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Rushad Pavri

In our lab, we study the phenomenon of antibody gene diversification in B lymphocytes – the process by which the immune system generates a vast repertoire of high-affinity antibodies essential to combat pathogenic challenges. We focus on the transcriptional and co-transcriptional mechanisms underlying these events using a combination of RNAi screening, genetic models, and genomic analysis.

Publications

2018

2017

2016

2014

Qian, J., Wang, Q., Dose, M., Pruett, N., Kieffer-Kwon, KR., Resch, W., Liang, G., Tang, Z., Mathé, E., Benner, C., Dubois, W., Nelson, S., Vian, L., Oliveira, TY., Jankovic, M., Hakim, O., Gazumyan, A., Pavri, R., Awasthi, P., Song, B., Liu, G., Chen, L., Zhu, S., Feigenbaum, L., Staudt, L., Murre, C., Ruan, Y., Robbiani, DF., Pan-Hammarström, Q., Nussenzweig, MC., Casellas, R. (2014)

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Cell. 159(7):1524-37
Wang, Q., Oliveira, T., Jankovic, M., Silva, IT., Hakim, O., Yao, K., Gazumyan, A., Mayer, CT., Pavri, R., Casellas, R., Nussenzweig, MC., Robbiani, DF. (2014)

Epigenetic targeting of activation-induced cytidine deaminase.

Proc Natl Acad Sci U S A. 111(52):18667-72

2011

Pavri, R., Nussenzweig, MC. (2011)

AID targeting in antibody diversity.

Adv Immunol. 110:1-26

2010

Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., Reina San-Martin, B., Barreto, V., Nieland, TJ., Root, DE., Casellas, R., Nussenzweig, MC. (2010)

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.

Cell. 143(1):122-33

2006

Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., Reinberg, D. (2006)

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

Cell. 125(4):703-17

2005

Pavri, R., Lewis, B., Kim, TK., Dilworth, FJ., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. (2005)

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.

Mol Cell. 18(1):83-96