöhrer, S., Arock, M., Zuber, J., Cerny-Reiterer, S., Johnsen, HE., Andreeff, M., Eaves, C. (2012)

Cancer stem cell definitions and terminology: the devil is in the details.

Nat Rev Cancer. 12(11):767-75

Herrmann, H., Blatt, K., Shi, J., Gleixner, KV., Cerny-Reiterer, S., Müllauer, L., Vakoc, CR., Sperr, WR., Horny, HP., Bradner, JE., Zuber, J., Valent, P. (2012)

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

Oncotarget. 3(12):1588-99

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, AR., Simon, J., Zhang, J., Luo, W., Hicks, J., Zender, L., Wang, XW., Powers, S., Wigler, M., Lowe, SW. (2012)

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.

Proc Natl Acad Sci U S A. 109(21):8212-7

Glaser, SP., Lee, EF., Trounson, E., Bouillet, P., Wei, A., Fairlie, WD., Izon, DJ., Zuber, J., Rappaport, AR., Herold, MJ., Alexander, WS., Lowe, SW., Robb, L., Strasser, A. (2012)

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.

Genes Dev. 26(2):120-5

Dow, LE., Premsrirut, PK., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, RA., Hannon, GJ., Lowe, SW. (2012)

A pipeline for the generation of shRNA transgenic mice.

Nat Protoc. 7(2):374-93

Bergerson, RJ., Collier, LS., Sarver, AL., Been, RA., Lugthart, S., Diers, MD., Zuber, J., Rappaport, AR., Nixon, MJ., Silverstein, KA., Fan, D., Lamblin, AF., Wolff, L., Kersey, JH., Delwel, R., Lowe, SW., O'Sullivan, MG., Kogan, SC., Adams, DJ., Largaespada, DA. (2012)

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Blood. 119(19):4512-23

McJunkin, K., Mazurek, A., Premsrirut, PK., Zuber, J., Dow, LE., Simon, J., Stillman, B., Lowe, SW. (2011)

Reversible suppression of an essential gene in adult mice using transgenic RNA interference.

Proc Natl Acad Sci U S A. 108(17):7113-8

Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, SP., Vanhaelen, Q., Shukalyuk, AI., Schmauss, G., Schramek, D., Schnuetgen, F., von Melchner, H., Ecker, JR., Stanford, WL., Zuber, J., Stark, A., Penninger, JM. (2011)

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Cell Stem Cell. 9(6):563-74

Zuber, J., Shi, J., Wang, E., Rappaport, AR., Herrmann, H., Sison, EA., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, MJ., Johns, C., Chicas, A., Mulloy, JC., Kogan, SC., Brown, P., Valent, P., Bradner, JE., Lowe, SW., Vakoc, CR. (2011)

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

Nature. 478(7370):524-8

Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, CD., Dickins, RA., Xu, Q., Hengartner, MO., Elledge, SJ., Hannon, GJ., Lowe, SW. (2011)

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

Mol Cell. 41(6):733-46

Zuber, J., McJunkin, K., Fellmann, C., Dow, LE., Taylor, MJ., Hannon, GJ., Lowe, SW. (2011)

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

Nat Biotechnol. 29(1):79-83

Premsrirut, PK., Dow, LE., Kim, SY., Camiolo, M., Malone, CD., Miething, C., Scuoppo, C., Zuber, J., Dickins, RA., Kogan, SC., Shroyer, KR., Sordella, R., Hannon, GJ., Lowe, SW. (2011)

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Cell. 145(1):145-58

Zuber, J., Rappaport, AR., Luo, W., Wang, E., Chen, C., Vaseva, AV., Shi, J., Weissmueller, S., Fellmann, C., Fellman, C., Taylor, MJ., Weissenboeck, M., Graeber, TG., Kogan, SC., Vakoc, CR., Lowe, SW. (2011)

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.

Genes Dev. 25(15):1628-40

Pardee, TS., Zuber, J., Lowe, SW. (2011)

Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner.

