Pavri Group

Rushad Pavri (Group Leader)


PhD 2006, University of Medicine and Dentistry of New Jersey
Postdoctoral Research at Rockefeller University, New York
Group Leader at the IMP Vienna since 2013
Scientific CV in PDF format

Molecular mechanisms of antibody diversification

In our lab, we study the phenomenon of antibody gene diversification in B lymphocytes - the process by which the immune system generates a vast repertoire of high-affinity antibodies essential to combat pathogenic challenges. We focus on the transcriptional and co-transcriptional mechanisms underlying these events using a combination of RNAi screening, genetic models, and genomic analysis.

Selected Publications

  • Pavri, R., Nussenzweig, MC. (2011). AID targeting in antibody diversity. Adv Immunol. 110:1-26 (abstract)
  • Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., Reina San-Martin, B., Barreto, V., Nieland, TJ., Root, DE., Casellas, R., Nussenzweig, MC. (2010). Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell. 143(1):122-33 (abstract)
  • Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., Reinberg, D. (2006). Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 125(4):703-17 (abstract)
  • Pavri, R., Lewis, B., Kim, TK., Dilworth, FJ., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. (2005). PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell. 18(1):83-96 (abstract)