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Jan-Michael Peters

To pass the genome from one generation to the next, eukaryotic cells first replicate their DNA, then biorient chromosomes on the mitotic spindle and finally separate their sister chromatids, thus enabling the division of one cell into two genetically identical daughter cells. We are interested in understanding these processes at the molecular level.



Dequeker, BJH., Scherr, MJ., Brandão, HB., Gassler, J., Powell, S., Gaspar, I., Flyamer, IM., Lalic, A., Tang, W., Stocsits, R., Davidson, IF., Peters, JM., Duderstadt, KE., Mirny, LA., Tachibana, K. (2022)

MCM complexes are barriers that restrict cohesin-mediated loop extrusion.

Nagano, M., Hu, B., Yokobayashi, S., Yamamura, A., Umemura, F., Coradin, M., Ohta, H., Yabuta, Y., Ishikura, Y., Okamoto, I., Ikeda, H., Kawahira, N., Nosaka, Y., Shimizu, S., Kojima, Y., Mizuta, K., Kasahara, T., Imoto, Y., Meehan, K., Stocsits, R., Wutz, G., Hiraoka, Y., Murakawa, Y., Yamamoto, T., Tachibana, K., Peters, JM., Mirny, LA., Garcia, BA., Majewski, J., Saitou, M. (2022)

Nucleome programming is required for the foundation of totipotency in mammalian germline development.

EMBO J. :e110600


Bauer, BW., Davidson, IF., Canena, D., Wutz, G., Tang, W., Litos, G., Horn, S., Hinterdorfer, P., Peters, JM. (2021)

Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism.

Cell. 184(21):5448-5464.e22
Davidson, IF., Peters, JM. (2021)

Genome folding through loop extrusion by SMC complexes.

Nat Rev Mol Cell Biol. 22(7):445-464
Peters, JM. (2021)

How DNA loop extrusion mediated by cohesin enables V(D)J recombination.

Curr Opin Cell Biol. 70:75-83


Hill, L., Ebert, A., Jaritz, M., Wutz, G., Nagasaka, K., Tagoh, H., Kostanova-Poliakova, D., Schindler, K., Sun, Q., Bönelt, P., Fischer, M., Peters, JM., Busslinger, M. (2020)

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.

Nature. 584(7819):142-147
Martinez-Chacin, RC., Bodrug, T., Bolhuis, DL., Kedziora, KM., Bonacci, T., Ordureau, A., Gibbs, ME., Weissmann, F., Qiao, R., Grant, GD., Cook, JG., Peters, JM., Wade Harper, J., Emanuele, MJ., Brown, NG. (2020)

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.

Nat Struct Mol Biol. 27(6):550-560
Mitter, M., Gasser, C., Takacs, Z., Langer, CCH., Tang, W., Jessberger, G., Beales, CT., Neuner, E., Ameres, SL., Peters, JM., Goloborodko, A., Micura, R., Gerlich, DW. (2020)

Conformation of sister chromatids in the replicated human genome.

Nature. 586(7827):139-144
Morales, C., Ruiz-Torres, M., Rodríguez-Acebes, S., Lafarga, V., Rodríguez-Corsino, M., Megías, D., Cisneros, DA., Peters, JM., Méndez, J., Losada, A. (2020)

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.

J Biol Chem. 295(1):146-157
Silva, MCC., Powell, S., Ladstätter, S., Gassler, J., Stocsits, R., Tedeschi, A., Peters, JM., Tachibana, K. (2020)

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes.

J Cell Biol. 219(4)
Sonn-Segev, A., Belacic, K., Bodrug, T., Young, G., VanderLinden, RT., Schulman, BA., Schimpf, J., Friedrich, T., Dip, PV., Schwartz, TU., Bauer, B., Peters, JM., Struwe, WB., Benesch, JLP., Brown, NG., Haselbach, D., Kukura, P. (2020)

Quantifying the heterogeneity of macromolecular machines by mass photometry.

Nat Commun. 11(1):1772
Thiecke, MJ., Wutz, G., Muhar, M., Tang, W., Bevan, S., Malysheva, V., Stocsits, R., Neumann, T., Zuber, J., Fraser, P., Schoenfelder, S., Peters, JM., Spivakov, M. (2020)

Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.

Cell Rep. 32(3):107929
van der Lelij, P., Newman, JA., Lieb, S., Jude, J., Katis, V., Hoffmann, T., Hinterndorfer, M., Bader, G., Kraut, N., Pearson, MA., Peters, JM., Zuber, J., Gileadi, O., Petronczki, M. (2020)

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

Life Sci Alliance. 3(7)
Wutz, G., Ladurner, R., St Hilaire, BG., Stocsits, RR., Nagasaka, K., Pignard, B., Sanborn, A., Tang, W., Várnai, C., Ivanov, MP., Schoenfelder, S., van der Lelij, P., Huang, X., Dürnberger, G., Roitinger, E., Mechtler, K., Davidson, IF., Fraser, P., Lieberman-Aiden, E., Peters, JM. (2020)

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.

