Busslinger Group Publications

2012

Vilagos, B., Hoffmann, M., Souabni, A., Sun, Q., Werner, B., Medvedovic, J., Bilic, I., Minnich, M., Axelsson, E., Jaritz, M., Busslinger, M. (2012). Essential role of EBF1 in the generation and function of distinct mature B cell types. J Exp Med. (abstract)

2011

Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, GT., Smyth, GK., Busslinger, M., Nutt, SL., Kallies, A. (2011). The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol. 12(4):304-11 (abstract)
Ebert, A., McManus, S., Tagoh, H., Medvedovic, J., Salvagiotto, G., Novatchkova, M., Tamir, I., Sommer, A., Jaritz, M., Busslinger, M. (2011). The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity. 34(2):175-87 (abstract)
Gimferrer, I., Hu, T., Simmons, A., Wang, C., Souabni, A., Busslinger, M., Bender, TP., Hernandez-Hoyos, G., Alberola-Ila, J. (2011). Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol. 186(7):3892-8 (abstract)
Guo, C., Yoon, HS., Franklin, A., Jain, S., Ebert, A., Cheng, HL., Hansen, E., Despo, O., Bossen, C., Vettermann, C., Bates, JG., Richards, N., Myers, D., Patel, H., Gallagher, M., Schlissel, MS., Murre, C., Busslinger, M., Giallourakis, CC., Alt, FW. (2011). CTCF-binding elements mediate control of V(D)J recombination. Nature. 477(7365):424-30 (abstract)
McManus, S., Ebert, A., Salvagiotto, G., Medvedovic, J., Sun, Q., Tamir, I., Jaritz, M., Tagoh, H., Busslinger, M. (2011). The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J. 30(12):2388-404 (abstract)
Medvedovic, J., Ebert, A., Tagoh, H., Busslinger, M. (2011). Pax5: a master regulator of B cell development and leukemogenesis. Adv Immunol. 111:179-206 (abstract)
Qin, H., Suzuki, K., Nakata, M., Chikuma, S., Izumi, N., Huong, le T., Maruya, M., Fagarasan, S., Busslinger, M., Honjo, T., Nagaoka, H. (2011). Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One. 6(12):e29141 (abstract)

2010

Bouchard, M., de Caprona, D., Busslinger, M., Xu, P., Fritzsch, B. (2010). Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 10:89 (abstract)
Johnson, BA., Kahler, DJ., Baban, B., Chandler, PR., Kang, B., Shimoda, M., Koni, PA., Pihkala, J., Vilagos, B., Busslinger, M., Munn, DH., Mellor, AL. (2010). B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A. 107(23):10644-8 (abstract)
Majewski, IJ., Ritchie, ME., Phipson, B., Corbin, J., Pakusch, M., Ebert, A., Busslinger, M., Koseki, H., Hu, Y., Smyth, GK., Alexander, WS., Hilton, DJ., Blewitt, ME. (2010). Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood. 116(5):731-9 (abstract)
Malin, S., McManus, S., Busslinger, M. (2010). STAT5 in B cell development and leukemia. Curr Opin Immunol. 22(2):168-76 (abstract)
Malin, S., McManus, S., Cobaleda, C., Novatchkova, M., Delogu, A., Bouillet, P., Strasser, A., Busslinger, M. (2010). Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 11(2):171-9 (abstract)
Vikstrom, I., Carotta, S., Lüthje, K., Peperzak, V., Jost, PJ., Glaser, S., Busslinger, M., Bouillet, P., Strasser, A., Nutt, SL., Tarlinton, DM. (2010). Mcl-1 is essential for germinal center formation and B cell memory. Science. 330(6007):1095-9 (abstract)

2009

Agrelo, R., Souabni, A., Novatchkova, M., Haslinger, C., Leeb, M., Komnenovic, V., Kishimoto, H., Gresh, L., Kohwi-Shigematsu, T., Kenner, L., Wutz, A. (2009). SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells. Dev Cell. 16(4):507-16 (abstract)
Decker, T., Pasca di Magliano, M., McManus, S., Sun, Q., Bonifer, C., Tagoh, H., Busslinger, M. (2009). Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity. 30(4):508-20 (abstract)
Hewitt, SL., Yin, B., Ji, Y., Chaumeil, J., Marszalek, K., Tenthorey, J., Salvagiotto, G., Steinel, N., Ramsey, LB., Ghysdael, J., Farrar, MA., Sleckman, BP., Schatz, DG., Busslinger, M., Bassing, CH., Skok, JA. (2009). RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 10(6):655-64 (abstract)

