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Elly Tanaka

Our group seeks to understand the cellular mechanisms underlying salamander limb and spinal cord regeneration as a model for how successful regeneration occurs in a vertebrate. This model acts as a starting point to rigorously investigate how mammals such as mice have lost regeneration capabilities over evolution. In addition, these studies act as a springboard to design novel strategies for regenerating or replacing mammalian tissues. Toward that end we have engineered three-dimensional spinal cord tissue from mouse embryonic stem cells and retinal pigment epithelia from human embryonic stem cells.

Publications

2023

Delás, MJ., Kalaitzis, CM., Fawzi, T., Demuth, M., Zhang, I., Stuart, HT., Costantini, E., Ivanovitch, K., Tanaka, EM., Briscoe, J. (2023)

Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.

 Dev Cell. 58(1):3-17.e8
Falcon, F., Tanaka, EM., Rodriguez-Terrones, D. (2023)

Transposon waves at the water-to-land transition.

 Curr Opin Genet Dev. 81:102059
Ishihara, K., Mukherjee, A., Gromberg, E., Brugués, J., Tanaka, EM., Jülicher, F. (2023)

Topological morphogenesis of neuroepithelial organoids.

 Nat Phys. 19(2):177-183
Kawaguchi, A., Tanaka, EM. (2023)

Chromosome Conformation Capture for Large Genomes.

 Methods Mol Biol. 2562:291-318
Masselink, W., Tanaka, EM. (2023)

Ethyl Cinnamate-Based Tissue Clearing Strategies.

 Methods Mol Biol. 2562:123-133
Murawala, P., Oliveira, CR., Okulski, H., Yun, MH., Tanaka, EM. (2023)

Baculovirus Production and Infection in Axolotls.

 Methods Mol Biol. 2562:369-387
Nowoshilow, S., Tanaka, EM. (2023)

Navigation and Use of Custom Tracks within the Axolotl Genome Browser.

 Methods Mol Biol. 2562:273-289
Tanaka, EM. (2023)

Now that We Got There, What Next?

 Methods Mol Biol. 2562:471-479
Taniguchi-Sugiura, Y., Tanaka, EM. (2023)

Artificial Insemination in Axolotl.

 Methods Mol Biol. 2562:417-423

2022

Echeverri, K., Fei, J., Tanaka, EM. (2022)

The Axolotl's journey to the modern molecular era.

 Curr Top Dev Biol. 147:631-658
Glotzer, GL., Tardivo, P., Tanaka, EM. (2022)

Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration.

 Elife. 11
Hu, Y., Pan, X., Shi, Y., Qiu, Y., Wang, L., Murawala, P., Liu, Y., Xing, W., Tanaka, EM., Fei, JF. (2022)

Muscles are barely required for the patterning and cell dynamics in axolotl limb regeneration.

 Front Genet. 13:1036641
Kaucka, M., Joven Araus, A., Tesarova, M., Currie, JD., Boström, J., Kavkova, M., Petersen, J., Yao, Z., Bouchnita, A., Hellander, A., Zikmund, T., Elewa, A., Newton, PT., Fei, JF., Chagin, AS., Fried, K., Tanaka, EM., Kaiser, J., Simon, A., Adameyko, I. (2022)

Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.

 Nat Commun. 13(1):6949
Lin, TY., Taniguchi-Sugiura, Y., Murawala, P., Hermann, S., Tanaka, EM. (2022)

Inducible and tissue-specific cell labeling in Cre-ERT2 transgenic Xenopus lines.

 Dev Growth Differ. 64(5):243-253
Lust, K., Maynard, A., Gomes, T., Fleck, JS., Camp, JG., Tanaka, EM., Treutlein, B. (2022)

Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration.

 Science. 377(6610):eabp9262
Nowoshilow, S., Fei, JF., Voss, SR., Tanaka, EM., Murawala, P. (2022)

Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.

