Tanaka Group

Elly Tanaka (Senior Scientist)

(Email)
Biography
Senior Scientist at the IMP, Vienna since autumn 2016
Director at DFG Center for Regenerative Therapies, Dresden, 2014 - 2016
W3 Full Professor, Center for Regenerative Therapies,
University of Technology, Dresden, 2008 - 2016
Group Leader, MPI of Molecular Cell Biology and Genetics, Dresden, 1999 - 2008
Post-doctoral fellow, Ludwig Cancer Research Institute, University College, London, 1994 - 1999
Scientific CV in PDF format

Molecular Mechanisms of Vertebrate Regeneration

Our group seeks to understand the cellular mechanisms underlying salamander limb and spinal cord regeneration as a model for how successful regeneration occurs in a vertebrate. This model acts as a starting point to rigorously investigate how mammals such as mice have lost regeneration capabilities over evolution.  In addition, these studies act as a springboard to design novel strategies for regenerating or replacing mammalian tissues.  Toward that end we have engineered three dimensional spinal cord tissue from mouse embryonic stem cells and retinal pigment epithelia from human embryonic stem cells.

Selected Publications

  • Currie, JD., Kawaguchi, A., Traspas, RM., Schuez, M., Chara, O., Tanaka, EM. (2016). Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools. Dev Cell. 39(4):411-423 (abstract)
  • Nacu, E., Gromberg, E., Oliveira, CR., Drechsel, D., Tanaka, EM. (2016). FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. Nature. 533(7603):407-10 (abstract)
  • Sugiura, T., Wang, H., Barsacchi, R., Simon, A., Tanaka, EM. (2016). MARCKS-like protein is an initiating molecule in axolotl appendage regeneration. Nature. 531(7593):237-40 (abstract)
  • Fei, JF., Schuez, M., Tazaki, A., Taniguchi, Y., Roensch, K., Tanaka, EM. (2014). CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration. Stem Cell Reports. 3(3):444-59 (abstract)
  • Meinhardt, A., Eberle, D., Tazaki, A., Ranga, A., Niesche, M., Wilsch-Bräuninger, M., Stec, A., Schackert, G., Lutolf, M., Tanaka, EM. (2014). 3D reconstitution of the patterned neural tube from embryonic stem cells. Stem Cell Reports. 3(6):987-99 (abstract)