Publications
2023
SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.
Corresponding preprint Cell Rep. 42(2):112070A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates
bioRxiv. 2023.07.27.550750Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.
Corresponding preprint Nat Commun. 14(1):3506A molecular network of conserved factors keeps ribosomes dormant in the egg.
Corresponding preprint Nature.eIF4E1b is a non-canonical eIF4E required for maternal mRNA dormancy
bioRxiv . 2023.05.24.542066Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species.
Corresponding preprint Nucleic Acids Res.2022
The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish.
Corresponding preprint Front Cell Dev Biol. 9:806982NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Corresponding preprint Genes Dev. 36(5-6):348-367A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing.
Corresponding preprint Front Mol Biosci. 9:801309Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
Corresponding preprint Commun Biol. 5(1):332A self-generated Toddler gradient guides mesodermal cell migration.
Corresponding preprint Sci Adv. 8(37):eadd2488SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection.
Corresponding preprint Exp Mol Med.2021
Systematic refinement of gene annotations by parsing mRNA 3' end sequencing datasets.
Methods Enzymol. 655:205-223Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition.
PLoS Genet. 17(2):e1009390The Fertilization Enigma: How Sperm and Egg Fuse.
Annu Rev Cell Dev Biol.The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.
Corresponding preprint Proc Natl Acad Sci U S A. 118(39)Reciprocal zebrafish-medaka hybrids reveal maternal control of zygotic genome activation timing
bioRxiv . 2021.11.03.467109Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos
bioRxiv . 2021.11.03.467172Head-to-head comparison of direct-input RT-PCR and RT-LAMP against RT-qPCR on extracted RNA for rapid SARS-CoV-2 diagnostics.
medRxiv. 2021.01.19.21250079Self-organized cell migration across scales - from single cell movement to tissue formation.
Development. 148(7)2020
Species-specific mechanisms during fertilization.
Curr Top Dev Biol. 140:121-1442019
Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Mol Cell. 74(1):158-172.e92018
The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Science. 361(6406):1029-10332017
Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Cell Rep. 20(9):2116-2130Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Elife. 6Nodal patterning without Lefty inhibitory feedback is functional but fragile.
Elife. 62016
Decoding sORF translation - from small proteins to gene regulation.
RNA Biol. 13(11):1051-1059Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.
Nat Commun. 7:116632015
Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.
PLoS One. 10(10):e0139504Identifying (non-)coding RNAs and small peptides: challenges and opportunities.
Bioessays. 37(1):103-122014
Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs.
PLoS One. 9(5):e98186Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
Science. 343(6172):1248636High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies.
Cell. 159(7):1698-710Canonical nucleosome organization at promoters forms during genome activation.
Genome Res. 24(2):260-62013
Ribosome profiling reveals resemblance between long non-coding RNAs and 5' leaders of coding RNAs.
Development. 140(13):2828-342012
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
Genome Res. 22(3):577-912011
Non-coding RNAs as regulators of embryogenesis.
Nat Rev Genet. 12(2):136-49Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners.
Proc Natl Acad Sci U S A. 108(14):5572-72010
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.
Nat Cell Biol. 12(2):185-92A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.
Curr Biol. 20(20):1787-982008
Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.
Dev Cell. 14(2):239-512006
Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.
Traffic. 7(10):1311-212004
Conservation of DNA methylation in dipteran insects.
Insect Mol Biol. 13(2):117-23