 Dev Dyn. 251(6):913-921
Oliveira, CR., Knapp, D., Elewa, A., Gerber, T., Gonzalez Malagon, SG., Gates, PB., Walters, HE., Petzold, A., Arce, H., Cordoba, RC., Subramanian, E., Chara, O., Tanaka, EM., Simon, A., Yun, MH. (2022)

Tig1 regulates proximo-distal identity during salamander limb regeneration.

 Nat Commun. 13(1):1141
Otsuki, L., Tanaka, EM. (2022)

Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.

 Cold Spring Harb Perspect Biol. 14(6)
Polikarpova, A., Ellinghaus, A., Schmidt-Bleek, O., Grosser, L., Bucher, CH., Duda, GN., Tanaka, EM., Schmidt-Bleek, K. (2022)

The specialist in regeneration-the Axolotl-a suitable model to study bone healing?

 NPJ Regen Med. 7(1):35

2021

Bassat, E., Tanaka, EM. (2021)

The cellular and signaling dynamics of salamander limb regeneration.

 Curr Opin Cell Biol. 73:117-123
Cura Costa, E., Otsuki, L., Rodrigo Albors, A., Tanaka, EM., Chara, O. (2021)

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.

 Elife. 10
Lin, TY., Gerber, T., Taniguchi-Sugiura, Y., Murawala, P., Hermann, S., Grosser, L., Shibata, E., Treutlein, B., Tanaka, EM. (2021)

Fibroblast dedifferentiation as a determinant of successful regeneration.

 Dev Cell. 56(10):1541-1551.e6
Masselink, W., Tanaka, EM. (2021)

Toward whole tissue imaging of axolotl regeneration.

 Dev Dyn. 250(6):800-806
Meyer, A., Schloissnig, S., Franchini, P., Du, K., Woltering, JM., Irisarri, I., Wong, WY., Nowoshilow, S., Kneitz, S., Kawaguchi, A., Fabrizius, A., Xiong, P., Dechaud, C., Spaink, HP., Volff, JN., Simakov, O., Burmester, T., Tanaka, EM., Schartl, M. (2021)

Giant lungfish genome elucidates the conquest of land by vertebrates.

 Nature. 590(7845):284-289
Poss, KD., Tanaka, EM. (2021)

A new society for regenerative biologists.

 Development. 148(3)
Schloissnig, S., Kawaguchi, A., Nowoshilow, S., Falcon, F., Otsuki, L., Tardivo, P., Timoshevskaya, N., Keinath, MC., Smith, JJ., Voss, SR., Tanaka, EM. (2021)

The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.

 Proc Natl Acad Sci U S A. 118(15)

2020

Almedawar, S., Vafia, K., Schreiter, S., Neumann, K., Khattak, S., Kurth, T., Ader, M., Karl, MO., Tsang, SH., Tanaka, EM. (2020)

MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.

 Stem Cell Reports. 14(3):374-389
Meyer, K., Morales-Navarrete, H., Seifert, S., Wilsch-Braeuninger, M., Dahmen, U., Tanaka, EM., Brusch, L., Kalaidzidis, Y., Zerial, M. (2020)

Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.

 Mol Syst Biol. 16(2):e8985
Nowoshilow, S., Tanaka, EM. (2020)

Introducing www.axolotl-omics.org - an integrated -omics data portal for the axolotl research community.

 Exp Cell Res. 394(1):112143
Pende, M., Vadiwala, K., Schmidbaur, H., Stockinger, AW., Murawala, P., Saghafi, S., Dekens, MPS., Becker, K., Revilla-I-Domingo, R., Papadopoulos, SC., Zurl, M., Pasierbek, P., Simakov, O., Tanaka, EM., Raible, F., Dodt, HU. (2020)

A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.

 Sci Adv. 6(22):eaba0365
Schreiter, S., Vafia, K., Barsacchi, R., Tsang, SH., Bickle, M., Ader, M., Karl, MO., Tanaka, EM., Almedawar, S. (2020)

A Human Retinal Pigment Epithelium-Based Screening Platform Reveals Inducers of Photoreceptor Outer Segments Phagocytosis.