Elife. 9


Canela, A., Maman, Y., Huang, SN., Wutz, G., Tang, W., Zagnoli-Vieira, G., Callen, E., Wong, N., Day, A., Peters, JM., Caldecott, KW., Pommier, Y., Nussenzweig, A. (2019)

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Mol Cell. 75(2):252-266.e8
Davidson, IF., Bauer, B., Goetz, D., Tang, W., Wutz, G., Peters, JM. (2019)

DNA loop extrusion by human cohesin.

Science. 366(6471):1338-1345
Holzmann, J., Politi, AZ., Nagasaka, K., Hantsche-Grininger, M., Walther, N., Koch, B., Fuchs, J., Dürnberger, G., Tang, W., Ladurner, R., Stocsits, RR., Busslinger, GA., Novák, B., Mechtler, K., Davidson, IF., Ellenberg, J., Peters, JM. (2019)

Absolute quantification of cohesin, CTCF and their regulators in human cells.

Elife. 8
Soh, YM., Davidson, IF., Zamuner, S., Basquin, J., Bock, FP., Taschner, M., Veening, JW., De Los Rios, P., Peters, JM., Gruber, S. (2019)

Self-organization of parS centromeres by the ParB CTP hydrolase.

Science. 366(6469):1129-1133
Watson, ER., Brown, NG., Peters, JM., Stark, H., Schulman, BA. (2019)

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

Trends Cell Biol. 29(2):117-134
Watson, ER., Grace, CRR., Zhang, W., Miller, DJ., Davidson, IF., Prabu, JR., Yu, S., Bolhuis, DL., Kulko, ET., Vollrath, R., Haselbach, D., Stark, H., Peters, JM., Brown, NG., Sidhu, SS., Schulman, BA. (2019)

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Proc Natl Acad Sci U S A. 116(35):17280-17289


Cai, Y., Hossain, MJ., Hériché, JK., Politi, AZ., Walther, N., Koch, B., Wachsmuth, M., Nijmeijer, B., Kueblbeck, M., Martinic-Kavur, M., Ladurner, R., Alexander, S., Peters, JM., Ellenberg, J. (2018)

Experimental and computational framework for a dynamic protein atlas of human cell division.

Nature. 561(7723):411-415
Ivanov, MP., Ladurner, R., Poser, I., Beveridge, R., Rampler, E., Hudecz, O., Novatchkova, M., Hériché, JK., Wutz, G., van der Lelij, P., Kreidl, E., Hutchins, JR., Axelsson-Ekker, H., Ellenberg, J., Hyman, AA., Mechtler, K., Peters, JM. (2018)

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.

EMBO J. 37(15)
Silva, MCC., Wutz, G., Tachibana, K., Peters, JM. (2018)

Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy.

Methods Cell Biol. 144:287-305
Stanyte, R., Nuebler, J., Blaukopf, C., Hoefler, R., Stocsits, R., Peters, JM., Gerlich, DW. (2018)

Dynamics of sister chromatid resolution during cell cycle progression.

J Cell Biol. 217(6):1985-2004
Weissmann, F., Peters, JM. (2018)

Expressing Multi-subunit Complexes Using biGBac.

Methods Mol Biol. 1764:329-343


Busslinger, GA., Stocsits, RR., van der Lelij, P., Axelsson, E., Tedeschi, A., Galjart, N., Peters, JM. (2017)

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.

Nature. 544(7651):503-507
Gassler, J., Brandão, HB., Imakaev, M., Flyamer, IM., Ladstätter, S., Bickmore, WA., Peters, JM., Mirny, LA., Tachibana, K. (2017)

A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.

EMBO J. 36(24):3600-3618
van der Lelij, P., Lieb, S., Jude, J., Wutz, G., Santos, CP., Falkenberg, K., Schlattl, A., Ban, J., Schwentner, R., Hoffmann, T., Kovar, H., Real, FX., Waldman, T., Pearson, MA., Kraut, N., Peters, JM., Zuber, J., Petronczki, M. (2017)

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

Elife. 6
Wutz, G., Várnai, C., Nagasaka, K., Cisneros, DA., Stocsits, RR., Tang, W., Schoenfelder, S., Jessberger, G., Muhar, M., Hossain, MJ., Walther, N., Koch, B., Kueblbeck, M., Ellenberg, J., Zuber, J., Fraser, P., Peters, JM. (2017)

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.

