Obenauf Group

Anna Obenauf (Group Leader)

(Email)

Biography
PhD 2010, Medical University of Graz, AT
Postdoctoral fellow at Memorial Sloan Kettering Cancer Center (MSKCC), USA
Group Leader at the IMP Vienna since winter 2015
Scientific CV in PDF format

Molecular Mechanisms of Metastasis and Drug Resistance

Metastasis is the final stage of cancer progression and is responsible for more than 90% of cancer related deaths, claiming millions of lives worldwide. Its systemic nature and resistance to existing therapies pose challenging problems in the treatment of patients with metastatic disease. Our lab aims to identify the molecular mechanisms of metastasis that allow cancer cells to infiltrate, survive and ultimately overtake distant organs. In addition, we investigate mechanisms of drug resistance limiting our efforts to control metastatic disease and the role of the tumor microenvironment in metastasis and drug resistance. Our ultimate goal is to translate basic research into innovative cancer therapies.

Selected Publications

  • Obenauf, AC., Zou, Y., Ji, AL., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, MC., Wiesner, T., Rosen, N., Lo, RS., Massagué, J. (2015). Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 520(7547):368-72 (abstract)
  • Valiente, M., Obenauf, AC., Jin, X., Chen, Q., Zhang, XH., Lee, DJ., Chaft, JE., Kris, MG., Huse, JT., Brogi, E., Massagué, J. (2014). Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 156(5):1002-16 (abstract)
  • Wiesner, T., Obenauf, AC., Murali, R., Fried, I., Griewank, KG., Ulz, P., Windpassinger, C., Wackernagel, W., Loy, S., Wolf, I., Viale, A., Lash, AE., Pirun, M., Socci, ND., Rütten, A., Palmedo, G., Abramson, D., Offit, K., Ott, A., Becker, JC., Cerroni, L., Kutzner, H., Bastian, BC., Speicher, MR. (2011). Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet. 43(10):1018-21 (abstract)
  • Obenauf, AC., Schwarzbraun, T., Auer, M., Hoffmann, EM., Waldispuehl-Geigl, J., Ulz, P., Günther, B., Duba, HC., Speicher, MR., Geigl, JB. (2010). Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes. J Cell Mol Med. 14(8):2078-84 (abstract)
  • Geigl, JB., Obenauf, AC., Waldispuehl-Geigl, J., Hoffmann, EM., Auer, M., Hörmann, M., Fischer, M., Trajanoski, Z., Schenk, MA., Baumbusch, LO., Speicher, MR. (2009). Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res. 37(15):e105 (abstract)

Grants