Publications
2023
Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.
Dev Cell. 58(1):3-17.e8Topological morphogenesis of neuroepithelial organoids.
Nat Phys. 19(2):177-183Chromosome Conformation Capture for Large Genomes.
Methods Mol Biol. 2562:291-318Ethyl Cinnamate-Based Tissue Clearing Strategies.
Methods Mol Biol. 2562:123-133Baculovirus Production and Infection in Axolotls.
Methods Mol Biol. 2562:369-387Navigation and Use of Custom Tracks within the Axolotl Genome Browser.
Methods Mol Biol. 2562:273-289Artificial Insemination in Axolotl.
Methods Mol Biol. 2562:417-4232022
The Axolotl's journey to the modern molecular era.
Curr Top Dev Biol. 147:631-658Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration.
Elife. 11Muscles are barely required for the patterning and cell dynamics in axolotl limb regeneration.
Front Genet. 13:1036641Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.
Nat Commun. 13(1):6949Inducible and tissue-specific cell labeling in Cre-ERT2 transgenic Xenopus lines.
Dev Growth Differ. 64(5):243-253Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration.
Science. 377(6610):eabp9262Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.
Dev Dyn. 251(6):913-921Tig1 regulates proximo-distal identity during salamander limb regeneration.
Nat Commun. 13(1):1141Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.
Cold Spring Harb Perspect Biol. 14(6)The specialist in regeneration-the Axolotl-a suitable model to study bone healing?
NPJ Regen Med. 7(1):352021
The cellular and signaling dynamics of salamander limb regeneration.
Curr Opin Cell Biol. 73:117-123Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.
Elife. 10Fibroblast dedifferentiation as a determinant of successful regeneration.
Dev Cell. 56(10):1541-1551.e6Toward whole tissue imaging of axolotl regeneration.
Dev Dyn. 250(6):800-806Giant lungfish genome elucidates the conquest of land by vertebrates.
Nature. 590(7845):284-289The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.
Proc Natl Acad Sci U S A. 118(15)2020
MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cell Reports. 14(3):374-389Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.
Mol Syst Biol. 16(2):e8985Introducing www.axolotl-omics.org - an integrated -omics data portal for the axolotl research community.
Exp Cell Res. 394(1):112143A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.
Sci Adv. 6(22):eaba0365A Human Retinal Pigment Epithelium-Based Screening Platform Reveals Inducers of Photoreceptor Outer Segments Phagocytosis.
Stem Cell Reports. 15(6):1347-1361Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.
Front Cell Dev Biol. 8:6223082019
The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts.
Biol Open. 8(7)Publisher Correction: Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 14(8):2597A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish.
Dev Neurobiol. 79(5):424-436Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.
Development. 146(3)2018
Application and optimization of CRISPR-Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum).
Nat Protoc. 13(12):2908-2943Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration.
Science. 362(6413)Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
Stem Cell Reports. 10(6):1751-1765The axolotl genome and the evolution of key tissue formation regulators.
Nature. 554(7690):50-55Author Correction: The axolotl genome and the evolution of key tissue formation regulators.
Nature. 559(7712):E2Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration.
Dev Biol. 433(2):262-2752017
Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration.
Proc Natl Acad Sci U S A. 114(47):12501-12506Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.
Methods Mol Biol. 1597:43-55Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.
Elife. 6A right-handed signalling pathway drives heart looping in vertebrates.
Nature. 549(7670):86-90Non-model model organisms.
BMC Biol. 15(1):55Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration.
Dev Biol. 432(1):63-71Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration.
Dev Cell. 40(6):608-617.e62016
Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools.
Dev Cell. 39(4):411-423FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration.
Nature. 533(7603):407-10Neural tube morphogenesis in synthetic 3D microenvironments.
Proc Natl Acad Sci U S A. 113(44):E6831-E6839Editorial overview: Cell reprogramming, regeneration and repair.
Curr Opin Genet Dev. 40:iv-viAccelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls.
Elife. 5MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.
Nature. 531(7593):237-40The Molecular and Cellular Choreography of Appendage Regeneration.
Cell. 165(7):1598-1608Accelerated Three-Dimensional Neuroepithelium Formation from Human Embryonic Stem Cells and Its Use for Quantitative Differentiation to Human Retinal Pigment Epithelium.
Methods Mol Biol. 1307:345-552015
Transgenesis in axolotl (Ambystoma mexicanum).
Methods Mol Biol. 1290:269-77High-efficiency electroporation of the spinal cord in larval axolotl.
Methods Mol Biol. 1290:115-25Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.
Elife. 4:e10230Cellular dynamics underlying regeneration of appropriate segment number during axolotl tail regeneration.
BMC Dev Biol. 15:482014
Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.
Invest Ophthalmol Vis Sci. 55(8):5431-44Mathematical modeling of regenerative processes.
Curr Top Dev Biol. 108:283-317Is salamander hindlimb regeneration similar to that of the forelimb? Anatomical and morphogenetic analysis of hindlimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative and developmental studies.
J Anat. 224(4):459-68Is salamander limb regeneration really perfect? Anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental, and evolutionary studies.
Anat Rec (Hoboken). 297(6):1076-89Development of fore- and hindlimb muscles in GFP-transgenic axolotls: morphogenesis, the tetrapod bauplan, and new insights on the forelimb-hindlimb enigma.
J Exp Zool B Mol Dev Evol. 322(2):106-27CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration.
Stem Cell Reports. 3(3):444-59Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination.
Nat Protoc. 9(3):529-40Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl.
Stem Cell Reports. 2(2):2433D reconstitution of the patterned neural tube from embryonic stem cells.
Stem Cell Reports. 3(6):987-99Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.
Cell Stem Cell. 14(2):174-872013
Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain.