EMBO J. 36(24):3573-3599


Brown, NG., VanderLinden, R., Watson, ER., Weissmann, F., Ordureau, A., Wu, KP., Zhang, W., Yu, S., Mercredi, PY., Harrison, JS., Davidson, IF., Qiao, R., Lu, Y., Dube, P., Brunner, MR., Grace, CRR., Miller, DJ., Haselbach, D., Jarvis, MA., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, SS., Kuhlman, B., Kirschner, MW., Harper, JW., Peters, JM., Stark, H., Schulman, BA. (2016)

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Cell. 165(6):1440-1453
Davidson, IF., Goetz, D., Zaczek, MP., Molodtsov, MI., Huis In 't Veld, PJ., Weissmann, F., Litos, G., Cisneros, DA., Ocampo-Hafalla, M., Ladurner, R., Uhlmann, F., Vaziri, A., Peters, JM. (2016)

Rapid movement and transcriptional re-localization of human cohesin on DNA.

EMBO J. 35(24):2671-2685
Hons, MT., Huis In 't Veld, PJ., Kaesler, J., Rombaut, P., Schleiffer, A., Herzog, F., Stark, H., Peters, JM. (2016)

Topology and structure of an engineered human cohesin complex bound to Pds5B.

Nat Commun. 7:12523
Isokane, M., Walter, T., Mahen, R., Nijmeijer, B., Hériché, JK., Miura, K., Maffini, S., Ivanov, MP., Kitajima, TS., Peters, JM., Ellenberg, J. (2016)

ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.

J Cell Biol. 212(6):647-59
Jarvis, MA., Brown, NG., Watson, ER., VanderLinden, R., Schulman, BA., Peters, JM. (2016)

Measuring APC/C-Dependent Ubiquitylation In Vitro.

Methods Mol Biol. 1342:287-303
Kim, JS., He, X., Orr, B., Wutz, G., Hill, V., Peters, JM., Compton, DA., Waldman, T. (2016)

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.

PLoS Genet. 12(2):e1005865
Ladurner, R., Kreidl, E., Ivanov, MP., Ekker, H., Idarraga-Amado, MH., Busslinger, GA., Wutz, G., Cisneros, DA., Peters, JM. (2016)

Sororin actively maintains sister chromatid cohesion.

EMBO J. 35(6):635-53
Qiao, R., Weissmann, F., Yamaguchi, M., Brown, NG., VanderLinden, R., Imre, R., Jarvis, MA., Brunner, MR., Davidson, IF., Litos, G., Haselbach, D., Mechtler, K., Stark, H., Schulman, BA., Peters, JM. (2016)

Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

Proc Natl Acad Sci U S A. 113(19):E2570-8
Weissmann, F., Petzold, G., VanderLinden, R., Huis In 't Veld, PJ., Brown, NG., Lampert, F., Westermann, S., Stark, H., Schulman, BA., Peters, JM. (2016)

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.

Proc Natl Acad Sci U S A. 113(19):E2564-9
Yamaguchi, M., VanderLinden, R., Weissmann, F., Qiao, R., Dube, P., Brown, NG., Haselbach, D., Zhang, W., Sidhu, SS., Peters, JM., Stark, H., Schulman, BA. (2016)

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

Mol Cell. 63(4):593-607


Brown, NG., VanderLinden, R., Watson, ER., Qiao, R., Grace, CR., Yamaguchi, M., Weissmann, F., Frye, JJ., Dube, P., Ei Cho, S., Actis, ML., Rodrigues, P., Fujii, N., Peters, JM., Stark, H., Schulman, BA. (2015)

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Proc Natl Acad Sci U S A. 112(17):5272-9
Chari, A., Haselbach, D., Kirves, JM., Ohmer, J., Paknia, E., Fischer, N., Ganichkin, O., Möller, V., Frye, JJ., Petzold, G., Jarvis, M., Tietzel, M., Grimm, C., Peters, JM., Schulman, BA., Tittmann, K., Markl, J., Fischer, U., Stark, H. (2015)

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.

Nat Methods. 12(9):859-65
Yamaguchi, M., Yu, S., Qiao, R., Weissmann, F., Miller, DJ., VanderLinden, R., Brown, NG., Frye, JJ., Peters, JM., Schulman, BA. (2015)

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

J Mol Biol. 427(8):1748-64
Yeh, C., Coyaud, É., Bashkurov, M., van der Lelij, P., Cheung, SW., Peters, JM., Raught, B., Pelletier, L. (2015)

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

Curr Biol. 25(17):2290-9


Brown, NG., Watson, ER., Weissmann, F., Jarvis, MA., VanderLinden, R., Grace, CRR., Frye, JJ., Qiao, R., Dube, P., Petzold, G., Cho, SE., Alsharif, O., Bao, J., Davidson, IF., Zheng, JJ., Nourse, A., Kurinov, I., Peters, JM., Stark, H., Schulman, BA. (2014)

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Mol Cell. 56(2):246-260
Huis in 't Veld, PJ., Herzog, F., Ladurner, R., Davidson, IF., Piric, S., Kreidl, E., Bhaskara, V., Aebersold, R., Peters, JM. (2014)

Characterization of a DNA exit gate in the human cohesin ring.

