To pass the genome from one generation to the next, eukaryotic cells first replicate their DNA, then biorient chromosomes on the mitotic spindle, and finally separate their sister chromatids, thus enabling division of one cell into two genetically identical daughter cells. We are interested in understanding these processes at the molecular level.
Hutchins, JR., Toyoda, Y., Hegemann, B., Poser, I., Hériché, JK., Sykora, MM., Augsburg, M., Hudecz, O., Buschhorn, BA., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, MM., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, AA., Peters, JM. (2010). Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science. 328(5978):593-9
(abstract)
2009
Herzog, F., Primorac, I., Dube, P., Lenart, P., Sander, B., Mechtler, K., Stark, H., Peters, JM. (2009). Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Science. 323(5920):1477-81
(abstract)
(fulltext)
2008
Wendt, KS., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., Yahata, K., Imamoto, F., Aburatani, H., Nakao, M., Imamoto, N., Maeshima, K., Shirahige, K., Peters, JM. (2008). Cohesin mediates transcriptional insulation by CCCTC-binding factor.
Nature. 451(7180):796-801
(abstract)
2007
Lénárt, P., Petronczki, M., Steegmaier, M., Di Fiore, B., Lipp, JJ., Hoffmann, M., Rettig, WJ., Kraut, N., Peters, JM. (2007). The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.
Curr Biol. 17(4):304-15
(abstract)
Petronczki, M., Glotzer, M., Kraut, N., Peters, JM. (2007). Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Dev Cell. 12(5):713-25
(abstract)
Projects & Memberships
"MitoCheck" (an integrated research project on cell cycle control within the 6th Framework Program (FP6) of the European Union)
EuroDyna web page (The EuroDyna Programme has been launched by the European Science Foundation in the year 2005.)