PLoS One. 8(5):e63457Foamy virus for efficient gene transfer in regeneration studies.
BMC Dev Biol. 13:17Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.
PLoS One. 8(5):e61352Muscle and connective tissue progenitor populations show distinct Twist1 and Twist3 expression profiles during axolotl limb regeneration.
Dev Biol. 373(1):196-204Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl.
Development. 140(3):513-8Progressive specification rather than intercalation of segments during limb regeneration.
Science. 342(6164):1375-9Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema.
PLoS Comput Biol. 9(3):e1002936Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.
PLoS One. 8(1):e545522012
Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies.
J Anat. 221(6):622-35Neural crest does not contribute to the neck and shoulder in the axolotl (Ambystoma mexicanum).
PLoS One. 7(12):e52244Reconstitution of the central and peripheral nervous system during salamander tail regeneration.
Proc Natl Acad Sci U S A. 109(34):E2258-66Reconstitution of the central nervous system during salamander tail regeneration from the implanted neurospheres.
Methods Mol Biol. 916:197-202Regeneration: the ultimate example of wound healing.
Semin Cell Dev Biol. 23(9):954-62Stem cells in the land of the rising sun: ISSCR 2012.
Cell Stem Cell. 11(5):607-14A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.
J Mol Cell Cardiol. 53(3):323-32Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins.
Nat Commun. 3:12792011
Gene expression profile of the regeneration epithelium during axolotl limb regeneration.
Dev Dyn. 240(7):1826-40Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species.
PLoS One. 6(3):e175902010
Vertebrates that regenerate as models for guiding stem cels.
Adv Exp Med Biol. 695:184-214Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain.
Development. 137(24):4127-34A model for cyst lumen expansion and size regulation via fluid secretion.
J Theor Biol. 264(3):1077-88Morphologic, functional, and occlusal characterization of mandibular lateral displacement malocclusion.
Am J Orthod Dentofacial Orthop. 137(4):454.e1-9; discussion 454-52009
Generation of transgenic axolotls (Ambystoma mexicanum).
Cold Spring Harb Protoc. 2009(8):pdb.prot5264Axolotl (Ambystoma mexicanum) in vitro fertilization.
Cold Spring Harb Protoc. 2009(8):pdb.prot5263Axolotl (Ambystoma mexicanum) limb and tail amputation.
Cold Spring Harb Protoc. 2009(8):pdb.prot5267Grafting axolotl (Ambystoma mexicanum) limb skin and cartilage from GFP+ donors to normal hosts.
Cold Spring Harb Protoc. 2009(8):pdb.prot5266Axolotl (Ambystoma mexicanum) embryonic transplantation methods.
Cold Spring Harb Protoc. 2009(8):pdb.prot5265The temporomandibular joint in a rheumatoid arthritis patient after orthodontic treatment.
Angle Orthod. 79(4):804-11Considering the evolution of regeneration in the central nervous system.
Nat Rev Neurosci. 10(10):713-23Ambystoma mexicanum, the axolotl: a versatile amphibian model for regeneration, development, and evolution studies.
Cold Spring Harb Protoc. 2009(8):pdb.emo1282008
Novel insights into the flexibility of cell and positional identity during urodele limb regeneration.
Cold Spring Harb Symp Quant Biol. 73:583-92Complications of needle electromyography: hematoma risk and correlation with anticoagulation and antiplatelet therapy.
Muscle Nerve. 38(4):1225-30Longitudinal alteration of the occlusal plane and development of different dentoskeletal frames during growth.
Am J Orthod Dentofacial Orthop. 134(5):602.e1-11; discussion 602-3Heads or tails: can Wnt tell which one is up?
Nat Cell Biol. 10(2):122-42007
Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor.
Cell Cycle. 6(9):1096-101A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.
Development. 134(11):2083-932006
A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration.
Dev Biol. 290(2):386-97Reversibility of the differentiated state: regeneration in amphibians.
Artif Organs. 30(10):743-552005
Genotyping of Toxoplasma gondii strains isolated from dogs with neurological signs.
Vet Parasitol. 127(1):23-7Proximodistal patterning during limb regeneration.
Dev Biol. 279(2):391-401Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins.
Development. 132(18):4131-42Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration.
Development. 132(14):3243-53Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum.
Dev Dyn. 232(1):162-702004
An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries.
Genome Biol. 5(9):R67Plasticity and reprogramming of differentiated cells in amphibian regeneration: partial purification of a serum factor that triggers cell cycle re-entry in differentiated muscle cells.
Cloning Stem Cells. 6(4):333-442003
Electroporation as a tool to study in vivo spinal cord regeneration.
Dev Dyn. 226(2):418-25Cell differentiation and cell fate during urodele tail and limb regeneration.
Curr Opin Genet Dev. 13(5):497-5012002
Ectoderm to mesoderm lineage switching during axolotl tail regeneration.
Science. 298(5600):1993-6Mechanisms of muscle dedifferentiation during regeneration.
Semin Cell Dev Biol. 13(5):353-602001
In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema.
Dev Biol. 236(1):151-642000
Generation of mononucleate cells from post-mitotic myotubes proceeds in the absence of cell cycle progression.
Differentiation. 66(4-5):239-461999
Thrombin regulates S-phase re-entry by cultured newt myotubes.
Curr Biol. 9(15):792-91998
A target of thrombin activation promotes cell cycle re-entry by urodele muscle cells.
Wound Repair Regen. 6(4):371-811997
Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein.
J Cell Biol. 136(1):155-651996
Stochastic dynamics of the nerve growth cone and its microtubules during neurite outgrowth.
Biotechnol Bioeng. 50(4):452-611995
1991
Microtubule behavior in the growth cones of living neurons during axon elongation.
J Cell Biol. 115(2):345-63