 Stem Cell Reports. 15(6):1347-1361
Soukup, V., Tazaki, A., Yamazaki, Y., Pospisilova, A., Epperlein, HH., Tanaka, EM., Cerny, R. (2020)

Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.

 Front Cell Dev Biol. 8:622308

2019

Currie, JD., Grosser, L., Murawala, P., Schuez, M., Michel, M., Tanaka, EM., Sandoval-Guzmán, T. (2019)

The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.

 Biol Open. 8(7)
Fei, JF., Lou, WP., Knapp, D., Murawala, P., Gerber, T., Taniguchi, Y., Nowoshilow, S., Khattak, S., Tanaka, EM. (2019)

Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

 Nat Protoc. 14(8):2597
Lust, K., Tanaka, EM. (2019)

A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish.

 Dev Neurobiol. 79(5):424-436
Masselink, W., Reumann, D., Murawala, P., Pasierbek, P., Taniguchi, Y., Bonnay, F., Meixner, K., Knoblich, JA., Tanaka, EM. (2019)

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.

 Development. 146(3)

2018

Fei, JF., Lou, WP., Knapp, D., Murawala, P., Gerber, T., Taniguchi, Y., Nowoshilow, S., Khattak, S., Tanaka, EM. (2018)

Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).

 Nat Protoc. 13(12):2908-2943
Gerber, T., Murawala, P., Knapp, D., Masselink, W., Schuez, M., Hermann, S., Gac-Santel, M., Nowoshilow, S., Kageyama, J., Khattak, S., Currie, JD., Camp, JG., Tanaka, EM., Treutlein, B. (2018)

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.

 Science. 362(6413)
Medelnik, JP., Roensch, K., Okawa, S., Del Sol, A., Chara, O., Mchedlishvili, L., Tanaka, EM. (2018)

Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.

 Stem Cell Reports. 10(6):1751-1765
Nowoshilow, S., Schloissnig, S., Fei, JF., Dahl, A., Pang, AWC., Pippel, M., Winkler, S., Hastie, AR., Young, G., Roscito, JG., Falcon, F., Knapp, D., Powell, S., Cruz, A., Cao, H., Habermann, B., Hiller, M., Tanaka, EM., Myers, EW. (2018)

The axolotl genome and the evolution of key tissue formation regulators.

 Nature. 554(7690):50-55
Nowoshilow, S., Schloissnig, S., Fei, JF., Dahl, A., Pang, AWC., Pippel, M., Winkler, S., Hastie, AR., Young, G., Roscito, JG., Falcon, F., Knapp, D., Powell, S., Cruz, A., Cao, H., Habermann, B., Hiller, M., Tanaka, EM., Myers, EW. (2018)

Author Correction: The axolotl genome and the evolution of key tissue formation regulators.

 Nature. 559(7712):E2
Oliveira, CR., Lemaitre, R., Murawala, P., Tazaki, A., Drechsel, DN., Tanaka, EM. (2018)

Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.

 Dev Biol. 433(2):262-275
Tanaka, EM. (2018)

Regenerating tissues.

 Science. 360(6387):374-375

2017

Fei, JF., Schuez, M., Knapp, D., Taniguchi, Y., Drechsel, DN., Tanaka, EM. (2017)

Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.

 Proc Natl Acad Sci U S A. 114(47):12501-12506
Ishihara, K., Ranga, A., Lutolf, MP., Tanaka, EM., Meinhardt, A. (2017)

Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.

