Elly Tanaka
Our group seeks to understand the cellular mechanisms underlying salamander limb and spinal cord regeneration as a model for how successful regeneration occurs in a vertebrate. This model acts as a starting point to rigorously investigate how mammals such as mice have lost regeneration capabilities over evolution. In addition, these studies act as a springboard to design novel strategies for regenerating or replacing mammalian tissues. Toward that end we have engineered three-dimensional spinal cord tissue from mouse embryonic stem cells and retinal pigment epithelia from human embryonic stem cells.