Peters Group

Jan-Michael Peters (Scientific Director, Senior Scientist)

PhD 1991, University Heidelberg
Postdoctoral Research at DKFZ Heidelberg & Harvard Medical School, Boston
Group Leader at the IMP Vienna 1996-2001
Senior Scientist at the IMP Vienna since 2002
Scientific Deputy Director 2011-2013
Scientific Director since 2013
Scientific CV in PDF format

Mitosis and chromosome biology

To pass the genome from one generation to the next, eukaryotic cells first replicate their DNA, then biorient chromosomes on the mitotic spindle and finally separate their  sister chromatids, thus enabling the division of one cell into two genetically identical daughter cells. We are interested in understanding these processes at the molecular level.

Mitosys Documentary

The documentary, Meetings of Minds, allows the scientists to speak for themselves in conversation with the artists. Four artist/scientist pairs have been selected to approach the subject of mitosis from different perspectives:

Ways of Saying
Shobana Jeyasingh / Kim Nasmyth
Ways of Seeing
Rob Kesseler / Melina Schuh
Ways of Being
Ackroyd & Harvey / Jan-Michael Peters

Ways of Growing
Lucy & Jorges Orta / Tony Hyman



Selected Publications

  • Tedeschi, A., Wutz, G., Huet, S., Jaritz, M., Wuensche, A., Schirghuber, E., Davidson, IF., Tang, W., Cisneros, DA., Bhaskara, V., Nishiyama, T., Vaziri, A., Wutz, A., Ellenberg, J., Peters, JM. (2013). Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature. 501(7468):564-8 (abstract)
  • Uzunova, K., Dye, BT., Schutz, H., Ladurner, R., Petzold, G., Toyoda, Y., Jarvis, MA., Brown, NG., Poser, I., Novatchkova, M., Mechtler, K., Hyman, AA., Stark, H., Schulman, BA., Peters, JM. (2012). APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol. 19(11):1116-23 (abstract)
  • Buschhorn, BA., Petzold, G., Galova, M., Dube, P., Kraft, C., Herzog, F., Stark, H., Peters, JM. (2011). Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol. 18(1):6-13 (abstract)
  • Hutchins, JR., Toyoda, Y., Hegemann, B., Poser, I., Hériché, JK., Sykora, MM., Augsburg, M., Hudecz, O., Buschhorn, BA., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, MM., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, AA., Peters, JM. (2010). Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 328(5978):593-9 (abstract)
  • Nishiyama, T., Ladurner, R., Schmitz, J., Kreidl, E., Schleiffer, A., Bhaskara, V., Bando, M., Shirahige, K., Hyman, AA., Mechtler, K., Peters, JM. (2010). Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 143(5):737-49 (abstract)