Marlovits Group

Thomas Marlovits (joint IMP-IMBA Group Leader)

PhD 1997, University of Vienna
Postdoctoral Research at University of Vienna, MPI of Biophysics & Yale University
Group Leader at the IMP/IMBA Vienna since 2005
Professor of Structural and Systems Biology since 2013
Deputy Director of CSSB-Centre for Structural Systems Biology, Hamburg, since 2014
Scientific CV in PDF format

Molecular Machines

Membrane-associated processes are a fundamental characteristic of all living cells. They ensure that the cells are able to effectively communicate with, and adapt to, their environment. The cells achieve this by either physically translocating molecules to the opposite site of a membrane, or by receiving, transmitting, and amplifying incoming signals. Our laboratory is interested in understanding the molecular mechanism underlying such processes. Specifically, we focus on machineries capable of translocating bacterial toxins into eukaryotic cells.

Selected Publications

  • DiMaio, F., Song, Y., Li, X., Brunner, MJ., Xu, C., Conticello, V., Egelman, E., Marlovits, TC., Cheng, Y., Baker, D. (2015). Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement. Nat Methods. 12(4):361-5 (abstract)
  • Radics, J., Königsmaier, L., Marlovits, TC. (2014). Structure of a pathogenic type 3 secretion system in action. Nat Struct Mol Biol. 21(1):82-7 (abstract)
  • Schraidt, O., Marlovits, TC. (2011). Three-dimensional model of Salmonella's needle complex at subnanometer resolution. Science. 331(6021):1192-5 (abstract)
  • Wagner, S., Königsmaier, L., Lara-Tejero, M., Lefebre, M., Marlovits, TC., Galán, JE. (2010). Organization and coordinated assembly of the type III secretion export apparatus. Proc Natl Acad Sci U S A. 107(41):17745-50 (abstract)
  • Marlovits, TC., Kubori, T., Lara-Tejero, M., Thomas, D., Unger, VM., Galán, JE. (2006). Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature. 441(7093):637-40 (abstract)