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Rushad Pavri

In our lab, we study the phenomenon of antibody gene diversification in B lymphocytes – the process by which the immune system generates a vast repertoire of high-affinity antibodies essential to combat pathogenic challenges. We focus on the transcriptional and co-transcriptional mechanisms underlying these events using a combination of RNAi screening, genetic models, and genomic analysis.

Publications

Qian, J., Wang, Q., Dose, M., Pruett, N., Kieffer-Kwon, KR., Resch, W., Liang, G., Tang, Z., Mathé, E., Benner, C., Dubois, W., Nelson, S., Vian, L., Oliveira, TY., Jankovic, M., Hakim, O., Gazumyan, A., Pavri, R., Awasthi, P., Song, B., Liu, G., Chen, L., Zhu, S., Feigenbaum, L., Staudt, L., Murre, C., Ruan, Y., Robbiani, DF., Pan-Hammarström, Q., Nussenzweig, MC., Casellas, R. (2014)B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell. 159(7):1524-37
Wang, Q., Oliveira, T., Jankovic, M., Silva, IT., Hakim, O., Yao, K., Gazumyan, A., Mayer, CT., Pavri, R., Casellas, R., Nussenzweig, MC., Robbiani, DF. (2014)Epigenetic targeting of activation-induced cytidine deaminase. Proc Natl Acad Sci U S A. 111(52):18667-72
Pavri, R., Nussenzweig, MC. (2011)AID targeting in antibody diversity. Adv Immunol. 110:1-26
Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., Reina San-Martin, B., Barreto, V., Nieland, TJ., Root, DE., Casellas, R., Nussenzweig, MC. (2010)Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell. 143(1):122-33
Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., Reinberg, D. (2006)Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 125(4):703-17
Pavri, R., Lewis, B., Kim, TK., Dilworth, FJ., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. (2005)PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell. 18(1):83-96