Busslinger Group
Meinrad Busslinger (Senior Scientist)
(Email)
PostDoc positions available!
Applicants please send an email to meinrad.busslinger(at)imp.ac.at
Stem cell commitment in hematopoiesis
Acquired immunity to pathogens depends on the differentiation of B and T lymphocytes from hematopoietic stem cells, which is controlled by a multitude of transcription factors. We are interested in understanding the process by which transcription factors regulate the commitment of early hematopoietic progenitors to lymphoid lineages and control their subsequent differentiation to B and T cells. We investigate the underlying transcriptional control mechanisms by using mouse
transgenic, cell biological, and genome-wide molecular approaches.
Selected Publications
- Malin, S., McManus, S., Cobaleda, C., Novatchkova, M., Delogu, A., Bouillet, P., Strasser, A., Busslinger, M. (2010). Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 11(2):171-9 (abstract)
- Decker, T., Pasca di Magliano, M., McManus, S., Sun, Q., Bonifer, C., Tagoh, H., Busslinger, M. (2009). Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity. 30(4):508-20 (abstract)
- Kwon, K., Hutter, C., Sun, Q., Bilic, I., Cobaleda, C., Malin, S., Busslinger, M. (2008). Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity. 28(6):751-62 (abstract)
- Cobaleda, C., Jochum, W., Busslinger, M. (2007). Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature. 449(7161):473-7 (abstract)
- Cobaleda, C., Schebesta, A., Delogu, A., Busslinger, M. (2007). Pax5: the guardian of B cell identity and function. Nat Immunol. 8(5):463-70 (abstract)
