BacPROTACs mediate targeted protein degradation in bacteria.Cell.
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.Nature. 599(7885):491-496
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.Nat Chem Biol.
miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.Sci Adv. 7(42):eabh1434
A molecular network of conserved factors keeps ribosomes dormant in the eggbioRxiv . 2021.11.03.467131
Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.Nat Commun. 12(1):3483
The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.Elife. 10
Structure of the peripheral arm of a minimalistic respiratory complex I.Structure.
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.Elife. 9
Quantifying the heterogeneity of macromolecular machines by mass photometry.Nat Commun. 11(1):1772
Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.Structure. 27(7):1124-1136.e4
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.Proc Natl Acad Sci U S A. 116(35):17280-17289
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.Cell. 172(3):454-464.e11
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.Cell. 170(4):701-713.e11
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.Nat Commun. 8:15578
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.Cell. 165(6):1440-1453
Mechanism of APC/CCDC20 activation by mitotic phosphorylation.Proc Natl Acad Sci U S A. 113(19):E2570-8
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.Mol Cell. 63(4):593-607
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.Nat Methods. 12(9):859-65
Structural determinants and mechanism of mammalian CRM1 allostery.Structure. 21(8):1350-60
Structural basis for cooperativity of CRM1 export complex formation.Proc Natl Acad Sci U S A. 110(3):960-5
A DNAzyme based label-free detection system for miniaturized assays.Mol Biosyst. 7(10):2882-9