 Methods Mol Biol. 1597:43-55
Kaucka, M., Zikmund, T., Tesarova, M., Gyllborg, D., Hellander, A., Jaros, J., Kaiser, J., Petersen, J., Szarowska, B., Newton, PT., Dyachuk, V., Li, L., Qian, H., Johansson, AS., Mishina, Y., Currie, JD., Tanaka, EM., Erickson, A., Dudley, A., Brismar, H., Southam, P., Coen, E., Chen, M., Weinstein, LS., Hampl, A., Arenas, E., Chagin, AS., Fried, K., Adameyko, I. (2017)

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

 Elife. 6
Ocaña, OH., Coskun, H., Minguillón, C., Murawala, P., Tanaka, EM., Galcerán, J., Muñoz-Chápuli, R., Nieto, MA. (2017)

A right-handed signalling pathway drives heart looping in vertebrates.

 Nature. 549(7670):86-90
Russell, JJ., Theriot, JA., Sood, P., Marshall, WF., Landweber, LF., Fritz-Laylin, L., Polka, JK., Oliferenko, S., Gerbich, T., Gladfelter, A., Umen, J., Bezanilla, M., Lancaster, MA., He, S., Gibson, MC., Goldstein, B., Tanaka, EM., Hu, CK., Brunet, A. (2017)

Non-model model organisms.

 BMC Biol. 15(1):55
Tazaki, A., Tanaka, EM., Fei, JF. (2017)

Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.

 Dev Biol. 432(1):63-71
Wagner, I., Wang, H., Weissert, PM., Straube, WL., Shevchenko, A., Gentzel, M., Brito, G., Tazaki, A., Oliveira, C., Sugiura, T., Shevchenko, A., Simon, A., Drechsel, DN., Tanaka, EM. (2017)

Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration.

 Dev Cell. 40(6):608-617.e6

2016

Currie, JD., Kawaguchi, A., Traspas, RM., Schuez, M., Chara, O., Tanaka, EM. (2016)

Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools.

 Dev Cell. 39(4):411-423
Nacu, E., Gromberg, E., Oliveira, CR., Drechsel, D., Tanaka, EM. (2016)

FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration.

 Nature. 533(7603):407-10
Ranga, A., Girgin, M., Meinhardt, A., Eberle, D., Caiazzo, M., Tanaka, EM., Lutolf, MP. (2016)

Neural tube morphogenesis in synthetic 3D microenvironments.

 Proc Natl Acad Sci U S A. 113(44):E6831-E6839
Reddien, PW., Tanaka, EM. (2016)

Editorial overview: Cell reprogramming, regeneration and repair.

 Curr Opin Genet Dev. 40:iv-vi
Rost, F., Rodrigo Albors, A., Mazurov, V., Brusch, L., Deutsch, A., Tanaka, EM., Chara, O. (2016)

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls.

 Elife. 5
Sugiura, T., Wang, H., Barsacchi, R., Simon, A., Tanaka, EM. (2016)

MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.

 Nature. 531(7593):237-40
Tanaka, EM. (2016)

The Molecular and Cellular Choreography of Appendage Regeneration.

 Cell. 165(7):1598-1608
Zhu, Y., Schreiter, S., Tanaka, EM. (2016)

Accelerated Three-Dimensional Neuroepithelium Formation from Human Embryonic Stem Cells and Its Use for Quantitative Differentiation to Human Retinal Pigment Epithelium.

 Methods Mol Biol. 1307:345-55

2015

Khattak, S., Tanaka, EM. (2015)

Transgenesis in axolotl (Ambystoma mexicanum).

 Methods Mol Biol. 1290:269-77
Rodrigo Albors, A., Tanaka, EM. (2015)

High-efficiency electroporation of the spinal cord in larval axolotl.

 Methods Mol Biol. 1290:115-25
Rodrigo Albors, A., Tazaki, A., Rost, F., Nowoshilow, S., Chara, O., Tanaka, EM. (2015)

Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.

 Elife. 4:e10230
Vincent, CD., Rost, F., Masselink, W., Brusch, L., Tanaka, EM. (2015)

Cellular dynamics underlying regeneration of appropriate segment number during axolotl tail regeneration.

 BMC Dev Biol. 15:48

2014

Ader, M., Tanaka, EM. (2014)

Modeling human development in 3D culture.