2008

Cobaleda, C., Busslinger, M. (2008). Developmental plasticity of lymphocytes. Curr Opin Immunol. 20(2):139-48 (abstract)
Graf, T., Busslinger, M. (2008). B young again. Immunity. 28(5):606-8 (abstract)
Guo, F., Tänzer, S., Busslinger, M., Weih, F. (2008). Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis. Blood. 112(3):551-9 (abstract)
Kwon, K., Hutter, C., Sun, Q., Bilic, I., Cobaleda, C., Malin, S., Busslinger, M. (2008). Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity. 28(6):751-62 (abstract)
Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., De La Rosa-Velazquez, IA., Espejo, A., Bedford, MT., Nussenzweig, A., Busslinger, M., Jenuwein, T. (2008). A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 22(15):2048-61 (abstract)

2007

Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., Flavell, RA. (2007). Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 27(1):89-99 (abstract)
Bruce, SJ., Rea, RW., Steptoe, AL., Busslinger, M., Bertram, JF., Perkins, AC. (2007). In vitro differentiation of murine embryonic stem cells toward a renal lineage. Differentiation. 75(5):337-49 (abstract)
Cobaleda, C., Jochum, W., Busslinger, M. (2007). Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature. 449(7161):473-7 (abstract)
Cobaleda, C., Schebesta, A., Delogu, A., Busslinger, M. (2007). Pax5: the guardian of B cell identity and function. Nat Immunol. 8(5):463-70 (abstract)
Fuxa, M., Busslinger, M. (2007). Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol. 178(12):8222-8 (abstract)
Fuxa, M., Busslinger, M. (2007). Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol. 178(5):3031-7 (abstract)
Martinez, J., Busslinger, M. (2007). Life beyond cleavage: the case of Ago2 and hematopoiesis. Genes Dev. 21(16):1983-8 (abstract)
Roessler, S., Györy, I., Imhof, S., Spivakov, M., Williams, RR., Busslinger, M., Fisher, AG., Grosschedl, R. (2007). Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol. 27(2):579-94 (abstract)
Schebesta, A., McManus, S., Salvagiotto, G., Delogu, A., Busslinger, GA., Busslinger, M. (2007). Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity. 27(1):49-63 (abstract)
Skok, JA., Gisler, R., Novatchkova, M., Farmer, D., de Laat, W., Busslinger, M. (2007). Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes. Nat Immunol. 8(4):378-87 (abstract)
Souabni, A., Jochum, W., Busslinger, M. (2007). Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood. 109(1):281-9 (abstract)

2006

Busslinger, M., Tarakhovsky, A. (2006). Epigenetic control of lymphopoiesis. In Epigenetics (Allis, Jenuwein, Reinberg, eds.); Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.. :397-414
Delogu, A., Schebesta, A., Sun, Q., Aschenbrenner, K., Perlot, T., Busslinger, M. (2006). Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity. 24(3):269-81 (abstract)
Grote, D., Souabni, A., Busslinger, M., Bouchard, M. (2006). Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 133(1):53-61 (abstract)
Savarese, F., Flahndorfer, K., Jaenisch, R., Busslinger, M., Wutz, A. (2006). Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol. 26(19):7167-77 (abstract)
Tagoh, H., Ingram, R., Wilson, N., Salvagiotto, G., Warren, AJ., Clarke, D., Busslinger, M., Bonifer, C. (2006). The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction. EMBO J. 25(5):1070-80 (abstract)
Weisheit, G., Gliem, M., Endl, E., Pfeffer, PL., Busslinger, M., Schilling, K. (2006). Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons. Eur J Neurosci. 24(2):466-78 (abstract)

2005

Ardouin, L., Rolink, AG., Mura, AM., Gommeaux, J., Melchers, F., Busslinger, M., Malissen, M., Malissen, B. (2005). Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells. Eur J Immunol. 35(3):977-86 (abstract)
Bouchard, M., Grote, D., Craven, SE., Sun, Q., Steinlein, P., Busslinger, M. (2005). Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Development. 132(11):2633-43 (abstract)
Pelayo, R., Hirose, J., Huang, J., Garrett, KP., Delogu, A., Busslinger, M., Kincade, PW. (2005). Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood. 105(11):4407-15 (abstract)
Roldán, E., Fuxa, M., Chong, W., Martinez, D., Novatchkova, M., Busslinger, M., Skok, JA. (2005). Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol. 6(1):31-41 (abstract)