Science. 346(6212):968-72
Ladurner, R., Bhaskara, V., Huis in 't Veld, PJ., Davidson, IF., Kreidl, E., Petzold, G., Peters, JM. (2014)

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.

Curr Biol. 24(19):2228-37
van der Lelij, P., Stocsits, RR., Ladurner, R., Petzold, G., Kreidl, E., Koch, B., Schmitz, J., Neumann, B., Ellenberg, J., Peters, JM. (2014)

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.

EMBO J. 33(22):2643-58


Frye, JJ., Brown, NG., Petzold, G., Watson, ER., Grace, CR., Nourse, A., Jarvis, MA., Kriwacki, RW., Peters, JM., Stark, H., Schulman, BA. (2013)

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Nat Struct Mol Biol. 20(7):827-35
Nishiyama, T., Sykora, MM., Huis in 't Veld, PJ., Mechtler, K., Peters, JM. (2013)

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.

Proc Natl Acad Sci U S A. 110(33):13404-9
Tedeschi, A., Wutz, G., Huet, S., Jaritz, M., Wuensche, A., Schirghuber, E., Davidson, IF., Tang, W., Cisneros, DA., Bhaskara, V., Nishiyama, T., Vaziri, A., Wutz, A., Ellenberg, J., Peters, JM. (2013)

Wapl is an essential regulator of chromatin structure and chromosome segregation.

Nature. 501(7468):564-8


Peters, JM., Nishiyama, T. (2012)

Sister chromatid cohesion.

Cold Spring Harb Perspect Biol. 4(11)
Uzunova, K., Dye, BT., Schutz, H., Ladurner, R., Petzold, G., Toyoda, Y., Jarvis, MA., Brown, NG., Poser, I., Novatchkova, M., Mechtler, K., Hyman, AA., Stark, H., Schulman, BA., Peters, JM. (2012)

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Nat Struct Mol Biol. 19(11):1116-23
Whelan, G., Kreidl, E., Peters, JM., Eichele, G. (2012)

The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.

Nucleus. 3(4):330-4
Whelan, G., Kreidl, E., Wutz, G., Egner, A., Peters, JM., Eichele, G. (2012)

Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.

EMBO J. 31(1):71-82


Alexander, J., Lim, D., Joughin, BA., Hegemann, B., Hutchins, JR., Ehrenberger, T., Ivins, F., Sessa, F., Hudecz, O., Nigg, EA., Fry, AM., Musacchio, A., Stukenberg, PT., Mechtler, K., Peters, JM., Smerdon, SJ., Yaffe, MB. (2011)

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Sci Signal. 4(179):ra42
Buschhorn, BA., Petzold, G., Galova, M., Dube, P., Kraft, C., Herzog, F., Stark, H., Peters, JM. (2011)

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

Nat Struct Mol Biol. 18(1):6-13
Grosstessner-Hain, K., Hegemann, B., Novatchkova, M., Rameseder, J., Joughin, BA., Hudecz, O., Roitinger, E., Pichler, P., Kraut, N., Yaffe, MB., Peters, JM., Mechtler, K. (2011)

Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.

Mol Cell Proteomics. 10(11):M111.008540
Hegemann, B., Hutchins, JR., Hudecz, O., Novatchkova, M., Rameseder, J., Sykora, MM., Liu, S., Mazanek, M., Lénárt, P., Hériché, JK., Poser, I., Kraut, N., Hyman, AA., Yaffe, MB., Mechtler, K., Peters, JM. (2011)

Systematic phosphorylation analysis of human mitotic protein complexes.

Sci Signal. 4(198):rs12


Hutchins, JR., Toyoda, Y., Hegemann, B., Poser, I., Hériché, JK., Sykora, MM., Augsburg, M., Hudecz, O., Buschhorn, BA., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, MM., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, AA., Peters, JM. (2010)

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Science. 328(5978):593-9
Mazanek, M., Roitinger, E., Hudecz, O., Hutchins, JR., Hegemann, B., Mitulović, G., Taus, T., Stingl, C., Peters, JM., Mechtler, K. (2010)

A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes.

J Chromatogr B Analyt Technol Biomed Life Sci. 878(5-6):515-24
Neumann, B., Walter, T., Hériché, JK., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, MH., Chapuis, C., Gerlich, DW., Schneider, R., Eils, R., Huber, W., Peters, JM., Hyman, AA., Durbin, R., Pepperkok, R., Ellenberg, J. (2010)

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Nature. 464(7289):721-7
Nishiyama, T., Ladurner, R., Schmitz, J., Kreidl, E., Schleiffer, A., Bhaskara, V., Bando, M., Shirahige, K., Hyman, AA., Mechtler, K., Peters, JM. (2010)

Sororin mediates sister chromatid cohesion by antagonizing Wapl.

