Tissue-restricted stem cells give rise to the different cell types of an organ by undergoing commitment to and subsequent differentiation along distinct lineages. By using a combination of mouse transgenic, cell biological and molecular approaches, we investigate the mechanisms by which transcription factors such as Pax5, E2A, Notch1 and GATA3 control the commitment of early hematopoietic progenitors to the lymphoid lineages.
Malin, S., McManus, S., Cobaleda, C., Novatchkova, M., Delogu, A., Bouillet, P., Strasser, A., Busslinger, M. (2010). Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Nat Immunol. 11(2):171-9
(abstract)
2009
Decker, T., Pasca di Magliano, M., McManus, S., Sun, Q., Bonifer, C., Tagoh, H., Busslinger, M. (2009). Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.
Immunity. 30(4):508-20
(abstract)
2008
Kwon, K., Hutter, C., Sun, Q., Bilic, I., Cobaleda, C., Malin, S., Busslinger, M. (2008). Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Immunity. 28(6):751-62
(abstract)
2007
Cobaleda, C., Jochum, W., Busslinger, M. (2007). Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.
Nature. 449(7161):473-7
(abstract)
Cobaleda, C., Schebesta, A., Delogu, A., Busslinger, M. (2007). Pax5: the guardian of B cell identity and function.
Nat Immunol. 8(5):463-70
(abstract)
Projects & Memberships
Member of The Epigenome Network of Excellence - NoE (2004-2009) EU 6th Framework Programme
Epigenetic Plasticity of the Mammalian Genome a joint research project funded by GEN-AU (GENome Research in AUstria) with the goal to build an epigenetic map of the mouse genome
EuTRACC (integrated project within the EU 6th Framework Programme)