2004

Bouchard, M., Souabni, A., Busslinger, M. (2004). Tissue-specific expression of cre recombinase from the Pax8 locus. Genesis. 38(3):105-9 (abstract)
Busslinger, M. (2004). Transcriptional control of early B cell development. Annu Rev Immunol. 22:55-79 (abstract)
Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, PA., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., Chen, CL., Busslinger, M., Goulding, M., Onimaru, H., Ma, Q. (2004). Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci. 7(5):510-7 (abstract)
Fuxa, M., Skok, J., Souabni, A., Salvagiotto, G., Roldan, E., Busslinger, M. (2004). Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev. 18(4):411-22 (abstract)
Höflinger, S., Kesavan, K., Fuxa, M., Hutter, C., Heavey, B., Radtke, F., Busslinger, M. (2004). Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J Immunol. 173(6):3935-44 (abstract)
Linderson, Y., Eberhard, D., Malin, S., Johansson, A., Busslinger, M., Pettersson, S. (2004). Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes. EMBO Rep. 5(3):291-6 (abstract)
Tagoh, H., Schebesta, A., Lefevre, P., Wilson, N., Hume, D., Busslinger, M., Bonifer, C. (2004). Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J. 23(21):4275-85 (abstract)

2003

Heavey, B., Charalambous, C., Cobaleda, C., Busslinger, M. (2003). Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J. 22(15):3887-97 (abstract)

2002

Bouchard, M., Souabni, A., Mandler, M., Neubüser, A., Busslinger, M. (2002). Nephric lineage specification by Pax2 and Pax8. Genes Dev. 16(22):2958-70 (abstract)
Mikkola, I., Heavey, B., Horcher, M., Busslinger, M. (2002). Reversion of B cell commitment upon loss of Pax5 expression. Science. 297(5578):110-3 (abstract)
Pfeffer, PL., Payer, B., Reim, G., di Magliano, MP., Busslinger, M. (2002). The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers. Development. 129(2):307-18 (abstract)
Schebesta, M., Heavey, B., Busslinger, M. (2002). Transcriptional control of B-cell development. Curr Opin Immunol. 14(2):216-23 (abstract)
Schebesta, M., Pfeffer, PL., Busslinger, M. (2002). Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity. 17(4):473-85 (abstract)
Souabni, A., Cobaleda, C., Schebesta, M., Busslinger, M. (2002). Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 17(6):781-93 (abstract)

2001

Ellis, T., Gambardella, L., Horcher, M., Tschanz, S., Capol, J., Bertram, P., Jochum, W., Barrandon, Y., Busslinger, M. (2001). The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev. 15(17):2307-19 (abstract)
Horcher, M., Eberhard, D., Busslinger, M. (2001). The role of PAX5 (BSAP) in early and late B-cell development. Transcription Factors: Normal and Malignant Development of Blood Cells (Ravid, K., Licht, Jd., eds.). :217-228
Horcher, M., Souabni, A., Busslinger, M. (2001). Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity. 14(6):779-90 (abstract)
Nutt, SL., Eberhard, D., Horcher, M., Rolink, AG., Busslinger, M. (2001). Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis. Int Rev Immunol. 20(1):65-82 (abstract)
Ye, W., Bouchard, M., Stone, D., Liu, X., Vella, F., Lee, J., Nakamura, H., Ang, SL., Busslinger, M., Rosenthal, A. (2001). Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nat Neurosci. 4(12):1175-81 (abstract)

2000

Bouchard, M., Pfeffer, P., Busslinger, M. (2000). Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. Development. 127(17):3703-13 (abstract)
Busslinger, M., Nutt, SL., Rolink, AG. (2000). Lineage commitment in lymphopoiesis. Curr Opin Immunol. 12(2):151-8 (abstract)
Eberhard, D., Jiménez, G., Heavey, B., Busslinger, M. (2000). Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family. EMBO J. 19(10):2292-303 (abstract)
Pfeffer, PL., Bouchard, M., Busslinger, M. (2000). Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary. Development. 127(5):1017-28 (abstract)
Revy, P., Busslinger, M., Tashiro, K., Arenzana, F., Pillet, P., Fischer, A., Durandy, A. (2000). A syndrome involving intrauterine growth retardation, microcephaly, cerebellar hypoplasia, B lymphocyte deficiency, and progressive pancytopenia. Pediatrics. 105(3):E39 (abstract)
Rolink, AG., Schaniel, C., Busslinger, M., Nutt, SL., Melchers, F. (2000). Fidelity and infidelity in commitment to B-lymphocyte lineage development. Immunol Rev. 175:104-11 (abstract)