Exp Hematol. 39(4):473-485.e4

Mavrakis, KJ., Wolfe, AL., Oricchio, E., Palomero, T., de Keersmaecker, K., McJunkin, K., Zuber, J., James, T., Khan, AA., Leslie, CS., Parker, JS., Paddison, PJ., Tam, W., Ferrando, A., Wendel, HG. (2010)

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.

Nat Cell Biol. 12(4):372-9

Zhao, Z., Zuber, J., Diaz-Flores, E., Lintault, L., Kogan, SC., Shannon, K., Lowe, SW. (2010)

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.

Genes Dev. 24(13):1389-402

Blobel, GA., Kadauke, S., Wang, E., Lau, AW., Zuber, J., Chou, MM., Vakoc, CR. (2009)

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

Mol Cell. 36(6):970-83

Zuber, J., Radtke, I., Pardee, TS., Zhao, Z., Rappaport, AR., Luo, W., McCurrach, ME., Yang, MM., Dolan, ME., Kogan, SC., Downing, JR., Lowe, SW. (2009)

Mouse models of human AML accurately predict chemotherapy response.

Genes Dev. 23(7):877-89

Guo, X., Keyes, WM., Papazoglu, C., Zuber, J., Li, W., Lowe, SW., Vogel, H., Mills, AA. (2009)

TAp63 induces senescence and suppresses tumorigenesis in vivo.

Nat Cell Biol. 11(12):1451-7

Bric, A., Miething, C., Bialucha, CU., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M., Hicks, J., McCombie, RW., Hemann, MT., Hannon, GJ., Powers, S., Lowe, SW. (2009)

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

Cancer Cell. 16(4):324-35

Zender, L., Xue, W., Zuber, J., Semighini, CP., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, JM., Schirmacher, P., McCombie, WR., Wigler, M., Hicks, J., Hannon, GJ., Powers, S., Lowe, SW. (2008)

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

Cell. 135(5):852-64

Zender, L., Zuber, J., Lowe, SW. (2007)

Snapshot: genetic mouse models of cancer.

Cell. 129(4):838

Tchernitsa, OI., Sers, C., Zuber, J., Hinzmann, B., Grips, M., Schramme, A., Lund, P., Schwendel, A., Rosenthal, A., Schäfer, R. (2004)

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.

Oncogene. 23(26):4536-55

Herzog, H., Zuber, J., Stroszczynski, C. (2004)

[Cyclosporin A-induced posterior reversible encephalopathy syndrome (PRES) in MRI].

Rofo. 176(9):1326-7

Trappe, RU., Riess, H., Lippek, F., Plotkin, M., Schumacher, V., Royer-Pokora, B., Hildebrandt, B., Zuber, J., Mapara, MY., Oertel, S., Dörken, B. (2004)

Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene.

J Pediatr Hematol Oncol. 26(12):820-3

Baskaynak, G., Kreuzer, KA., Schwarz, M., Zuber, J., Audring, H., Riess, H., Dörken, B., le Coutre, P. (2003)

Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment.

Eur J Haematol. 70(4):231-4

Schäfer, R., Tchernitsa, OI., Zuber, J., Sers, C. (2003)

Dissection of signal-regulated transcriptional modules by signaling pathway interference in oncogene-transformed cells.

Adv Enzyme Regul. 43:379-91

Sers, C., Tchernitsa, OI., Zuber, J., Diatchenko, L., Zhumabayeva, B., Desai, S., Htun, S., Hyder, K., Wiechen, K., Agoulnik, A., Scharff, KM., Siebert, PD., Schäfer, R. (2002)

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

Adv Enzyme Regul. 42:63-82

Zuber, J., Tchernitsa, OI., Hinzmann, B., Schmitz, AC., Grips, M., Hellriegel, M., Sers, C., Rosenthal, A., Schäfer, R. (2000)

A genome-wide survey of RAS transformation targets.

Nat Genet. 24(2):144-52

Tchernitsa, OI., Zuber, J., Sers, C., Brinckmann, R., Britsch, SK., Adams, V., Schäfer, R. (1999)

Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators.

Oncogene. 18(39):5448-54

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