Publications
2025
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
bioRxiv.PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.
Proc Natl Acad Sci U S A. 122(14):e2417218122The UBR Domain of Plant Ubr1 Homolog PRT6 Accommodates Basic and Hydrophobic Amino Termini for Substrate Recognition.
J Mol Biol. 437(4):168939FakET: Simulating cryo-electron tomograms with neural style transfer.
Structure. 33(4):820-827.e42024
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
bioRxiv. 2024.04.23.590688A dual ribosomal system in the zebrafish soma and germline
bioRxiv. doi:10.1101/2024.08.29.610041Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape
bioRxiv. 2024.08.26.609756CowScape: Quantitative reconstruction of the conformational landscape of biological macromolecules from cryo-EM data
arXiv. 2402.11589A dual ribosomal system in the zebrafish soma and germline.
bioRxiv.The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.
Nat Commun. 15(1):7511A multivalent adaptor mechanism drives the nuclear import of proteasomes
625870.2023
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
EMBO J. 42(16):e113348Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat Struct Mol Biol. 30(11):1663-1674Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.
Structure. 31(1):4-19A molecular network of conserved factors keeps ribosomes dormant in the egg.
Corresponding preprint Nature.2022
Cryo-EM structure of the plant 26S proteasome.
Plant Commun. 3(3):100310Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.
Science. 378(6615):eabn5637Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Nat Struct Mol Biol. 29(9):942-953BacPROTACs mediate targeted protein degradation in bacteria.
Corresponding preprint Cell. 185(13):2338-2353.e182021
Structure of the peripheral arm of a minimalistic respiratory complex I.
Structure.miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.
Sci Adv. 7(42):eabh1434AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
Nature. 599(7885):491-496HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat Chem Biol.Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
Nat Commun. 12(1):3483The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
Corresponding preprint Elife. 102020
Quantifying the heterogeneity of macromolecular machines by mass photometry.
Nat Commun. 11(1):1772Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife. 92019
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc Natl Acad Sci U S A. 116(35):17280-17289Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure. 27(7):1124-1136.e42018
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
Cell. 172(3):454-464.e112017
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun. 8:15578Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell. 170(4):701-713.e112016
Mechanism of APC/CCDC20 activation by mitotic phosphorylation.
Proc Natl Acad Sci U S A. 113(19):E2570-8Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell. 165(6):1440-1453Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol Cell. 63(4):593-6072015
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
Nat Methods. 12(9):859-652013
Structural basis for cooperativity of CRM1 export complex formation.
Proc Natl Acad Sci U S A. 110(3):960-5Structural determinants and mechanism of mammalian CRM1 allostery.
Structure. 21(8):1350-602011
A DNAzyme based label-free detection system for miniaturized assays.
Mol Biosyst. 7(10):2882-9