1999

Czerny, T., Halder, G., Kloter, U., Souabni, A., Gehring, WJ., Busslinger, M. (1999). twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol Cell. 3(3):297-307 (abstract)
Eberhard, D., Busslinger, M. (1999). The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. Cancer Res. 59(7 Suppl):1716s-1724s; discussion 1724s-1725s (abstract)
Nutt, SL., Busslinger, M. (1999). Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Biol Chem. 380(6):601-11 (abstract)
Nutt, SL., Heavey, B., Rolink, AG., Busslinger, M. (1999). Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 401(6753):556-62 (abstract)
Nutt, SL., Rolink, AG., Busslinger, M. (1999). The molecular basis of B-cell lineage commitment. Cold Spring Harb Symp Quant Biol. 64:51-9 (abstract)
Nutt, SL., Vambrie, S., Steinlein, P., Kozmik, Z., Rolink, A., Weith, A., Busslinger, M. (1999). Independent regulation of the two Pax5 alleles during B-cell development. Nat Genet. 21(4):390-5 (abstract)
Rolink, AG., Nutt, SL., Melchers, F., Busslinger, M. (1999). Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature. 401(6753):603-6 (abstract)
Rolink, A., Nutt, S., Busslinger, M., ten Boekel, E., Seidl, T., Andersson, J., Melchers, F. (1999). Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene. Cold Spring Harb Symp Quant Biol. 64:21-5 (abstract)
Schwarz, M., Alvarez-Bolado, G., Dressler, G., Urbánek, P., Busslinger, M., Gruss, P. (1999). Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech Dev. 82(1-2):29-39 (abstract)

1998

Busslinger, M., Nutt, SL. (1998). Role of the transcription factor BSAP [Pax-5] in B-cell development. Molecular Biology of B-Cell and T-Cell Development (eds. Monroe, JG., Rothenberg, EV.). :83-110
Macchia, PE., Lapi, P., Krude, H., Pirro, MT., Missero, C., Chiovato, L., Souabni, A., Baserga, M., Tassi, V., Pinchera, A., Fenzi, G., Grüters, A., Busslinger, M., Di Lauro, R. (1998). PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet. 19(1):83-6 (abstract)
Morrison, AM., Jäger, U., Chott, A., Schebesta, M., Haas, OA., Busslinger, M. (1998). Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma. Blood. 92(10):3865-78 (abstract)
Morrison, AM., Nutt, SL., Thévenin, C., Rolink, A., Busslinger, M. (1998). Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation. Semin Immunol. 10(2):133-42 (abstract)
Nutt, SL., Morrison, AM., Dörfler, P., Rolink, A., Busslinger, M. (1998). Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J. 17(8):2319-33 (abstract)
Pfeffer, PL., Gerster, T., Lun, K., Brand, M., Busslinger, M. (1998). Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development. 125(16):3063-74 (abstract)
Thévenin, C., Nutt, SL., Busslinger, M. (1998). Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis. J Exp Med. 188(4):735-44 (abstract)