 Curr Opin Cell Biol. 31:23-8
Carido, M., Zhu, Y., Postel, K., Benkner, B., Cimalla, P., Karl, MO., Kurth, T., Paquet-Durand, F., Koch, E., Münch, TA., Tanaka, EM., Ader, M. (2014)

Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.

 Invest Ophthalmol Vis Sci. 55(8):5431-44
Chara, O., Tanaka, EM., Brusch, L. (2014)

Mathematical modeling of regenerative processes.

 Curr Top Dev Biol. 108:283-317
Diogo, R., Murawala, P., Tanaka, EM. (2014)

Is salamander hindlimb regeneration similar to that of the forelimb? Anatomical and morphogenetic analysis of hindlimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative and developmental studies.

 J Anat. 224(4):459-68
Diogo, R., Nacu, E., Tanaka, EM. (2014)

Is salamander limb regeneration really perfect? Anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental, and evolutionary studies.

 Anat Rec (Hoboken). 297(6):1076-89
Diogo, R., Tanaka, EM. (2014)

Development of fore- and hindlimb muscles in GFP-transgenic axolotls: morphogenesis, the tetrapod bauplan, and new insights on the forelimb-hindlimb enigma.

 J Exp Zool B Mol Dev Evol. 322(2):106-27
Fei, JF., Schuez, M., Tazaki, A., Taniguchi, Y., Roensch, K., Tanaka, EM. (2014)

CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration.

 Stem Cell Reports. 3(3):444-59
Khattak, S., Murawala, P., Andreas, H., Kappert, V., Schuez, M., Sandoval-Guzmán, T., Crawford, K., Tanaka, EM. (2014)

Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination.

 Nat Protoc. 9(3):529-40
Khattak, S., Schuez, M., Richter, T., Knapp, D., Haigo, SL., Sandoval-Guzmán, T., Hradlikova, K., Duemmler, A., Kerney, R., Tanaka, EM. (2014)

Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl.

 Stem Cell Reports. 2(2):243
Meinhardt, A., Eberle, D., Tazaki, A., Ranga, A., Niesche, M., Wilsch-Bräuninger, M., Stec, A., Schackert, G., Lutolf, M., Tanaka, EM. (2014)

3D reconstitution of the patterned neural tube from embryonic stem cells.

 Stem Cell Reports. 3(6):987-99
Sandoval-Guzmán, T., Wang, H., Khattak, S., Schuez, M., Roensch, K., Nacu, E., Tazaki, A., Joven, A., Tanaka, EM., Simon, A. (2014)

Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.

 Cell Stem Cell. 14(2):174-87

2013

Jászai, J., Graupner, S., Tanaka, EM., Funk, RH., Huttner, WB., Brand, M., Corbeil, D. (2013)

Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain.

 PLoS One. 8(5):e63457
Khattak, S., Sandoval-Guzmán, T., Stanke, N., Protze, S., Tanaka, EM., Lindemann, D. (2013)

Foamy virus for efficient gene transfer in regeneration studies.

 BMC Dev Biol. 13:17
Knapp, D., Schulz, H., Rascon, CA., Volkmer, M., Scholz, J., Nacu, E., Le, M., Novozhilov, S., Tazaki, A., Protze, S., Jacob, T., Hubner, N., Habermann, B., Tanaka, EM. (2013)

Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.

 PLoS One. 8(5):e61352
Kragl, M., Roensch, K., Nüsslein, I., Tazaki, A., Taniguchi, Y., Tarui, H., Hayashi, T., Agata, K., Tanaka, EM. (2013)

Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration.

 Dev Biol. 373(1):196-204
Nacu, E., Glausch, M., Le, HQ., Damanik, FF., Schuez, M., Knapp, D., Khattak, S., Richter, T., Tanaka, EM. (2013)

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl.

 Development. 140(3):513-8
Roensch, K., Tazaki, A., Chara, O., Tanaka, EM. (2013)

Progressive specification rather than intercalation of segments during limb regeneration.

