Cochella Group

Luisa Cochella (Group Leader)


PhD 2006, Johns Hopkins School of Medicine, Baltimore
Postdoctoral Research at Columbia University, New York
Group Leader at the IMP Vienna since 2013
Scientific CV in PDF format

Spatio-temporal specificity of miRNA function and its role in cell-type specification

One of the main goals of developmental biology is to understand how the different cell types that constitute a multicellular organism are specified during its development. We are currently exploring the contribution of miRNA-mediated gene expression regulation to the diversification of the genetic programs that control cell differentiation. We are interested in how miRNAs themselves are regulated to achieve highly specific expression patterns in order to generate this diversity of cell types, as well as how miRNAs were integrated into gene regulatory networks during evolution.

Selected Publications

  • Drexel, T., Mahofsky, K., Latham, R., Zimmer, M., Cochella, L. (2016). Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans. Genes Dev. (abstract)
  • Cochella, L., Tursun, B., Hsieh, YW., Galindo, S., Johnston, RJ., Chuang, CF., Hobert, O. (2014). Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1. Genes Dev. 28(1):34-43 (abstract)
  • Cochella, L., Hobert, O. (2012). Diverse functions of microRNAs in nervous system development. Curr Top Dev Biol. 99:115-43 (abstract)
  • Cochella, L., Hobert, O. (2012). Embryonic priming of a miRNA locus predetermines postmitotic neuronal left/right asymmetry in C. elegans. Cell. 151(6):1229-42 (abstract)
  • Didiano, D., Cochella, L., Tursun, B., Hobert, O. (2010). Neuron-type specific regulation of a 3'UTR through redundant and combinatorially acting cis-regulatory elements. RNA. 16(2):349-63 (abstract)