Publications
2025
A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings.
Life Sci Alliance. 8(10)Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse.
Curr Opin Genet Dev. 93:1023522024
Bouncer’s receptor on sperm: Investigating sperm-egg compatibility in fish
bioRxiv. 2024.12.13.628393PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy
bioRxiv. 2024.12.04.626795A conserved fertilization complex bridges sperm and egg in vertebrates.
Corresponding preprint Cell. 187(25):7066-7078.e22A dual ribosomal system in the zebrafish soma and germline
bioRxiv. doi:10.1101/2024.08.29.610041tRNA expression and modification landscapes, and their dynamics during zebrafish embryo development.
Corresponding preprint Nucleic Acids Res.Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis
bioRxiv. 10.1101/2024.06.11.598492v1The molecular mechanisms underpinning maternal mRNA dormancy.
Biochem Soc Trans.eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
Corresponding preprint EMBO Rep. 25(1):404-4272023
SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.
Corresponding preprint Cell Rep. 42(2):112070A molecular network of conserved factors keeps ribosomes dormant in the egg.
Corresponding preprint Nature.Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.
Corresponding preprint Nat Commun. 14(1):3506Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species.
Corresponding preprint Nucleic Acids Res.2022
SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection.
Corresponding preprint Exp Mol Med.A self-generated Toddler gradient guides mesodermal cell migration.
Corresponding preprint Sci Adv. 8(37):eadd2488A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.
Corresponding preprint Front Mol Biosci. 9:801309Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
Corresponding preprint Commun Biol. 5(1):332NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Corresponding preprint Genes Dev. 36(5-6):348-367The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.
Corresponding preprint Front Cell Dev Biol. 9:8069822021
Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.
medRxiv. 2021.01.19.21250079Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos
bioRxiv. 2021.11.03.467172Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing
bioRxiv. 2021.11.03.467109The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.
Corresponding preprint Proc Natl Acad Sci U S A. 118(39)The Fertilization Enigma: How Sperm and Egg Fuse.
Annu Rev Cell Dev Biol.Systematic refinement of gene annotations by parsing mRNA 3' end sequencing datasets.
Methods Enzymol. 655:205-223Self-organized cell migration across scales - from single cell movement to tissue formation.
Development. 148(7)Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.
PLoS Genet. 17(2):e10093902020
Species-specific mechanisms during fertilization.
Curr Top Dev Biol. 140:121-1442019
Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Mol Cell. 74(1):158-172.e92018
The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Science. 361(6406):1029-10332017
Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Elife. 6Nodal patterning without Lefty inhibitory feedback is functional but fragile.
Elife. 6Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Cell Rep. 20(9):2116-21302016
Decoding sORF translation - from small proteins to gene regulation.
RNA Biol. 13(11):1051-1059Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.
Nat Commun. 7:116632015
Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.
PLoS One. 10(10):e0139504Identifying (non-)coding RNAs and small peptides: challenges and opportunities.
Bioessays. 37(1):103-122014
Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs.
PLoS One. 9(5):e98186Canonical nucleosome organization at promoters forms during genome activation.
Genome Res. 24(2):260-6Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
Science. 343(6172):1248636High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies.
Cell. 159(7):1698-7102013
Ribosome profiling reveals resemblance between long non-coding RNAs and 5' leaders of coding RNAs.
Development. 140(13):2828-342012
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
Genome Res. 22(3):577-912011
Non-coding RNAs as regulators of embryogenesis.
Nat Rev Genet. 12(2):136-49Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners.
Proc Natl Acad Sci U S A. 108(14):5572-72010
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.
Nat Cell Biol. 12(2):185-92A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.
Curr Biol. 20(20):1787-982008
Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.
Dev Cell. 14(2):239-512006
Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.
Traffic. 7(10):1311-212004
Conservation of DNA methylation in dipteran insects.
Insect Mol Biol. 13(2):117-23