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Ref2213: Master’s Thesis in RNA biology and super-resolution microscopy – Balzarotti & Plaschka Labs

The Balzarotti and Plaschka labs have a joint open position for a Master’s student at the Research Institute of Molecular Pathology (IMP) to study mRNA processing in human cells using super-resolution microscopy.

The successful candidate will engineer human cell lines using CRISPR-Cas9 and learn how to acquire and analyze super-resolution microscopy data using a state-of-the-art MINFLUX microscope. He/she will investigate the spatial organization of mRNA processes in cells at an unprecedented resolution, and further be exposed to a variety of molecular biology techniques and microscopy methods.

The ideal applicant will be highly motivated, have a strong interest in biophysics and gene expression, and have experience in light microscopy. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn both high-end light microscopy and cell engineering. The position is available from autumn 2022 and remains open until filled. The student will receive a monthly stipend.

To apply please send a CV and cover letter to:

Manuela Steurer
manuela.steurer[at]imp.ac.at
www.imp.ac.at; www.viennabiocenter.org 

Further reading

T. Pühringer, U. Hohmann, L. Fin, B. Pacheco-Fiallos, U. Schellhaas, J. Brennecke, C. Plaschka. Structure of the human core transcription-export complex reveals a hub for multivalent interactions. eLife (2020) 9:e61503.

C. Plaschka, P.-C. Lin, C. Charenton, K. Nagai. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422.

F. Balzarotti, Y. Eilers, K. C. Gwosch, A. Gynna, V. Westphal, F. Stefani, J. Elf, S. Hell. Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes. Science (2017) 355, 6325, 606-612

K. C. Gwosch, J. K. Pape, F. Balzarotti, P. Hoess, J. Ellenberg, J. Ries, S. Hell. MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells. Nature Methods (2020), 17, 217–224