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Ref2015: Master’s Thesis in Structural Biology (cryo-EM) – Cochella/Plaschka Labs

The Cochella and Plaschka labs have an open position for a joint Master’s student at the Research Institute of Molecular Pathology (IMP) to reveal the structural basis of an unusual pre-mRNA splicing mechanism.

The successful candidate will be exposed to a variety of molecular biology techniques, including the engineering of C. elegans worms using CRISPR/Cas9, the biochemical preparation of the complex and structure determination by cryo-electron microscopy (cryo-EM).

The ideal applicant will be highly motivated, have a strong interest in structural biology and have experience in standard biochemistry methods. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn cell biology tools, biochemistry and cryo-EM. The position is available from fall 2020 and remains open until filled. The student will receive a monthly stipend.

To apply please send a CV and cover letter to: 

Dr. Luisa Cochella (luisa.cochella[at] and 
Dr. Clemens Plaschka (clemens.plaschka[at];

Further reading

C. Plaschka, A.J. Newman, K. Nagai. Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast. Cold Spring Harb Perspect Biol. (2019) 11(5)

C. Plaschka, P.-C. Lin, C. Charenton, K. Nagai. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422.

C. Plaschka, P.-C. Lin, K. Nagai . Structure of a pre-catalytic spliceosome. Nature (2017) 546, 617-621.