 Science. 342(6164):1375-9
Simon, A., Tanaka, EM. (2013)

Limb regeneration.

 Wiley Interdiscip Rev Dev Biol. 2(2):291-300
Stewart, R., Rascón, CA., Tian, S., Nie, J., Barry, C., Chu, LF., Ardalani, H., Wagner, RJ., Probasco, MD., Bolin, JM., Leng, N., Sengupta, S., Volkmer, M., Habermann, B., Tanaka, EM., Thomson, JA., Dewey, CN. (2013)

Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema.

 PLoS Comput Biol. 9(3):e1002936
Zhu, Y., Carido, M., Meinhardt, A., Kurth, T., Karl, MO., Ader, M., Tanaka, EM. (2013)

Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.

 PLoS One. 8(1):e54552

2012

Diogo, R., Tanaka, EM. (2012)

Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies.

 J Anat. 221(6):622-35
Epperlein, HH., Khattak, S., Knapp, D., Tanaka, EM., Malashichev, YB. (2012)

Neural crest does not contribute to the neck and shoulder in the axolotl (Ambystoma mexicanum).

 PLoS One. 7(12):e52244
Knapp, D., Tanaka, EM. (2012)

Regeneration and reprogramming.

 Curr Opin Genet Dev. 22(5):485-93
McHedlishvili, L., Mazurov, V., Grassme, KS., Goehler, K., Robl, B., Tazaki, A., Roensch, K., Duemmler, A., Tanaka, EM. (2012)

Reconstitution of the central and peripheral nervous system during salamander tail regeneration.

 Proc Natl Acad Sci U S A. 109(34):E2258-66
McHedlishvili, L., Mazurov, V., Tanaka, EM. (2012)

Reconstitution of the central nervous system during salamander tail regeneration from the implanted neurospheres.

 Methods Mol Biol. 916:197-202
Murawala, P., Tanaka, EM., Currie, JD. (2012)

Regeneration: the ultimate example of wound healing.

 Semin Cell Dev Biol. 23(9):954-62
Plath, K., Srivastava, D., Alvarez-Buylla, A., Tanaka, EM., Kriegstein, AR. (2012)

Stem cells in the land of the rising sun: ISSCR 2012.

 Cell Stem Cell. 11(5):607-14
Protze, S., Khattak, S., Poulet, C., Lindemann, D., Tanaka, EM., Ravens, U. (2012)

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

 J Mol Cell Cardiol. 53(3):323-32
Tanaka, EM. (2012)

Regenerative biology: Skin, heal thyself.

 Nature. 489(7417):508-10
Tapia, N., Reinhardt, P., Duemmler, A., Wu, G., Araúzo-Bravo, MJ., Esch, D., Greber, B., Cojocaru, V., Rascon, CA., Tazaki, A., Kump, K., Voss, R., Tanaka, EM., Schöler, HR. (2012)

Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins.

 Nat Commun. 3:1279

2011

Campbell, LJ., Suárez-Castillo, EC., Ortiz-Zuazaga, H., Knapp, D., Tanaka, EM., Crews, CM. (2011)

Gene expression profile of the regeneration epithelium during axolotl limb regeneration.

 Dev Dyn. 240(7):1826-40
Jászai, J., Fargeas, CA., Graupner, S., Tanaka, EM., Brand, M., Huttner, WB., Corbeil, D. (2011)

Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species.

 PLoS One. 6(3):e17590
Nacu, E., Tanaka, EM. (2011)

Limb regeneration: a new development?

 Annu Rev Cell Dev Biol. 27:409-40
Tanaka, EM., Reddien, PW. (2011)

The cellular basis for animal regeneration.

 Dev Cell. 21(1):172-85

2010

Antos, CL., Tanaka, EM. (2010)

Vertebrates that regenerate as models for guiding stem cels.

 Adv Exp Med Biol. 695:184-214
Berg, DA., Kirkham, M., Beljajeva, A., Knapp, D., Habermann, B., Ryge, J., Tanaka, EM., Simon, A. (2010)

Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain.

