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Ref2114: Master's Thesis in Structural Biology (cryo-EM)

The research group of Clemens Plaschka has an open position for a Master’s student at the Research Institute of Molecular Pathology (IMP) to study a key step in human mRNA processing.


The successful candidate will carry out research on an essential multi-subunit complex involved in mRNA processing. He/she will be exposed to a variety of molecular biology techniques, including biochemical preparation of the complex from insect cells (cloning, purification), structure determination by cryo-electron microscopy (cryo-EM), and functional assays.


The ideal applicant will be highly motivated, have a strong interest in structural biology and have experience in standard biochemistry methods. We offer an exciting research project, outstanding infrastructure, and an excellent opportunity to learn both biochemistry and cryo-EM. The position is available from spring 2022 and remains open until filled. The student will receive a monthly stipend.

To apply please send a CV and cover letter to:

Dr. Clemens Plaschka

Further reading

T. Pühringer*, U. Hohmann*, L. Fin, B. Pacheco-Fiallos, U. Schellhaas, J. Brennecke, C. Plaschka. Structure of the human core transcription-export complex reveals a hub for multivalent interactions. eLife (2020) 9:e61503.

C. Plaschka*, P.-C. Lin*, C. Charenton, K. Nagai. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422.

C. Plaschka*, P.-C. Lin*, K. Nagai. Structure of a pre-catalytic spliceosome. Nature (2017) 546, 617-621.

*Equal contribution.