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Ref2016: Master’s Thesis in Structural Biology (cryo-EM) – Plaschka Lab

The Plaschka lab has an open position for a Master’s student at the Research Institute of Molecular Pathology (IMP) to study a key step in human mRNA processing.

The successful candidate will carry out research on an essential multi-subunit complex involved in mRNA processing. He/she will be exposed to a variety of molecular biology techniques, including biochemical preparation of the complex from insect cells (cloning, purification), structure determination by cryo-electron microscopy (cryo-EM), and functional assays.

The ideal applicant will be highly motivated, have a strong interest in structural biology and have experience in standard biochemistry methods. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn both biochemistry and cryo-EM. The position is available from fall 2020 and remains open until filled. The student will receive a monthly stipend.

To apply please send a CV and cover letter to: 

Dr. Clemens Plaschka
clemens.plaschka[at]imp.ac.at
www.imp.ac.at; www.viennabiocenter.org

Further reading

C. Plaschka, A.J. Newman, K. Nagai. Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast. Cold Spring Harb Perspect Biol. (2019) 11(5)

C. Plaschka, P.-C. Lin, C. Charenton, K. Nagai. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422.

C. Plaschka, P.-C. Lin, K. Nagai . Structure of a pre-catalytic spliceosome. Nature (2017) 546, 617-621.