 Development. 137(24):4127-34
Gin, E., Tanaka, EM., Brusch, L. (2010)

A model for cyst lumen expansion and size regulation via fluid secretion.

 J Theor Biol. 264(3):1077-88
Ishizaki, K., Suzuki, K., Mito, T., Tanaka, EM., Sato, S. (2010)

Morphologic, functional, and occlusal characterization of mandibular lateral displacement malocclusion.

 Am J Orthod Dentofacial Orthop. 137(4):454.e1-9; discussion 454-5

2009

Khattak, S., Richter, T., Tanaka, EM. (2009)

Generation of transgenic axolotls (Ambystoma mexicanum).

 Cold Spring Harb Protoc. 2009(8):pdb.prot5264
Khattak, S., Tanaka, EM. (2009)

Axolotl (Ambystoma mexicanum) in vitro fertilization.

 Cold Spring Harb Protoc. 2009(8):pdb.prot5263
Kragl, M., Tanaka, EM. (2009)

Axolotl (Ambystoma mexicanum) limb and tail amputation.

 Cold Spring Harb Protoc. 2009(8):pdb.prot5267
Kragl, M., Tanaka, EM. (2009)

Grafting axolotl (Ambystoma mexicanum) limb skin and cartilage from GFP+ donors to normal hosts.

 Cold Spring Harb Protoc. 2009(8):pdb.prot5266
Nacu, E., Knapp, D., Tanaka, EM., Epperlein, HH. (2009)

Axolotl (Ambystoma mexicanum) embryonic transplantation methods.

 Cold Spring Harb Protoc. 2009(8):pdb.prot5265
Sasaguri, K., Ishizaki-Takeuchi, R., Kuramae, S., Tanaka, EM., Sakurai, T., Sato, S. (2009)

The temporomandibular joint in a rheumatoid arthritis patient after orthodontic treatment.

 Angle Orthod. 79(4):804-11
Tanaka, EM., Ferretti, P. (2009)

Considering the evolution of regeneration in the central nervous system.

 Nat Rev Neurosci. 10(10):713-23
Voss, SR., Epperlein, HH., Tanaka, EM. (2009)

Ambystoma mexicanum, the axolotl: a versatile amphibian model for regeneration, development, and evolution studies.

 Cold Spring Harb Protoc. 2009(8):pdb.emo128

2008

Kragl, M., Knapp, D., Nacu, E., Khattak, S., Schnapp, E., Epperlein, HH., Tanaka, EM. (2008)

Novel insights into the flexibility of cell and positional identity during urodele limb regeneration.

 Cold Spring Harb Symp Quant Biol. 73:583-92
Lynch, SL., Boon, AJ., Smith, J., Harper, CM., Tanaka, EM. (2008)

Complications of needle electromyography: hematoma risk and correlation with anticoagulation and antiplatelet therapy.

 Muscle Nerve. 38(4):1225-30
Tanaka, EM., Sato, S. (2008)

Longitudinal alteration of the occlusal plane and development of different dentoskeletal frames during growth.

 Am J Orthod Dentofacial Orthop. 134(5):602.e1-11; discussion 602-3
Tanaka, EM., Weidinger, G. (2008)

Micromanaging regeneration.

 Genes Dev. 22(6):700-5
Tanaka, EM., Weidinger, G. (2008)

Heads or tails: can Wnt tell which one is up?

 Nat Cell Biol. 10(2):122-4

2007

Lööf, S., Straube, WL., Drechsel, D., Tanaka, EM., Simon, A. (2007)

Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor.

 Cell Cycle. 6(9):1096-101
McHedlishvili, L., Epperlein, HH., Telzerow, A., Tanaka, EM. (2007)

A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.

 Development. 134(11):2083-93

2006

Sobkow, L., Epperlein, HH., Herklotz, S., Straube, WL., Tanaka, EM. (2006)

A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration.