Cell. 143(5):737-49
Schmitz, MH., Held, M., Janssens, V., Hutchins, JR., Hudecz, O., Ivanova, E., Goris, J., Trinkle-Mulcahy, L., Lamond, AI., Poser, I., Hyman, AA., Mechtler, K., Peters, JM., Gerlich, DW. (2010)

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

Nat Cell Biol. 12(9):886-93


Herzog, F., Primorac, I., Dube, P., Lenart, P., Sander, B., Mechtler, K., Stark, H., Peters, JM. (2009)

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.

Science. 323(5920):1477-81
Lawo, S., Bashkurov, M., Mullin, M., Ferreria, MG., Kittler, R., Habermann, B., Tagliaferro, A., Poser, I., Hutchins, JR., Hegemann, B., Pinchev, D., Buchholz, F., Peters, JM., Hyman, AA., Gingras, AC., Pelletier, L. (2009)

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.

Curr Biol. 19(10):816-26
Mitulović, G., Stingl, C., Steinmacher, I., Hudecz, O., Hutchins, JR., Peters, JM., Mechtler, K. (2009)

Preventing carryover of peptides and proteins in nano LC-MS separations.

Anal Chem. 81(14):5955-60
Nativio, R., Wendt, KS., Ito, Y., Huddleston, JE., Uribe-Lewis, S., Woodfine, K., Krueger, C., Reik, W., Peters, JM., Murrell, A. (2009)

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

PLoS Genet. 5(11):e1000739
Peters, JM., Bhaskara, V. (2009)

Cohesin acetylation: from antiestablishment to establishment.

Mol Cell. 34(1):1-2
Wendt, KS., Peters, JM. (2009)

How cohesin and CTCF cooperate in regulating gene expression.

Chromosome Res. 17(2):201-14


Kastner, B., Fischer, N., Golas, MM., Sander, B., Dube, P., Boehringer, D., Hartmuth, K., Deckert, J., Hauer, F., Wolf, E., Uchtenhagen, H., Urlaub, H., Herzog, F., Peters, JM., Poerschke, D., Lührmann, R., Stark, H. (2008)

GraFix: sample preparation for single-particle electron cryomicroscopy.

Nat Methods. 5(1):53-5
Koch, B., Kueng, S., Ruckenbauer, C., Wendt, KS., Peters, JM. (2008)

The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells.

Chromosoma. 117(2):199-210
Peters, JM. (2008)

Checkpoint control: the journey continues.

Curr Biol. 18(4):R170-2
Peters, JM., Tedeschi, A., Schmitz, J. (2008)

The cohesin complex and its roles in chromosome biology.

Genes Dev. 22(22):3089-114
Petronczki, M., Lénárt, P., Peters, JM. (2008)

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Dev Cell. 14(5):646-59
Poser, I., Sarov, M., Hutchins, JR., Hériché, JK., Toyoda, Y., Pozniakovsky, A., Weigl, D., Nitzsche, A., Hegemann, B., Bird, AW., Pelletier, L., Kittler, R., Hua, S., Naumann, R., Augsburg, M., Sykora, MM., Hofemeister, H., Zhang, Y., Nasmyth, K., White, KP., Dietzel, S., Mechtler, K., Durbin, R., Stewart, AF., Peters, JM., Buchholz, F., Hyman, AA. (2008)

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.

Nat Methods. 5(5):409-15
Taylor, S., Peters, JM. (2008)

Polo and Aurora kinases: lessons derived from chemical biology.

Curr Opin Cell Biol. 20(1):77-84
Vernos, I., Peters, JM. (2008)

Twenty years of cell-cycle conferences in Roscoff.

Nat Cell Biol. 10(8):877-80
Wendt, KS., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., Yahata, K., Imamoto, F., Aburatani, H., Nakao, M., Imamoto, N., Maeshima, K., Shirahige, K., Peters, JM. (2008)

Cohesin mediates transcriptional insulation by CCCTC-binding factor.

Nature. 451(7180):796-801


Jiménez, JL., Hegemann, B., Hutchins, JR., Peters, JM., Durbin, R. (2007)

A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database.

Genome Biol. 8(5):R90
Lénárt, P., Petronczki, M., Steegmaier, M., Di Fiore, B., Lipp, JJ., Hoffmann, M., Rettig, WJ., Kraut, N., Peters, JM. (2007)

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Curr Biol. 17(4):304-15
Lipp, JJ., Hirota, T., Poser, I., Peters, JM. (2007)

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.

J Cell Sci. 120(Pt 7):1245-55
Mazanek, M., Mituloviae, G., Herzog, F., Stingl, C., Hutchins, JR., Peters, JM., Mechtler, K. (2007)

Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.

Nat Protoc. 2(5):1059-69
Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., Hirota, T. (2007)

The complete removal of cohesin from chromosome arms depends on separase.

J Cell Sci. 120(Pt 23):4188-96
Peters, JM. (2007)

Cell biology: the checkpoint brake relieved.

