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The Molecular Basis of Migration
One of the most remarkable aspects of life, whether it be a single cell or a multicellular organism, is the ability to move. This is even more astounding when one considers that this movement is frequently equipped with directionality. Whether it be a migratory bird that crosses continents, or a cell that inches forward a micrometer at a time, both have a drive, a direction and a destination. What molecular mechanisms underlie this migration? I am investigating two very different forms of migration: (1) the migration of neurons; and (2) the migration of animals mediated by magnetic fields.
Braun, A., Breuss, M., Salzer, MC., Flint, J., Cowan, NJ., Keays, DA. (2010). Tuba8 is expressed at low levels in the developing mouse and human brain.
Am J Hum Genet. 86(5):819-22; author reply 822-3
(abstract)
2009
Jaglin, XH., Poirier, K., Saillour, Y., Buhler, E., Tian, G., Bahi-Buisson, N., Fallet-Bianco, C., Phan-Dinh-Tuy, F., Kong, XP., Bomont, P., Castelnau-Ptakhine, L., Odent, S., Loget, P., Kossorotoff, M., Snoeck, I., Plessis, G., Parent, P., Beldjord, C., Cardoso, C., Represa, A., Flint, J., Keays, DA., Cowan, NJ., Chelly, J. (2009). Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.
Nat Genet. 41(6):746-52
(abstract)
2008
Tian, G., Kong, XP., Jaglin, XH., Chelly, J., Keays, D., Cowan, NJ. (2008). A pachygyria-causing alpha-tubulin mutation results in inefficient cycling with CCT and a deficient interaction with TBCB.
Mol Biol Cell. 19(3):1152-61
(abstract)
2007
Keays, DA., Tian, G., Poirier, K., Huang, GJ., Siebold, C., Cleak, J., Oliver, PL., Fray, M., Harvey, RJ., Molnár, Z., Piñon, MC., Dear, N., Valdar, W., Brown, SD., Davies, KE., Rawlins, JN., Cowan, NJ., Nolan, P., Chelly, J., Flint, J. (2007). Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.
Cell. 128(1):45-57
(abstract)
