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Ref2303: Master's thesis in innate immunology (Gaidt Lab)

The Gaidt group at the Research Institute of Molecular Pathology (IMP) has an open Master’s Thesis position to explore a novel innate immune pathway. We are looking for an enthusiastic student with an interest in immunology and molecular biology. If you are passionate about research and want to work on an exciting project at the intersection of innate immunity and gene regulation in a highly collaborative research environment, you may be the one we are looking for!

The Gaidt lab is a multidisciplinary research group interested in the molecular mechanisms of host-pathogen interactions, innate immunology and anti-tumor immunity. We apply functional genomics, molecular biology, biochemistry and in vivo mouse models to study immune functions and find creative ways to exploit them for therapeutic benefit. Our lab is at the Research Institute of Molecular Pathology (IMP) at the Vienna BioCenter, a life-science hub in the vibrant city of Vienna, Austria.

We have previously identified a novel innate immune pathway called MORC3-MRE that recognizes the enzymatic activities of DNA viruses to induce the anti-viral cytokine interferon (IFN). This project aims at identifying novel players in this pathway and their molecular functions in sensing DNA viruses. It involves genome-engineering using CRISPR/Cas9, functional genetics, molecular biology, deep sequencing and bioinformatic tools. The ideal applicant will be highly motivated, has a strong interest in immunology and has experience in standard mammalian cell culture.

Applications with a cover letter outlining your research interests, transcript of records and your CV should be sent moritz.gaidt[at] Applications are considered until the position is filled. The student will receive a monthly stipend.

Group webpage:

Selected publications:

M.M. Gaidt#, A. Morrow, M.R. Fairgrieve, J.P. Karr, N. Yosef and R.E. Vance#, Selfguarding
of MORC3 enables virulence factor-triggered immunity, Nature 600, 138–142
(2021). #co-corresponding authors