Nature. 446(7138):868-9
Schmitz, J., Watrin, E., Lénárt, P., Mechtler, K., Peters, JM. (2007)

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.

Curr Biol. 17(7):630-6
Steegmaier, M., Hoffmann, M., Baum, A., Lénárt, P., Petronczki, M., Krssák, M., Gürtler, U., Garin-Chesa, P., Lieb, S., Quant, J., Grauert, M., Adolf, GR., Kraut, N., Peters, JM., Rettig, WJ. (2007)

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Curr Biol. 17(4):316-22
Watrin, E., Peters, JM. (2007)

Molecular biology. How and when the genome sticks together.

Science. 317(5835):209-10


Buschhorn, BA., Peters, JM. (2006)

How APC/C orders destruction.

Nat Cell Biol. 8(3):209-11
Gerlich, D., Hirota, T., Koch, B., Peters, JM., Ellenberg, J. (2006)

Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.

Curr Biol. 16(4):333-44
Gerlich, D., Koch, B., Dupeux, F., Peters, JM., Ellenberg, J. (2006)

Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.

Curr Biol. 16(15):1571-8
Kraft, C., Gmachl, M., Peters, JM. (2006)

Methods to measure ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.

Methods. 38(1):39-51
Kueng, S., Hegemann, B., Peters, BH., Lipp, JJ., Schleiffer, A., Mechtler, K., Peters, JM. (2006)

Wapl controls the dynamic association of cohesin with chromatin.

Cell. 127(5):955-67
Lénárt, P., Peters, JM. (2006)

Checkpoint activation: don't get mad too much.

Curr Biol. 16(11):R412-4
Mujezinovic, N., Raidl, G., Hutchins, JR., Peters, JM., Mechtler, K., Eisenhaber, F. (2006)

Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.

Proteomics. 6(19):5117-31
Peters, JM. (2006)

The anaphase promoting complex/cyclosome: a machine designed to destroy.

Nat Rev Mol Cell Biol. 7(9):644-56
Watrin, E., Peters, JM. (2006)

Cohesin and DNA damage repair.

Exp Cell Res. 312(14):2687-93
Watrin, E., Schleiffer, A., Tanaka, K., Eisenhaber, F., Nasmyth, K., Peters, JM. (2006)

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.

Curr Biol. 16(9):863-74
Wirth, KG., Wutz, G., Kudo, NR., Desdouets, C., Zetterberg, A., Taghybeeglu, S., Seznec, J., Ducos, GM., Ricci, R., Firnberg, N., Peters, JM., Nasmyth, K. (2006)

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.

J Cell Biol. 172(6):847-60


Dube, P., Herzog, F., Gieffers, C., Sander, B., Riedel, D., Müller, SA., Engel, A., Peters, JM., Stark, H. (2005)

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

Mol Cell. 20(6):867-79
Hauf, S., Roitinger, E., Koch, B., Dittrich, CM., Mechtler, K., Peters, JM. (2005)

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

PLoS Biol. 3(3):e69
Herzog, F., Peters, JM. (2005)

Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome.

Methods Enzymol. 398:175-95
Hirota, T., Lipp, JJ., Toh, BH., Peters, JM. (2005)

Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin.

Nature. 438(7071):1176-80
Kraft, C., Vodermaier, HC., Maurer-Stroh, S., Eisenhaber, F., Peters, JM. (2005)

The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

Mol Cell. 18(5):543-53
McGuinness, BE., Hirota, T., Kudo, NR., Peters, JM., Nasmyth, K. (2005)

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.

PLoS Biol. 3(3):e86
Peters, JM. (2005)

Cyclin degradation: don't mes(s) with meiosis.

Curr Biol. 15(12):R461-3


Acquaviva, C., Herzog, F., Kraft, C., Pines, J. (2004)

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

Nat Cell Biol. 6(9):892-8
Giménez-Abián, JF., Sumara, I., Hirota, T., Hauf, S., Gerlich, D., de la Torre, C., Ellenberg, J., Peters, JM. (2004)

Regulation of sister chromatid cohesion between chromosome arms.

Curr Biol. 14(13):1187-93
Hirota, T. (2004)

[Setting the stage for mitosis: kinase regulation of prophase].

Tanpakushitsu Kakusan Koso. 49(8):1183-94
Hirota, T., Gerlich, D., Koch, B., Ellenberg, J., Peters, JM. (2004)

Distinct functions of condensin I and II in mitotic chromosome assembly.

J Cell Sci. 117(Pt 26):6435-45
Máthé, E., Kraft, C., Giet, R., Deák, P., Peters, JM., Glover, DM. (2004)

The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

Curr Biol. 14(19):1723-33
Sumara, I., Giménez-Abián, JF., Gerlich, D., Hirota, T., Kraft, C., de la Torre, C., Ellenberg, J., Peters, JM. (2004)

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.

Curr Biol. 14(19):1712-22
Vodermaier, HC. (2004)

APC/C and SCF: controlling each other and the cell cycle.