 Dev Biol. 290(2):386-97
Straube, WL., Tanaka, EM. (2006)

Reversibility of the differentiated state: regeneration in amphibians.

 Artif Organs. 30(10):743-55

2005

da Silva, AV., Pezerico, SB., de Lima, VY., d'Arc Moretti, L., Pinheiro, JP., Tanaka, EM., Ribeiro, MG., Langoni, H. (2005)

Genotyping of Toxoplasma gondii strains isolated from dogs with neurological signs.

 Vet Parasitol. 127(1):23-7
Echeverri, K., Tanaka, EM. (2005)

Proximodistal patterning during limb regeneration.

 Dev Biol. 279(2):391-401
Mercader, N., Tanaka, EM., Torres, M. (2005)

Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins.

 Development. 132(18):4131-42
Schnapp, E., Kragl, M., Rubin, L., Tanaka, EM. (2005)

Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration.

 Development. 132(14):3243-53
Schnapp, E., Tanaka, EM., Tamaka, EM. (2005)

Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum.

 Dev Dyn. 232(1):162-70

2004

Habermann, B., Bebin, AG., Herklotz, S., Volkmer, M., Eckelt, K., Pehlke, K., Epperlein, HH., Schackert, HK., Wiebe, G., Tanaka, EM. (2004)

An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries.

 Genome Biol. 5(9):R67
Straube, WL., Brockes, JP., Drechsel, DN., Tanaka, EM. (2004)

Plasticity and reprogramming of differentiated cells in amphibian regeneration: partial purification of a serum factor that triggers cell cycle re-entry in differentiated muscle cells.

 Cloning Stem Cells. 6(4):333-44

2003

Echeverri, K., Tanaka, EM. (2003)

Electroporation as a tool to study in vivo spinal cord regeneration.

 Dev Dyn. 226(2):418-25
Tanaka, EM. (2003)

Cell differentiation and cell fate during urodele tail and limb regeneration.

 Curr Opin Genet Dev. 13(5):497-501
Tanaka, EM. (2003)

Regeneration: if they can do it, why can't we?

 Cell. 113(5):559-62

2002

Echeverri, K., Tanaka, EM. (2002)

Ectoderm to mesoderm lineage switching during axolotl tail regeneration.

 Science. 298(5600):1993-6
Echeverri, K., Tanaka, EM. (2002)

Mechanisms of muscle dedifferentiation during regeneration.

 Semin Cell Dev Biol. 13(5):353-60

2001

Echeverri, K., Clarke, JD., Tanaka, EM. (2001)

In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema.

 Dev Biol. 236(1):151-64

2000

Velloso, CP., Kumar, A., Tanaka, EM., Brockes, JP. (2000)

Generation of mononucleate cells from post-mitotic myotubes proceeds in the absence of cell cycle progression.

 Differentiation. 66(4-5):239-46

1999

Tanaka, EM., Drechsel, DN., Brockes, JP. (1999)

Thrombin regulates S-phase re-entry by cultured newt myotubes.

 Curr Biol. 9(15):792-9

1998

Tanaka, EM., Brockes, JP. (1998)

A target of thrombin activation promotes cell cycle re-entry by urodele muscle cells.

 Wound Repair Regen. 6(4):371-81

1997

Tanaka, EM., Gann, AA., Gates, PB., Brockes, JP. (1997)

Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein.

 J Cell Biol. 136(1):155-65

1996

Odde, DJ., Tanaka, EM., Hawkins, SS., Buettner, HM. (1996)

Stochastic dynamics of the nerve growth cone and its microtubules during neurite outgrowth.

 Biotechnol Bioeng. 50(4):452-61

1995

Tanaka, EM., Gann, AF. (1995)

Limb development. The budding role of FGF.

 Curr Biol. 5(6):594-7

1991

Tanaka, EM., Kirschner, MW. (1991)

Microtubule behavior in the growth cones of living neurons during axon elongation.

 J Cell Biol. 115(2):345-63