Publications
2020
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife. 9Quantifying the heterogeneity of macromolecular machines by mass photometry.
Nat Commun. 11(1):17722019
Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure. 27(7):1124-1136.e4Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc Natl Acad Sci U S A.2018
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
Cell. 172(3):454-464.e112017
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell. 170(4):701-713.e11Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun. 8:155782016
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell. 165(6):1440-1453Mechanism of APC/CCDC20 activation by mitotic phosphorylation.
Proc Natl Acad Sci U S A. 113(19):E2570-8Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol Cell. 63(4):593-6072015
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
Nat Methods. 12(9):859-652013
Structural determinants and mechanism of mammalian CRM1 allostery.
Structure. 21(8):1350-60Structural basis for cooperativity of CRM1 export complex formation.
Proc Natl Acad Sci U S A. 110(3):960-52011
A DNAzyme based label-free detection system for miniaturized assays.
Mol Biosyst. 7(10):2882-9