Curr Biol. 14(18):R787-96
Vodermaier, HC., Peters, JM. (2004)

APC activators caught by their tails?

Cell Cycle. 3(3):265-6


Gabellini, D., Colaluca, IN., Vodermaier, HC., Biamonti, G., Giacca, M., Falaschi, A., Riva, S., Peverali, FA. (2003)

Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.

EMBO J. 22(14):3715-24
Hauf, S. (2003)

Fine tuning of kinetochore function by phosphorylation.

Cell Cycle. 2(3):228-9
Hauf, S., Cole, RW., LaTerra, S., Zimmer, C., Schnapp, G., Walter, R., Heckel, A., van Meel, J., Rieder, CL., Peters, JM. (2003)

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

J Cell Biol. 161(2):281-94
Kraft, C. (2003)

Mitotic entry: tipping the balance.

Curr Biol. 13(11):R445-6
Kraft, C., Herzog, F., Gieffers, C., Mechtler, K., Hagting, A., Pines, J., Peters, JM. (2003)

Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

EMBO J. 22(24):6598-609
Terret, ME., Wassmann, K., Waizenegger, I., Maro, B., Peters, JM., Verlhac, MH. (2003)

The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.

Curr Biol. 13(20):1797-802
Vodermaier, HC., Gieffers, C., Maurer-Stroh, S., Eisenhaber, F., Peters, JM. (2003)

TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

Curr Biol. 13(17):1459-68
Yeong, FM., Hombauer, H., Wendt, KS., Hirota, T., Mudrak, I., Mechtler, K., Loregger, T., Marchler-Bauer, A., Tanaka, K., Peters, JM., Ogris, E. (2003)

Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A.

Curr Biol. 13(23):2058-64


Hagting, A., Den Elzen, N., Vodermaier, HC., Waizenegger, IC., Peters, JM., Pines, J. (2002)

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

J Cell Biol. 157(7):1125-37
Peters, JM. (2002)

Anaphase-promoting complex.

Encyclopedia of Molecular Medicine. :193-6
Sumara, I., Vorlaufer, E., Stukenberg, PT., Kelm, O., Redemann, N., Nigg, EA., Peters, JM. (2002)

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.

Mol Cell. 9(3):515-25
Vodermaier, HC., Peters, JM. (2002)

Conspiracy to disarm APC in interphase.

Nat Cell Biol. 4(5):E119-20
Waizenegger, I., Giménez-Abián, JF., Wernic, D., Peters, JM. (2002)

Regulation of human separase by securin binding and autocleavage.

Curr Biol. 12(16):1368-78


Gieffers, C., Dube, P., Harris, JR., Stark, H., Peters, JM. (2001)

Three-dimensional structure of the anaphase-promoting complex.

Mol Cell. 7(4):907-13
Hauf, S., Waizenegger, IC., Peters, JM. (2001)

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.

Science. 293(5533):1320-3
Jallepalli, PV., Waizenegger, IC., Bunz, F., Langer, S., Speicher, MR., Peters, JM., Kinzler, KW., Vogelstein, B., Lengauer, C. (2001)

Securin is required for chromosomal stability in human cells.

Cell. 105(4):445-57
Nasmyth, K., Peters, JM., Uhlmann, F. (2001)

Splitting the chromosome: cutting the ties that bind sister chromatids.

Novartis Found Symp. 237:113-33; discussion 133-8, 158-63
Reimann, JD., Freed, E., Hsu, JY., Kramer, ER., Peters, JM., Jackson, PK. (2001)

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Cell. 105(5):645-55
Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O., Ushiki, T., Nojima, K., Fukagawa, T., Waizenegger, IC., Peters, JM., Earnshaw, WC., Takeda, S. (2001)

Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells.

Dev Cell. 1(6):759-70
Sørensen, CS., Lukas, C., Kramer, ER., Peters, JM., Bartek, J., Lukas, J. (2001)

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.

Mol Cell Biol. 21(11):3692-703
Vodermaier, HC. (2001)

Cell cycle: Waiters serving the Destruction machinery.

Curr Biol. 11(20):R834-7
Wendt, KS., Vodermaier, HC., Jacob, U., Gieffers, C., Gmachl, M., Peters, JM., Huber, R., Sondermann, P. (2001)

Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.

Nat Struct Biol. 8(9):784-8


Gieffers, C., Schleiffer, A., Peters, JM. (2000)

Cullins and cell cycle control.

Protoplasma. 211:20-28
Gmachl, M., Gieffers, C., Podtelejnikov, AV., Mann, M., Peters, JM. (2000)

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.

Proc Natl Acad Sci U S A. 97(16):8973-8
Kramer, ER., Scheuringer, N., Podtelejnikov, AV., Mann, M., Peters, JM. (2000)

Mitotic regulation of the APC activator proteins CDC20 and CDH1.