1997

Brandt, WF., Schwager, SU., Rodrigues, JA., Busslinger, M. (1997). Isolation and amino acid sequence analysis reveal an ancient evolutionary origin of the cleavage stage (CS) histones of the sea urchin. Eur J Biochem. 247(3):784-91 (abstract)
Chlichlia, K., Busslinger, M., Peter, ME., Walczak, H., Krammer, PH., Schirrmacher, V., Khazaie, K. (1997). ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death. Oncogene. 14(19):2265-72 (abstract)
Czerny, T., Bouchard, M., Kozmik, Z., Busslinger, M. (1997). The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 subfamily. Mech Dev. 67(2):179-92 (abstract)
De Monte, L., Thienes, CP., Monticelli, S., Busslinger, M., Gould, HJ., Vercelli, D. (1997). Regulation of human epsilon germline transcription: role of B-cell-specific activator protein. Int Arch Allergy Immunol. 113(1-3):35-8 (abstract)
Kozmik, Z., Czerny, T., Busslinger, M. (1997). Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. EMBO J. 16(22):6793-803 (abstract)
Mandl, B., Brandt, WF., Superti-Furga, G., Graninger, PG., Birnstiel, ML., Busslinger, M. (1997). The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins. Mol Cell Biol. 17(3):1189-200 (abstract)
Nutt, SL., Thévenin, C., Busslinger, M. (1997). Essential functions of Pax-5 (BSAP) in pro-B cell development. Immunobiology. 198(1-3):227-35 (abstract)
Nutt, SL., Urbánek, P., Rolink, A., Busslinger, M. (1997). Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev. 11(4):476-91 (abstract)
Schwarz, M., Alvarez-Bolado, G., Urbánek, P., Busslinger, M., Gruss, P. (1997). Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc Natl Acad Sci U S A. 94(26):14518-23 (abstract)
Thienes, CP., De Monte, L., Monticelli, S., Busslinger, M., Gould, HJ., Vercelli, D. (1997). The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter. J Immunol. 158(12):5874-82 (abstract)
Urbánek, P., Fetka, I., Meisler, MH., Busslinger, M. (1997). Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Proc Natl Acad Sci U S A. 94(11):5703-8 (abstract)

1996

Busslinger, M., Klix, N., Pfeffer, P., Graninger, PG., Kozmik, Z. (1996). Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci U S A. 93(12):6129-34 (abstract)
Dörfler, P., Busslinger, M. (1996). C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8. EMBO J. 15(8):1971-82 (abstract)
Fialka, I., Schwarz, H., Reichmann, E., Oft, M., Busslinger, M., Beug, H. (1996). The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol. 132(6):1115-32 (abstract)
Reimer, K., Urbánek, P., Busslinger, M., Ehret, G. (1996). Normal brainstem auditory evoked potentials in Pax5-deficient mice despite morphologic alterations in the auditory midbrain region. Audiology. 35(1):55-61 (abstract)

1995

Bergers, G., Graninger, P., Braselmann, S., Wrighton, C., Busslinger, M. (1995). Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol Cell Biol. 15(7):3748-58 (abstract)
Busslinger, M., Urbánek, P. (1995). The role of BSAP (Pax-5) in B-cell development. Curr Opin Genet Dev. 5(5):595-601 (abstract)
Chlichlia, K., Moldenhauer, G., Daniel, PT., Busslinger, M., Gazzolo, L., Schirrmacher, V., Khazaie, K. (1995). Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis. Oncogene. 10(2):269-77 (abstract)
Czerny, T., Busslinger, M. (1995). DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol Cell Biol. 15(5):2858-71 (abstract)
Kozmik, Z., Sure, U., Rüedi, D., Busslinger, M., Aguzzi, A. (1995). Deregulated expression of PAX5 in medulloblastoma. Proc Natl Acad Sci U S A. 92(12):5709-13 (abstract)
Reikerstorfer, A., Holz, H., Stunnenberg, HG., Busslinger, M. (1995). Low affinity binding of interleukin-1 beta and intracellular signaling via NF-kappa B identify Fit-1 as a distant member of the interleukin-1 receptor family. J Biol Chem. 270(30):17645-8 (abstract)
Stapleton, P., Kozmik, Z., Weith, A., Busslinger, M. (1995). The gene coding for the B cell surface protein CD19 is localized on human chromosome 16p11. Hum Genet. 95(2):223-5 (abstract)
Vorechovský, I., Koskinen, S., Paganelli, R., Smith, CI., Busslinger, M., Hammarström, L. (1995). The PAX5 gene: a linkage and mutation analysis in candidate human primary immunodeficiencies. Immunogenetics. 42(2):149-52 (abstract)

