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Rushad Pavri

In our lab, we study the phenomenon of antibody gene diversification in B lymphocytes – the process by which the immune system generates a vast repertoire of high-affinity antibodies essential to combat pathogenic challenges. We focus on the transcriptional and co-transcriptional mechanisms underlying these events using a combination of RNAi screening, genetic models, and genomic analysis.



Costea, J., Schoeberl, UE., Malzl, D., von der Linde, M., Fitz, J., Gupta, A., Makharova, M., Goloborodko, A., Pavri, R. (2023)

A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination.

Corresponding preprint Mol Cell. 83(5):681-697.e7


Peycheva, M., Neumann, T., Malzl, D., Nazarova, M., Schoeberl, UE., Pavri, R. (2022)

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations.

Science. 377(6612):eabj5502
Pre-printSchoeberl, U. E., Fitz, J., Froussios, K., Valieris, R., Makharova, M., Ourailidis, I., Bauer, B., Neumann, T., Wiedemann, E., Steininger, M., Garcia, A. C., Mastrovito, M., Mouquet, H., Tojal Da Silva, I., Pavri, R. (2022)

Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscape

bioRxiv . 2022.05.21.492925


Appel, LM., Franke, V., Bruno, M., Grishkovskaya, I., Kasiliauskaite, A., Kaufmann, T., Schoeberl, UE., Puchinger, MG., Kostrhon, S., Ebenwaldner, C., Sebesta, M., Beltzung, E., Mechtler, K., Lin, G., Vlasova, A., Leeb, M., Pavri, R., Stark, A., Akalin, A., Stefl, R., Bernecky, C., Djinovic-Carugo, K., Slade, D. (2021)

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.

Nat Commun. 12(1):6078
Pre-printPeycheva,M., Neumann, T., Malzl, D., Nazarova, M., Schoeberl, U., and Pavri, R. (2021)

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations

bioRxiv . 2021.05.29.446276


Fitz, J., Neumann, T., Steininger, M., Wiedemann, EM., Garcia, AC., Athanasiadis, A., Schoeberl, UE., Pavri, R. (2020)

Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction.

Nat Genet. 52(5):505-515





Qian, J., Wang, Q., Dose, M., Pruett, N., Kieffer-Kwon, KR., Resch, W., Liang, G., Tang, Z., Mathé, E., Benner, C., Dubois, W., Nelson, S., Vian, L., Oliveira, TY., Jankovic, M., Hakim, O., Gazumyan, A., Pavri, R., Awasthi, P., Song, B., Liu, G., Chen, L., Zhu, S., Feigenbaum, L., Staudt, L., Murre, C., Ruan, Y., Robbiani, DF., Pan-Hammarström, Q., Nussenzweig, MC., Casellas, R. (2014)

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Cell. 159(7):1524-37
Wang, Q., Oliveira, T., Jankovic, M., Silva, IT., Hakim, O., Yao, K., Gazumyan, A., Mayer, CT., Pavri, R., Casellas, R., Nussenzweig, MC., Robbiani, DF. (2014)

Epigenetic targeting of activation-induced cytidine deaminase.

Proc Natl Acad Sci U S A. 111(52):18667-72


Pavri, R., Nussenzweig, MC. (2011)

AID targeting in antibody diversity.

Adv Immunol. 110:1-26


Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., Reina San-Martin, B., Barreto, V., Nieland, TJ., Root, DE., Casellas, R., Nussenzweig, MC. (2010)

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.

Cell. 143(1):122-33


Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., Reinberg, D. (2006)

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

Cell. 125(4):703-17


Pavri, R., Lewis, B., Kim, TK., Dilworth, FJ., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. (2005)

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.

Mol Cell. 18(1):83-96