Mol Biol Cell. 11(5):1555-69
Nasmyth, K., Peters, JM., Uhlmann, F. (2000)

Splitting the chromosome: cutting the ties that bind sister chromatids.

Science. 288(5470):1379-85
Petersen, BO., Wagener, C., Marinoni, F., Kramer, ER., Melixetian, M., Lazzerini Denchi, E., Gieffers, C., Matteucci, C., Peters, JM., Helin, K. (2000)

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.

Genes Dev. 14(18):2330-43
Sorensen, CS., Lukas, C., Kramer, ER., Peters, JM., Bartek, J., Lukas, J. (2000)

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis.

Mol Cell Biol. 20(20):7613-23
Sumara, I., Vorlaufer, E., Gieffers, C., Peters, BH., Peters, JM. (2000)

Characterization of vertebrate cohesin complexes and their regulation in prophase.

J Cell Biol. 151(4):749-62
Waizenegger, IC., Hauf, S., Meinke, A., Peters, JM. (2000)

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.

Cell. 103(3):399-410


Gieffers, C., Peters, BH., Kramer, ER., Dotti, CG., Peters, JM. (1999)

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.

Proc Natl Acad Sci U S A. 96(20):11317-22
Grossberger, R., Gieffers, C., Zachariae, W., Podtelejnikov, AV., Schleiffer, A., Nasmyth, K., Mann, M., Peters, JM. (1999)

Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.

J Biol Chem. 274(20):14500-7
Lukas, C., Sørensen, CS., Kramer, E., Santoni-Rugiu, E., Lindeneg, C., Peters, JM., Bartek, J., Lukas, J. (1999)

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.

Nature. 401(6755):815-8
Peters, JM. (1999)

Subunits and substrates of the anaphase-promoting complex.

Exp Cell Res. 248(2):339-49


Kramer, ER., Gieffers, C., Hölzl, G., Hengstschläger, M., Peters, JM. (1998)

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.

Curr Biol. 8(22):1207-10
Peters, JM. (1998)

SCF and APC: the Yin and Yang of cell cycle regulated proteolysis.

Curr Opin Cell Biol. 10(6):759-68
Peters, JM., King, RW., Deshaies, RJ. (1998)

Cell cycle control by ubiquitin-dependent proteolysis.

Ubiquitin and the biology of the cell (eds. Peters, JM., Harris, JR., Finley, D.) . :345-87
Vorlaufer, E., Peters, JM. (1998)

Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis.

Mol Biol Cell. 9(7):1817-31
Yu, H., Peters, JM., King, RW., Page, AM., Hieter, P., Kirschner, MW. (1998)

Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

Science. 279(5354):1219-22


Juang, YL., Huang, J., Peters, JM., McLaughlin, ME., Tai, CY., Pellman, D. (1997)

APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle.

Science. 275(5304):1311-4
Zirwes, RF., Kouzmenko, AP., Peters, JM., Franke, WW., Schmidt-Zachmann, MS. (1997)

Topogenesis of a nucleolar protein: determination of molecular segments directing nucleolar association.

Mol Biol Cell. 8(2):231-48


Cohen-Fix, O., Peters, JM., Kirschner, MW., Koshland, D. (1996)

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

Genes Dev. 10(24):3081-93
King, RW., Deshaies, RJ., Peters, JM., Kirschner, MW. (1996)

How proteolysis drives the cell cycle.

Science. 274(5293):1652-9
Peters, JM., King, RW., Höög, C., Kirschner, MW. (1996)

Identification of BIME as a subunit of the anaphase-promoting complex.

Science. 274(5290):1199-201
Yu, H., King, RW., Peters, JM., Kirschner, MW. (1996)

Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation.

Curr Biol. 6(4):455-66


Acharya, U., Jacobs, R., Peters, JM., Watson, N., Farquhar, MG., Malhotra, V. (1995)

The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events.

Cell. 82(6):895-904
King, RW., Peters, JM., Tugendreich, S., Rolfe, M., Hieter, P., Kirschner, MW. (1995)

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.

Cell. 81(2):279-88
Rabouille, C., Levine, TP., Peters, JM., Warren, G. (1995)

An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments.

Cell. 82(6):905-14


Peters, JM. (1994)

Proteasomes: protein degradation machines of the cell.

Trends Biochem Sci. 19(9):377-82
Peters, JM., Franke, WW., Kleinschmidt, JA. (1994)

Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.

J Biol Chem. 269(10):7709-18


Peters, JM., Cejka, Z., Harris, JR., Kleinschmidt, JA., Baumeister, W. (1993)

Structural features of the 26 S proteasome complex.

J Mol Biol. 234(4):932-7


Peters, JM., Harris, JR., Lustig, A., Müller, S., Engel, A., Volker, S., Franke, WW. (1992)

Ubiquitous soluble Mg(2+)-ATPase complex. A structural study.

J Mol Biol. 223(2):557-71