1994

Bergers, G., Reikerstorfer, A., Braselmann, S., Graninger, P., Busslinger, M. (1994). Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 13(5):1176-88 (abstract)
Busslinger, M., Bergers, G. (1994). Identification of AP-1-regulated genes. The Fos and Jun families of transcription factors (eds. Angel, PE., Herrlich, PA.). :133-50
Liao, F., Birshtein, BK., Busslinger, M., Rothman, P. (1994). The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription. J Immunol. 152(6):2904-11 (abstract)
Schäfer, BW., Czerny, T., Bernasconi, M., Genini, M., Busslinger, M. (1994). Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes. Nucleic Acids Res. 22(22):4574-82 (abstract)
Urbánek, P., Wang, ZQ., Fetka, I., Wagner, EF., Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell. 79(5):901-12 (abstract)
Vorechovský, I., Kozmík, Z., Hammarström, L., Smith, CI., Busslinger, M. (1994). An intragenic TaqI RFLP at the PAX5 locus. Hum Mol Genet. 3(4):681 (abstract)
Vorechovský, I., Kurzbauer, R., Kozmík, Z., Hammarström, L., Smith, CI., Busslinger, M. (1994). SSCP/SacI polymorphism in the PAX5 gene. Hum Mol Genet. 3(5):839 (abstract)

1993

Braselmann, S., Graninger, P., Busslinger, M. (1993). A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci U S A. 90(5):1657-61 (abstract)
Czerny, T., Schaffner, G., Busslinger, M. (1993). DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7(10):2048-61 (abstract)
Kozmik, Z., Kurzbauer, R., Dörfler, P., Busslinger, M. (1993). Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol. 13(10):6024-35 (abstract)
Stapleton, P., Weith, A., Urbánek, P., Kozmik, Z., Busslinger, M. (1993). Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet. 3(4):292-8 (abstract)
Wrighton, C., Busslinger, M. (1993). Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts. Mol Cell Biol. 13(8):4657-69 (abstract)

1992

Adams, B., Dörfler, P., Aguzzi, A., Kozmik, Z., Urbánek, P., Maurer-Fogy, I., Busslinger, M. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6(9):1589-607 (abstract)
Braselmann, S., Bergers, G., Wrighton, C., Graninger, P., Superti-Furga, G., Busslinger, M. (1992). Identification of Fos target genes by the use of selective induction systems. J Cell Sci Suppl. 16:97-109 (abstract)
Busslinger, MI., Kaiser, G. (1992). Surgical significance of the duplex kidney with bifid ureter. Eur J Pediatr Surg. 2(3):150-1 (abstract)
Kozmik, Z., Wang, S., Dörfler, P., Adams, B., Busslinger, M. (1992). The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol Cell Biol. 12(6):2662-72 (abstract)
Reichmann, E., Schwarz, H., Deiner, EM., Leitner, I., Eilers, M., Berger, J., Busslinger, M., Beug, H. (1992). Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell. 71(7):1103-16 (abstract)

1991

Superti-Furga, G., Bergers, G., Picard, D., Busslinger, M. (1991). Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc Natl Acad Sci U S A. 88(12):5114-8 (abstract)

1990

Barberis, A., Widenhorn, K., Vitelli, L., Busslinger, M. (1990). A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 4(5):849-59 (abstract)

1989

Barberis, A., Superti-Furga, G., Busslinger, M. (1989). The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa. Nucleic Acids Res. 17(17):7114 (abstract)
Barberis, A., Superti-Furga, G., Vitelli, L., Kemler, I., Busslinger, M. (1989). Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin. Genes Dev. 3(5):663-75 (abstract)
Birnstiel, ML., Busslinger, M. (1989). Dangerous liaisons: spermatozoa as natural vectors for foreign DNA? Cell. 57(5):701-2 (abstract)
Birnstiel, ML., Busslinger, M. (1989). Further liaisons with sperm. Science. 245(4915):243-4 (abstract)
Southgate, C., Busslinger, M. (1989). In vivo and in vitro expression of U7 snRNA genes: cis- and trans-acting elements required for RNA polymerase II-directed transcription. EMBO J. 8(2):539-49 (abstract)
Superti-Furga, G., Barberis, A., Schreiber, E., Busslinger, M. (1989). The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts. Biochim Biophys Acta. 1007(2):237-42 (abstract)

1988

Cosson, J., Kemler, I., Tanno, S., Busslinger, M. (1988). Promoter of a somatic histone H2B gene of the sea urchin. Nucleic Acids Res. 16(9):4175 (abstract)
Superti-Furga, G., Barberis, A., Schaffner, G., Busslinger, M. (1988). The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene. EMBO J. 7(10):3099-107 (abstract)
Vitelli, L., Kemler, I., Lauber, B., Birnstiel, ML., Busslinger, M. (1988). Developmental regulation of micro-injected histone genes in sea urchin embryos. Dev Biol. 127(1):54-63 (abstract)

