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Luisa Cochella

One of the main goals of developmental biology is to understand how the different cell types that constitute a multicellular organism are specified during its development. We are currently exploring the different mechanisms of gene expression regulation that control this process. We are interested in how the transcriptional history of a cell influences its fate as well as in how post-transcriptional mechanisms contribute to the diversification of the genetic programs that control cell differentiation.



Charest, J., Daniele, T., Wang, J., Bykov, A., Mandlbauer, A., Asparuhova, M., Röhsner, J., Gutiérrez-Pérez, P., Cochella, L. (2020)

Combinatorial Action of Temporally Segregated Transcription Factors.

Dev Cell. 55(4):483-499.e7
Dexheimer, PJ., Cochella, L. (2020)

MicroRNAs: From Mechanism to Organism.

Front Cell Dev Biol. 8:409
Dexheimer, PJ., Wang, J., Cochella, L. (2020)

Two MicroRNAs Are Sufficient for Embryonic Patterning in C. elegans.

Curr Biol. 30(24):5058-5065.e5
Finger, F., Ottens, F., Springhorn, A., Drexel, T., Proksch, L., Metz, S., Cochella, L., Hoppe, T. (2020)

Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling.

Nat Metab. 2(1):126


Finger, F., Ottens, F., Springhorn, A., Drexel, T., Proksch, L., Metz, S., Cochella, L., Hoppe, T. (2019)

Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling

Nature Metabolism. 1:350–359
Hong, RL., Riebesell, M., Bumbarger, DJ., Cook, SJ., Carstensen, HR., Sarpolaki, T., Cochella, L., Castrejon, J., Moreno, E., Sieriebriennikov, B., Hobert, O., Sommer, RJ. (2019)

Evolution of neuronal anatomy and circuitry in two highly divergent nematode species.

Elife. 8


Alberti, C., Manzenreither, RA., Sowemimo, I., Burkard, TR., Wang, J., Mahofsky, K., Ameres, SL., Cochella, L. (2018)

Cell-type specific sequencing of microRNAs from complex animal tissues.

Nat Methods. 15(4):283-289


Alberti, C., Cochella, L. (2017)

A framework for understanding the roles of miRNAs in animal development.

Development. 144(14):2548-2559


Drexel, T., Mahofsky, K., Latham, R., Zimmer, M., Cochella, L. (2016)

Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans.

Genes Dev. 30(18):2042-2047


Cochella, L., Tursun, B., Hsieh, YW., Galindo, S., Johnston, RJ., Chuang, CF., Hobert, O. (2014)

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Genes Dev. 28(1):34-43


Cochella, L., Hobert, O. (2012)

Diverse functions of microRNAs in nervous system development.

Curr Top Dev Biol. 99:115-43


Poole, RJ., Bashllari, E., Cochella, L., Flowers, EB., Hobert, O. (2011)

A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans.

PLoS Genet. 7(6):e1002109
Zheng, G., Cochella, L., Liu, J., Hobert, O., Li, WH. (2011)

Temporal and spatial regulation of microRNA activity with photoactivatable cantimirs.

ACS Chem Biol. 6(12):1332-8


Didiano, D., Cochella, L., Tursun, B., Hobert, O. (2010)

Neuron-type specific regulation of a 3'UTR through redundant and combinatorially acting cis-regulatory elements.

RNA. 16(2):349-63


Tursun, B., Cochella, L., Carrera, I., Hobert, O. (2009)

A toolkit and robust pipeline for the generation of fosmid-based reporter genes in C. elegans.

PLoS One. 4(3):e4625


Cochella, L., Brunelle, JL., Green, R. (2007)

Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome.

Nat Struct Mol Biol. 14(1):30-6


Youngman, EM., Cochella, L., Brunelle, JL., He, S., Green, R. (2006)

Two distinct conformations of the conserved RNA-rich decoding center of the small ribosomal subunit are recognized by tRNAs and release factors.

Cold Spring Harb Symp Quant Biol. 71:545-9


Cochella, L., Green, R. (2005)

Fidelity in protein synthesis.

Curr Biol. 15(14):R536-40
Cochella, L., Green, R. (2005)

An active role for tRNA in decoding beyond codon:anticodon pairing.

Science. 308(5725):1178-80


Cochella, L., Green, R. (2004)

Wobble during decoding: more than third-position promiscuity.

Nat Struct Mol Biol. 11(12):1160-2
Cochella, L., Green, R. (2004)

Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system.

Proc Natl Acad Sci U S A. 101(11):3786-91


Alonso, GD., Pereira, CA., Remedi, MS., Paveto, MC., Cochella, L., Ivaldi, MS., Gerez de Burgos, NM., Torres, HN., Flawiá, MM. (2001)

Arginine kinase of the flagellate protozoa Trypanosoma cruzi. Regulation of its expression and catalytic activity.

FEBS Lett. 498(1):22-5