7th Symposium on Structural Proteomics
- 23 October 2017 - 25 October 2017
- IMP, Vienna, Austria
The 7th Symposium on Structural Proteomics will address topics such as cross-linking mass spectrometry, ion mobility mass spectrometry, hydrogen-deuterium exchange and covalent labeling methods.
A key focus of protein chemistry is to gain structural information regarding proteins and protein complexes. Mass spectrometry-related techniques are emerging as versatile methods that can contribute complementary information to high resolution techniques. Ion mobility-mass spectrometry reports on the whole range of structures in which a protein can exist, while hydrogen-deuterium exchange and cross-linking mass spectrometry provide information on protein structure and dynamics at a localized level. The development of such alternative techniques to study protein behavior is essential to gain insight into the structure-function relationships of proteins that are not amenable to traditional techniques. This is particularly important to address proteins that exist in a dynamic entity of conformations, or a heterogeneous ensemble of stoichiometries.
The major challenge for post-genomic research is to functionally assign and validate many novel target genes and their corresponding proteins. Functional genomics approaches have, therefore, gained considerable attention in the quest to convert this massive data set into useful information. One of the crucial components for the functional understanding of unassigned proteins is the analysis of their experimental or modeled 3D structures. Structural proteomics initiatives are generating protein structures at an unprecedented rate but our current knowledge of 3D-structural space is still limited. One powerful future aspect will be the combination of methods like electron microscopy and cross-linking.
The conference is organised by Karl Mechtler, Rebeca Beveridge, Evgeniy Petrotchenko and Christoph Borcher. It will begin with a practical workshop on cross-linking mass spectrometry.
For more information and registration, visit the conference website: www.structuralproteomics.net