Busslinger Group
Meinrad Busslinger (Senior Scientist)
(Email)
PostDoc & Technician position available!
Stem cell commitment in hematopoiesis
Acquired immunity to pathogens depends on the differentiation of B and T lymphocytes from hematopoietic stem cells, which is controlled by a multitude of transcription factors. We are interested in understanding the process by which transcription factors regulate the commitment of early hematopoietic progenitors to lymphoid lineages and control their subsequent differentiation to B and T cells. We investigate the underlying transcriptional control mechanisms by using mouse
transgenic, cell biological, and genome-wide molecular approaches.
Selected Publications
- Vilagos, B., Hoffmann, M., Souabni, A., Sun, Q., Werner, B., Medvedovic, J., Bilic, I., Minnich, M., Axelsson, E., Jaritz, M., Busslinger, M. (2012). Essential role of EBF1 in the generation and function of distinct mature B cell types. J Exp Med. (abstract)
- Ebert, A., McManus, S., Tagoh, H., Medvedovic, J., Salvagiotto, G., Novatchkova, M., Tamir, I., Sommer, A., Jaritz, M., Busslinger, M. (2011). The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity. 34(2):175-87 (abstract)
- Medvedovic, J., Ebert, A., Tagoh, H., Busslinger, M. (2011). Pax5: a master regulator of B cell development and leukemogenesis. Adv Immunol. 111:179-206 (abstract)
- Malin, S., McManus, S., Cobaleda, C., Novatchkova, M., Delogu, A., Bouillet, P., Strasser, A., Busslinger, M. (2010). Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 11(2):171-9 (abstract)
- Cobaleda, C., Jochum, W., Busslinger, M. (2007). Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature. 449(7161):473-7 (abstract)
