Marlovits Group
Thomas Marlovits (joint IMP-IMBA Group Leader)
Molecular Machines
Membrane-associated processes are a fundamental characteristic of all living cells. They ensure that the cells are able to effectively communicate with, and adapt to, their environment. The cells achieve this by either physically translocating molecules to the opposite site of a membrane or by receiving, transmitting, and amplifying incoming signals.
Our laboratory is interested in understanding the molecular mechanism underlying such processes. Specifically, we focus on machineries capable of translocating bacterial toxins into eukaryotic cells.
Movie (Quick Time Player required)
Movie: Computer-generated model of the of the Infective Apparatus of Salmonella;
Artwork: IMP-IMBA/ Kulcsar
Selected Publications
- Schraidt, O., Marlovits, TC. (2011). Three-dimensional model of Salmonella's needle complex at subnanometer resolution. Science. 331(6021):1192-5 (abstract)
- Schraidt, O., Lefebre, MD., Brunner, MJ., Schmied, WH., Schmidt, A., Radics, J., Mechtler, K., Galán, JE., Marlovits, TC. (2010). Topology and organization of the Salmonella typhimurium type III secretion needle complex components. PLoS Pathog. 6(4):e1000824 (abstract)
- Wagner, S., Königsmaier, L., Lara-Tejero, M., Lefebre, M., Marlovits, TC., Galán, JE. (2010). Organization and coordinated assembly of the type III secretion export apparatus. Proc Natl Acad Sci U S A. 107(41):17745-50 (abstract)
- Marlovits, TC., Kubori, T., Lara-Tejero, M., Thomas, D., Unger, VM., Galán, JE. (2006). Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature. 441(7093):637-40 (abstract)
- Marlovits, TC., Kubori, T., Sukhan, A., Thomas, DR., Galán, JE., Unger, VM. (2004). Structural insights into the assembly of the type III secretion needle complex. Science. 306(5698):1040-2 (abstract)