1987

Barberis, A., Superti-Furga, G., Busslinger, M. (1987). Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell. 50(3):347-59 (abstract)

1986

Kemler, I., Busslinger, M. (1986). Characterization of two nonallelic pairs of late histone H2A and H2B genes of the sea urchin: differential regulation in the embryo and tissue-specific expression in the adult. Mol Cell Biol. 6(11):3746-54 (abstract)

1985

Birnstiel, ML., Busslinger, M., Strub, K. (1985). Transcription termination and 3' processing: the end is in site! Cell. 41(2):349-59 (abstract)
Busslinger, M., Barberis, A. (1985). Synthesis of sperm and late histone cDNAs of the sea urchin with a primer complementary to the conserved 3' terminal palindrome: evidence for tissue-specific and more general histone gene variants. Proc Natl Acad Sci U S A. 82(17):5676-80 (abstract)
Busslinger, M., Schümperli, D., Birnstiel, ML. (1985). Regulation of histone gene expression. Cold Spring Harb Symp Quant Biol. 50:665-70 (abstract)

1984

Strub, K., Galli, G., Busslinger, M., Birnstiel, ML. (1984). The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing. EMBO J. 3(12):2801-7 (abstract)

1983

Busslinger, M., deBoer, E., Wright, S., Grosveld, FG., Flavell, RA. (1983). The sequence GGCmCGG is resistant to MspI cleavage. Nucleic Acids Res. 11(11):3559-69 (abstract)
Busslinger, M., Flavell, RA. (1983). DNA methylation and the regulation of globin gene expression. Prog Clin Biol Res. 134:193-203 (abstract)
Busslinger, M., Hurst, J., Flavell, RA. (1983). DNA methylation and the regulation of globin gene expression. Cell. 34(1):197-206 (abstract)
Flavell, RA., Grosveld, F., Busslinger, M., de Boer, E., Kioussis, D., Mellor, AL., Golden, L., Weiss, E., Hurst, J., Bud, H., Bullman, H., Simpson, E., James, R., Townsend, AR., Taylor, PM., Schmidt, W., Ferluga, J., Leben, L., Santamaria, M., Atfield, G., Festenstein, H. (1983). Structure and expression of the human globin genes and murine histocompatibility antigen genes. Cold Spring Harb Symp Quant Biol. 47 Pt 2:1067-78 (abstract)

1982

Flavell, RA., Bud, H., Bullman, H., Busslinger, M., deBoer, E., deKleine, A., Golden, L., Groffen, J., Grosveld, FG., Mellor, AL., Moschonas, N., Weiss, E. (1982). The structure and expression of mammalian gene clusters. Prog Clin Biol Res. 103 Pt A:37-55 (abstract)
Flavell, RA., Moschonas, NK., deBoer, E., Grosveld, GC., Busslinger, M., Dahl, HH., Grosveld, FG. (1982). Phenotypic analysis of globin gene expression: the thalassaemias. Prog Clin Biol Res. 85 Pt A:25-39 (abstract)
Grosveld, F., Busslinger, M., Grosveld, G., Groffen, J., DeKleine, A., Flavell, RA. (1982). The structure and expression of the haemoglobin genes. Adv Exp Med Biol. 158:65-80 (abstract)

1981

Busslinger, M., Moschonas, N., Flavell, RA. (1981). Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Cell. 27(2 Pt 1):289-98 (abstract)

1980

Busslinger, M., Portmann, R., Irminger, JC., Birnstiel, ML. (1980). Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants. Nucleic Acids Res. 8(5):957-77 (abstract)

1979

Busslinger, M., Portmann, R., Birnsteil, ML. (1979). A regulatory sequence near the 3' end of sea urchin histone genes. Nucleic Acids Res. 6(9):2997-3008 (abstract)

1978

Birnstiel, ML., Kressmann, A., Schaffner, W., Portmann, R., Busslinger, M. (1978). Aspects of the regulation of histone genes. Philos Trans R Soc Lond B Biol Sci. 283(997):319-24 (abstract)

1976

Cherry, RJ., Bürkli, A., Busslinger, M., Schneider, G., Parish, GR. (1976). Rotational diffusion of band 3 proteins in the human erythrocyte membrane. Nature. 263(5576):389-93 (abstract)