Peters Group
Jan-Michael Peters (Scientific Deputy Director, Senior Scientist)
Mitosis and chromosome biology
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To pass the genome from one generation to the next, eukaryotic cells first replicate their DNA, then biorient chromosomes on the mitotic spindle and finally separate their sister chromatids, enabling division of one cell into two genetically identical daughter cells. We are interested in understanding these processes at the molecular level.
Selected Publications
- Hutchins, JR., Toyoda, Y., Hegemann, B., Poser, I., Hériché, JK., Sykora, MM., Augsburg, M., Hudecz, O., Buschhorn, BA., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, MM., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, AA., Peters, JM. (2010). Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 328(5978):593-9 (abstract)
- Nishiyama, T., Ladurner, R., Schmitz, J., Kreidl, E., Schleiffer, A., Bhaskara, V., Bando, M., Shirahige, K., Hyman, AA., Mechtler, K., Peters, JM. (2010). Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 143(5):737-49 (abstract)
- Herzog, F., Primorac, I., Dube, P., Lenart, P., Sander, B., Mechtler, K., Stark, H., Peters, JM. (2009). Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science. 323(5920):1477-81 (abstract) (fulltext)
- Wendt, KS., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., Yahata, K., Imamoto, F., Aburatani, H., Nakao, M., Imamoto, N., Maeshima, K., Shirahige, K., Peters, JM. (2008). Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 451(7180):796-801 (abstract)
- Kueng, S., Hegemann, B., Peters, BH., Lipp, JJ., Schleiffer, A., Mechtler, K., Peters, JM. (2006). Wapl controls the dynamic association of cohesin with chromatin. Cell. 127(5):955-67 (abstract)
To mark the 10th anniversary of Developmental Cell, the journal has introduced a series of ‘PaperPicks’. In these, editorial board members pick a paper that they particularly liked. Angelika Amon chose the 2007 Dev Cell paper from Jan Peters’ group. Here she explains why and Jan Peters talks about the implications of their findings:
http://www.cell.com/developmental-cell/abstract/S1534-5807(11)00175-4
